Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft tissue sarcomas

CONCLUSIONS: These results support the safety and activity of intratumorally-delivered, collagen-anchoring cytokines for inflammatory polarization of the canine soft tissue sarcoma tumor microenvironment. We are further evaluating the efficacy of this approach in additional canine cancers, including oral malignant melanoma.PMID:37014656 | DOI:10.1158/1078-0432.CCR-23-0006

Source: Clinical Cancer Research - April 4, 2023 Category: Cancer & Oncology Authors: Jordan A Stinson Allison Sheen Noor Momin Jordan Hampel Rebecca Bernstein Rebecca Kamerer Bahaa Fadl-Alla Jonathan Samuelson Elizabeth Fink Timothy M Fan K Dane Wittrup Source Type: research