Cutaneous involvement as an initial presentation of disseminated cryptococcosis in a renal allograft recipient
(Source: Infection)
Source: Infection - March 1, 2024 Category: Infectious Diseases Source Type: research
Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over 100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to clinical trials. In preclinical studies, mice vaccinated with an attenuated strain of C. neoformans deleted of three cryptococcal chitin deacetylases (Cn-cda1Δ2Δ3Δ) were protected against a lethal challenge with C. neoformans strain KN99. While Cn-cda1Δ2Δ3Δ extended the survival of mice infected with C. gattii strain R265 compared to unvaccinated groups, we were unable to demonstrate fungal clearance as robust as that seen following KN99 challenge...
Source: Frontiers in Immunology - February 26, 2024 Category: Allergy & Immunology Source Type: research
Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis
AbstractPurpose of ReviewThis review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who improve but suffer from a recurrence of symptoms. This scenario is well known to those who frequently care for patients with cryptococcal meningitis but is not well understood. We highlight major gaps in knowledge.Recent FindingsWe recently summarized our experience with 28 persons with paradoxical immune reconstitution inflammatory syndrome (IRIS) and 81 persons with microbiological relapse. CD4 count and cerebrospinal fluid white blood cell count were higher in IRIS than ...
Source: Current HIV/AIDS Reports - February 24, 2024 Category: Infectious Diseases Source Type: research
Disseminated nocardiosis and anti-GM-CSF antibodies
We report an apparently immunocompetent woman presenting with disseminated nocardiosis without any evidence of PAP. Clinical data and radiological images were retrospectively collected. Lymphocyte populations were analyzed by flow cytometry. Anti-GM-CSF autoantibodies were measured by ELISA. A 55-year-old otherwise healthy woman presented with cerebral and pulmonary abscesses. Personal and familial history of infections or autoimmunity were negative. After extensive examinations, a final diagnosis of disseminated nocardiosis was made. Immunologic investigations including neutrophilic function and IFN- γ/IL-12 circuitry fa...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 20, 2024 Category: Microbiology Source Type: research
Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.PMID:38368645 | DOI:10.1016/j.ijmm.2024.151614 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - February 18, 2024 Category: Microbiology Authors: Johanna Kessel Anna-Catharina Rossaert Tilman Lingscheid Jan Grothe Thomas Harrer Christoph Wyen Daniela Tominski T Bollinger Anna Katharina Kehr Sven Kalbitz Christian Hoffmann Oliver Cornely Uwe Koppe Christoph Stephan Volker Rickerts Source Type: research
Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.PMID:38368645 | DOI:10.1016/j.ijmm.2024.151614 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - February 18, 2024 Category: Microbiology Authors: Johanna Kessel Anna-Catharina Rossaert Tilman Lingscheid Jan Grothe Thomas Harrer Christoph Wyen Daniela Tominski T Bollinger Anna Katharina Kehr Sven Kalbitz Christian Hoffmann Oliver Cornely Uwe Koppe Christoph Stephan Volker Rickerts Source Type: research
Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.PMID:38368645 | DOI:10.1016/j.ijmm.2024.151614 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - February 18, 2024 Category: Microbiology Authors: Johanna Kessel Anna-Catharina Rossaert Tilman Lingscheid Jan Grothe Thomas Harrer Christoph Wyen Daniela Tominski T Bollinger Anna Katharina Kehr Sven Kalbitz Christian Hoffmann Oliver Cornely Uwe Koppe Christoph Stephan Volker Rickerts Source Type: research
Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.PMID:38368645 | DOI:10.1016/j.ijmm.2024.151614 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - February 18, 2024 Category: Microbiology Authors: Johanna Kessel Anna-Catharina Rossaert Tilman Lingscheid Jan Grothe Thomas Harrer Christoph Wyen Daniela Tominski T Bollinger Anna Katharina Kehr Sven Kalbitz Christian Hoffmann Oliver Cornely Uwe Koppe Christoph Stephan Volker Rickerts Source Type: research
Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.PMID:38368645 | DOI:10.1016/j.ijmm.2024.151614 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - February 18, 2024 Category: Microbiology Authors: Johanna Kessel Anna-Catharina Rossaert Tilman Lingscheid Jan Grothe Thomas Harrer Christoph Wyen Daniela Tominski T Bollinger Anna Katharina Kehr Sven Kalbitz Christian Hoffmann Oliver Cornely Uwe Koppe Christoph Stephan Volker Rickerts Source Type: research
COVID-19 associated with cryptococcosis: a scoping review
CONCLUSION: Cryptococcosis in COVID-19 patients has been reported more frequently. However, it is still not as common as other fungal infections associated with COVID-19. Few patients have some classic immunosuppression factors. The factors associated with mortality were male sex, age, ICU admission, MV, secondary infections, and lymphopenia.PMID:38361915 | PMC:PMC10868154 | DOI:10.1177/20499361241232851 (Source: Adv Data)
Source: Adv Data - February 16, 2024 Category: Epidemiology Authors: Alvaro Quincho-Lopez Nuvith Poma Juan Jos é Montenegro-Idrogo Source Type: research
COVID-19 associated with cryptococcosis: a scoping review
CONCLUSION: Cryptococcosis in COVID-19 patients has been reported more frequently. However, it is still not as common as other fungal infections associated with COVID-19. Few patients have some classic immunosuppression factors. The factors associated with mortality were male sex, age, ICU admission, MV, secondary infections, and lymphopenia.PMID:38361915 | PMC:PMC10868154 | DOI:10.1177/20499361241232851 (Source: Adv Data)
Source: Adv Data - February 16, 2024 Category: Epidemiology Authors: Alvaro Quincho-Lopez Nuvith Poma Juan Jos é Montenegro-Idrogo Source Type: research
Rapid Cryptococcus electroporated-lysis and sensitive detection on a miniaturized platform
Biosens Bioelectron. 2024 Apr 15;250:116096. doi: 10.1016/j.bios.2024.116096. Epub 2024 Feb 1.ABSTRACTFast and accurate detection of Cryptococcus and precise differentiation of its subtypes is of great significance in protecting people from cryptococcal disease and preventing its spread in populations. However, traditional Cryptococcus identification and detection techniques still face significant challenges in achieving high analysis speed as well as high sensitivity. In this work, we report an electric microfluidic biochip. Compared to conventional methods that take several hours or even a day, this chip can detect Crypt...
Source: Biosensors and Bioelectronics - February 5, 2024 Category: Biotechnology Authors: Xiangzhu Kong Long Cheng Zaizai Dong Yemei Huang Xinying Xue Zhiying Wang Yusen Wang Xuelei Zang Haisheng Qian Lingqian Chang Yang Wang Source Type: research
Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review
With the development of society, pulmonary fungal diseases, represented by pulmonary aspergillosis and pulmonary cryptococcosis, have become increasingly common. However, there is a lack of clear understanding... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 16, 2024 Category: Infectious Diseases Authors: Xidong Wang, Shaoqiang Li, Mangui Zhu, Ye Qiu, Yilei Hui, Yongming Li, Yangqing Zhan, Yan Wang, Feng Ye and Zhengtu Li Tags: Research Source Type: research
In vitro characterization and molecular epidemiology of Cryptococcus spp. isolates from non-HIV patients in Guangdong, China
ConclusionPhenotypically variant and non-wild-type strains were found in Guangdong, and a significant proportion of these strains had MIC values near the ECV values towards the 6 antifungal drugs, and resistance was observed for 4 out of 6 drugs. The molecular type was highly homogeneous but compositionally diverse, with rare types found. Enhanced surveillance of the aetiology and evolution and continuous monitoring of antifungal susceptibility are needed to provide references for decision-making in the health sector and optimization of disease prevention and control. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 15, 2024 Category: Microbiology Source Type: research
