Fungicide-tolerant persister formation during cryptococcal pulmonary infection
Cell Host Microbe. 2024 Feb 14;32(2):276-289.e7. doi: 10.1016/j.chom.2023.12.012. Epub 2024 Jan 11.ABSTRACTBacterial persisters, a subpopulation of genetically susceptible cells that are normally dormant and tolerant to bactericides, have been studied extensively because of their clinical importance. In comparison, much less is known about the determinants underlying fungicide-tolerant fungal persister formation in vivo. Here, we report that during mouse lung infection, Cryptococcus neoformans forms persisters that are highly tolerant to amphotericin B (AmB), the standard of care for treating cryptococcosis. By exploring s...
Source: Cell Host and Microbe - January 12, 2024 Category: Microbiology Authors: Weixin Ke Yuyan Xie Yingying Chen Hao Ding Leixin Ye Haoning Qiu Hao Li Lanyue Zhang Lei Chen Xiuyun Tian Zhenghao Shen Zili Song Xin Fan Jian-Fa Zong Zhengyan Guo Xiaoyu Ma Meng Xiao Guojian Liao Cui Hua Liu Wen-Bing Yin Zhiyang Dong Feng Yang Yuan-Ying Source Type: research
GSE233619 Fungicide-tolerant persister formation during cryptococcal pulmonary infection
Contributors : Weixin Ke ; Yingying Chen ; Yuyan Xie ; Linqi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans var. grubii H99Bacterial persisters, a subpopulation of genetically susceptible cells that are normally dormant and tolerant to bactericides, have been studied extensively because of their clinical importance. In comparison, much less is known about the determinants underlying fungicide-tolerant fungal persister formation in vivo. Here, we report that during mouse lung infection, Cryptococcus neoformans forms persisters that are highly tolerant to amphoteric...
Source: GEO: Gene Expression Omnibus - January 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cryptococcus neoformans var. grubii H99 Source Type: research
Benign Presentation Of A Fatal Infection In Heart Transplant Patient
We present a case of cryptococcal meningitis in a heart transplant recipient who survived after an unusual initial presentation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Mohil Garg, Phillip Lam, Richa Gupta, Farooq Sheikh, Maria E. Rodrigo Tags: 306 Source Type: research
Cryptococcosis in oncology patients: a case series in a tertiary care cancer centre
Iran J Microbiol. 2023 Dec;15(6):821-825. doi: 10.18502/ijm.v15i6.14163.ABSTRACTCryptococcosis, a relatively uncommon infection in cancer patients is often associated with delayed diagnosis and high fatality rate due to its highly heterogeneous and protean manifestations. Early recognition and initiation of appropriate antifungal therapy might have a favourable outcome in such cases. Here we report three cases of Cryptococcosis among cancer patients in a tertiary care cancer centre in South India. All three patients were males of different ages at presentation with immunosuppression in the form of solid organ or hematologi...
Source: Iranian Journal of Microbiology - December 29, 2023 Category: Microbiology Authors: Sagila Savithri Gangadharan Swapna Raveendranath Source Type: research
