Using laboratory data to assess the impact of coronavirus (COVID-19) on reflex cryptococcal antigenaemia (CrAg) testing in South Africa
by Naseem Cassim, Lindi Marie Coetzee, Manuel Pedro da Silva, Wendy Susan Stevens, Deborah Kim Glencross
BackgroundCoronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. Due to the rapid spread globally, it was declared a pandemic in March 2020. Social distancing and lockdown measures were introduced to limit transmission. These strategies could potentially impact the diagnosis and treatment of patients with advanced HIV who are susceptible to secondary infections like cryptococcal disease. In South Africa, reflexed cryptococcal antige...
Source: PLoS One - September 28, 2023 Category: Biomedical Science Authors: Naseem Cassim Source Type: research
Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis < em > in vivo < /em >
Antimicrob Agents Chemother. 2023 Sep 26:e0045923. doi: 10.1128/aac.00459-23. Online ahead of print.ABSTRACTCryptococcus neoformans (Cn) is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococcal meningoencephalitis (CME) in humans. Recommended treatment for CME is Amphotericin B (AmpB) and 5-fluorocytosine (5-FC). Though effective, AmpB has displayed numerous adverse side effects due to its potency and nephrotoxicity, prompting investigation into alternative treatments. Palmitoylethanolamide (PEA) is an immunomodulatory compound capable of promoting neuroprotection and reducing inflammation. To...
Source: Antimicrobial Agents and Chemotherapy - September 26, 2023 Category: Microbiology Authors: Melissa E Munzen Marta Reguera Gomez Mohamed F Hamed Vanessa Enriquez Claudia L Charles-Ni ño Michael R Dores Karina Alvi ña Luis R Martinez Source Type: research
Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis < em > in vivo < /em >
Antimicrob Agents Chemother. 2023 Sep 26:e0045923. doi: 10.1128/aac.00459-23. Online ahead of print.ABSTRACTCryptococcus neoformans (Cn) is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococcal meningoencephalitis (CME) in humans. Recommended treatment for CME is Amphotericin B (AmpB) and 5-fluorocytosine (5-FC). Though effective, AmpB has displayed numerous adverse side effects due to its potency and nephrotoxicity, prompting investigation into alternative treatments. Palmitoylethanolamide (PEA) is an immunomodulatory compound capable of promoting neuroprotection and reducing inflammation. To...
Source: Antimicrobial Agents and Chemotherapy - September 26, 2023 Category: Microbiology Authors: Melissa E Munzen Marta Reguera Gomez Mohamed F Hamed Vanessa Enriquez Claudia L Charles-Ni ño Michael R Dores Karina Alvi ña Luis R Martinez Source Type: research
Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis < em > in vivo < /em >
Antimicrob Agents Chemother. 2023 Sep 26:e0045923. doi: 10.1128/aac.00459-23. Online ahead of print.ABSTRACTCryptococcus neoformans (Cn) is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococcal meningoencephalitis (CME) in humans. Recommended treatment for CME is Amphotericin B (AmpB) and 5-fluorocytosine (5-FC). Though effective, AmpB has displayed numerous adverse side effects due to its potency and nephrotoxicity, prompting investigation into alternative treatments. Palmitoylethanolamide (PEA) is an immunomodulatory compound capable of promoting neuroprotection and reducing inflammation. To...
Source: Antimicrobial Agents and Chemotherapy - September 26, 2023 Category: Microbiology Authors: Melissa E Munzen Marta Reguera Gomez Mohamed F Hamed Vanessa Enriquez Claudia L Charles-Ni ño Michael R Dores Karina Alvi ña Luis R Martinez Source Type: research
Meningeal cryptococcosis and SARS-CoV-2 infection in people living with HIV/AIDS
CONCLUSIONS: No statistically significant differences were observed between the two groups (A and B) considering: intracranial hypertension, presence of Cryptococcus antigens in cerebrospinal fluid, sensorium deterioration or mortality. The detection of Cryptococcus antigens in serum by lateral flow assay was highly effective to rapidly diagnose cryptococcosis in patients with HIV/AIDS who also developed COVID-19. Patients of both groups consulted for cryptoccocosis sometime after, in comparison with the pre-pandemic cases related to this infection.PMID:37721913 | DOI:10.7705/biomedica.6872 (Source: Biomedica : Revista del...
Source: Biomedica : Revista del Instituto Nacional de Salud - September 18, 2023 Category: International Medicine & Public Health Authors: Fernando Antonio Messina Andr és Benchetrit Andrea Bocassi Mar ía de Las Mercedes Romero Sof ía Bauer Emmanuel Mar ín Facundo Bertera Guillermo Onis Mat ías Enzenhofer Milagro S ánchez Lilia Mammana Dana Mijalovsky Gabriela Santiso Source Type: research
