Cutaneous Naganishia albida (Cryptococcus albidus) infection: a case report and literature review
We describe a case of an immunocompetent older male with cutaneous cryptococcosis caused by Naganishia albida following skin trauma, and conduct a literature review in PubMed, Lilacs, and Embase. Only six previous similar reports were found. The seven cases (including ours) were widely distributed geographically (Brazil, the US, the UK, Hungary, South Korea, and Iran), all males, and their ages varied, ranging from 14 to 86 years. Four individuals had underlying skin diseases (Sezary Syndrome, psoriasis, and skin rash without etiology) plus potentially immunosuppressive underlying conditions (diabetes mellitus, kidney tran...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - December 6, 2023 Category: Tropical Medicine Authors: V ítor Falcão de Oliveira Alexandre Pereira Funari Mariane Taborda Adriana Satie Gon çalves Kono Magri Anna Sara Levin Marcello Mihailenko Chaves Magri Source Type: research
Cutaneous Naganishia albida (Cryptococcus albidus) infection: a case report and literature review
We describe a case of an immunocompetent older male with cutaneous cryptococcosis caused by Naganishia albida following skin trauma, and conduct a literature review in PubMed, Lilacs, and Embase. Only six previous similar reports were found. The seven cases (including ours) were widely distributed geographically (Brazil, the US, the UK, Hungary, South Korea, and Iran), all males, and their ages varied, ranging from 14 to 86 years. Four individuals had underlying skin diseases (Sezary Syndrome, psoriasis, and skin rash without etiology) plus potentially immunosuppressive underlying conditions (diabetes mellitus, kidney tran...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - December 6, 2023 Category: Tropical Medicine Authors: V ítor Falcão de Oliveira Alexandre Pereira Funari Mariane Taborda Adriana Satie Gon çalves Kono Magri Anna Sara Levin Marcello Mihailenko Chaves Magri Source Type: research
Cutaneous cryptococcosis in an adult male of sub-saharan origin
Rameshwari Thakur, Avneet Singh Kalsi, Pragya KushwahaIndian Journal of Sexually Transmitted Diseases and AIDS 2023 44(2):161-163Cryptococcosis is caused by the inhalation of the desiccated encapsulated yeast or basidiospores, which are found in the environment. After the infectious particles reach the lungs, get disseminated hematogenously in various organs. Meningoencephalitis is one of the most common manifestations, especially in sub-Saharan Africa. The dermal lesions can be either primary due to the traumatic implantation of infectious propagule or secondary in patients with disseminated infection due to cryptococcus....
Source: Indian Journal of Sexually Transmitted Diseases - December 6, 2023 Category: Infectious Diseases Authors: Rameshwari Thakur Avneet Singh Kalsi Pragya Kushwaha Source Type: research
Diagnosis and management of cryptococcal meningitis in HIV-infected adults
Clin Microbiol Rev. 2023 Nov 28:e0015622. doi: 10.1128/cmr.00156-22. Online ahead of print.ABSTRACTSUMMARYCryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of all deaths related to advanced HIV disease, with the burden of disease predominantly experienced by people in resource-limited countries. Major advancements in diagnostics have introduced low-cost, easy-to-use antigen tests with remarkably high sensitivity and specificity. These tests have led to improved diagnostic accuracy and are esse...
Source: Clinical Microbiology Reviews - November 28, 2023 Category: Microbiology Authors: Thomas C McHale David R Boulware John Kasibante Kenneth Ssebambulidde Caleb P Skipper Mahsa Abassi Source Type: research
Diagnosis and management of cryptococcal meningitis in HIV-infected adults
Clin Microbiol Rev. 2023 Nov 28:e0015622. doi: 10.1128/cmr.00156-22. Online ahead of print.ABSTRACTSUMMARYCryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of all deaths related to advanced HIV disease, with the burden of disease predominantly experienced by people in resource-limited countries. Major advancements in diagnostics have introduced low-cost, easy-to-use antigen tests with remarkably high sensitivity and specificity. These tests have led to improved diagnostic accuracy and are esse...
Source: Clinical Microbiology Reviews - November 28, 2023 Category: Microbiology Authors: Thomas C McHale David R Boulware John Kasibante Kenneth Ssebambulidde Caleb P Skipper Mahsa Abassi Source Type: research
Macrophages-derived exo-miR-4449 induced by Cryptococcus affects HUVEC permeability and promotes pyroptosis in BEAS-2B via the HIC1 pathway
In this study, we investigated the changes of microRNAs in macrophage exosomes (exo-miRNAs) in cryptococcal infections and the role of markedly altered exo-miRNAs in the modulation of Human Umbilical Vein Endothelial Cells (HUVEC) permeability and ROS accumulation and pyroptosis in Human Bronchial Epithelioid Cells (BEAS-2B). Techniques such as microarray analysis and real-time quantitative PCR were used to detect different exo-miRNAs and to screen for the most highly expressed exo-miRNAs. Then its mimics were transfected into HUVEC to study its effect on the monolayer permeability of HUVEC. Finally, the relationship betwe...
Source: Cytokine - November 23, 2023 Category: Molecular Biology Authors: Xiaohua Li Junping Xu Xin Lin Qiong Lin Tianxing Yu Lin Chen Lifang Chen Xiaoqing Huang Xueping Zhang Geng Chen Liyu Xu Source Type: research
Macrophages-derived exo-miR-4449 induced by Cryptococcus affects HUVEC permeability and promotes pyroptosis in BEAS-2B via the HIC1 pathway
In this study, we investigated the changes of microRNAs in macrophage exosomes (exo-miRNAs) in cryptococcal infections and the role of markedly altered exo-miRNAs in the modulation of Human Umbilical Vein Endothelial Cells (HUVEC) permeability and ROS accumulation and pyroptosis in Human Bronchial Epithelioid Cells (BEAS-2B). Techniques such as microarray analysis and real-time quantitative PCR were used to detect different exo-miRNAs and to screen for the most highly expressed exo-miRNAs. Then its mimics were transfected into HUVEC to study its effect on the monolayer permeability of HUVEC. Finally, the relationship betwe...
Source: Cytokine - November 23, 2023 Category: Molecular Biology Authors: Xiaohua Li Junping Xu Xin Lin Qiong Lin Tianxing Yu Lin Chen Lifang Chen Xiaoqing Huang Xueping Zhang Geng Chen Liyu Xu Source Type: research
Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report
We report a case of endobronchial cryptococcosis during ICS treatment for uncontrolled asthma, highlighting the importance of paying attention to central airway lesions during ICS treatment for asthma. AbstractCryptococcosis typically manifests as pulmonary lesions, with endobronchial lesions occurring rarely. Inhaled corticosteroids (ICS) may be a risk factor for cryptococcosis of the larynx but not of the bronchi. Here, we report a case involving a 73-year-old Japanese man who developed endobronchial cryptococcosis during ICS treatment for asthma. Chest computed tomography showed right mainstem bronchial stenosis and ast...
Source: Respirology Case Reports - November 18, 2023 Category: Respiratory Medicine Authors: Jun Sasaki,
Takashi Kinoshita,
Misa Sudou,
Takayuki Horii,
Reiko Takaki,
Masahiro Mitsuoka,
Masaki Tominaga,
Tomotaka Kawayama,
Tomoaki Hoshino Tags: CASE REPORT Source Type: research
Serum sphingolipids aid in diagnosing adult HIV-negative patients with pulmonary cryptococcosis: a clinical cohort study
CONCLUSIONS: This is the first study to report the use of the SPL Cer (d18:1/18:0) as a serum biomarker for diagnosing Cryptococcus spp. infection in HIV-negative patients.PMID:37969309 | PMC:PMC10636466 | DOI:10.21037/jtd-23-125 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 16, 2023 Category: Respiratory Medicine Authors: Lee-Fong Yau Wai-Him Chan Yuan-Xiang Li Yang-Qing Zhan Jie Huang Xin-Qing Lin Shao-Qiang Li Jing-Lu Yang Hu-Dan Pan Xi-Dong Wang Ye Qiu Gao-Neng Fang Zhi-Hong Jiang Feng Ye Jing-Rong Wang Zheng-Tu Li Source Type: research
