Q & A With FDA Commissioner Robert Califf
After serving as commissioner of the US Food and Drug Administration (FDA) under President Obama, Robert M. Califf, MD, recently returned to the role, overseeing a critical federal agency that regulates food, drugs, therapeutics, and medical devices in the US. In a wide-ranging discussion with JAMA Deputy Editor Gregory Curfman, MD, Califf discusses COVID-19 vaccine modifications, the FDA’s approach to evaluating evidence, and efforts to combat health misinformation. Recorded April 26, 2022. Related Content: (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - May 4, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 896: Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Sc...
Source: This Week in Virology - MP3 Edition - May 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for Vaccine in Young Children Filed (Moderna) Public Health Impact of Vaccines in US (BMJ) FDA authorizes first approved t...
Source: This Week in Virology - MP3 Edition - April 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: COVID and diabetes, what the science says
The true disability cost of the COVID-19 pandemic is still unknown, but more and more studies are adding to the list of potential fallout from even mild COVID 19 infection. In this episode of Coronapod we discuss a massive association study which links COVID-19 cases with an increase in the risk of developing type 2 diabetes. We delve into the numbers to ask how big the risk might be? Whether any casual relationship can be drawn from this association? And what might be in store from future research into COVID and chronic disease?News: Diabetes risk rises after COVID, massive study finds See acast.com/privacy...
Source: Nature Podcast - April 29, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune response to booster, 5-11 year olds (Pfizer) Children and vaccination (AAP) Hospitalization of 5-11 year olds (MMWR) Test usin...
Source: This Week in Virology - MP3 Edition - April 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Reducing “COVID-19 Misinformation” While Preserving Free Speech
Misinformation about COVID-19 (such as around vaccines, masks, and ineffective drugs) has circulated widely during the pandemic, and much of this misinformation is protected by the Free Speech Clause of the First Amendment. Professor of Surgery and Perioperative Care and Professor of Law William M. Sage, MD, JD, from the University of Texas at Austin, is interviewed in this JAMA podcast. Related Content: Reducing “COVID-19 Misinformation” While Preserving Free Speech (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - April 19, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 890: Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Ce...
Source: This Week in Virology - MP3 Edition - April 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospital admissions during Omicron and Delta variant outbreaks (Lancet) Viral load in unvaccinat...
Source: This Week in Virology - MP3 Edition - April 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Quality improvement and wellbeing are inextricably linked
Over the course of the last few years, the BMJ has published a series of articles in our Quality Improvement series - aiming to give those new to improvement science a good grasp of how to think about changing things in healthcare.
Then covid-19 came along, and it seemed like all of healthcare was now aimed at just surviving in the face of the pandemic, and all thoughts of quality improvement projects went out the window... But did they?
Cat Chatfield, is joined by Will Warburton, former director of quality improvement at t he Health Foundation, and advisor on the series.To read all of the open access articles mentioned...
Source: The BMJ Podcast - April 15, 2022 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Quality improvement and wellbeing are inextricably linked
Over the course of the last few years, the BMJ has published a series of articles in our Quality Improvement series - aiming to give those new to improvement science a good grasp of how to think about changing things in healthcare.
Then covid-19 came along, and it seemed like all of healthcare was now aimed at just surviving in the face of the pandemic, and all thoughts of quality improvement projects went out the window... But did they?
Cat Chatfield, is joined by Will Warburton, former director of quality improvement at the Health Foundation, and advisor on the series.
To read all of the open access articles mentioned...
Source: The BMJ Podcast - April 15, 2022 Category: General Medicine Authors: BMJ Group Source Type: podcasts
TWiV 888: Molnupiravir with Richard Plemper
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferrets (Nat Commun) Letters read on TWiV 888 Timestamps by Jolene. Thanks! Weekly Picks Brianne – BioRender Poster Builder A...
Source: This Week in Virology - MP3 Edition - April 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Are medicines that block interleukin ‐1 (a protein involved in immune responses) effective treatments for COVID‐19 and do they cause unwanted effects?
Cochrane is producing a growing series of reviews on the care of patients with COVID-19. In January 2022, we published a new review of a group of treatments called interleukin-1 blocking agents and we asked lead author, Mauricia Davidson from Cochrane France, to tell us about the findings. (Source: Podcasts from The Cochrane Library)
Source: Podcasts from The Cochrane Library - April 11, 2022 Category: General Medicine Authors: Cochrane Source Type: podcasts
JAMA Neurology : Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients With COVID-19
Interview with Cheng-Ying Ho, MD, PhD, author of Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients With COVID-19. Hosted by Cynthia E. Armand, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - April 11, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
TWiV 887: Bonfire of the monocytes
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 variant (bioRxiv) Scott Henley on influenza vaccine growth in eggs (TWiV 480) Fc receptor dependent entry of SARS-CoV-2 into ...
Source: This Week in Virology - MP3 Edition - April 10, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine does in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MMWR) Long COVID in children (Future Med) Fourth vaccine dose in Israel (NEJM) No need for fourth vaccine dose (Eur Med Agency)...
Source: This Week in Virology - MP3 Edition - April 9, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
