TWiV 964: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incide...
Source: This Week in Virology - MP3 Edition - December 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
COVID deaths: three times the official toll
In this episode:00:47 Estimating pandemic-associated mortalityThis week, a team of researchers working with the World Health Organization have used statistical modelling to estimate the number of excess deaths associated with the COVID-19 pandemic in 2020 and 2021. The work estimates that there were almost 15 million deaths either directly or indirectly attributed to the pandemic, almost three times higher than the official toll.Research article: Msemburi et al.News and Views: Global estimates of excess deaths from COVID-19Editorial: Missing data mean we’ll probably never know how many people died of COVID08:35 Research ...
Source: Nature Podcast - December 14, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 963: Feline coronavirus with Gary Whittaker
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease. Hosts: Vincent Racaniello Guest: Gary Whittaker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe) TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature) Distinct spike proteins of feline coronaviruses (Viruses) Feline coronavirus and feline infectious peritonitis (J...
Source: This Week in Virology - MP3 Edition - December 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 959: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for...
Source: This Week in Virology - MP3 Edition - December 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Talk Evidence - endometriosis, falling, and better EBM
In this month's episode, Helen Juan and Joe delve into the clinical - with a new review of endometriosis, and why the difficulty in diagnosis has lead to a dearth of evidence and attention on the condition.
Joe tells us about a risk prediction tool that could be useful in helping to mitigate some of the problems of antihypertensive treatments.
We're also having a geek out about a group of papers we've published lately, on how well evidence is created, maintained, and diseminated.
Reading list;
Development and external validation of a risk prediction model for falls in patients with an indication for antihypertensive t...
Source: The BMJ Podcast - December 2, 2022 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Talk Evidence - endometriosis, falling, and better EBM
In this month's episode, Helen Juan and Joe delve into the clinical - with a new review of endometriosis, and why the difficulty in diagnosis has lead to a dearth of evidence and attention on the condition.
Joe tells us about a risk prediction tool that could be useful in helping to mitigate some of the problems of antihypertensive treatments.
We're also having a geek out about a group of papers we've published lately, on how well evidence is created, maintained, and diseminated.
Reading list;
Development and external validation of a risk prediction model for falls in patients with an indication for antihypertensive t...
Source: The BMJ Podcast - December 2, 2022 Category: General Medicine Authors: BMJ Group Source Type: podcasts
TWiV 957: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospit...
Source: This Week in Virology - MP3 Edition - November 26, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 955: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccina...
Source: This Week in Virology - MP3 Edition - November 19, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 952: Jake Scott put the ID in COVID-19
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron variant reproduction ex vivo (Nature) Clinical outcomes with Omicron (Nat Med) Low neutralizing antibodies induced by bivalent booster (NEJM) Antibody responses to bivalent booster (bioRxiV...
Source: This Week in Virology - MP3 Edition - November 6, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 952: Jake Scott put the ID in COVID-19
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Omicron variant reproduction ex vivo (Nature) Clinical outcomes with Omicron (Nat Med) Low neutralizing antibodies i...
Source: This Week in Virology - MP3 Edition - November 6, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 951: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, lo...
Source: This Week in Virology - MP3 Edition - November 5, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 949: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity a...
Source: This Week in Virology - MP3 Edition - October 29, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Racism in Health: the harms of biased medicine
When COVID-19 hit it didn't kill indiscriminately. In the US, being Black, Hispanic, or Native American meant you had a much greater risk of death than if you were white. And these disparities are mirrored across the world.In this episode we explore the complex tale behind this disparity. Throughout history, racism and biases have been embedded within medical technology, along the clinicians who use it. Cultural concepts of race have been falsely conflated with biology. The way medicine is taught, has reinforced flawed stereotypes. Disease itself, has been racialised. All of this adds up to barriers to care and worse healt...
Source: Nature Podcast - October 28, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Ivermectin for Mild to Moderate COVID-19, Persistent Symptoms Following COVID-19, Review of Hypercalcemia, and more
Editors' Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief of JAMA, the Journal of the American Medical Association, for the October 25, 2022, issue. (Source: JAMA: This Week's Audio Commentary)
Source: JAMA: This Week's Audio Commentary - October 25, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 948: Breathless with David Quammen
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Boston Quammens (TWiV 408) Breathless by David Quammen Spillover by David Quammen Song of the Dodo by David Quammen Timestamps by Jolene. Thanks! Weekly Picks David – Shepherd Brianne – Adventure Aquarium Kathy â€...
Source: This Week in Virology - MP3 Edition - October 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
