TWiV 997: Inside Omicron with Mohsan Saeed
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Mohsan Saeed Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • Spike and nsp6 determinants of Omicron attenuation (Nature) •China releases genomic data from Wuhan market (Science) •Timestamps by Jolene. Thanks! Weekly Picks Rich – For pian...
Source: This Week in Virology - MP3 Edition - April 2, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 996: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-f...
Source: This Week in Virology - MP3 Edition - April 1, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 994: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital ...
Source: This Week in Virology - MP3 Edition - March 25, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Higher-Dose Ivermectin for Outpatients With COVID-19, Trends in Cardiovascular Risk Factor Prevalence and Control in US Adults, Review of Chronic Lymphocytic Leukemia, and more
Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief of JAMA, the Journal of the American Medical Association, for the March 21, 2023 issue. (Source: JAMA: This Week's Audio Commentary)
Source: JAMA: This Week's Audio Commentary - March 21, 2023 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 993: COVID-19 drives autoimmunity
TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol) •Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) •Letters read on TWiV 993 •Timestamps by Jolene. Tha...
Source: This Week in Virology - MP3 Edition - March 19, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 992: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thr...
Source: This Week in Virology - MP3 Edition - March 18, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 990: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 inf...
Source: This Week in Virology - MP3 Edition - March 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 989: Antibody cross-reactivity is metal
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) •Cross-protective mAbs against respiratory viruses (Nat Comm) •RSV prefusion F protein vaccine in older adults (NEJM) •Ad26.RSV.preF–RSV preF protein vaccine (NEJM) •Let...
Source: This Week in Virology - MP3 Edition - March 5, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 988: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six ch...
Source: This Week in Virology - MP3 Edition - March 4, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 987: Convalescing with Casadevall
Arturo Casadevall returns to TWiV to explain the use of convalescent serum to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Arturo Casadevall Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 MicrobeTV Discord Server Early treatment of COVID-19 with convalescent plasma (NEJM) Neutralization of SARS-CoV-2 by convalescent plasma (Nat Comm) Convalescent COVID-19 plasma for immunocompromised patients (JAMA N...
Source: This Week in Virology - MP3 Edition - February 26, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 986: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients ...
Source: This Week in Virology - MP3 Edition - February 25, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected,...
Source: This Week in Virology - MP3 Edition - February 18, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Are corticosteroids (anti-inflammatory medicines) given orally or by injection an effective treatment for people with COVID-19?
Cochrane has produced a series of reviews relevant to the COVID-19 pandemic and is keeping these up-to-date in light of new evidence. In November 2022, we published the second version of a living systematic review on systemic corticosteroids and, in this podcast, the first authors, Mirko Griesel of the University of Leipzig Medical Center and Carina Wagner of the University Hospital in Cologne in Germany, talk about the evidence they ’ve found and the potential effects of these drugs. (Source: Podcasts from The Cochrane Library)
Source: Podcasts from The Cochrane Library - February 13, 2023 Category: General Medicine Authors: Cochrane Source Type: podcasts
TWiV 982: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillu...
Source: This Week in Virology - MP3 Edition - February 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 908: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of c...
Source: This Week in Virology - MP3 Edition - February 4, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
