The 11 < sup > th < /sup > Conference on metal toxicity and carcinogenesis
Toxicol Appl Pharmacol. 2024 Apr 20:116935. doi: 10.1016/j.taap.2024.116935. Online ahead of print.ABSTRACTMetal exposure is linked to numerous pathological outcomes including cancer, cardiovascular disease, and diabetes. Over the past decades, we have made significant progress in our understanding of how metals are linked to disease, but there is still much to learn. In October 2022, experts studying the consequences of metal exposures met in Montréal, Québec, to discuss recent advances and knowledge gaps for future research. Here, we present a summary of presentations and discussions had at the meeting.PMID:38648938 | ...
Source: Toxicology and Applied Pharmacology - April 22, 2024 Category: Toxicology Authors: Koren K Mann Ke Jian Lu Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
The 11 < sup > th < /sup > Conference on metal toxicity and carcinogenesis
Toxicol Appl Pharmacol. 2024 Apr 20:116935. doi: 10.1016/j.taap.2024.116935. Online ahead of print.ABSTRACTMetal exposure is linked to numerous pathological outcomes including cancer, cardiovascular disease, and diabetes. Over the past decades, we have made significant progress in our understanding of how metals are linked to disease, but there is still much to learn. In October 2022, experts studying the consequences of metal exposures met in Montréal, Québec, to discuss recent advances and knowledge gaps for future research. Here, we present a summary of presentations and discussions had at the meeting.PMID:38648938 | ...
Source: Toxicology and Applied Pharmacology - April 22, 2024 Category: Toxicology Authors: Koren K Mann Ke Jian Lu Source Type: research
C/EBP β: A transcription factor associated with the irreversible progression of Alzheimer's disease
CONCLUSION: The overexpression of C/EBPβ accelerates the irreversible progression of AD pathophysiology. Additionally, C/EBPβ plays a crucial role in mediating multiple pathways linked to AD pathology, some of which engender vicious cycles, leading to the establishment of feedback mechanisms. To sum up, targeting C/EBPβ could hold promise as a therapeutic strategy not only for AD but also for other degenerative diseases.PMID:38644578 | PMC:PMC11033503 | DOI:10.1111/cns.14721 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Qing Yao Chubing Long Pengcheng Yi Guangyong Zhang Wei Wan Xiuqin Rao Jun Ying Weidong Liang Fuzhou Hua Source Type: research
The emerging therapies are reshaping the first-line treatment for advanced hepatocellular carcinoma: a systematic review and network meta-analysis
CONCLUSION: Compared with sorafenib and lenvatinib, combination therapies based on ICIs significantly improved the prognosis of advanced HCC and demonstrated similar safety. At the same time, the optimal treatment approach should be tailored to individual patient characteristics, such as etiology, tumor staging, and serum alpha-fetoprotein levels. With lower incidence rates of treatment-related adverse events and non-inferior efficacy compared to sorafenib, ICI monotherapies should be prioritized as a first-line treatment approach for patients who are not suitable candidates for ICI-combined therapies.TRIAL REGISTRATION: P...
Source: Adv Data - April 22, 2024 Category: Epidemiology Authors: Wei Peng Yangxun Pan Lan Xie Zhoutian Yang Zhiwei Ye Jinbin Chen Juncheng Wang Dandan Hu Li Xu Zhongguo Zhou Minshan Chen Aiping Fang Yaojun Zhang Source Type: research
The 11 < sup > th < /sup > Conference on metal toxicity and carcinogenesis
Toxicol Appl Pharmacol. 2024 Apr 20:116935. doi: 10.1016/j.taap.2024.116935. Online ahead of print.ABSTRACTMetal exposure is linked to numerous pathological outcomes including cancer, cardiovascular disease, and diabetes. Over the past decades, we have made significant progress in our understanding of how metals are linked to disease, but there is still much to learn. In October 2022, experts studying the consequences of metal exposures met in Montréal, Québec, to discuss recent advances and knowledge gaps for future research. Here, we present a summary of presentations and discussions had at the meeting.PMID:38648938 | ...
Source: Toxicology and Applied Pharmacology - April 22, 2024 Category: Toxicology Authors: Koren K Mann Ke Jian Lu Source Type: research
Systematic review of the efficacy of stereotactic ablative radiotherapy for oligoprogressive disease in metastatic cancer
CONCLUSIONS: SABR appears to have clinical benefit in oligoprogresssive prostate, lung, and renal patients. However, the optimal management of patients with oligoprogressive disease is still somewhat uncertain due to lack of prospective data. This will hopefully become clearer in the near future with the publication of further randomised trials.PMID:38648995 | DOI:10.1016/j.radonc.2024.110288 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 22, 2024 Category: Radiology Authors: Emma Doyle Angus J Killean Stephen Harrow Iain D Phillips Source Type: research
Remote neuropsychological assessment of patients with neurological disorders and injuries--a study protocol for a cross-sectional case-control validation study
This study protocol describes a cross-sectional study aimed at validating the newly developed digitalized neuropsychological test battery Mindmore Remote in patients with neurological disorders and injuries. Diagnoses comprise traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, brain tumour and epilepsy. 50 patients in each patient group will be included. In addition, 50 healthy controls will be recruited. All participants will undergo both testing with Mindmore Remote at home and traditional neuropsychological assessment face-to-face in a randomised order. The primary outcome is the association ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Berginström, N., Andersson, L. Tags: Open access, Neurology Source Type: research
Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial
Introduction
Cancer-related cognitive impairment is common among people diagnosed with and treated for cancer. This can be a distressing and disabling side effect for impacted individuals. Interventions to mitigate cognitive dysfunction are available, but, to date, most have been trialled in samples that are largely or exclusively composed of people with solid tumours. Intervention strategies to support cognitive functioning are needed, but there is a paucity of research in this area. The main aim of this study is to test the feasibility and acceptability of methods and procedures intended for use in a definitive trial of ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Gates, P., Green, H. J., Gough, K., Dhillon, H., Vardy, J. L., Dickinson, M., Guarnera, J., Krishnasamy, M., Livingston, P. M., White, V., Ugalde, A., Caeyenberghs, K. Tags: Open access, Haematology (incl blood transfusion) Source Type: research
An underrecognized association: immune checkpoint inhibitor-related aortitis, a case report with the review of the literature
AbstractImmune-checkpoint inhibitors (ICIs) are considered as the novel treatment modality in certain cancers. They may soon be used widely even as the first-line option for cancer treatment due to their remarkable efficacies and impacts on survival rates, particularly in cases of advanced metastatic cancer. Of note, these agents might unveil new autoimmune diseases as well as causing flare-ups of a pre-existing autoimmune disease. Data in this field have been accumulated during recent years. Early detection and a collaborative approach are, therefore, crucial in the management of a patient who presents with any of these c...
Source: International Cancer Conference Journal - April 22, 2024 Category: Cancer & Oncology Source Type: research
Renal pelvic plasmacytoid subtype urothelial carcinoma accompanied with solitary mammary metastasis
AbstractA 72-year-old female was referred to our institution for further evaluation of right renal tumor detected during work-up for macroscopic hematuria in other hospital. CT urography performed at our institution suggested renal pelvic tumor. Voiding cytology was atypical. CT also revealed a small mass in the right mammary gland. Percutaneous needle biopsies were performed on the right mammary gland and renal mass, leading to a pathological diagnosis of UC with plasmacytoid subtype, suggesting metastasis from the renal pelvic UC to the mammary gland. She had a favorable response to four cycles of dose-dense MVAC therapy...
Source: International Cancer Conference Journal - April 22, 2024 Category: Cancer & Oncology Source Type: research
Successful curative treatment for a ruptured pancreatic acinar cell carcinoma by radical resection following modified FOLFIRINOX: a case report and literature review
AbstractPancreatic acinar cell carcinoma (PACC) is a rare pancreatic tumor type, and ruptured pancreatic tumors are rarer. Computed tomography (CT) in a 48-year-old man incidentally revealed a raptured pancreatic tail tumor. The patient was treated conservatively because he was asymptomatic, and his general condition was stable. After a detailed examination, the pancreatic tumor was diagnosed as raptured PACC. Considering the potential infiltration of tumor cells into the hematoma within the omental sac, our decision is to initiate chemotherapy as the primary course of action. A liquid biopsy was performed, and comprehensi...
Source: International Cancer Conference Journal - April 22, 2024 Category: Cancer & Oncology Source Type: research
Advocate from Home for Medicare Payment Reform on Capitol Hill
As ACR leaders and volunteers visit Capitol Hill to advocate for stabilizing Medicare physician payment rates, you can join the effort from anywhere. Send your lawmakers a message today through the Legislative Action Center. (Source: The Rheumatologist)
Source: The Rheumatologist - April 21, 2024 Category: Rheumatology Authors: From the College Tags: Legislation & Advocacy Advocacy Leadership Conference Source Type: research
Planning Travel to State Rheumatology Conferences
Much more than just CME, state society meetings offer a way to expand your professional network, explore what other states are working on and even build in some leisure time or family activities. (Source: The Rheumatologist)
Source: The Rheumatologist - April 20, 2024 Category: Rheumatology Authors: Joseph Cantrell, JD Tags: Education & Training Professional Topics state society Source Type: research
Isolation and characterization of novel degradation products in Fenoverine by LC-QTOF-MS/MS, LC-MSn and 2D-NMR
This study investigates the degradation profile of Fenoverine (FEN), an antispasmodic drug, following the International Conference on Harmonization (ICH) Q1A (R2) guidelines. FEN is stable in the presence of light,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 20, 2024 Category: Chemistry Authors: Krishnam Raju CH Source Type: research
