Functional therapy and adenotonsillectomy clinical trial for class II malocclusion (FACT-II): protocol for a randomised controlled trial
This study is approved by the Ethics Committee of the School and Hospital of Stomatology, Wuhan University (no. 2022-D07). The research findings will be faithfully disseminated through scientific conferences or published articles.
Trial registration number
ChiCTR2200061703 (https://www.chictr.org.cn). (Source: BMJ Open)
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Guo, F., Lv, C., Tang, B., Lin, L., Zhang, C., Zheng, J., Zhao, T., He, H. Tags: Open access, Dentistry and oral medicine Source Type: research
Protocol for an independent patient data meta-analysis of prophylactic mesh placement for incisional hernia prevention after abdominal aortic aneurysm surgery: a collaborative European Hernia Society project (I-PREVENT-AAA)
Introduction
Incisional hernia (IH) is a prevalent and potentially dangerous complication of abdominal surgery, especially in high-risk groups. Mesh reinforcement of the abdominal wall has been studied as a potential intervention to prevent IHs. Randomised controlled trials (RCTs) have demonstrated that prophylactic mesh reinforcement after abdominal surgery, in general, is effective and safe. In patients with abdominal aortic aneurysm (AAA), prophylactic mesh reinforcement after open repair has not yet been recommended in official guidelines, because of relatively small sample sizes in individual trials. Furthermore, the ...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: van den Berg, R., den Hartog, F. P. J., Bali, C., Matsagkas, M., Bevis, P. M., Earnshaw, J. J., Debus, E. S., Honig, S., Berrevoet, F., Detry, O., Stabilini, C., Muysoms, F., Tanis, P. J., European Hernia Society Prophylactic mesh study group collaborator Tags: Open access, Surgery Source Type: research
Cost-effectiveness of a radio intervention to stimulate early childhood development: protocol for an economic evaluation of the SUNRISE trial in Burkina Faso
Introduction
Approximately 250 million children under 5 years of age are at risk of poor development in low-income and middle-income countries. However, existing early childhood development (ECD) interventions can be expensive, labour intensive and challenging to deliver at scale. Mass media may offer an alternative approach to ECD intervention. This protocol describes the planned economic evaluation of a cluster-randomised controlled trial of a radio campaign promoting responsive caregiving and opportunities for early learning during the first 3 years of life in rural Burkina Faso (SUNRISE trial).
Methods and analysis
Th...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Palmer, T., Clare, A., Fearon, P., Head, R., Hill, Z., Kagone, B., Kirkwood, B., Manu, A., Skordis, J., on behalf of the SUNRISE team Tags: Open access, Health economics Source Type: research
Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol
This study will evaluate the efficacy of 4CMenB against N. gonorrhoeae infection in men (cis and trans), transwomen and non-binary people who have sex with men (hereafter referred to as GBM+).
Methods and analysis
This is a double-blind, randomised placebo-controlled trial in GBM+, either HIV-negative on pre-exposure prophylaxis against HIV or living with HIV (CD4 count >350 cells/mm3), who have had a diagnosis of gonorrhoea or infectious syphilis in the last 18 months (a key characteristic associated with a high risk of N. gonorrhoeae infection). Participants are randomised 1:1 to receive two doses of 4CMenB or placeb...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Seib, K. L., Donovan, B., Thng, C., Lewis, D. A., McNulty, A., Fairley, C. K., Yeung, B., Jin, F., Fraser, D., Bavinton, B. R., Law, M., Chen, M. Y., Chow, E. P. F., Whiley, D. M., Mackie, B., Jennings, M. P., Jennison, A. V., Lahra, M. M., Grulich, A. E. Tags: Open access, Infectious diseases Source Type: research
Pelphix: Surgical Phase Recognition from X-ray Images in Percutaneous Pelvic Fixation
Med Image Comput Comput Assist Interv. 2023 Oct;14228:133-143. doi: 10.1007/978-3-031-43996-4_13. Epub 2023 Oct 1.ABSTRACTSurgical phase recognition (SPR) is a crucial element in the digital transformation of the modern operating theater. While SPR based on video sources is well-established, incorporation of interventional X-ray sequences has not yet been explored. This paper presents Pelphix, a first approach to SPR for X-ray-guided percutaneous pelvic fracture fixation, which models the procedure at four levels of granularity - corridor, activity, view, and frame value - simulating the pelvic fracture fixation workflow a...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - April 15, 2024 Category: Radiology Authors: Benjamin D Killeen Han Zhang Jan Mangulabnan Mehran Armand Russell H Taylor Greg Osgood Mathias Unberath Source Type: research
Pediatric anesthesiology in Brazil, Chile, and Mexico
CONCLUSIONS: Brazil an upper middle-income country, population 203 million, has a public system insufficiently resourced and a private system, resulting in inequitable safety and accessibility. Surgical complications constitute the third leading cause of mortality. Anesthesiology residency is 3 years, with required rotations in pediatric anesthesia; five hospitals offer pediatric anesthesia fellowships. Anesthesiology is a physician-only practice. A Pediatric Anesthesia Committee within the Brazilian Society of Anesthesiology offers education through seasonal courses and workshops including pediatric advanced life support....
Source: Paediatric Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Vin ícius Caldeira Quintão Mario Concha Lina Andrea Sarmiento Arg üello Silvana Cavallieri Luis I Cortinez Gabriel Soares de Sousa Marcella Marino Malavazzi Clemente Ricardo Vieira Carlos Juan Manuel Rodr íguez Karla Guti érrez Denis H Jablonka Anner Source Type: research
Pelphix: Surgical Phase Recognition from X-ray Images in Percutaneous Pelvic Fixation
Med Image Comput Comput Assist Interv. 2023 Oct;14228:133-143. doi: 10.1007/978-3-031-43996-4_13. Epub 2023 Oct 1.ABSTRACTSurgical phase recognition (SPR) is a crucial element in the digital transformation of the modern operating theater. While SPR based on video sources is well-established, incorporation of interventional X-ray sequences has not yet been explored. This paper presents Pelphix, a first approach to SPR for X-ray-guided percutaneous pelvic fracture fixation, which models the procedure at four levels of granularity - corridor, activity, view, and frame value - simulating the pelvic fracture fixation workflow a...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - April 15, 2024 Category: Radiology Authors: Benjamin D Killeen Han Zhang Jan Mangulabnan Mehran Armand Russell H Taylor Greg Osgood Mathias Unberath Source Type: research
Chemists Invent Drugs and Drugs Save Lives
ChemMedChem. 2024 Apr 14:e202400074. doi: 10.1002/cmdc.202400074. Online ahead of print.ABSTRACTDrug molecules are the centrepiece of modern medical therapies, providing relief from pain, combatting infections and providing a myriad of other therapeutic effects. The quest for new and improved drug molecules drives medical research, and the introduction of a new drug frequently becomes a newsworthy event capturing the attention of the press and general public. And yet, misconceptions abound. Often, the general public thinks that drug molecules are designed, created, and invented by physicians rather than chemists - a misund...
Source: ChemMedChem - April 15, 2024 Category: Chemistry Authors: Donald F Weaver Source Type: research
Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement
Conclusions: HAP is associated with adverse health effects in observational studies. However, it remains unclear which household energy interventions reduce exposure, improve health, can be scaled, and are sustainable. Researchers should engage with policy makers and practitioners working to scale cleaner energy solutions to understand and address their information needs.PMID:38619436 | DOI:10.1164/rccm.202402-0398ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 15, 2024 Category: Intensive Care Authors: Peggy S Lai Nicholas L Lam Bill Gallery Alison G Lee Heather Adair-Rohani Donee Alexander Kalpana Balakrishnan Iwona Bisaga Zoe A Chafe Thomas Clasen Anait é Díaz-Artiga Andrew Grieshop Kat Harrison Stella M Hartinger Darby Jack Seyram Kaali Melissa Lyd Source Type: research
Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement
Conclusions: HAP is associated with adverse health effects in observational studies. However, it remains unclear which household energy interventions reduce exposure, improve health, can be scaled, and are sustainable. Researchers should engage with policy makers and practitioners working to scale cleaner energy solutions to understand and address their information needs.PMID:38619436 | DOI:10.1164/rccm.202402-0398ST (Source: Respiratory Care)
Source: Respiratory Care - April 15, 2024 Category: Respiratory Medicine Authors: Peggy S Lai Nicholas L Lam Bill Gallery Alison G Lee Heather Adair-Rohani Donee Alexander Kalpana Balakrishnan Iwona Bisaga Zoe A Chafe Thomas Clasen Anait é Díaz-Artiga Andrew Grieshop Kat Harrison Stella M Hartinger Darby Jack Seyram Kaali Melissa Lyd Source Type: research
Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement
Conclusions: HAP is associated with adverse health effects in observational studies. However, it remains unclear which household energy interventions reduce exposure, improve health, can be scaled, and are sustainable. Researchers should engage with policy makers and practitioners working to scale cleaner energy solutions to understand and address their information needs.PMID:38619436 | DOI:10.1164/rccm.202402-0398ST (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2024 Category: Respiratory Medicine Authors: Peggy S Lai Nicholas L Lam Bill Gallery Alison G Lee Heather Adair-Rohani Donee Alexander Kalpana Balakrishnan Iwona Bisaga Zoe A Chafe Thomas Clasen Anait é Díaz-Artiga Andrew Grieshop Kat Harrison Stella M Hartinger Darby Jack Seyram Kaali Melissa Lyd Source Type: research
Pediatric anesthesiology in Brazil, Chile, and Mexico
CONCLUSIONS: Brazil an upper middle-income country, population 203 million, has a public system insufficiently resourced and a private system, resulting in inequitable safety and accessibility. Surgical complications constitute the third leading cause of mortality. Anesthesiology residency is 3 years, with required rotations in pediatric anesthesia; five hospitals offer pediatric anesthesia fellowships. Anesthesiology is a physician-only practice. A Pediatric Anesthesia Committee within the Brazilian Society of Anesthesiology offers education through seasonal courses and workshops including pediatric advanced life support....
Source: Paediatric Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Vin ícius Caldeira Quintão Mario Concha Lina Andrea Sarmiento Arg üello Silvana Cavallieri Luis I Cortinez Gabriel Soares de Sousa Marcella Marino Malavazzi Clemente Ricardo Vieira Carlos Juan Manuel Rodr íguez Karla Guti érrez Denis H Jablonka Anner Source Type: research
Pelphix: Surgical Phase Recognition from X-ray Images in Percutaneous Pelvic Fixation
Med Image Comput Comput Assist Interv. 2023 Oct;14228:133-143. doi: 10.1007/978-3-031-43996-4_13. Epub 2023 Oct 1.ABSTRACTSurgical phase recognition (SPR) is a crucial element in the digital transformation of the modern operating theater. While SPR based on video sources is well-established, incorporation of interventional X-ray sequences has not yet been explored. This paper presents Pelphix, a first approach to SPR for X-ray-guided percutaneous pelvic fracture fixation, which models the procedure at four levels of granularity - corridor, activity, view, and frame value - simulating the pelvic fracture fixation workflow a...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - April 15, 2024 Category: Radiology Authors: Benjamin D Killeen Han Zhang Jan Mangulabnan Mehran Armand Russell H Taylor Greg Osgood Mathias Unberath Source Type: research
Chemists Invent Drugs and Drugs Save Lives
ChemMedChem. 2024 Apr 14:e202400074. doi: 10.1002/cmdc.202400074. Online ahead of print.ABSTRACTDrug molecules are the centrepiece of modern medical therapies, providing relief from pain, combatting infections and providing a myriad of other therapeutic effects. The quest for new and improved drug molecules drives medical research, and the introduction of a new drug frequently becomes a newsworthy event capturing the attention of the press and general public. And yet, misconceptions abound. Often, the general public thinks that drug molecules are designed, created, and invented by physicians rather than chemists - a misund...
Source: ChemMedChem - April 15, 2024 Category: Chemistry Authors: Donald F Weaver Source Type: research
