Clinical status and perspective on the application of immunotherapy combined with chemotherapy in advanced non-small cell lung cancer: a review
Chin Clin Oncol. 2024 Apr 8:cco-23-92. doi: 10.21037/cco-23-92. Online ahead of print.ABSTRACTThe therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has been significantly improved by developing immunotherapy represented by programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) immune checkpoint inhibitors (ICI). Furthermore, immunotherapy combined with chemotherapy is an essential treatment strategy for driver-negative advanced NSCLC, especially in a population with PD-L1 <50%, and leads to long-term survival in the entire population regardless of the PD-L1 expression status. Howeve...
Source: Clinical Lung Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Tianming Wang Liang Zhang Ying Cheng Source Type: research
Breast Ultrasound Tumor Classification Using a Hybrid Multitask CNN-Transformer Network
In this study, we proposed a hybrid multitask deep neural network called Hybrid-MT-ESTAN, designed to perform BUS tumor classification and segmentation using a hybrid architecture composed of CNNs and Swin Transformer components. The proposed approach was compared to nine BUS classification methods and evaluated using seven quantitative metrics on a dataset of 3,320 BUS images. The results indicate that Hybrid-MT-ESTAN achieved the highest accuracy, sensitivity, and F1 score of 82.7%, 86.4%, and 86.0%, respectively.PMID:38601088 | PMC:PMC11006090 | DOI:10.1007/978-3-031-43901-8_33 (Source: MICCAI International Conference o...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - April 11, 2024 Category: Radiology Authors: Bryar Shareef Min Xian Aleksandar Vakanski Haotian Wang Source Type: research
Expert teleconsultation involving patients and their primary neurologists for the management of multiple sclerosis in regions without specialists
ConclusionsThe present study suggested that our expert teleconsultation system for MS reduces the burden on patients of visiting distant MS-specialized clinics, and enhances knowledge of MS management for the primary neurologists. It also promotes trust between patients and their primary neurologists, and taken together, these aspects could collectively lead to independent and sustainable MS management in regions without MS specialists. (Source: Clinical and Experimental Neuroimmunology)
Source: Clinical and Experimental Neuroimmunology - April 11, 2024 Category: Neurology Authors: Yusei Miyazaki,
Shigehisa Ura,
Kazuhiro Horiuchi,
Takeshi Matsuoka,
Hideki Houzen,
Kazufumi Tsuzaka,
Yuichi Makino,
Manami Koshida,
Genko Oyama,
Chika Sato,
Ryoji Naganuma,
Itaru Amino,
Sachiko Akimoto,
Masaaki Niino,
Naoya Minami,
Eri Taka Tags: ORIGINAL ARTICLE Source Type: research
Real-world effectiveness of sotrovimab for the treatment of SARS-CoV-2 infection during Omicron BA.2 and BA.5 subvariant predominance: a systematic literature review
ConclusionsThis systematic literature review suggests continued effectiveness of sotrovimab in preventing severe clinical outcomes during BA.2 and BA.5 predominance, both against active/untreated comparators and compared with BA.1 predominance. (Source: Infection)
Source: Infection - April 11, 2024 Category: Infectious Diseases Source Type: research
Wicked: The Musical
On Thursday, October 26, 2023, with a group of fellow AACAP annual conference goers, we saw the musical Wicked. Wicked is a beautiful and thought-provoking musical, telling the Wizard of Oz story from the perspective of Elphaba, the Wicked Witch of the West. In the musical, Elphaba starts out life at a disadvantage, as she is born with green skin. She is rejected from the beginning, with her father declaring “take it away!” (act 1, scene 1). The story picks up as she starts boarding school, largely to care for her younger sister, Nessa. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - April 11, 2024 Category: Psychiatry Authors: Elizabeth Lobel, Thomas Pak Tags: Book forum Source Type: research
Real-world effectiveness of sotrovimab for the treatment of SARS-CoV-2 infection during Omicron BA.2 and BA.5 subvariant predominance: a systematic literature review
ConclusionsThis systematic literature review suggests continued effectiveness of sotrovimab in preventing severe clinical outcomes during BA.2 and BA.5 predominance, both against active/untreated comparators and compared with BA.1 predominance. (Source: Infection)
Source: Infection - April 11, 2024 Category: Infectious Diseases Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research
Preparing Nurse Practitioner Graduates for the Transition to Practice
CONCLUSION: Current educational programs lack the time to thoroughly address NP graduates' learning needs regarding transition to practice. A partnership between faculties and a state professional organization is an innovative approach to meet students' educational desires. Delivery of a virtual conference during the pandemic proved to be cost effective. [J Nurs Educ. 2024;63(X):XXX-XXX.].PMID:38598787 | DOI:10.3928/01484834-20240320-01 (Source: The Journal of Nursing Education)
Source: The Journal of Nursing Education - April 10, 2024 Category: Nursing Authors: Sandra K Paddock Ann Hayden Maria Ruud Source Type: research
