Aggressive variant prostate cancer with multiple subcutaneous metastases: a case report
AbstractA 71-year-old man with bone metastasis of hormone-sensitive prostate cancer was treated with androgen deprivation therapy and apalutamide. Radium-223 and radiation therapy were administered after it become castration resistant. Although prostate-specific antigen levels remained low, multiple subcutaneous metastases of neuroendocrine prostate cancer were observed. A review of the pre-treatment prostate needle biopsy revealed a small component with features suggestive of neuroendocrine differentiation. Phosphatase and tensine homolog loss and tumor protein p53 overexpression were observed, confirming the diagnosis of...
Source: International Cancer Conference Journal - April 18, 2024 Category: Cancer & Oncology Source Type: research
BRAF-mutant microsatellite-stable rectal cancer with acquired KRAS mutation leading to drug resistance in liver metastasis
AbstractBRAF-mutant microsatellite-stable colorectal cancer (CRC), metastasized to distant sites, is associated with a poor prognosis. However, the BEACON CRC regimen, comprising a BRAF inhibitor, MEK inhibitor, and anti-EGFR antibody, offered a prolonged prognosis. Nonetheless, resistance to this regimen may occur, as observed in our reported case of CRC, where aKRAS mutation was identified in addition to theBRAF V600E mutation. Here, we present a case of 74-year-old woman with rectal cancer (pT4bN1bM0 Stage IIIc) harboring theBRAF V600E mutation. After resection of the primary tumor and during adjuvant chemotherapy using...
Source: International Cancer Conference Journal - April 18, 2024 Category: Cancer & Oncology Source Type: research
BASHH feedback from the 2023 IUSTI-Europe conference in Malta
There is a growing relationship between BASHH and IUSTI.1 In 2023, several BASHH scholars were invited to give feedback on the IUSTI conference in Malta. Asymptomatic STI screening: Chris Kenyon, (Belgium) Despite good evidence for HIV and syphilis screening in asymptomatic patients, evidence is lacking for other STIs, for example, Neisseria gonorrhoeae and Chlamydia trachomatis. Kenyon et al2 highlighted the potential harms of widespread screening for asymptomatic STIs, particularly in HIV-pre-exposure prophylaxis (HIV-PrEP) cohorts, namely increased antimicrobial consumption and antimicrobial resistance (AMR). In Belgium...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Richardson, D., Butler, M., Bull Olozabal, O., Gupta, N., Naser, F., Sultan, B., Caswell, R. J. Tags: BASHH column Source Type: research
Effect and outcome of equity, diversity and inclusion programs in healthcare institutions: a systematic review protocol
The objective of this systematic review is to assess the effects and outcomes of EDI programmes in healthcare institutions.
Methods
We will conduct Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review of studies on EDI programmes and describe their effects and outcomes in healthcare institutions. We will search PubMed, Scopus, Web of Science, CINAHL and PsycINFO databases. Selected studies will include randomised control trials (RCTs), non-RCTs and cross-sectional studies published either in English or French. Quality appraisal of studies and a narrative synthesis of extracted dat...
Source: BMJ Open - April 18, 2024 Category: General Medicine Authors: Buh, A., Kang, R., Kiska, R., Fung, S. G., Solmi, M., Scott, M., Salman, M., Lee, K., Milone, B., Wafy, G., Syed, S., Dhaliwal, S., Gibb, M., Akbari, A., Brown, P. A., Hundemer, G. L., Sood, M. M. Tags: Open access, Health services research Source Type: research
Exploratory study of using Magnetic resonance Prognostic Imaging markers for Radiotherapy In Cervix cancer (EMPIRIC): a prospective cohort study protocol
Introduction
Radical chemoradiotherapy represents the gold standard for locally advanced cervical cancer. However, despite significant progress in improving local tumour control, distant relapse continues to impact overall survival. The development of predictive and prognostic biomarkers is consequently important to risk-stratify patients and identify populations at higher risk of poorer treatment response and survival outcomes. Exploratory study of using Magnetic resonance Prognostic Imaging markers for Radiotherapy In Cervix cancer (EMPIRIC) is a prospective exploratory cohort study, which aims to investigate the role of...
Source: BMJ Open - April 18, 2024 Category: General Medicine Authors: Abdul-Latif, M., Chowdhury, A., Tharmalingam, H., Taylor, N. J., Lakhani, A., Padhani, A., Hoskin, P., Tsang, Y. Tags: Open access, Radiology and imaging Source Type: research
Management of advanced prostate cancer in the Asia-Pacific region: Summary of the Asia-Pacific Advanced Prostate Cancer Consensus Conference 2023
CONCLUSION: The use of next-generation imaging, genetic testing, and new treatment combinations is increasing the complexity and duration of prostate cancer management. Familiarity with new diagnostic and treatment options is growing in the APAC region. Insights highlight the continued importance of a multidisciplinary approach that includes nuclear medicine, genetic counseling, and quality-of-life expertise. The APAC APCCC meeting provides an important opportunity to share practice and identify APAC-specific issues and considerations in areas of low evidence where clinical experience is growing.PMID:38628049 | DOI:10.1111...
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Edmund Chiong Declan G Murphy Nicholas Buchan Kenneth Chen Sarah S Chen Melvin L K Chua Agus Rizal Hamid Ravindran Kanesvaran Makarand Khochikar Jason Letran Bannakij Lojanapiwat Indranil Mallik Chee Fai Ng Teng Aik Ong Darren M C Poon Yeong-Shiau Pu Marn Source Type: research
Management of advanced prostate cancer in the Asia-Pacific region: Summary of the Asia-Pacific Advanced Prostate Cancer Consensus Conference 2023
CONCLUSION: The use of next-generation imaging, genetic testing, and new treatment combinations is increasing the complexity and duration of prostate cancer management. Familiarity with new diagnostic and treatment options is growing in the APAC region. Insights highlight the continued importance of a multidisciplinary approach that includes nuclear medicine, genetic counseling, and quality-of-life expertise. The APAC APCCC meeting provides an important opportunity to share practice and identify APAC-specific issues and considerations in areas of low evidence where clinical experience is growing.PMID:38628049 | DOI:10.1111...
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Edmund Chiong Declan G Murphy Nicholas Buchan Kenneth Chen Sarah S Chen Melvin L K Chua Agus Rizal Hamid Ravindran Kanesvaran Makarand Khochikar Jason Letran Bannakij Lojanapiwat Indranil Mallik Chee Fai Ng Teng Aik Ong Darren M C Poon Yeong-Shiau Pu Marn Source Type: research
Randomised controlled, patient-blinded, multicentre, superiority trial to evaluate the efficacy of the line-attached sheath-type traction device for endoscopic submucosal dissection in patients with superficial gastric neoplasms
BMJ Open. 2024 Apr 17;14(4):e078974. doi: 10.1136/bmjopen-2023-078974.ABSTRACTINTRODUCTION: EndoTrac is a line-attached sheath-type traction device that enables us to control the direction and the force of traction during endoscopic submucosal dissection (ESD). The efficacy of EndoTrac for gastric ESD has not been fully verified.METHODS AND ANALYSIS: The G-Trac study is a multicentre (nine general hospitals and two university hospitals in Japan) collaborative trial assessing the efficacy of EndoTrac for gastric ESDs. Patients with superficial gastric neoplasms will be enrolled and randomly assigned to undergo either conven...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Hirofumi Abe Tomoya Sako Yoshinobu Yamamoto Atsushi Ikeda Fumiaki Kawara Takayuki Ose Toshitatsu Takao Yasuaki Kitamura Ryusuke Ariyoshi Yoshinori Morita Tsukasa Ishida Takuya Ikegawa Ryosuke Ishida Tetsuya Yoshizaki Hiroya Sakaguchi Takashi Toyonaga Yuzo Source Type: research
Protocol for a Randomized Controlled Trial to Evaluate a Permissive Blood Pressure Target Versus Usual Care in Critically Ill Children with Hypotension (PRESSURE)
CONCLUSIONS: Trial findings will be disseminated in U.K. national and international conferences and in peer-reviewed journals.PMID:38629915 | DOI:10.1097/PCC.0000000000003516 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Robert Darnell Alanna Brown Emma Laing Julia Edwards David A Harrison Joseph C Manning Mark J Peters Padmanabhan Ramnarayan Samiran Ray Zia Sadique Barnaby R Scholefield Dermot Shortt Lamprini Lampro Carly Au Kathy M Rowan Paul Mouncey David P Inwald Prot Source Type: research
Decision-making for congenital anomalies diagnosed during pregnancy: a narrative review
ConclusionMany factors contribute to an individual ’s decision-making after a diagnosis of a fetal anomalies diagnosed in the second trimester of pregnancy, ranging from personal beliefs and goals to shared experiences of others and access to care. Understanding how sources of information may be deemed both as facilitators and barriers to differen t individuals during the decision-making process is important for healthcare providers in order to understand how to most effectively support patients. There is a dearth of information on training healthcare professionals to provide support to patients facing these decisions. (...
Source: Journal of Assisted Reproduction and Genetics - April 17, 2024 Category: Reproduction Medicine Source Type: research
Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial
This study will compare the incidence of preterm-PE with delivery at <37 weeks’ gestation, as the primary outcome, of three different interventional groups: (1) aspirin 75 mg daily, (2) aspirin 150 mg daily and (3) aspirin 75 mg with metformin 1.5 g daily. 957 participants per treatment group are required to detect a significant difference of 59% in the reduction of the incidence of preterm-PE with 80% power and type I error of 5%. Pregnancy and neonatal outcomes will be collected and analysed.
Ethics and dissemination
Ethical approval for the study was obtained from the Joint Chinese University of Hong Kong&ndas...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Liu, J., Shen, L., Nguyen-Hoang, L., Zhou, Q., Wang, C. C., Lu, X., Sahota, D., Chong, K. C., Ying, H., Gu, W., Zhou, R., Yang, H., Jiang, Y., Chen, D., Li, X., Poon, L. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Effect of metacognitive therapy on depression in patients with chronic disease: a protocol for a systematic review and meta-analysis
This article is a literature review that does not include patients’ identifiable information. Therefore, ethical approval is not required in this protocol. The findings of this systematic review and meta-analysis will be published in a peer-reviewed journal as well as presentations at relevant conferences.
PROSPERO registration number
CRD42023411105. (Source: BMJ Open)
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Zhang, Z., Wang, P., Gu, J., Zhang, Q., Sun, C., Wang, P. Tags: Open access, Mental health Source Type: research
Randomised controlled, patient-blinded, multicentre, superiority trial to evaluate the efficacy of the line-attached sheath-type traction device for endoscopic submucosal dissection in patients with superficial gastric neoplasms
Introduction
EndoTrac is a line-attached sheath-type traction device that enables us to control the direction and the force of traction during endoscopic submucosal dissection (ESD). The efficacy of EndoTrac for gastric ESD has not been fully verified.
Methods and analysis
The G-Trac study is a multicentre (nine general hospitals and two university hospitals in Japan) collaborative trial assessing the efficacy of EndoTrac for gastric ESDs. Patients with superficial gastric neoplasms will be enrolled and randomly assigned to undergo either conventional ESD or EndoTrac ESD. Allocation will be stratified according to tumour ...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Abe, H., Sako, T., Yamamoto, Y., Ikeda, A., Kawara, F., Ose, T., Takao, T., Kitamura, Y., Ariyoshi, R., Morita, Y., Ishida, T., Ikegawa, T., Ishida, R., Yoshizaki, T., Sakaguchi, H., Toyonaga, T., Kodama, Y. Tags: Open access, Gastroenterology and hepatology Source Type: research
Evaluation of a manualised neurofeedback training in psychosomatic-psychotherapeutic outpatient treatment (Neuro-pp-out): study protocol for a clinical mixed-methods pilot study
Introduction
Electroencephalographic neurofeedback (NFB), as a non-invasive form of brainwave training, has been shown to be effective in the treatment of various mental health disorders. However, only few results regarding manualised and standardised NFB trainings exist. This makes comparison as well as replication of studies difficult. Therefore, we developed a standard manual for NFB training in patients with mental health disorders attending a psychosomatic outpatient clinic. The current study aims at investigating the conduction of a standardised manual for NFB training in patients with mental health disorders. If suc...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Schmidt, K. L., Kowalski, A., Schweda, A., Dörrie, N., Skoda, E. M., Bäuerle, A., Teufel, M. Tags: Open access, Mental health Source Type: research
Restrictive use of Restraints and Delirium Duration in the Intensive Care Unit (R2D2-ICU): protocol for a French multicentre parallel-group open-label randomised controlled trial
Introduction
Physical restraint (PR) is prescribed in patients receiving invasive mechanical ventilation in the intensive care unit (ICU) to avoid unplanned removal of medical devices. However, it is associated with an increased risk of delirium. We hypothesise that a restrictive use of PR, as compared with a systematic use, could reduce the duration of delirium in ICU patients receiving invasive mechanical ventilation.
Methods and analysis
The Restrictive use of Restraints and Delirium Duration in ICU (R2D2-ICU) study is a national multicentric, parallel-group, randomised (1:1) open-label, controlled, superiority trial, ...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Sonneville, R., Couffignal, C., Sigaud, F., Godard, V., Audibert, J., Contou, D., Celier, A., Djibre, M., Schmidt, J., Jaquet, P., Mekontso Dessap, A., Bourel, C., Bellot, R., Roy, C., Lamara, F., Essardy, F., Timsit, J.-F., Cornic, R., Bouadma, L., On be Tags: Open access, Intensive care Source Type: research
