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Effect of melanin biosynthesis inhibition in the antifungal susceptibility of chromoblastomycosis agents
Antimicrob Agents Chemother. 2021 May 10:AAC.00546-21. doi: 10.1128/AAC.00546-21. Online ahead of print.ABSTRACTChromoblastomycosis (CBM) is a chronic subcutaneous infection caused by genera of melanized fungi: Fonsecaea, Cladophialophora, Phialophora, Exophiala and Rhinocladiella Melanin is a virulence factor known to influence antifungal susceptibility. A specific inhibitor of melanin biosynthesis is tricyclazole. The aim of this study was to evaluate the effect of melanin inhibition on antifungal susceptibility of chromoblastomycosis agents and describe the susceptibility profile of some unusual CBM agents. Seventy-six ...
Source: Antimicrobial Agents and Chemotherapy - May 11, 2021 Category: Microbiology Authors: Daiane Heidrich Danielle Machado Pagani Alessandra Koehler Karine de Oliveira Alves Maria L úcia Scroferneker Source Type: research

Chromoblastomycosis caused by Fonsecaea monophora in Mexico
Publication date: June 2021Source: Journal of Medical Mycology, Volume 31, Issue 2Author(s): Pablo Campos-Macias, Roberto Arenas, Caren J. Aquino, Marina Romero-Navarrete, Fernando Martínez-Hernández, Luary C. Martínez-Chavarría, Juan Xicohtencatl-Cortes, Rigoberto Hernández-Castro (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - March 9, 2021 Category: Biology Source Type: research

The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry?
by Sanaz Nargesi, Felix Bongomin, Mohammad T. Hedayati The World Health Organization (WHO) considers mycetoma, chromoblastomycosis, and paracoccidioidomycosis to be fungal neglected tropical diseases (FNTDs). Depending on climatic, cultural, and economic contexts, these diseases have a similar geographical distribution as many other diseases, particul arly tuberculosis (TB) and malaria, but are often less targeted by the national and many international healthcare systems. Another subgroup of fungal infections, such as candidiasis, cryptococcosis, pneumocystosis, histoplasmosis, and to a lesser extent, aspergillosis, are k...
Source: PLoS Neglected Tropical Diseases - February 9, 2021 Category: Tropical Medicine Authors: Sanaz Nargesi Source Type: research

Chromoblastomycosis caused by Fonseca monophora in Mexico
Publication date: Available online 19 January 2021Source: Journal of Medical MycologyAuthor(s): P Campos-Macias, R Arenas, C J Aquino, M Romero-Navarrete, F Martínez-Hernández, L C Martínez-Chavarría, J Xicohtencatl-Cortes, R Hernández-Castro (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 20, 2021 Category: Biology Source Type: research

Chromoblastomycosis by Exophiala jeanselmei associated with squamous cell carcinoma
Publication date: March 2021Source: Journal of Medical Mycology, Volume 31, Issue 1Author(s): Jiaqi Wang, Mengyan Zhu, Ping Wang (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 9, 2021 Category: Biology Source Type: research

Chromoblastomycosis: A Neglected Occupational Disease
Chromoblastomycosis (CBM) is a chronic progressive cutaneous fungal infection caused by several naturally pigmented fungi which are commonly seen in tropical and subtropical climates. The infection is secondary to trauma or autoinoculation. A majority of the cases from India are reported from the sub-Himalayan belt and South India. Fungal diseases other than mycetoma are considered neglected diseases by the World Health Organization. The global burden of CBM could be even greater than mycetoma and can lead to potential incapacity for labor. Here, we present a case of cutaneous CBM from Kerala, India. A 57-year-old male far...
Source: Infectious Diseases in Clinical Practice - December 11, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Mycobacterium marinum infection simulating chromomycosis: a case report.
We report one case of chronic and extensive M. marinum cutaneous infection simulating chromoblastomycosis and review the pertinent literature. A 52-year-old farmer reported a 32-year chronic skin problem on his right lower limb, resulting from contact with cacti. It consisted of skin lesion presenting with dyschromic atrophic center plate and verrucous borders with hematic crusts, extending from the knee anteriorly to the inferior third of the right leg. Mycobacterium marinum infection was detected by histopathological examination of a skin fragment, culture for mycobacteria and genetic mapping of the culture material. The...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - December 4, 2020 Category: Tropical Medicine Authors: Bezerra GH, Honório MLP, Costa VLDC, Vechi HT, Alves MDM, Britto MHMF, Rocha KBF, Carvalho LD Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Lower limb nodulo-ulcerative lesion in kidney transplant recipient & #8211; An unusual diagnosis
Shikha Khandelwal, Pankaj Beniwal, Vinay Malhotra, Vartul Gupta, Nisha GaurIndian Journal of Nephrology 2020 30(6):427-429 A 56-year-old kidney transplant recipient presented with a progressive cauliflower-like growth on the plantar surface of the right foot and on workup found to have chromoblastomycosis, which was successfully treated by antifungal agent and surgical excision with no recurrence. Chromoblastomycosis belongs to the heterogeneous group of subcutaneous mycoses. It is caused by various pigmented (dematiaceous) fungi, which gain entry into the skin via traumatic implantation. The case is of interest because i...
Source: Indian Journal of Nephrology - December 4, 2020 Category: Urology & Nephrology Authors: Shikha Khandelwal Pankaj Beniwal Vinay Malhotra Vartul Gupta Nisha Gaur Source Type: research

17409 A new method for in vitro production of Fonsecaea pedrosoi fumagoid cells in a synthetic medium
Introduction: Fonsecaea pedrosoi is the principal etiologic agent of chromoblastomycosis, a chronic infection of the skin and subcutaneous tissue. This dimorphic fungus is found in tissues in the form of spherical cells known as sclerotic, Medlar or fumagoid cells. Several methods have been reported to induce the formation of in vitro fumagoid cells based on acidic media supplemented with propranolol or platelet activating factor. However, it is very difficult to achieve the proliferation and growth of these tissue forms, which has hindered the physiologic knowledge of this microorganism in its parasitic phase. (Source: Jo...
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Thelma Laura Orizaga y Quiroga, Jos é E. Gonzalez, Carmen Molina-Torres, Debanhi K. Luna Garza, Sonia S. Ocampo-Garza Source Type: research

Fonsecaeapedrosoi Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions
Chromoblastomycosis is a chronic and progressive subcutaneous mycosis caused mainly by the fungus Fonsecaea pedrosoi. The infection is characterized by erythematous papules and histological sections demonstrating an external layer of fibrous tissue and an internal layer of thick granulomatous inflammatory tissue containing mainly macrophages and neutrophils. Several groups are studying the roles of the innate and adaptive immune systems in F. pedrosoi infection; however, few studies have focused on the role of neutrophils in this infection. In the current study, we verify the importance of murine neutrophils in the killing...
Source: Frontiers in Immunology - October 21, 2020 Category: Allergy & Immunology Source Type: research

Clinical aspects of previously treated chromoblastomycosis: a case series from Madagascar
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 30, 2020 Category: Infectious Diseases Authors: Fandresena Arilala Sendrasoa, Naina Harinjara Razanakoto, Mendrika Fifaliana Rakotoarisaona, Malalaniaina Andrianarison, Onivola Raharolahy, Tahinamandranto Rasamoelina, Irina Mamisoa Ranaivo, Moril Sata, Volatantely Ratovonjanahary, Dani èle Maubon, Mal Source Type: research