Unique Oral Presentations of Deep Fungal Infections: A Report of Four Cases
We report four new cases of deep fungal infections, diagnosed as histoplasmosis, blastomycosis and chromoblastomycosis, exhibiting unique oral and perioral presentations. Awareness of these unusual entities can help dental and medical practitioners expedite proper multidisciplinary care and minimize morbidity and mortality. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - September 4, 2020 Category: Pathology Source Type: research
Exophiala lecanii-corni keratitis presenting as a serpiginous pigmented superficial lesion: a case report
We report a case of Exophiala lecanii-corni (E lecanii-corni) keratitis presenting as a serpiginous pigmented superficial lesion after DSAEK.
Patient concerns:
An 81-year-old woman who had undergone cataract surgeries, suffered from decreased vision in the left eye. She was diagnosed BK and she underwent DSAEK. Two months after DSAEK, a pigmented superficial lesion developed on the left cornea. The lesion migrated and recurred repeatedly and she was referred to our department. Best corrected vision was 20/220.
Diagnoses:
Light microscopy of a corneal scraping revealed branching fungal hyphae. Fungal culture showed gr...
Source: Medicine - September 4, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Case Report: Treatment of Chromoblastomycosis with Combinations including Acitretin: A Report of Two Cases.
Abstract
Chromoblastomycosis is a cutaneous fungal infection caused by dematiaceous fungi that belong to the order Chaetothyriales and family Herpotrichiellaceae. This infection is prevalent in tropical and subtropical areas and has been designated as a neglected tropical disease according to the WHO. Chromoblastomycosis infection is difficult to treat, and there are limited therapeutic options, making urgent the characterization of new medicines or approaches to treat such infection. In the present case report, two patients with extensive chromoblastomycosis lesions were treated with the combination of it...
Source: The American Journal of Tropical Medicine and Hygiene - August 16, 2020 Category: Tropical Medicine Authors: Belda W, Criado PR, Domingues Passero LF Tags: Am J Trop Med Hyg Source Type: research
Case for diagnosis. Pruritic erythematosquamous lesion in the auricle,
Abstract Chromoblastomycosis is a subcutaneous mycosis with chronic evolution that mainly affects the lower limbs and, less frequently, the auricles. Clinically, it presents with papillary verrucous, nodular, and/or tumoral lesions, whether isolated or infiltrated, forming plaques and, sometimes, atrophic in some areas. Histopathologically, it is characterized by a dermal granulomatous inflammatory infiltrate, and the diagnosis can be confirmed by the presence of fumagoid bodies in anatomopathological or direct mycological exams. The treatment to be indicated will depend on the extent and location of the lesions, using sys...
Source: Anais Brasileiros de Dermatologia - August 12, 2020 Category: Dermatology Source Type: research
Genomics and Virulence of Fonsecaea pugnacius, Agent of Disseminated Chromoblastomycosis
Among agents of chromoblastomycosis, Fonsecaea pugnacius presents a unique type of infection because of its secondary neurotropic dissemination from a chronic cutaneous case in an immunocompetent patient. Neurotropism occurs with remarkable frequency in the fungal family Herpotrichiellaceae, possibly associated with the ability of some species to metabolize aromatic hydrocarbons. In an attempt to understand this new disease pattern, were conducted genomic analysis of Fonsecaea pugnacius (CBS 139214) performed with de novo assembly, gene prediction, annotation and mitochondrial genome assembly, supplemented with animal infe...
Source: Frontiers in Genetics - August 3, 2020 Category: Genetics & Stem Cells Source Type: research
Chromoblastomycosis: A Case of a Verrucous Plaque from the Tropics.
PMID: 32758344 [PubMed - in process] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 31, 2020 Category: Tropical Medicine Authors: Carcamo PM, Schwalb A, Seas C Tags: Am J Trop Med Hyg Source Type: research
A comparative study of extracellular enzymes from chromoblastomycosis agents reveals the potential association of phospholipase with the severity of the lesions
Publication date: Available online 8 July 2020Source: Microbial PathogenesisAuthor(s): Alexandra M. Montoya, Cintia Amaral Montesino, Diego Carrión-Álvarez, Gloria M. González, Olga C. Rojas (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - July 9, 2020 Category: Infectious Diseases Source Type: research
Early immune response against < i > Fonsecaea pedrosoi < /i > requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis
by Isaque Medeiros Siqueira, Marcel W üthrich, Mengyi Li, Huafeng Wang, Lucas de Oliveira La-Casas, Raffael Júnio Araújo de Castro, Bruce Klein, Anamelia Lorenzetti Bocca
Chromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the disease, mainly because of its recalcitrant nature. The correct activation of host immune response is critical to avoid funga l persistence in the tissue and disease chronification. CD4+ T cells are crucial for the development of protective immunity toF.pedrosoi infection. Here, we...
Source: PLoS Neglected Tropical Diseases - June 14, 2020 Category: Tropical Medicine Authors: Isaque Medeiros Siqueira Source Type: research
Muriform Cells Can Reproduce by Dividing in an Athymic Murine Model of Chromoblastomycosis due to Fonsecaea pedrosoi.
Abstract
Transformation of Fonsecaea pedrosoi into muriform cells enhances the resistance against phagocytosis and elimination by host immune cells, and links to the chronicity of chromoblastomycosis. Here, we aim to determine whether the muriform cells can reproduce in tissue without reverse transformation into hyphal form by using an experimental nu/nu-BALB/c mouse model of chromoblastomycosis due to F. pedrosoi. During the whole 81-day observation period, most of the hyphal inocula had transformed into muriform cells at 75 days postinoculation and maintained as this parasitic morphology till 81 days pos...
Source: The American Journal of Tropical Medicine and Hygiene - June 7, 2020 Category: Tropical Medicine Authors: Dong B, Liu W, Li R, Chen Y, Tong Z, Zhang X, Chen L, Li D Tags: Am J Trop Med Hyg Source Type: research
Molecules, Vol. 25, Pages 2594: Mycetoma and Chromoblastomycosis: Perspective for Diagnosis Improvement Using Biomarkers
Conclusion: Confirmatory diagnosis based on specific diagnostic biomarkers will be the basis for the optimal treatment of mycetoma and chromoblastomycosis. It will be part of the global management of NTDs under the umbrella of stewardship activities. (Source: Molecules)
Source: Molecules - June 1, 2020 Category: Chemistry Authors: Anne-Lise Bienvenu Stephane Picot Tags: Review Source Type: research
A case of Mycetoma-like chromoblastomycosis in Qatar
Publication date: Available online 30 May 2020Source: IDCasesAuthor(s): Gawahir Mohamed Ali, Wael Goravey, Saad Taj-Aldeen, Mahir Petkar, Issam Al-Bozom, Hamad Abdel Hadi (Source: IDCases)
Source: IDCases - May 31, 2020 Category: Infectious Diseases Source Type: research
Chromoblastomycosis caused by Cladophialophora carrionii
(Source: Infection)
Source: Infection - May 24, 2020 Category: Infectious Diseases Source Type: research
Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar
T. Rasamoelina et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - May 4, 2020 Category: Infectious Diseases Source Type: research
Endemic Chromoblastomycosis Caused Predominantly by Fonsecaea nubica, Madagascar1
T. Rasamoelina et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - May 4, 2020 Category: Infectious Diseases Source Type: research
[Management of chromoblastomycosis, a challenge for limited-resource countries such as Madagascar].
CONCLUSION: Although unavailable in Madagascar, posaconazole and isavoconazole appear to be effective in treating chromoblastomycosis.
PMID: 32220474 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 23, 2020 Category: Dermatology Authors: Sendrasoa FA, Rakotoarisaona MF, Ranaivo IM, Razanakoto NH, Sata M, Raharolahy O, Andrianarison M, Ratovonjanahary V, Rasamoelina T, Rapelanoro Rabenja F, Ramarozatovo LS Tags: Ann Dermatol Venereol Source Type: research
