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A Variety of Fungal Species on the Green Frogs' Skin (Pelophylax esculentus complex) in South Banat
Microb Ecol. 2022 Nov 2. doi: 10.1007/s00248-022-02135-0. Online ahead of print.ABSTRACTIn the last several decades, amphibian populations have been declining worldwide. Many factors have been linked to global amphibian decline, including habitat destruction, pollution, introduced species, global environmental changes, and emerging infectious diseases. Recent studies of amphibian skin infections were mainly focused on the presence of chytridiomycosis, neglecting other members of the frogs' skin communities. The diversity pattern of fungal dwellers on the skin of green frogs (Pelophylax esculentus complex) was investigated....
Source: Microbial Ecology - November 2, 2022 Category: Microbiology Authors: Milo š Stupar Željko Savković Katarina Breka Sr đan Stamenković Imre Krizmani ć Jelena Vukojevi ć Milica Ljaljevi ć Grbić Source Type: research

Chromoblastomycosis: A case series from Eastern China
by Sujun Liu, Huilin Zhi, Hong Shen, Wenwen Lv, Bo Sang, Qiuping Li, Yan Zhong, Zehu Liu, Xiujiao Xia Chromoblastomycosis (CBM) is a chronic fungal infection of the cutaneous and subcutaneous tissues caused by brown pigmented fungi.Fonsecaea monophora is one of the most common pathogens of CBM in China. Most formal cases have been reported from Southern China, however, the infection is not uncommon in Eastern China where very few case series are available. To describe the clinical aspects of CBM, we report a series of 11 cases between 2018 and 2021 at a single medical center in Eastern China. The patients were predominate...
Source: PLoS Neglected Tropical Diseases - September 26, 2022 Category: Tropical Medicine Authors: Sujun Liu Source Type: research

Mycetoma, chromoblastomycosis and other deep fungal infections: diagnostic and treatment approach
Purpose of review to review recent advances in the epidemiology, diagnosis, and treatment of deep fungal infections Recent findings Mycetoma and chromoblastomycosis are the only deep fungal infections incorporated in the list of neglected tropical diseases. These infections start in the skin but progress to deep tissues if not recognized early. A wide array of fungal pathogens are the causative agents. Molecular methods allow for early and accurate identification of the pathogens, but are unfortunately not available in endemic areas. Treatment options are mostly based upon clinical experience rather than on well...
Source: Current Opinion in Infectious Diseases - September 16, 2022 Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina Coyle Source Type: research

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box ® that present synergism with itraconazole
CONCLUSIONS: These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.PMID:36102413 | PMC:PMC9467274 | DOI:10.1590/0074-02760220089 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - September 14, 2022 Category: Infectious Diseases Authors: Rowena Alves Coelho Gabriela Machado Alves Maria Helena Galdino Figueiredo-Carvalho Fernando Almeida-Silva Gabriela Rodrigues de Souza Maria Cristina da Silva Louren ço F ábio Brito-Santos Ana Claudia Fernandes Amaral Rodrigo Almeida-Paes Source Type: research

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box ® that present synergism with itraconazole
CONCLUSIONS: These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.PMID:36102413 | DOI:10.1590/0074-02760220089 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - September 14, 2022 Category: Infectious Diseases Authors: Rowena Alves Coelho Gabriela Machado Alves Maria Helena Galdino Figueiredo-Carvalho Fernando Almeida-Silva Gabriela Rodrigues de Souza Maria Cristina da Silva Louren ço F ábio Brito-Santos Ana Claudia Fernandes Amaral Rodrigo Almeida-Paes Source Type: research

CARD9 deficiency predisposing chromoblastomycosis: A case report and comparative transcriptome study
In this study, we report for the first time a patient of chromoblastomycosis caused by Phialophora expanda, who harbored CARD9 mutation. Through a series of in vivo and in vitro studies, especially a comparative transcriptome study, we compared this case with our former patient suffering from phaeohyphomycosis caused by Phialophora americana. We showed that P. expanda is prone to forming sclerotic bodies both in vitro and in Card9 knockout mice, and has a stronger immunogenicity than P. americana. These data preliminary demonstrated that besides host defense, fungal specificity also contributed to the clinical phenotype in...
Source: Frontiers in Immunology - September 9, 2022 Category: Allergy & Immunology Source Type: research