Rising Eosinophilia After a Trip to the Caribbean in an HIV-Infected Man: Infections of Leisure?
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Letter to the Editor Source Type: research

Pubic Symphysis Septic Arthritis Caused by Pasteurella multocida: Report of the First Known Case and Review of the Literature
Pubic symphysis septic arthritis is rare. To our knowledge, pubic symphysis septic arthritis caused by Pasteurella multocida has not been previously reported. A 79-year-old woman presented to the emergency department with a 3-day history of progressively severe left groin pain and swelling with unintentional 20-lb weight loss. Physical examination was negative except for the presence of a tender, fluctuant mass approximately 6 × 2-cm dimensions extending from the midpubic symphysis area to the left femoral crease. Computed tomography scan of the abdomen/pelvis confirmed a multiloculated mass in the area of the pubic ...
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Fatal Postpartum Infection
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Images in ID–What's the Diagnosis? Source Type: research

Salmonella enteritidis Endocarditis and Recurrent Urinary Tract Infections in an Immunocompromised Renal Transplant Patient
We present a renal transplant patient who developed recurrent urinary tract infections with Salmonella enteritidis, complicated by bacteremia and endocarditis, and discuss our management for this challenging case. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Fusobacterium-Associated Pylephlebitis Complicated by Hepatic Abscess Following Roux-en-Y Gastric Bypass Surgery–Gastrointestinal Variant of Lemierre Syndrome: A Case Report
This report describes a rare case of acute pylephlebitis complicated by hepatic abscess formation secondary to Fusobacterium nucleatum. The patient is a 48-year-old woman who presented with worsening abdominal pain and malaise for 3 weeks. She had a Roux-en-Y gastric bypass surgery 4 months earlier that showed a phlegmon at the surgical site on a contrast computed tomography scan postsurgery. Physical examination revealed right upper quadrant tenderness, and magnetic resonance imaging of the liver showed portal vein thrombosis with multiple hepatic abscesses. The patient was started empirically on cefepime and metronidazol...
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

An Unusual Cause of Recurrent Pleural Effusion
In conclusion, patients with liver disease have an increased risk of cryptococcosis. A high index of suspicion must be maintained for infection and should be considered in patients with recurrent effusions. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Previously Unreported Presentation of Anaplasmosis in an Endemic Area: A Report of 2 Cases
Human granulocytic anaplasmosis or anaplasmosis is a zoonotic disease that is endemic to certain geographic areas of the United States. Anaplasmosis is caused by Anaplasma phagocytophilum, an intracellular bacterium that is transmitted to humans by deer ticks. The clinical presentation can vary from a subclinical infection to fulminant disease resulting in multiorgan failure and death. Patients commonly present with fever, malaise, myalgia, headache, nausea, vomiting, arthralgia, and cough. Central nervous system involvement has also been reported. Here, we present 2 cases that presented with significant diagnostic challen...
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Cellulitis and Sepsis Secondary to Serratia marcescens in a Patient With HIV
We describe a case of bullous leg cellulitis secondary to Serratia marcescens in a patient with a complex background including well-controlled HIV and venous insufficiency secondary to multiple deep vein thrombosis. Despite appropriate antibiotic therapy with meropenem, her condition deteriorated, requiring intensive care unit support. She was reviewed multiple times by the surgical teams, who felt that surgical intervention was not warranted. After a switch in antibiotics to ciprofloxacin, she made a sustained and complete recovery. S. marcescens cellulitis is a rare entity, but certain clinical features are common to mo...
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Case of Kaposi Sarcoma–Related Immune Reconstitution Inflammatory Syndrome
We describe the uncommon presentation of undiagnosed Kaposi sarcoma after antiretroviral therapy initiation. Kaposi sarcoma can manifest after initiation of antiretroviral therapy and may necessitate cytotoxic chemotherapy. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Seronegative West Nile Virus in a Patient With Stage 4 Follicular Cell Lymphoma: ERRATUM
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Errata Source Type: research

Factors Associated With Intensive Care Attention of Dengue Patients: A Retrospective Cohort Study From a Single Center
This study aimed to identify indicative markers for intensive care unit admission. Methods A retrospective study was conducted via recruiting dengue patients (≥15 years) admitted to Hospital Serdang, Malaysia, from January to April 2017. Results In total, 455 patients were included in this study. Among the factors considered, older age (P = 0.0226), Chinese (P = 0.0297), dengue with comorbidity (P = 0.0039), severe dengue (P (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Oral Antimicrobial Agents for Urinary Tract Infections Due to Enterobacteriales Species
Conclusions Oral antimicrobial agents have a limited role as empiric treatment of UTIs due to antibiotic-resistant Enterobacteriales species, with the exception of nitrofurantoin for E. coli including ESBL-producing strains. Oral cephalosporins were the second most susceptible agents to E. coli. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

A Case of Murine Typhus Presenting With Hemophagocytic Lymphohistiocytosis: ERRATUM
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Errata Source Type: research

Epidemiology and Microbiology of Bacterial Bloodstream Infection in a Tertiary Hospital in Nigeria
Conclusions Gram-negative bacteria are the leading cause of bacteremia with resistance to commonly prescribed antibiotics. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

A Single-Center Experience and Literature Review of Management Strategies for Clostridium difficile Infection in Hematopoietic Stem Cell Transplant Patients
Conclusions Clostridium difficile infection has an incidence rate of 9.4% in HSCT recipients. Established risk factors including age, sex, cancer type, and transplant type were not identified as risk factors in our population. However, longer LOS and use of more than 4 lines of antibiotics were observed among those with CDI compared with those without CDI. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

A Case of Sphingobacterium spiritivorum Bacteremia and Literature Review
We present a case of a 72-year-old white man who presented with cellulitis and sepsis secondary to S. spiritivorum. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Chlamydia pneumoniae Infections in an Immunocompetent Patient Compared With a Neutropenic Cancer Patient: A Case Series and Review of Literature
This article reviewed the limited literature regarding C. pneumoniae and immunosuppressed cancer patients, concluding that prompt diagnosis and standard recommended treatment of C. pneumoniae will provide favorable outcomes. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 26, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Undetectable Phosphorus Level in a Case of Legionnaires' Disease
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Letter to the Editor Source Type: research

Nocardia farcinica Brain Abscess Mimicking Progression of Malignancy in a Patient With Posterior Fossa Glioma
A patient presented with visual changes raising suspicion of progression of underlying brain cancer requiring craniotomy. Final results showed Nocardia farcinica brain infection instead. Nocardiosis should be considered in patients receiving corticosteroids as management can be lifesaving. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Report Source Type: research

The Wisdom of Solomon
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Reflections of an ID Specialist Source Type: research

Unique Facial and Oral Lesions in a Patient With Human Immunodeficiency Virus
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Images in ID – What's The Diagnosis? Source Type: research

Recurrent Bacteremia Due to an Infected Inferior Vena Cava Graft in a Patient With Metastatic Renal Cell Carcinoma
We present a case wherein a 60-year-old man diagnosed as having renal cell carcinoma (status after pancreaticoduodenectomy) developed recurrent bacteremia with multiple enteric pathogens over a 2-year period because of an infected vascular graft. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Invasive Aspergillosis of the Liver in an Immunocompetent Patient
We present a case of invasive hepatic aspergillosis in an immunocompetent patient. We aim to highlight the challenges faced in the diagnosis and management of hepatic aspergillosis in an immunocompetent host and also review the available literature. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Perinephric Abscess and Bacteremia Due to Lactobacillus Species in a Diabetic Adult: An Uncommon Presentation
We describe a case of a diabetic and morbidly obese, but otherwise healthy man, who developed bacteremia and perinephric abscess due to Lactobacillus species. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Successful Aztreonam Desensitization Protocol
We present a patient with an extensive history of hypersensitivity to multiple antibiotics and symptoms of potential gentamicin toxicity requiring aztreonam desensitization for the treatment of bacteremia. A desensitization protocol was created, and sequential rapid aztreonam desensitization was executed with no hypersensitivity reactions. This protocol provides guidance to other providers who need to use aztreonam where drug hypersensitivity is a concern. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Case of Recurrent Pericarditis in Association With Asymptomatic Urethral Chlamydia trachomatis Infection
Extragenital manifestations of Chlamydia trachomatis infection can be challenging to diagnose. A previously healthy 33-year-old man presented with pericarditis recurring despite anti-inflammatory therapy and progressing to cardiac tamponade. Pericardiocentesis yielded bloody-appearing fluid with increased neutrophils and negative standard cultures. The patient reported recent unprotected sexual exposure, and urine nucleic acid amplification test detected C. trachomatis. He had no urogenital, ocular, or joint symptoms. The result of an extensive workup for other causes of pericarditis was negative, including HLA-B27 testing...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Fecal Microbiota Transplantation After Oral Vancomycin for Recurrent Clostridium difficile Infection
Conclusions Fecal microbiota transplantation preceded by a standard 2-week vancomycin regimen for the treatment of patients with rCDI seems to be safe and effective. Further research is needed to explore optimal pretreatment regimens before the FMT to prevent FMT failure. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Streamlining to Oral β-Lactam Versus Fluoroquinolone as Definitive Therapy for Enterobacteriaceae Bacteremia
Conclusions Clinical outcomes were similar between those treated with oral BL compared with FQ. Oral BL may be considered for definitive treatment of EB. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Epidemiology and Outcome of Hospitalized Infants With Pertussis
The objective of this study was to review the epidemiology and outcome of infants with pertussis. Methods We identified infants with diagnosis of pertussis and compared demographic and outcome data with others who did not have pertussis. Infants with pertussis were matched 1:1 with correlative propensity score using sex, hospital region, income quartiles, race, ventilation status, and All Patients Refined Diagnosis Related Groups severity score. Results A total of 2920 pertussis cases were identified (prevalence: 4.7/1000 discharges). Females (49% vs 43%), Hispanics (35% vs 25%), and lower income quartile group (39% ...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Ceftolozane/Tazobactam for the Treatment of Osteomyelitis Due to Multidrug-Resistant Pseudomonas aeruginosa
We conducted a retrospective study of 18 patients who were treated with ceftolozane/tazobactam (C/T) for greater than 48 hours for multidrug-resistant Pseudomonas aeruginosa (MDR-PA) osteomyelitis. Osteomyelitis was diagnosed by imaging, presence of systemic inflammatory signs and symptoms, elevated C-reactive protein, and positive culture for MDR-PA. Clinical cure was defined as complete or partial resolution of signs and symptoms of infection without need for escalation of antimicrobials during inpatient and outpatient therapy. The cohort was mostly male (81.2%) with a median age of 58.5 (53.5–68.5) years. The majo...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Impact of Peptide Nucleic Acid Fluorescence in Situ Hybridization Testing for Coagulase-Negative Staphylococci in a Pediatric Setting
Conclusions Despite an observed decrease in vancomycin exposure with use of rapid PNA-FISH testing, the full benefits of rapid diagnostic testing are unrealized in the absence of an appropriate stewardship protocol. Further studies may allow determination of the full impact of rapid diagnostic testing in pediatric settings. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Impact of Vaccination on Morbidity and Mortality in Adults Hospitalized With Influenza A, 2014–2015
Discussion Vaccination during the 2014–2015 season was associated with reduced morbidity and mortality among adults hospitalized with influenza A, despite the poor vaccine matching recognized during that season. Our findings suggest that during seasons with poor vaccine matching vaccination may afford protection against poor outcomes in patients hospitalized with influenza A. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Acute Parotitis Due to Candida glabrata: A Case Report and Literature Review
This report describes the case of a 60-year-old man who developed acute parotitis with abscess formation. The causative agent of the parotid abscess was Candida glabrata, which is an unusual cause of salivary gland pathology because it typically inhabits the oral cavity as a commensal microorganism. Acute parotitis occurs most often in elderly patients who are debilitated by systemic disease or as a postoperative complication. This case is interesting because the patient was immunocompetent and had no obvious risk factors for fungal parotitis other than poor dentition. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Herpes Simplex Virus 1 Hepatitis Leading to Liver Failure and Hemophagocytic Lymphohistiocytosis: Case Report and Review of the Literature
A 65-year-old immunocompetent adult presented with fever, fatigue, and laboratory evidence of acute liver failure. He was unable to undergo liver biopsy secondary to coagulopathy. His herpes simplex virus 1 (HSV-1) polymerase chain reaction level was elevated in the serum, leading to presumptive diagnosis of HSV-1–associated hepatitis. His course was complicated by rising ferritin, and workup revealed hemophagocytic lymphohistiocytosis suspected to be secondary to infection with HSV-1. He improved on intravenous acyclovir and completed a 21-day course. Review of the literature demonstrates that this is the fourth cas...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Pacemaker Infections Caused by Rapidly Growing Mycobacteria: Presentation of 3 Cases and Review of the Literature
We report 3 cases managed at our institution and review 21 cases found in the literature. Most patients underwent device removal and were managed with more than 1 antibiotic for at least 4 weeks. All but 2 patients achieved cure. It is important to recognize these organisms as potential etiologies of pacemaker infections and to request special culture media and stains. Furthermore, it is reasonable for antibiotic choice to be guided by susceptibility reports, and at least initially, more than 1 antibiotic is recommended. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Dengue Fever in End-Stage Renal Failure Patient: Case Report and Updated Literature Review in the Diagnostic and Management Challenges
We report a case of a man with ESRF with a delayed diagnosis of dengue viral infection, who admitted at the critical phase of the illness. Despite that, he managed to recover uneventfully with tailored management in his fluid replacement, medication adjustment, and dialysis prescription. Hence, a high index of suspicion is needed when an ESRF patient presents with fever in a dengue-endemic area. A multidisciplinary approach with good collaboration between physician and nephrologist is needed to ensure the best outcome. Renal replacement therapy and medications should be individually tailored according to the patient's clin...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Review Articles Source Type: research

Highlights of Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America
Asymptomatic bacteriuria is a common cause of unnecessary antimicrobial use. The Infectious Diseases Society of America has published an update of the clinical practice guideline for the management of asymptomatic bacteriuria. The guideline provides recommendations for avoidance of antimicrobial use for the great majority of patients with asymptomatic bacteriuria. Included in the recommendations is to refrain from screening with urinalysis and/or urine culture for older patients with cognitive impairment or fall and rather to look for alternative causes of altered mental status (eg, dehydration, metabolic causes, medicatio...
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Clinical Guidelines Source Type: research

The Benefit of Influenza Vaccines: Beyond Prevention of Clinical Infection
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - November 1, 2019 Category: Infectious Diseases Tags: Editorial Comment Source Type: research

Simultaneous Serratia Marcescens Osteomyelitis and Presumed Endocarditis
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Immunodeficiency and Ataxia: An Atypical Presentation of Cryptococcal Meningitis in an Human Immunodeficiency Virus–Positive Individual
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

What Are the Chances?
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Reflections of an ID Specialist Source Type: research

A Case of Foot Drop and Linear Erythematous Plaques
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Images in ID—What's the Diagnosis? Source Type: research

Failure of Doxycycline Postexposure Prophylaxis in Human Brucellosis Contracted Through Needlestick Injury
This article presents the case of a high-risk male patient who incurred a needlestick injury as part of his work as a veterinary assistant. The patient was treated with a 21-day course of doxycycline upon first presentation but nonetheless developed brucellosis infection. It is proposed that a dual prophylaxis of doxycycline and rifampin prescribed on the day of exposure would have been a more effective intervention compared with monotherapy of doxycycline and that symptom monitoring and serological follow-up should have been carried out to reduce the risk of complications. This article recommends improvements in the enfo...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Case of Murine Typhus Presenting With Hemophagocytic Lymphohistiocytosis
We report the case of a 39-year-old man for whom murine typhus was diagnosed with serological evaluation and HLH was diagnosed via bone marrow biopsy and other studies. Although HLH has been previously described with scrub typhus, and iron overload has been described with murine typhus infection, our case represents the first report of HLH diagnosed concurrently with a murine typhus infection. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Case Report: Unusual Initial Presentation of Atypical Pneumonia in a Young Immunocompetent Patient
Mycoplasma pneumoniae is a well-known cause of community-acquired respiratory tract infection, specifically in the childhood population, and represents approximately 15% of all community-acquired pneumonia cases. Mycoplasma pneumoniae is also known for its extrapulmonary manifestations, with cardiovascular presentation being one of the most common. Gastrointestinal manifestations of the disease have been described as well, and evidence stipulates that it could be the first presentation of a M. pneumoniae infection. In our case, a cholestatic pattern was documented initially prior to pulmonary manifestations. Reviewed liter...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Sepsis, Helicoid Bacteremia, and Pneumatosis Intestinalis
Spirochetal or helical configurations are unusual among human pathogens. The number of organisms that will grow in standard blood culture media and stain well with Gram stain is even less common. This is a fatal case of sepsis with pneumatosis intestinalis due to the anaerobic spiral-formed pathogen Anaerobiospirillum succiniciproducens. It is followed by a brief discussion of organisms to consider when the laboratory calls to report “a spirochete is growing in the blood culture” along with a caveat in choosing antimicrobial therapy when A. succiniciproducens is a possibility. Human pathogens configured as hel...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Seronegative West Nile Virus in a Patient With Stage 4 Follicular Cell Lymphoma
West Nile virus (WNV) is an arbovirus, which is transmitted by mosquitoes. Transmission peaks in the late summer and early fall. In 2018, Virginia had 47 total cases of WNV, 37 of which were neuroinvasive with 7 reported deaths. Risk factors for neuroinvasive WNV include advanced age, history of organ transplantation, and hematologic malignancy especially those actively undergoing chemotherapy. Here we discuss a case of a patient with stage 4 follicular cell lymphoma with recent chemotherapy and radiation therapy, who was found to have severe neuroinvasive seronegative WNV encephalitis with flaccid paralysis. (Source: Infe...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Clostridium septicum Triad: Infected Aortic Aneurysm, Empyema, and Colon Cancer
Infected aortic aneurysm is a rare occurrence accounting for 2.6% of described aneurysms. Staphylococcus species and Salmonella species are the most frequently isolated microbes, with Clostridium septicum being decidedly less commonly detected. It is well documented that C. septicum bacteremia in the presence of an infected aneurysm is strongly associated with gastrointestinal cancer, particularly colorectal adenocarcinoma. Although blood cultures were repeatedly negative, a left pleural effusion culture grew C. septicum. The patient was treated with an endovascular prosthesis and prolonged antibiotic therapy including lif...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Case Reports Source Type: research

Outcomes of Extended Infusion Cefepime in Pediatric Patients
The objective of this study was to compare clinical outcomes in children receiving extended and traditional infusion cefepime. Methods This was a retrospective cohort study of patients aged 31 days to 17 years receiving extended or traditional infusion cefepime for at least 48 hours for a susceptible gram-negative bacteremia at a tertiary care children's hospital. The primary outcome was a composite clinical outcome comprised of infection-related mortality within 14 days of antibiotic initiation, bacteremic relapse within 30 days of culture clearance, and treatment failure. Results Sixty-seven patients were included;...
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research

Microbiological Spectrum of Infection-Related Febrile Episodes in Adult Patients With Hematologic Malignancies: A Prospective Cohort From a Tertiary Center in Iran
Conclusions Our study highlighted the high rates of prescription of broad-spectrum antimicrobials in the empirical regimen of patients and a poor adherence to appropriate deescalation strategies after the second key time point of antimicrobial therapy among physicians in charge of patients with hematologic malignancies. It also emphasizes the importance of developing infrastructure for implementation and adherence to antimicrobial stewardship strategies in hematologic malignancy wards in developing countries such as Iran. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - August 29, 2019 Category: Infectious Diseases Tags: Original Articles Source Type: research