A Bit of Caution in the Empirical Treatment of Complicated Urinary Tract Infections
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Ibuprofen and Severe Acute Respiratory Syndrome Coronavirus 2 Infection Are Synergistic on Cell Death
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Moving Goal Posts
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Reflections of an ID Specialist—Invited Source Type: research

Left-Sided Headache in a Salvadorian Woman
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Radiology for ID Source Type: research

A Unilateral Pain in the Neck
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Images in ID—What's the Diagnosis? Source Type: research

Fungal Osteomyelitis of the Temporal Bone and the Importance of Prompt Histopathologic Evaluation in Diagnosis
Fungal skull-base osteomyelitis of the temporal bone is an extremely rare condition associated with significant morbidity and mortality. Challenges in diagnosis, specifically accurate identification of pathogens, can complicate and delay appropriate treatment. This is a case of an 82-year-old man with a history of chronic kidney disease, prostate cancer, and type 2 diabetes mellitus. He had a history Bell palsy with complete facial paralysis 1 year prior and a 9-month history of worsening otalgia and otorrhea. Noncontrast computed tomography of the temporal bone revealed a well-developed, opacified mastoid with bone erosio...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Disseminated Streptococcus pneumoniae Infection Associated With an Intrauterine Device
We present a case of septic shock due to S. pneumoniae associated with an intrauterine device in an immunocompromised patient. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Klebsiella pneumoniae Causing Liver Abscess, Endophthalmitis, and Cavitary Pneumonia
We report a case of hypervirulent K. pneumoniae bacteremia causing hepatic abscess, endophthalmitis, and cavitary pneumonia in a diabetic male. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Exotic Pets as a Vector for Leptospirosis: An Original and Difficult to Prove Mode of Transmission
We report a case of human leptospirosis whose highly suspected vector was a domestic ferret. Careful questioning did not reveal any recent usual context of leptospirosis transmission in our patient, and the only vector found was his pets, which had been in contact with rodents in previous years. Urinary sampling is technically difficult in ferrets, and the bacterial shedding is intermittent, so the evidence of chronic carriage in exotic pets is rarely reported. To be aware that exotic pets are a potential source of infection is important to suspect this polymorphic disease. The exposure to contaminated water or rodents by ...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Intrathecal Hyaluronidase in Tubercular Arachnoiditis: The Unexplored Adjuvant
Intrathecal hyaluronidase for short duration as an adjuvant for treatment of tubercular arachnoiditis was tried in the past, and although the initial results were promising, surprisingly, no further confirmatory studies were undertaken and have not come into routine clinical use. We did a retrospective chart review of 25 patients who had tubercular meningitis with spinal or opticochiasmatic arachnoiditis who were given weekly intrathecal hyaluronidase for 10 weeks, in addition to antitubercular drugs and steroids. Of the 19 patients with spinal tubercular arachnoiditis, 10 were independent by the time of completion of ther...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Immunology/Microbiology for ID Source Type: research

Role of Image-Guided Biopsy in the Diagnosis and Antimicrobial Management of Vertebral Osteomyelitis: A Retrospective Cohort Study
This study is a retrospective chart review of 83 patients (49 men, 34 women; age range, 28–92 years; mean age, 56.9 years) with a diagnosis of vertebral osteomyelitis on imaging (computed tomography or magnetic resonance imaging) who underwent a fluoroscopy-guided biopsy from January 2010 to May 2015. Data collection included patient demographic information; etiology/risk factors for vertebral osteomyelitis; antibiotic exposure within 30 days before biopsy; blood, urine, and bone culture results; and any postprocedural change in antibiotic therapy. The primary outcome is culture yield from biopsy, whereas the seconda...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Doripenem Pharmacokinetics in Hemodialysis
Conclusions A low-flux dialyzer removes about half of the total amount of doripenem in blood circulation for 4 hours. Therefore, drug dosage adjustment is required for end-stage renal disease patients undergoing hemodialysis. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Minocycline Intravenous for the Treatment of Serious Infections Due to Gram-Negative Nonpseudomonal Bacteria, Including Stenotrophomonas maltophilia, Acinetobacter baumannii, and Burkholderia cepacia
Conclusions Minocycline demonstrated that high in vitro susceptibility against problematic gram-negative pathogens and administered as an IV formulation was associated with good clinical and microbiologic outcomes alone or in combination in a seriously ill patient population. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Retrospective Analysis of Vancomycin Use in Febrile Neutropenic Patients
Conclusion Vancomycin use is common, and despite adherence to guideline concordant prescribing, those receiving vancomycin had poorer clinical outcomes. There is a need for identification of more specific risk factors for gram-positive infections, and more education on the appropriate use of vancomycin to promote proper utilization and ensure optimal patient outcomes. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Respiratory Syncytial Virus Outbreak in a Veterans Affairs Long-term Care Facility
Conclusions Respiratory syncytial virus is highly infectious and can easily cause an outbreak in an LTCF. Polymerase chain reaction testing was contributory to identify cases rapidly. Rapid PCR results and intensified infection control measures were instrumental to halt the outbreak. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Extrapulmonary Manifestations of SARS-CoV-2: A Brief Review
On December 30, 2019, the first reports of a group of patients with unknown etiology pneumonia appeared in Wuhan city, Hubei province, China. Taking into consideration the large amount of similar nucleotide sequences between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the past epidemic coronavirus, it will be appropriate to expect that such pathogens share the same cell line tropism and systemic pathology. Although several studies have, so far, identified the clinical characteristics of COVID-19 cases, there is very little knowledge on the extrapulmonary affection of SARS-CoV-2. (Source: Infectious Dis...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Review Articles Source Type: research

Haemophilus Species, a Rare Cause of Vertebral Osteomyelitis: Case Report and Review of the Literature
We report a case of Haemophilus parainfluenzae vertebral osteomyelitis and review the English-language literature for cases of H. parainfluenzae and Haemophilus influenzae vertebral osteomyelitis. Fourteen previously reported cases are described alongside our case. The median age was 66 years. Twelve patients (80%) had infection involving the lumbar/sacral vertebrae. Nine (60%) had a possible predisposing factor, including prior respiratory infections and procedures involving mucosal surfaces. Only 4 patients were febrile, and another 4 had symptoms suggesting cord compression. The diagnosis was established by growth of th...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Review Articles Source Type: research

Highlights of Clinical Practice Guideline for the Management of Community-Acquired Pneumonia: 2019 Update by the American Thoracic Society and Infectious Diseases Society of America
Pneumonia is the leading cause of morbidity and mortality in the United States. The American Thoracic Society and The Infectious Diseases Society of America recently published updated guidelines for the diagnosis and treatment of community-acquired pneumonia. Initial antibiotic therapy should cover for Streptococcus pneumoniae, Haemophilus influenzae, and other gram-negative bacilli. Patients who have risk factors for the development of antibiotic resistant pathogens, such as methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa should have appropriate empiric coverage for these pathogens. The recommended ...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Clinical Guidelines Source Type: research

Vitamin A for the Management of Measles in the United States
Measles is an acute, highly contagious disease that results from infection with the measles virus and is a significant cause of morbidity and mortality worldwide. Vitamin A has been recommended for decades by the American Academy of Pediatrics and the World Health Organization to manage measles in hospitalized children. However, recent studies show that vitamin A has not been used appropriately to treat US children with measles—either by not using vitamin A at all or by using insufficiently low doses. In November 2019, the National Foundation for Infectious Diseases convened a summit that included multidisciplinary s...
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: NFID Clinical Updates Source Type: research

Haemophilus—Bad to the Bone
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 25, 2020 Category: Infectious Diseases Tags: Editorial Comment Source Type: research

Preventive Measures, Advice, and Vaccinations for Traveling US Veterans
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Letter to the Editor Source Type: research

Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is a rare immunopathological syndrome, which can be fatal if not diagnosed early. It is characterized by excessive immune activation and can be observed in all age groups depending on the causes of HLH. Here, we describe a case of cytomegalovirus-induced HLH in an immunocompromised host which was diagnosed in the setting of high clinical suspicion and insufficient diagnostic information. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Case Report Source Type: research

The Textbook Patient
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Reflections of an ID Specialist Source Type: research

Isolated Eosinophilic Pleural Effusion
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Images in ID–What’s the Diagnosis? Source Type: research

Multiorgan Failure in Immunosuppressed Patient: Unremembered Parasite
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Images in ID—What's the Diagnosis? Source Type: research

First Reported Case of Postneurosurgical Ventriculoperitonitis Due to Kocuria rhizophila Following a Ventriculoperitoneal Shunt Placement
We report here for the first time a case of ventriculoperitonitis due to K. rhizophila in adult, identified by MALDI-TOF mass spectrometry and 16S rRNA gene sequencing. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Case Report: Mixed Meningoencephalitis by: Aspergillus fumigatus: and a Pigmented Mold in a Young Woman With No Evident Immunosuppression
Fungal meningitis is often a fatal condition, particularly in immunosuppressed patients. Herein, we describe the case of a previously healthy young woman with a history of epidural anesthesia for a cesarean delivery in another hospital 3 months prior. The patient complained of chronic migraine-like headache before admission to our center. After 5 weeks, a cerebrospinal fluid culture in Sabouraud agar grew a mold, later identified as Aspergillus fumigatus. The patient died after 114 days of hospitalization despite being administered with voriconazole for 45 days. At autopsy, a pigmented mold consistent with phaeohyphomycosi...
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

A Complicated Case of Haemophilus influenzae Endocarditis in an Adult
Bacterial causes for infective endocarditis have changed over the years, with Staphylococcus aureus now being the most common pathogen isolated. With the advent of routine childhood vaccinations, invasive infections caused by Haemophilus influenzae have become rare. We wish to report a case of infective endocarditis caused by H. influenzae that was complicated by meningitis, septic arthritis, and stroke. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Cryptococcal Pneumonia Following Influenza in an Immunocompetent Patient
We describe the case of a 42-year-old immunocompetent man who developed severe pneumonia with Cryptococcus neoformans var. grubii following influenza A infection. With the commencement of liposomal amphotericin and flucytosine, his condition dramatically deteriorated. Secondary bacterial infection following influenza is a well-recognized phenomenon and there are increasing reports of invasive aspergillosis occurring in the critically ill; however, secondary infection with cryptococcus in the immunocompetent patient is rare. The absence of an immunological defect in our patient raises the possibility of influenza predisposi...
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Clostridioides difficile Infections in Adult and Pediatric Intestinal and Multivisceral Transplant Patients: The Experience of a Single, Tertiary-Care Transplant Center From 2009 to 2018
Conclusions For certain solid organ transplant recipients, an association between CDI and allograft loss, rejection, and mortality has been shown. Although limited by sample size, we observed that early CDI was not associated with those outcomes in the present investigation. Multicenter studies are merited to explore risk factors for CDI and associations with transplant-related outcomes in intestinal and multivisceral transplant recipients. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Impact of Daptomycin Minimum Inhibitory Concentration on Clinical Cure Rates for Vancomycin-Resistant Enterococcus Infections
The objective was to compare clinical outcomes for patients who had a VRE bloodstream infection (BSI) and a daptomycin MIC of 2 mg/L or greater (low MIC group) versus a daptomycin MIC of 3 to 4 mg/L (high MIC group). Methods This was a single-center, retrospective study of adult patients receiving 48 hours or more of daptomycin therapy. The following primary and secondary outcomes were assessed: microbiological cure, clinical cure, and 30-day all-cause mortality. Results Sixty-five patients were included in this analysis: 16 patients in the low MIC group and 49 in the high MIC group. Patients in the high MIC group re...
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Improving Microbe Detection and Optimizing Antibiotic Use in Neonatal Sepsis With Multiplex Polymerase Chain Reaction: A Comparative Cohort Study
Conclusions Polymerase chain reaction improves diagnostic yield in neonatal health care–associated infection and can help decrease duration of antibiotic therapy. Resistance to broad spectrum antibiotics is uncommon. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

The Clinical Impact of 16S Ribosomal RNA Polymerase Chain Reaction Bacterial Sequencing in Infectious Endocarditis: A Single Center Experience
Conclusions 16S rRNA PCR sequencing is a useful tool for obtaining a microbiologic diagnosis in cases of possible or culture-negative endocarditis. The test has potential to impact patient care and in a subset of cases could be used to deescalate antibiotic therapy. However, testing delays and cumbersome resulting methods impede bacterial sequencing from reaching its full potential as a diagnostic modality. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research

Intestinal Spirochetes in Cancer Patients: Our Experience and Review of the Literature
We present a series of 3 case reports of human intestinal spirochetosis in immunocompromised cancer patients at the Moffitt Cancer Center and Research Institute. The aim of this study is to increase awareness of this entity in immunocompromised cancer patients and non–HIV-positive immunosuppressed patients, particularly when presenting with gastrointestinal symptoms of unclear etiology. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Review Articles Source Type: research

Empyema Necessitans Due to Methicillin-Sensitive Staphylococcus aureus: Case Report and Review
Empyema refers to a collection of pus in the pleural cavity. Empyema necessitans is a rare complication of an empyema that refers to an insidious extension of the pus through the parietal pleura into the neighboring subcutaneous tissue of the chest wall or, less often, other thoracic structures. Left untreated, the purulent material may penetrate the chest wall forming a fistula or subcutaneous abscess. Drainage and empiric antimicrobial therapy should be started when the diagnosis is made and adjusted once the infecting organism is identified. Mycobacterium tuberculosis and Actinomyces species, both generally slow-growing...
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Review Articles Source Type: research

Bundling Probiotics With Antimicrobial Stewardship Programs for the Prevention of Clostridiodes difficile Infections in Acute Care Hospitals
Conclusions The panel members agreed with the statements developed and concluded that a bundle with specific probiotics with evidence-based efficacy should be appropriately incorporated into ASPs for the prevention of CDI. Care should be taken when planning the method of probiotic implementation and measures for monitoring adherence to protocol should be included. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Review Articles Source Type: research

From 1990 to 2020: The 30-Year History of the Identification of Difficult to Culture Pathogens
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - April 24, 2020 Category: Infectious Diseases Tags: Editorial Comment Source Type: research

Marked Reduction of Vancomycin Utilization in a Veterans Hospital
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Letter to the Editor Source Type: research

The Paradoxical Response in an Immunocompromised Patient With Disseminated Mycobacterium chelonae Infection
The paradoxical response, a form of immune reconstitution inflammatory syndrome, merits immunosuppression in addition to antimycobacterial therapy in patients with nontuberculous mycobacterial (NTM) infections. Well-described in Mycobacterium tuberculosis infections, the paradoxical response in NTM infections is less defined. We share an immunocompromised host with disseminated NTM and the paradoxical response. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

The Devil Is in the Detail
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Reflections of an ID Specialist Source Type: research

A Case of a Necrotic Cutaneous Lesion
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Images in ID–What's the Diagnosis? Source Type: research

A Man With Chronic Diarrhea and Weight Loss
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Images in ID–What's the Diagnosis? Source Type: research

An Unexpected Etiology for Abdominal Pain and Diarrhea in an Argentinian Immigrant
No abstract available (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Images in ID–What's the Diagnosis? Source Type: research

The First Case Report of Septic Arthritis and Osteomyelitis of the Knee Caused by Candida viswanathii
An elderly lady was diagnosed in 2015 with septic arthritis and osteomyelitis of the knee caused by Candida viswanathii. This is the first report of a nonmeningitic, noncandidemic osteoarticular infection due to this rare Candida since the first 2 isolations in cerebrospinal fluid in 1959 and 1976, respectively. She was successfully treated with 2 repeat arthroscopic washouts and 16 months of susceptible antifungal therapy with full recovery. The contributing factors of this successful treatment include prompt molecular identification of this rare Candida species, adequate source control with arthrotomies, susceptibility d...
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Tempestuous Course of Enterococcus Infective Endocarditis — From Daptomycin Lung Toxicity to Successful Treatment With Surgery and Fosfomycin Combination Therapy
We report a patient with E. faecalis IE who had allergy to β-lactam and during treatment had developed daptomycin lung toxicity. He was subsequently treated with intravenous fosfomycin and surgery with aortic valve replacement. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Brain Abscess Caused by Resistant Streptococcus pneumoniae
Brain abscess can have multiple sources such as traumatic brain injury, prior neurosurgical procedure, contiguous spread from a local source, or hematogenous spread of a systemic infection. Streptococcus pneumoniae has been isolated from brain abscesses with hematogenous spread from paranasal sinusitis. This case encompasses an unusual presentation of a resistant S. pneumoniae isolate causing brain abscess in a patient with a history of neurosurgical procedure highlighting challenges in empiric therapy, further management, and outcomes. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Aspergillus flavus Left Ventricular Assist Device Driveline Exit Site Infection
We present a unique case of localized Aspergillus left ventricular assist device driveline exit site infection successfully treated with debridement, antifungal therapy, and device retention, but the course was complicated by emergence of triazole resistance. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Colectomy Averted: A Successful Case Report of Fidaxomicin Administration Through a Loop Ileostomy for Fulminant: Clostridioides difficile: Infection
We describe an off-label route of fidaxomicin administration through a loop ileostomy twice daily with successful outcome. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Clinical and Microbiological Diagnosis of Nonprimary Cytomegalovirus Infection in Pregnancy With Symptomatic Congenital Cytomegalovirus Infection
We report a case of nonprimary CMV infection in pregnancy with fetal neurological alterations. A positive quantitative polymerase chain reaction in amniotic fluid (AF) confirmed the diagnosis of cCMV infection that triggered a voluntary termination of pregnancy. Quantitative polymerase chain reaction assays of AF are used to confirm a fetal cCMV infection, and the invasive amniocentesis procedure is justified when abnormalities are found in ultrasound control, although they are not validated to use in AF. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Case Reports Source Type: research

Antimicrobial Stewardship Metrics that Matter
Conclusions Documented indication showed strong association with clinical success, providing support for use of the Centers for Disease Control's Core Elements as a metric for quality of care. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - March 1, 2020 Category: Infectious Diseases Tags: Original Articles Source Type: research