Combination of amphotericin B and terbinafine against melanized fungi associated with chromoblastomycosis.
Abstract Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa. This combination could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora. PMID: 29581111 [PubMed - as supplied by publisher] (Source: An...
Source: Antimicrobial Agents and Chemotherapy - March 26, 2018 Category: Microbiology Authors: Deng S, Lei W, de Hoog GS, Yang L, Vitale RG, Rafati H, Seyedmousavi M, Tolooe A, van der Lee H, Liao W, Verweij PE, Seyedmousavi S Tags: Antimicrob Agents Chemother Source Type: research

Cover Image
The cover image, by Liya He et al., is based on the Original Article Successful treatment of chromoblastomycosis of 10‐year duration due to Fonsecaea nubica, DOI: 10.1111/myc.12732. (Source: Mycoses)
Source: Mycoses - March 13, 2018 Category: Research Tags: COVER IMAGE Source Type: research

Transformation of < i > Fonsecaea pedrosoi < /i > into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN- γ production
by Bilin Dong, Zhongsheng Tong, Ruoyu Li, Sharon C.-A. Chen, Weihuang Liu, Wei Liu, Yao Chen, Xu Zhang, Yiqun Duan, Dongsheng Li, Liuqing ChenFonsecaea pedrosoi (F.pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Experimental studies in murine models have shown that the absence of CD4+ T cells impairs host defense againstF.pedrosoi infection. Clinical research has also suggested that a relatively low level of the Th1 cytokine INF- γ and inefficient T cel...
Source: PLoS Neglected Tropical Diseases - February 26, 2018 Category: Tropical Medicine Authors: Bilin Dong Source Type: research

Image Gallery: Uncommon presentation of facial chromoblastomycosis caused by Cladophialophora  carrionii
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 8, 2018 Category: Dermatology Authors: R. ‐J. Wang, R.‐Y. Li Tags: Image Correspondence Source Type: research

Genetic manipulation of Fonsecaea pedrosoi using particles bombardment and Agrobacterium mediated transformation
Publication date: Available online 2 January 2018 Source:Microbiological Research Author(s): Camille Silva Florencio, Fabiana Alves Silva Brandão, Marcus de Mello Teixeira, Anamélia Lorenzetti Bocca, Maria Sueli S. Felipe, Vânia Aparecida Vicente, Larissa Fernandes Fonsecaea pedrosoi, a melanized fungal pathogen that causes Chromoblastomycosis, a human disease with a worldwide distribution. Biolistic is a widely used technique for direct delivery of genetic material into intact cells by particles bombardment. Another well-established transformation method is Agrobacterium-mediated transformation (ATMT), which i...
Source: Microbiological Research - January 3, 2018 Category: Infectious Diseases Source Type: research

Mechanisms of copper and zinc homeostasis in pathogenic black fungi
Publication date: Available online 13 December 2017 Source:Fungal Biology Author(s): Mirelle Garcia Silva-Bailão, Kassyo Lobato Potenciano da Silva, Laura Raniere Borges dos Anjos, Patrícia de Souza Lima, Marcus de Melo Teixeira, Célia Maria de Almeida Soares, Alexandre Melo Bailão Black fungi comprise a diverse group of melanized microorganisms that can be found in a variety of environments, fact that make some of them considered extremophiles. Many species are able to adapt and grow in humans, being responsible for infections that range from mild cutaneous injuries to fatal brain diseases in healthy individu...
Source: Fungal Biology - December 14, 2017 Category: Biology Source Type: research

Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina
Publication date: Available online 8 December 2017 Source:Medical Mycology Case Reports Author(s): Marcelo Label, Luciana C. Karayan, Sybren De Hoog, Javier Afeltra, Togo Bustamante, Roxana G. Vitale Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. Fonsecaea monophora has a global distribution along the equator. Cases outside the (sub)tropics have thus far mostly been ...
Source: Medical Mycology Case Reports - December 9, 2017 Category: Biology Source Type: research

Successful treatment of chromoblastomycosis of 10 ‐year duration due to Fonsecaea nubica
This article is protected by copyright. All rights reserved. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Authors: Liya He, Jianchi Ma, Xin Mei, Sha Lu, Xiqing Li, Liyan Xi Tags: Original Article Source Type: research

Successful treatment of chromoblastomycosis of 10 ‐year duration due to Fonsecaea nubica
Mycoses,Volume 61, Issue 4, Page 231-236, April 2018. (Source: Mycoses)
Source: Mycoses - November 25, 2017 Category: Research Source Type: research

The Major Chromoblastomycosis Etiologic Agent Fonsecaea pedrosoi Activates the NLRP3 Inflammasome
Raffael J únio Araújo de Castro, Isaque Medeiros Siqueira, Márcio Sousa Jerônimo, Angelina Maria Moreschi Basso, Paulo Henrique de Holanda Veloso Junior, Kelly Grace Magalhães, Luiza Chaves Leonhardt, Stephan Alberto Machado de Oliveira, Pedro Henrique Bürgel, Aldo Henrique Tavares, Anamélia Lorenzetti Bocca (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 20, 2017 Category: Allergy & Immunology Source Type: research

Chromoblastomycosis of the leg.
Authors: Sali AP, Sahay A Abstract CASE REPORT: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Histopathological examination of the skin biopsy revealed the presence of characteristic pigmented sclerotic bodies with pseudoepitheliomatous hyperplasia of the overlying epithelium. The case was report...
Source: Polish Journal of Pathology - October 16, 2017 Category: Pathology Tags: Pol J Pathol Source Type: research

Comparative Genomics of Sibling Species of Fonsecaea Associated with Human Chromoblastomycosis
Vania A. Vicente, Vin ícius A. Weiss, Amanda Bombassaro, Leandro F. Moreno, Flávia F. Costa, Roberto T. Raittz, Aniele C. Leão, Renata R. Gomes, Anamelia L. Bocca, Gheniffer Fornari, Raffael J. A. de Castro, Jiufeng Sun, Helisson Faoro, Michelle Z. Tadra-Sfeir, Valter Baura, Eduardo Balsanelli, Sandro R. Almeida, Suel en S. Dos Santos, Marcus de Melo Teixeira, Maria S. Soares Felipe, Mariana Machado Fidelis do Nascimento, Fabio O. Pedrosa, Maria B. Steffens, Derlene Attili-Angelis, Mohammad J. Najafzadeh, Flávio Queiroz-Telles, Emanuel M. Souza, Sybren De Hoog (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - October 9, 2017 Category: Microbiology Source Type: research

Longitudinal melanonychia due to voriconazole therapy during treatment of chromoblastomycosis
(Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 1, 2017 Category: Dermatology Authors: P. R. Criado, F. D. Cosenza, W. B. Junior, P. S. Ferreira Tags: Viewpoints in dermatology ● Correspondence Source Type: research

Chromoblastomycosis: tissue modifications during itraconazole treatment
Conclusion: Parasitic and tissue changes verified in this study can reflect the parasite-host dynamics under itraconazole action. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - September 21, 2017 Category: Dermatology Source Type: research