Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of < i > Fonsecaea monophora < /i >
In conclusion, we confirmed the crucial role of C-terminal TE in maintaining fully function ofpks1 inF.monophora. Deletion of TE negatively impacts on the synthesis of melanin and metabolites that eventually affect growth and virulence ofF.monophora. Any potential inhibitor of TE then could be a novel antifungal target for drug development. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - June 13, 2022 Category: Tropical Medicine Authors: Minying Li Source Type: research
Pathogenicity and Growth Conditions Modulate Fonsecaea Extracellular Vesicles ’ Ability to Interact With Macrophages
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous mycosis caused by black, dimorphic, and filamentous fungi of the Herpothrichiellaceae family, such as species of the genus Fonsecaea. These fungi can switch between the saprophytic forms (conidia and hyphae) and the pathogenic form, the muriform cells (MCs), which is considered an essential mechanism for fungal virulence. Nearly all types of cells can produce membranous structures formed by a lipid bilayer that communicate extracellularly with other cells, known as “extracellular vesicles” (EVs), which may act as virulence factors, as observed for severa...
Source: Frontiers in cellular and infection microbiology - June 9, 2022 Category: Microbiology Source Type: research
In vivo reflectance confocal microscopy, dermoscopy, high-frequency ultrasonography, and histopathology features in a case of chromoblastomycosis
by Gabriela A. Giraldelli, J éssica L. C. S. Baka, Rosane Orofino-Costa, Juan Piñeiro-Maceira, Elisa Barcaui, Carlos B. Barcaui (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 3, 2022 Category: Tropical Medicine Authors: Gabriela A. Giraldelli Source Type: research
Molecular Characteristics of Regional Chromoblastomycosis in Guangdong, China: Epidemiological, Clinical, Antifungal Susceptibility, and Serum Cytokine Profiles of 45 Cases
In conclusion, we investigated the molecular epidemiological, clinical, and laboratory characteristics of CBM in Guangdong, China, which may assist further clinical therapy, as well as fundamental pathogenesis studies of CBM. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 18, 2022 Category: Microbiology Source Type: research
Doubly Misdiagnosed: Exophiala Masquerading as Squamous Cell Carcinoma and Chromoblastomycosis
Abstract:
Deep cutaneous fungal infections (DCFI) can arise in the setting of skin trauma and immunosuppression. DCFI may be secondary to chromoblastomycosis, which is typically characterized by pseudoepitheliomatous hyperplasia histologically and can be mistaken for squamous cell carcinoma. In addition, “copper penny” spore–like pigmented yeast forms on Grocott's methenamine silver stain can suggest chromoblastomycosis, but this finding is not specific. By contrast, phaeohyphomycosis characteristically exhibits circumscribed pseudocyst or abscess on histopathology, and both yeast and hyphae can be seen. Our case...
Source: The American Journal of Dermatopathology - December 18, 2021 Category: Pathology Tags: Extraordinary Case Report Source Type: research
Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis
J Immunol Res. 2021 Nov 1;2021:9742832. doi: 10.1155/2021/9742832. eCollection 2021.ABSTRACTChromoblastomycosis (CBM) is a neglected human disease, caused by different species of pigmented dematiaceous fungi that cause subcutaneous infections. This disease has been considered an occupational disease, occurring among people working in the field of agriculture, particularly in low-income countries. In 1914, the first case of CBM was described in Brazil, and although efforts have been made, few scientific and technological advances have been made in this area. In the field of fungi and host cell relationship, a very reduced n...
Source: Cell Research - November 11, 2021 Category: Cytology Authors: Luiz Felipe Domingues Passero Italo Novais Cavallone Walter Belda Source Type: research
Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis
J Immunol Res. 2021 Nov 1;2021:9742832. doi: 10.1155/2021/9742832. eCollection 2021.ABSTRACTChromoblastomycosis (CBM) is a neglected human disease, caused by different species of pigmented dematiaceous fungi that cause subcutaneous infections. This disease has been considered an occupational disease, occurring among people working in the field of agriculture, particularly in low-income countries. In 1914, the first case of CBM was described in Brazil, and although efforts have been made, few scientific and technological advances have been made in this area. In the field of fungi and host cell relationship, a very reduced n...
Source: Journal of Immunology Research - November 11, 2021 Category: Allergy & Immunology Authors: Luiz Felipe Domingues Passero Italo Novais Cavallone Walter Belda Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - September 28, 2021 Category: Tropical Medicine Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 28, 2021 Category: Infectious Diseases Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - September 28, 2021 Category: Tropical Medicine Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 28, 2021 Category: Infectious Diseases Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - September 28, 2021 Category: Tropical Medicine Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 28, 2021 Category: Infectious Diseases Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
Case Report: Short-Term Application of Topical Imiquimod Is Practical for Chromoblastomycosis
We describe a refractory case of chromoblastomycosis in which the lesion did not respond to initial treatment, but then use of topical imiquimod cured the lesion successfully.PMID:34583329 | DOI:10.4269/ajtmh.21-0735 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - September 28, 2021 Category: Tropical Medicine Authors: Xiao-Wen Huang Mei-Nian Xu Si-Qi Dai Kang Zeng Li Li Source Type: research
