Estimated glomerular filtration rate using creatinine-based chronic kidney disease epidemiology collaboration equation
AA Rani, V ViswanathanIndian Journal of Nephrology 2018 28(6):492-493 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: AA Rani V Viswanathan Source Type: research

Improving crossmatch techniques and graft outcomes
L VincentIndian Journal of Nephrology 2018 28(6):491-492 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: L Vincent Source Type: research

Cystinuria in a 13-Month-Old girl with absence of mutations in the SLC3A1 and SLC7A9 genes
MD Al-MendalawiIndian Journal of Nephrology 2018 28(6):490-490 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: MD Al-Mendalawi Source Type: research

Kidney transplantation from a hepatitis C virus-positive donor to a hepatitis C virus-negative recipient
We report the successful transplantation of an HCV-negative recipient transplanted with an HCV-positive donor kidney. Donor was treated with sofosbuvir and ribavirin for 12 weeks. At 10th and 16th weeks of starting treatment, her HCV-RNA PCR was negative. Three weeks later, transplantation was performed with basiliximab induction and triple immunosuppression with tacrolimus, mycophenolate, and prednisolone. The recipient was administered sofosbuvir and ribavirin for 12 weeks. He attained good graft function with a stable creatinine. His serial alanine transaminases were normal on 3rd, 6th, and 12th months, respectively. Si...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: M Kamalkiran V Ravikiran C Shashidhar K. V. R Prasad V Yeldandi Source Type: research

An unusual association of renal cell carcinoma and renal malakoplakia with focal segmental glomerulosclerosis in an elderly patient
M Vijayan, P Koshy, R Parthasarathy, M Mathew, G AbrahamIndian Journal of Nephrology 2018 28(6):485-487 The association of malignancy and glomerulonephritis may be missed, especially in elderly patients. Here, we report a case of eosinophilic variant of renal cell carcinoma and renal parenchymal malakoplakia discovered on renal biopsy in a patient with steroid-dependent nephrotic syndrome. The presence of malakoplakia in our biopsy was probably due to systemic steroid therapy for glomerulonephritis, presence of concomitant asymptomatic urinary tract infection, and/or history of diabetes mellitus. The patient had remission...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: M Vijayan P Koshy R Parthasarathy M Mathew G Abraham Source Type: research

Autosomal dominant polycystic kidney disease: Presence of hypomorphic alleles in PKD1 Gene
S Pandita, D Khullar, R Saxena, IC VermaIndian Journal of Nephrology 2018 28(6):482-484 Autosomal dominant polycystic kidney disease is characterized by multiple cysts in both kidneys manifesting in adult life. In general, the disorder is caused by a pathogenic variant in one allele of PKD1 or PKD2 genes, while the other allele is normal. Pathogenic variants in both the alleles are rare and have variable phenotypes, from lethal or perinatal presentation to a mild form in later adulthood, depending on the type of variant. Here, we describe a proband with two variants (p.Thr1773Ile and p.Ala1871Thr in trans) in PKD1 gene, w...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: S Pandita D Khullar R Saxena IC Verma Source Type: research

Allopurinol-induced drug reactions with eosinophilia and systemic symptoms syndrome with interstitial nephritis
We report a case of DRESS syndrome in a 64-year-old man, induced by allopurinol treatment for asymptomatic hyperuricemia, started 8 weeks earlier but stopped only 3 days after because of the onset of rash. The diagnosis was retained due to combining of interstitial nephritis with the clinical findings of fever, skin rash, cervical lymphadenopathy, eosinophilia, and reactivation of human herpesviruses specifically HHV-6. The glucocorticoids were started to relieve hypersensitivity. Five days later, the patient became afebrile, and the rash improved significantly. However, interstitial nephritis with renal function impairmen...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: T Aatif J Fatihi H El Annaz O Qamouss Source Type: research

Crystalline nephropathy in renal transplant: A series of 4 cases
K Mnif, S Yaich, M Mars, K Kammoun, F Fendri, K Charfeddine, F Jarraya, T Boudawara, J HachichaIndian Journal of Nephrology 2018 28(6):472-476 Crystals are particles of endogenous inorganic or organic composition that can trigger kidney injury when deposited or formed inside the kidney. The most common forms of crystalline nephropathies (CNs) are nephrocalcinosis and oxalate nephropathy. The causes of early allograft dysfunction are changing constantly, and recently calcium oxalate (CaOx) crystal deposition has been added to this list. CaOx deposition in renal allograft is important and probably under-recognized cause of ...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: K Mnif S Yaich M Mars K Kammoun F Fendri K Charfeddine F Jarraya T Boudawara J Hachicha Source Type: research

Xanthogranulomatous pyelonephritis: Intrahepatic and intrathoracic extension
U Anandh, N Birajdar, R Kumar, S BabuIndian Journal of Nephrology 2018 28(6):468-471 A 32-year-old female presented to us with worsening cough and expectoration, low-grade fever, and malaise for 3 months. She gave a history of pregnancy loss secondary to urinary tract infection (UTI) a year back. At that time, she was told to have an obstructive right renal calculus. She also had a history of recurrent UTI in the past 1 year. She had no other comorbidities. Her clinical evaluation revealed an enlarged right kidney and reduced air entry in the right hemithorax. Radiological investigations revealed a large right kidney inva...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: U Anandh N Birajdar R Kumar S Babu Source Type: research

Systemic lupus erythematosus with linear IgA bullous dermatosis and renal vascular lesions: An extremely rare association
We report a rare case of systemic lupus erythematosus presenting initially with cutaneous manifestations of linear IgA bullous dermatosis. Later the patient developed renal abnormalities due to thrombotic microangiopathy and lupus nephritis with inflammatory necrotizing vasculitis. Paucity of immune deposits was observed on Immunofluorescence. This association of SLE with these cutaneous and renal lesions is rarely reported in the literature. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: R Malipatel V Gnanapriya A Manocha YK Inchara Source Type: research

Hepatitis C virus-associated membranoproliferative glomerulonephritis treated with directly acting antiviral therapy
We present one such patient who presented to us with HCV-associated MPGN without detectable CG, who recovered completely with directly acting antiviral therapy without any immunosuppression. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: S Nayak A Kataria MK Sharma A Rastogi E Gupta A Singh SC Tiwari Source Type: research

Acute pyelonephritis: A single-center experience
L Umesha, SM Shivaprasad, EN Rajiv, MM Satish Kumar, V Leelavathy, CG Sreedhara, MR NiranjanIndian Journal of Nephrology 2018 28(6):454-461 Acute pyelonephritis (APN), although a common clinical entity, still not much is known about the clinical profile in the Indian scenario. We prospectively collected clinical, biochemical, and radiological data of patients hospitalized with a diagnosis of APN from March 2014 to June 2016. A total of 296 cases were included in the study. Mean age was 53.85 ± 9.78 years. Male to females ratio was 1.93:1. Among the risk factors recognized for complicated pyelonephritis (PN), diabetes...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: L Umesha SM Shivaprasad EN Rajiv MM Satish Kumar V Leelavathy CG Sreedhara MR Niranjan Source Type: research

Prevalence and clinical correlates of white coat effect in patients with chronic kidney disease and the role of automated blood pressure device in its assessment
Conclusion: WCE is a highly prevalent and underdiagnosed entity in patients with CKD. Automated machine is a useful and time-saving tool in detection of WCE in patients with CKD attending the outpatient clinic and guide management. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: Srinivas Shenoy Shankar Prasad Nagaraju Nileshwar R Rau Ravindra A Prabhu Uday Venkat Mateti Dharshan Rangaswamy Indu R Rao Karan Saraf Source Type: research

Role of blood oxygen level-dependent MRI in differentiation of acute renal allograft dysfunction
Hira Lal, Ezaz Mohamed, Neelam Soni, Priyank Yadav, Manoj Jain, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Amit Gupta, RK SharmaIndian Journal of Nephrology 2018 28(6):441-447 Early graft dysfunction after renal transplantation manifests as acute rejection (AR) or acute tubular necrosis (ATN). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method of assessing tissue oxygenation, which may be useful for predicting acute allograft dysfunction. This was a prospective study involving 40 patients scheduled for renal transplantation from August 2012 to August 2014. In addition, 15 h...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: Hira Lal Ezaz Mohamed Neelam Soni Priyank Yadav Manoj Jain Dharmendra Bhadauria Anupma Kaul Narayan Prasad Amit Gupta RK Sharma Source Type: research

Optimization of treatment modality in elderly end-stage renal disease population: Peritoneal dialysis versus transplant
A Kaul, MR Behera, R Kishore, B Karthikeyan, DS Bhadauria, P Mishra, N Prasad, A Gupta, RK SharmaIndian Journal of Nephrology 2018 28(6):433-440 Despite kidney transplantation (KT) being considered as the best treatment modality for end-stage renal disease (ESRD), patient and graft survival in the elderly population is poorer than younger individuals. Many authors argue that prolonged life expectancy outweighs the risk of remaining on dialysis, but few studies had compared the treatment modalities, especially with peritoneal dialysis (PD). A retrospective study was conducted at a tertiary care institute to compare outcome...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: A Kaul MR Behera R Kishore B Karthikeyan DS Bhadauria P Mishra N Prasad A Gupta RK Sharma Source Type: research

Urinary neutrophil gelatinase-associated lipocalin and urinary soluble CXCL16 as biomarkers of activity in pediatric lupus nephritis
This study was conducted on 80 patients diagnosed as SLE by the Systemic Lupus International Collaborating Clinics criteria and 60 apparently healthy individuals as controls. Global and renal disease activities were evaluated by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and renal SLEDAI, respectively. uNGAL and urinary CXCL16 were measured for all participants by ELISA. Renal biopsy was done for all cases at initial diagnosis and was graded using ISN/RPS classification. uNGAL and CXCL16 were higher in patients than in the controls (8.9 ± 3.56 ng/dl and 1067 ± 367 ug/L vs. 2.26 ± 1.95 ng/dl...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: MA El-Gamasy W El-Naghy Source Type: research

Skin microcirculatory changes in relation to arteriovenous fistula maturation
In this study, we evaluated the changes of skin microvascular perfusion over the extremity with AVF maturation using the laser Doppler fluximetry (LDF). A total of 45 patients with chronic kidney disease, Stages IV–V, were included; they had undergone AVF creation from July 2014 to June 2016 at our institute. The measurement of skin microvascular perfusion was accomplished proximal and distal to the fistula anastomosis site: pre- and post-operative day 1, week 2, week 6, and week 12. Thirty-two patients with mean age of 55.6 had achieved AVF maturation. There were 40.6% radial-based and 59.4% brachial-based A...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: Siew Cheng Chai Wan Azman Wan Sulaiman Arman Zaharil Mat Saad Aida Hanum Rasool Amran Ahmed Shokri Source Type: research

Epidemiology and outcomes of acute kidney injury in critically ill: Experience from a tertiary care center
This study aims to identify the etiology, short-term outcomes, and determinants of mortality in patients with AKI admitted to multiple medical and surgical Intensive Care Units (ICU's) in a tertiary care center. The study also aims to compare the clinical characteristics and outcomes of community-acquired AKI (CAAKI) and hospital-acquired AKI (HAAKI). A prospective, observational study was done from June 2013 to October 2015. All patients over 18 years with AKI admitted in various medical and surgical ICU's seeking nephrology referral were included. AKI was defined according to KDIGO criteria. The follow-up period ...
Source: Indian Journal of Nephrology - December 14, 2018 Category: Urology & Nephrology Authors: PS Priyamvada R Jayasurya Vijay Shankar S Parameswaran Source Type: research

Anti A/B antibody titer rebound: Are we making it worse ? Be aware of your intravenous immunoglobulin
A Kher, A Agarwal, P Jha, D Bansal, M Madken, AS Narula, R Khurana, V KherIndian Journal of Nephrology 2018 28(5):407-409 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: A Kher A Agarwal P Jha D Bansal M Madken AS Narula R Khurana V Kher Source Type: research

Time to revisit the use of nontunneled dialysis vascular catheters even in cost-limited setting
J Sethi, S Bagai, R Ramachandran, V Kumar, M Rathi, HS Kohli, KL GuptaIndian Journal of Nephrology 2018 28(5):406-407 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: J Sethi S Bagai R Ramachandran V Kumar M Rathi HS Kohli KL Gupta Source Type: research

IgA nephropathy in a patient with IgG myeloma
B Sangeeta Lakshmi, SV Padmavathi Devi, N Sai Sameera, A Sunnesh Reddy, R Ram, Vishnubotla Siva KumarIndian Journal of Nephrology 2018 28(5):404-406 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: B Sangeeta Lakshmi SV Padmavathi Devi N Sai Sameera A Sunnesh Reddy R Ram Vishnubotla Siva Kumar Source Type: research

Successful treatment of renal infiltration complicated by atypical hemolytic uremic syndrome in a leukemic child
We present a case of 9-year-old boy who developed life-threatening aHUS in the 1st week of Burkitt leukemia/lymphoma diagnosis with renal infiltration. Complete resolution of aHUS was achieved after therapeutic plasma exchange. This is an uncommon complication of Burkitt leukemia/lymphoma in a pediatric case. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: & #214; E Ozmen N Alici B Topuz M Akg & #252;l E Akkuzu & #214; Akdemir N Buyan S G & #246;ral Z Kaya Source Type: research

Membranous nephropathy in a patient with charcot-marie-tooth disease: Association of myelin mutations
U Anandh, R Nikalji, A ParickIndian Journal of Nephrology 2018 28(5):397-400 A 40-year-old female presented to the neurologist with gradually progressive weakness of distal and proximal muscles of both lower limbs and cramps for 2 years. She gave a history of similar illness in her paternal grandmother and her father. Her examination revealed bilateral foot drop and mild proximal muscle weakness. She was diagnosed to have peripheral neuropathy and subsequently treated conservatively. Over the next year, she noticed progressive swelling of both lower limb and frothy urine. A nephrology consultation was obtained, and a rena...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: U Anandh R Nikalji A Parick Source Type: research

Late posttransplant lymphoproliferative disease: Report of a rare case and role of positron emission tomography-computed tomography
We present a rare case report of a perigraft PTLD developing 12 years after renal transplantation sparing the graft, in an Epstein–Barr virus-negative patient. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: P Yadav N Kumar N Prasad H Lal Source Type: research

Early eosinophilic antibody-mediated rejection in a renal allograft recipient
H Satish, Sreejith Parameswaran, BH Srinivas, NG Rajesh, R Jayasurya, Rajesh Padhi, PS PriyamvadaIndian Journal of Nephrology 2018 28(5):389-392 Although the predominant component of acute allograft rejection is the T-cells, the milieu is not devoid of other inflammatory cells including plasma cells, eosinophils, and histiocytes. Apart from the CD8 T cell and CD4 T cell-FasL cytotoxicity, experimental models had proven a pivotal role of Th-2 cells in acute rejection, and these have been associated with marked tissue eosinophilia. Herein, we present a unique case of severe eosinophilic acute antibody-mediated rejection in ...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: H Satish Sreejith Parameswaran BH Srinivas NG Rajesh R Jayasurya Rajesh Padhi PS Priyamvada Source Type: research

Adenovirus interstitial nephritis: An unusual cause for early graft dysfunction
We describe a rare case of adenovirus interstitial nephritis in a 37-year-old man, 4 weeks following deceased donor renal transplantation. He presented with gross hematuria and acute graft dysfunction. A renal biopsy revealed necrotizing tubulointerstitial nephritis with intranuclear viral inclusions in the tubular epithelial cells. Immunohistochemistry and polymerase chain reaction confirmed adenovirus infection. Reduction in immunosuppression alone resulted in rapid improvement of graft function. Awareness of the clinical and characteristic biopsy findings may help establish the correct diagnosis, which is crucial as dis...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: G Seralathan AA Kurien Source Type: research

Head drop and flaccid weakness in infantile nephrotic syndrome
We report here a case of infantile nephrotic syndrome with DHS caused by severe hypokalemia. Electrocardiogram showed flat T- and U-waves. Multiple factors including recurrent diarrhea, prolonged diuretic and corticosteroid use, hypomagnesemia, poor intake, and malnutrition caused hypokalemia in the case. Head drop and flaccid weakness resolved completely after potassium and magnesium supplementation. Potassium levels should be monitored and corrected promptly in these settings. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: GS Dhooria Source Type: research

Warfarin-related nephropathy
We report a 50-year-old Indian woman who was on prolonged anticoagulant therapy post-mitral valve replacement. She presented with AKI, and renal biopsy was suggestive of ACRN. Steroids were given and her creatinine levels reached within the normal range in 2 weeks. A presumptive diagnosis of ACRN should be made if a severe warfarin coagulopathy is present and if other causes of AKI have been excluded, in patients with chronic anticoagulant therapy. Renal function should be monitored regularly in patients who are on anticoagulant therapy. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: Anvesh Golla R Goli VK Nagalla BV Kiran D. S. B Raju MS Uppin Source Type: research

Posttransplant lymphoproliferative disorder: Experience from a pediatric nephrology unit in North India
We report the experience of PTLD among pediatric renal allograft recipients at a pediatric nephrology center in North India. Four cases of PTLD were identified from among records of 95 pediatric renal allograft recipients over a period of 21 years. Constitutional and localizing symptoms were present in three patients each. The diagnosis was suggested on positron emission tomography in three patients and confirmed by histopathology in all. Sites affected included tonsils, cervical lymph nodes, duodenum, and para-aortic lymph nodes in one patient each. The lymphocytic infiltrate was polymorphic in three patients and monomorp...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: RW Thergaonkar S Bhardwaj A Sinha AK Dinda R Kumar A Bagga RN Srivastava P Hari Source Type: research

Coronary angiography profile at the time of hemodialysis initiation in end-stage renal disease population: A retrospective analysis
M Surendra, S Raju, KK Mukku, CH Ved Prakash, N RajuIndian Journal of Nephrology 2018 28(5):370-373 Cardiovascular disease is associated with increased mortality in dialysis population. However, there are very few studies that assessed the prevalence of coronary artery disease (CAD) at the time of initiation of hemodialysis (HD). The present study was aimed to assess the prevalence of CAD in end-stage renal disease (ESRD) patients at the time of initiation of HD and the risk factors for CAD in this population. This was a single-center retrospective study and included ESRD patients who underwent coronary angiography (CAG) ...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: M Surendra S Raju KK Mukku CH Ved Prakash N Raju Source Type: research

Spectrum of hypokalemic paralysis from a tertiary care center in India
G Chandramohan, T Dineshkumar, R Arul, M Seenivasan, J Dhanapriya, R Sakthirajan, T Balasubramaniyan, N Gopalakrishnan1Indian Journal of Nephrology 2018 28(5):365-369 Hypokalemic paralysis is an important and reversible cause of acute flaccid paralysis. The treating physician faces unique diagnostic and therapeutic challenges. We did a prospective study and included all patients with acute flaccid weakness and documented serum potassium of <3.5 mEq/L during the period between January 2009 and August 2015. We studied the incidence, etiology, clinical profile, and acid–base disturbances in patients presenting with...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: G Chandramohan T Dineshkumar R Arul M Seenivasan J Dhanapriya R Sakthirajan T Balasubramaniyan N Gopalakrishnan1 Source Type: research

Osteopontin, cardiovascular risk factors and carotid intima-media thickness in chronic kidney disease
V Chaitanya, N Harini Devi, MM Suchitra, P. V. L. N Srinivasa Rao, B Vijaya Lakshmi, V Siva KumarIndian Journal of Nephrology 2018 28(5):358-364 The pleiotropic cytokine osteopontin (OPN) is found to be involved in the pathogenesis of both kidney and cardiovascular disease (CVD). We evaluated the relationship between OPN, other cardiovascular risk factors and carotid intima-media thickness (CIMT) in chronic kidney disease (CKD) (predialysis) patients. This is a 2-year cross-sectional prospective study involving 75 patients with CKD from stage 1 to stage 5 attending the nephrology outpatient department and 25 healthy contr...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: V Chaitanya N Harini Devi MM Suchitra P. V. L. N Srinivasa Rao B Vijaya Lakshmi V Siva Kumar Source Type: research

Efficacy and cost comparison of ertapenem as outpatient parenteral antimicrobial therapy in acute pyelonephritis due to extended-spectrum beta-lactamase-producing Enterobacteriaceae
V Ramasubramanian, P Murlidharan, S Nambi, S Pavithra, S Puthran, T PetigaraIndian Journal of Nephrology 2018 28(5):351-357 Outpatient parenteral antimicrobial therapy (OPAT) programs are becoming an increasingly popular trend in clinical practice as they offer several benefits to both patients and health-care setups. While OPAT is an established clinical practice in the Western world, the concept itself is alien to patients in India as they prefer the security of hospitals to receive antibiotics over OPAT. We evaluated the clinical response and cost comparison of ertapenem under OPAT versus inpatient settings in patients...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: V Ramasubramanian P Murlidharan S Nambi S Pavithra S Puthran T Petigara Source Type: research

Relationship of creatinine and cystatin C-based estimated glomerular filtration rates with measured glomerular filtration rate in healthy kidney donors from South Asia
S Kakde, S Alexander, VG David, S Jacob, A Mohapatra, AT Valson, B Gopal, CK Jacob, J Hephzibah, V Tamilarasi, S VarugheseIndian Journal of Nephrology 2018 28(5):345-350 Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation is currently recommended for the estimation of glomerular filtration rate (GFR). This retrospective study aimed to evaluate the correlation between creatinine and cysC-based estimated GFRs and measured GFR in healthy adults. Consecutive healthy adults who were accepted as voluntary kidney donors at our center between January 2008 and December 2012 were included in the study. The 336 indi...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: S Kakde S Alexander VG David S Jacob A Mohapatra AT Valson B Gopal CK Jacob J Hephzibah V Tamilarasi S Varughese Source Type: research

Development of an experimental model of a decellularized kidney scaffold by perfusion mode and analyzing the three-dimensional extracellular matrix architecture by edge detection method
SI Almelkar, S Bethapudi, SN RathIndian Journal of Nephrology 2018 28(5):339-344 Renal transplant is treatment of choice for the patients with end stage renal disease. The kidney transplants are expensive and there are risks of immunological and infectious complications. We planned to develop an in vitro decellularized kidney scaffold model using sheep kidney. Kidney decellularization was carried out by perfusing chemical detergents such as sodium dodecyl sulfate (SDS), SDS and trypsin, and SDS and ethylenediaminetetraacetic acid solvent solution. Complete kidney was decellularized in 5 days by perfusing various chemical ...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: SI Almelkar S Bethapudi SN Rath Source Type: research

Effect of hemodialysis on corrected QT interval and QTc dispersion
PM Sohal, A Goel, D Gupta, N Aslam, J Sandhu, JS Sandhu, EE John, D SharmaIndian Journal of Nephrology 2018 28(5):335-338 Hemodialysis patients are at higher risk of cardiovascular disease due to traditional and dialysis-related risk factors. Our aim was to study the effects of hemodialysis on the corrected QT interval (QTc) and QTc dispersion in chronic kidney disease (CKD) without clinically manifest heart disease. Two hundred cases of CKD on chronic intermittent hemodialysis of >3 months' duration were included in the study. Twelve-lead electrocardiography and samples for serum creatinine, potassium, calcium, a...
Source: Indian Journal of Nephrology - September 10, 2018 Category: Urology & Nephrology Authors: PM Sohal A Goel D Gupta N Aslam J Sandhu JS Sandhu EE John D Sharma Source Type: research

Corrigendum: Direct-acting antiviral agents in Hepatitis C Virus infected renal allograft recipients: Treatment and outcome experience from single center
Indian Journal of Nephrology 2018 28(4):333-333 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Source Type: research

Difficult vascular access in a patient on chronic hemodialysis
G Kumar, MJ Hamoudeh, NM Noureldin, I Alaqqad, N Airon, E AlkhasawnehIndian Journal of Nephrology 2018 28(4):330-332 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: G Kumar MJ Hamoudeh NM Noureldin I Alaqqad N Airon E Alkhasawneh Source Type: research

Colonic ulcerations in a patient on hemodialysis
N Birajdar, J Dekate, V Reddy, U AnandhIndian Journal of Nephrology 2018 28(4):329-330 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: N Birajdar J Dekate V Reddy U Anandh Source Type: research

Rare cause of bright red gross hematuria in a child
G Kumar, O AlMasri, J Al Mistarihi, MK AlGhabra, M HobeldinIndian Journal of Nephrology 2018 28(4):327-328 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: G Kumar O AlMasri J Al Mistarihi MK AlGhabra M Hobeldin Source Type: research

Outbreak of Ralstonia mannitolilytica in hemodialysis unit: A case series
M Shankar, S Rampure, V Siddini, H Sudarshan BallalIndian Journal of Nephrology 2018 28(4):323-326 Ralstonia mannitolilytica is a Gram-negative soil bacteria. It is an emerging opportunistic pathogen in hospital-acquired infections. Maintenance hemodialysis patients at Manipal Hospital Outpatient Haemodialysis unit, Bengaluru, witnessed an outbreak of R. mannitolilytica infection between October 2016 and November 2016. Five patients were infected and one of them presented with infective endocarditis. All patients were successfully treated with antibiotic according to culture and sensitivity pattern. Immediately following ...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: M Shankar S Rampure V Siddini H Sudarshan Ballal Source Type: research

Lipectomy technique as a second-stage procedure for primarily matured, deep outflow vein in obese individuals
We present a case of a 57-year-old obese female with ESRD and matured, deeply running, inadequate for cannulation arteriovenous fistula. We present a technique of lipectomy with wide resection of adipose tissue from superior and lateral surfaces of outflow vein. Postoperatively, the skin without the underlying adipose tissue collapses allowing easy cannulation of the long segment of outflow vein with two needles. Lipectomy of mature but deeply located outflow vein is a second-stage elective procedure. Wide resection of adipose tissue helps create easy to access cannulation zone in obese individuals. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: L Sulkowski M Matyja A Pasternak Source Type: research

Persistent left superior vena cava in a hemodialysis patient
We report a case of PLSVC in a patient with chronic kidney disease which was identified following a difficult catheterization into the right internal jugular vein (IJV). The catheterization was attempted through the left IJV and the position of which could not be confirmed with check radiograph and two-dimensional echo. PLSVC was suspected in the computed tomography angiography and was confirmed following digital subtraction angiography. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: G Anvesh Sree Bhushan Raju S Rammurti K Prasad Source Type: research

Tunneled hemodialysis catheter-associated right atrial thrombus presenting with septic pulmonary embolism
We report the case of a patient undergoing HD through tunneled venous catheter who presented with catheter dysfunction and sepsis and was diagnosed to have CRAT with septic embolism. CRAT formation has a significant association with catheter-related infection. The need for early diagnosis and various treatment options for this entity are highlighted. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: SV Vyahalkar NM Dedhia GS Sheth M. A. R. Pathan Source Type: research

Mitochondrial neurogastrointestinal encephalomyopathy: A nonrenal indication for peritoneal dialysis
VS Chandra, B Sanggetha Lakshmi, S. V. V Padmavathi Devi, N Praveen, NS Sameera, AS Reddy, R Ram, VS KumarIndian Journal of Nephrology 2018 28(4):310-313 Mitochondrial neurogastrointestinal encephalomyopathy is a rare autosomal recessive disorder characterized by severe muscle wasting, gastrointestinal dysmotility, leukoencephalopathy, peripheral neuropathy, and ophthalmoplegia. The pathogenesis involves the accumulation of very high concentrations of nucleosides dThd and dUrd along with depletion of nucleotide dCTP. One of the treatment measures is the removal of nucleosides dThd and dUrd by hemodialysis and peritoneal d...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: VS Chandra B Sanggetha Lakshmi S. V. V Padmavathi Devi N Praveen NS Sameera AS Reddy R Ram VS Kumar Source Type: research

Lymphorrhea: An unusual complication of jugular venous catheterization for hemodialysis
We report a case of a 62-year-old female who underwent tunneled catheter insertion in the left internal jugular vein under ultrasound and fluoroscopic guidance, which was followed by pericatheter serous discharge. Fluid examination confirmed the diagnosis of lymphorrhea, and lymphoscintigraphy facilitated its localization. This case is reported for its rarity and with a discussion on literature review, complications of lymphorrhea, and their management. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: D Bajpai TE Jamale NK Hase SB Thakare RB Deshpande SJ Patil Source Type: research

Hypertriglyceridemia causing continuous renal replacement therapy dysfunction in a patient with end-stage liver disease
We report the case of a critically ill liver transplant patient in the Intensive Care Unit who was found to have recurrent filter clotting during continuous renal replacement therapy (CRRT). The patient had increased serum triglycerides (TGs), which was identified approximately 2 weeks into hospitalization and initially believed to be due to prolonged propofol use. The patient's elevated TGs ultimately caused her blood to become lipemic, causing the dialytic circuit to become nonfunctional and placed the patient in imminent danger due to hyperkalemia and metabolic acidosis. Therapeutic plasma exchange was emergently us...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: DC McLaughlin DC Fang BA Nolot PK Guru Source Type: research

Ultrafiltration by peritoneal route in refractory chronic congestive cardiac failure
This study aims to study the ultrafiltration by peritoneal route in refractory heart failure patients with respect to change in functional status, renal parameters, left ventricular ejection fraction, number of days of hospitalization, and level of myocardial depressant factors. This was a prospective observational study conducted in Nephrology Department of tertiary care hospital. We studied patients with refractory heart failure who had persistent symptoms requiring frequent admissions despite optimal medical decongestion or had dyselectrolytemia with worsening renal parameters. The data were collected at baseline and th...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: S Hedau R Chakravarthi V Reddy Source Type: research

Continuous ambulatory peritoneal dialysis catheter insertion technique: A comparative study of percutaneous versus surgical insertion
PM Dogra, AK Hooda, G Shanmugraj, SK PramanikIndian Journal of Nephrology 2018 28(4):291-297 Continuous ambulatory peritoneal dialysis (CAPD) is a standard renal replacement therapy, but there is a lack of consensus for catheter insertion method and type of catheter used. We retrospectively analyzed 140 peritoneal dialysis catheters (PDC) inserted in 139 CAPD patients by two methods; percutaneous (Group “P,” n = 47) and surgical mini laparotomy (Group “S,” n = 93) technique over a 39-month period, with cumulative experience of 2415 catheter-months: 745 catheter-months for Group “PR...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: PM Dogra AK Hooda G Shanmugraj SK Pramanik Source Type: research

Effects of citrate acid concentrate on hemodialysis adequacy, reuse, and quality of life: A prospective randomized crossover trial
SP Nagaraju, S Kosuru, R Parthasarathy, AS Mareddy, RP Attur, D Rangaswamy, S Prasad, S Kaza, S Shenoy, K Saraf, S. L. K Laxminarayana, UV Mateti, V GuddattuIndian Journal of Nephrology 2018 28(4):287-290 We conducted a randomized crossover trial to identify whether the use of citrate dialysate (CD) for bicarbonate hemodialysis is beneficial compared to regular acetate dialysate (AD) in terms of adequacy, reuse, and quality of life. Thirty-two stable end-stage renal disease patients on twice-weekly maintenance hemodialysis were randomly assigned to CD or AD fluid in a single-blinded randomized prospective crossover trial ...
Source: Indian Journal of Nephrology - August 6, 2018 Category: Urology & Nephrology Authors: SP Nagaraju S Kosuru R Parthasarathy AS Mareddy RP Attur D Rangaswamy S Prasad S Kaza S Shenoy K Saraf S. L. K Laxminarayana UV Mateti V Guddattu Source Type: research