Severe hypertriglyceridemia-induced acute pancreatitis: Successful management by plasmapheresis
B. N. R Ramesh, S Raju, M Surendra, K Prasad, V KrishnaIndian Journal of Nephrology 2019 29(3):217-219 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: B. N. R Ramesh S Raju M Surendra K Prasad V Krishna Source Type: research

Use of commercially available multiplex polymerase chain reaction in detection of organism in culture negative peritonitis in peritoneal dialysis
I Veerappan, R Balasubramaniam, R Sethuraman, S RanjanIndian Journal of Nephrology 2019 29(3):215-217 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: I Veerappan R Balasubramaniam R Sethuraman S Ranjan Source Type: research

Pancytopenia as a complication of primary hyperoxaluria
M Khosravi, S Kord, M MokhtariIndian Journal of Nephrology 2019 29(3):214-215 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: M Khosravi S Kord M Mokhtari Source Type: research

Stent graft placement for treatment of prosthetic graft outflow stenosis, a viable long-term solution: A case report
We describe a case of arteriovenous graft outflow stenosis, which led to complete thrombosis of the graft, which was rescued by surgical thrombectomy and stent graft placement across the venous end of the anastomosis with good results. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: Pranay Pawar Achintya Sharma MK Ayyappan Kapil Mathur Jithin Jagan Radhakrishnan Raju Source Type: research

Collapsing glomerulopathy superimposed on diabetic nephropathy
We report on a patient with DN who has undergone renal biopsy due to massive proteinuria and rapid loss of renal function. Renal biopsy was suggestive of CG superimposed on DN. He was treated conservatively, however, progressed to end-stage renal disease rapidly. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: Praveen Kumar Etta MV Rao S Gowrishankar Source Type: research

Coexistent amyloid fibrils in a patient with combined light chain deposition disease and light chain cast nephropathy
Urmila Anandh, Anusha Patrick, Alok SharmaIndian Journal of Nephrology 2019 29(3):204-206 Monoclonal secretion of light chains can affect the kidney with varied morphologic manifestations. Myeloma cast nephropathy, proximal tubulopathies, monoclonal immunoglobulin deposition disease, amyloidosis, and tubulointerstitial nephritis are often noted in the renal biopsy of these patients. Most often the histopathological manifestations affect only one compartment of the nephron (tubules, capillaries, glomerulus). Case reports of a combination of cast nephropathy and monoclonal light chain deposition disease are also reported in...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: Urmila Anandh Anusha Patrick Alok Sharma Source Type: research

Renal intra-arterial heparin flushing for blood pressure control in refractory hypertension: A new method to salvage the unsalvageable renal artery stenosis
Bayushi Eka Putra, Jonny , Alfonsus Hilarius SoewandiIndian Journal of Nephrology 2019 29(3):200-203 Refractory hypertension is a type of hypertension that requires special attention. Secondary causes of hypertension should be considered when uncontrolled blood pressure is present, especially in younger patients (<30 years). In this case, the presence of bilateral renal artery stenosis resulted in refractory hypertension and end-stage renal disease requiring renal replacement therapy in the form of hemodialysis. The main challenges will be discussed in this case is to deliver the most beneficial therapy considering th...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: Bayushi Eka Putra Jonny Alfonsus Hilarius Soewandi Source Type: research

Left inferior vena cava from the perspective of laparoscopic donor surgeon: Anatomic considerations and surgical implications
This article highlights the surgical anatomy and clinical implications of this rare condition from the perspective of laparoscopic donor surgeon. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: K Madhavan S Jain P Shridhar D Bhirud Y Patidar V Jain Source Type: research

Metformin-associated encephalopathy in hemodialysis
We report a patient on maintenance hemodialysis from standalone unit presented to us with abnormal neurological signs and symptoms. His medication chart included metformin, which he was taking for quite a long time. Computed tomography brain showed hypointensity in bilateral basal ganglia. Magnetic resonance imaging (MRI) brain showed hyperintensity in T2/fluid-attenuated inversion recovery sequences suggestive of Lentiform fork sign. We stopped metformin, and he was continued on regular hemodialysis. He showed dramatic improvement in neurological manifestations. Two months later, we repeated MRI brain, which showed resolu...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: SP Simon J Thomas Source Type: research

Ischemic colitis in association with sevelamer crystals
We present a 35-year-old HIV patient with end-stage renal disease on hemodialysis who developed colonic hemorrhage and perforation. Imaging showed ischemic gangrene of bowel wall. Histopathology was consistent with transmural ischemic necrosis with deposition of fibrin thrombi and sevelamer crystals. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: KC Keri V Veitla NS Samji Source Type: research

Plasma free homocysteine levels in children with idiopathic nephrotic syndrome
Venkatesh Arumugam, Abhijeet Saha, Manpreet Kaur, Bobbity Deepthi, Trayambak Basak, Shantanu Sengupta, Ajay Bhatt, Vineeta V Batra, Ashish D UpadhyayIndian Journal of Nephrology 2019 29(3):186-190 Altered metabolism of homocysteine in children with idiopathic nephrotic syndrome leads to raised plasma-free homocysteine levels. Elevated free homocysteine causes endothelial cell dysfunction and promotes early atherosclerosis and glomerulosclerosis. In this analytical study with a longitudinal follow-up, 29 children with first episode of nephrotic syndrome (FENS) aged 1–16 years along with 30 age andgender-matched healt...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: Venkatesh Arumugam Abhijeet Saha Manpreet Kaur Bobbity Deepthi Trayambak Basak Shantanu Sengupta Ajay Bhatt Vineeta V Batra Ashish D Upadhyay Source Type: research

Dietary counseling by renal dietician improves the nutritional status of hemodialysis patients
KL Vijaya, Mesa Aruna, S. V. L Narayana Rao, Pathapati Rama MohanIndian Journal of Nephrology 2019 29(3):179-185 Proper nutrition may reverse the malnutrition and can modulate renal function in hemodialysis patients. In majority of the dialysis units in India, nutritional advice is given by health professionals working in dialysis. We compared the impact of dietary counseling by a renal dietitian, on nutritional status with that by health professionals working in dialysis units in patients undergoing maintenance hemodialysis. Nutritional assessments were made using subjective global assessment (SGA) scale, which combines ...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: KL Vijaya Mesa Aruna S. V. L Narayana Rao Pathapati Rama Mohan Source Type: research

Functional status in hemodialysis - A comparative study with FIM, ADLQ and 7D5L instruments
N Viswanath, KT Harichandra Kumar, Satish Haridasan, Sreejith Parameswaran, PS PriyamvadaIndian Journal of Nephrology 2019 29(3):172-178 There is only limited information on the functional status (FS) of patients receiving hemodialysis (HD) from developing countries where the etiology of chronic kidney disease (CKD) and demographic profile are different. The study aims to assess the FS in patients with CKD using three validated generic instruments. A total of 116 adult patients on HD with a dialysis vintage >3 months were enrolled. FS was assessed using three generic tools – Functional Independence Measure (FIM)...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: N Viswanath KT Harichandra Kumar Satish Haridasan Sreejith Parameswaran PS Priyamvada Source Type: research

Urinary albumin excretion, estimated glomerular filtration rate, and prevalence of microalbuminuria in obese nondiabetic and nonhypertensive adults: A cross-sectional study
Conclusion: Younger, class 1 obese patients had a higher UAE, eGFR, and three times higher MAU prevalence, even in absence of diabetes and hypertension, with a correlation between anthropometry and eGFR as compared with nonobese individuals. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: VR Bhatt VB Khese SL Jadhav AL Kakrani Source Type: research

Gender differences in dose of erythropoietin to maintain hemoglobin target in hemodialysis patients
JA Coronado Daza, G Urrútia CuchiIndian Journal of Nephrology 2019 29(3):160-165 Dialysis patients receiving erythropoietin (EPO) for anemia management are a challenge due to the significant interindividual variability in erythropoietic response. Our objective was to determine if there is a gender-dependent difference in the EPO doses required to maintain the hemoglobin (Hb) targets in adult patients undergoing hemodialysis. We conducted a historic cohort study with a 12-month follow-up. We include patients with the Hb target, normal serum albumin, and normal transferrin saturation index. Monthly data were gathered f...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: JA Coronado Daza G Urr & #250;tia Cuchi Source Type: research

Therapeutic plasma exchange in renal disorders
D Ranganathan, GT JohnIndian Journal of Nephrology 2019 29(3):151-159 Nephrologists use hemodialysis and hemofiltration to remove low molecular weight toxic constituents, and increasingly deploy therapeutic plasma exchange (TPE)/plasmapheresis to eliminate higher molecular weight substances such as immunoglobulins or immune complexes from plasma. This review discusses different modalities of TPE, their application in renal disorders, its rationale and complications. TPE is recommended based on evidence, in alloantibody-mediated diseases such as humoral antibody mediated renal transplant rejection, autoantibody mediated gl...
Source: Indian Journal of Nephrology - May 9, 2019 Category: Urology & Nephrology Authors: D Ranganathan GT John Source Type: research

Corrigendum
Indian Journal of Nephrology 2019 29(2):149-149 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Source Type: research

Urinary sediment profile in proliferative and nonproliferative glomerulonephritis by bright-field and phase-contrast microscopy
P Joshi, S Vanajakshi, S GowrishankarIndian Journal of Nephrology 2019 29(2):148-148 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: P Joshi S Vanajakshi S Gowrishankar Source Type: research

Crescentic glomerulonephritis and membranous nephropathy: An unusual association
Y Zajjari, K Hassani, S Benbria, D El KabbajIndian Journal of Nephrology 2019 29(2):146-147 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Y Zajjari K Hassani S Benbria D El Kabbaj Source Type: research

Acute lymphoblastic leukemia presenting with isolated nephromegaly
N Arora, A Saha, D Bobbity, P MandalIndian Journal of Nephrology 2019 29(2):144-146 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: N Arora A Saha D Bobbity P Mandal Source Type: research

Digital gangrene in a dialysis patient due to calciphylaxis and systemic polyarteritis nodosa: A diagnostic dilemma
Neeraj Jain, Jasmine Sethi, Raja Ramachandran, Vivek Kumar, Manish Rathi, HS Kohli, KL GuptaIndian Journal of Nephrology 2019 29(2):143-144 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Neeraj Jain Jasmine Sethi Raja Ramachandran Vivek Kumar Manish Rathi HS Kohli KL Gupta Source Type: research

Primary membranous glomerulonephritis-associated with schistosomal nephropathy
Walaa Hosny Mohammad Ibrahim, Mostafa Gaafar Aly, Marwa Kamal Abdo, Wesam IsmailIndian Journal of Nephrology 2019 29(2):140-142 The association of bilharziasis with membranous nephropathy (MN) has long been debated. The relatively recent use of antibodies against the M-type phospholipase A2 receptor (PLA2R) has been proposed as a valuable tool to discriminate the idiopathic from secondary MNs. Anti-PLA2R antibodies are found in sera from about 70% of iMN patients, in contrast to patients with secondary MN, in whom serum anti-PLA2R antibodies could not be detected. In the current case report, we detected anti-PLA2R ant...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Walaa Hosny Mohammad Ibrahim Mostafa Gaafar Aly Marwa Kamal Abdo Wesam Ismail Source Type: research

Bladder carcinoma associated with BK virus in a renal allograft recipient
In this report, we have described a patient who developed BK virus nephropathy followed 3 years later by bladder carcinoma. Interestingly, while the tumor tissue demonstrated BK virus, the adjacent normal urothelium was stained negative for BK virus. Considering the viral potential to inhibit tumor suppressors and its differential localization within tumor tissue, it is possible that the virus contributes to tumorigenesis. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: L Gaur A Gupta P Meena A Shingada P Gupta DS Rana Source Type: research

Intestinal tuberculosis: A rare case of massive gastrointestinal bleed in a post-renal transplant recipient
We report an uncommon cause of anemia in a post-renal transplant patient due to massive lower gastrointestinal (LGI) bleed. The index case had a normal upper and LGI endoscopy, but the 99technetium labeled red blood cell scan showed active bleeding from terminal ileum and caecum. Microscopic examination of the resected specimen revealed tubercular granuloma with acid-fast bacilli. Intestinal TB should be a differential diagnosis for massive LGI bleed in immunosuppressed patients in developing country. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: N Pattanashetti S Gupta S Rana D Dahiya A Das V Kumar M Rathi HS Kohli KL Gupta R Ramachandran Source Type: research

Pulmonary calcifications: Is it an entity in the new world dialysis patient ?
R Kauntia, V Bhargava, P Gupta, DS RanaIndian Journal of Nephrology 2019 29(2):128-131 Metastatic pulmonary calcification (MPC) has been described in the literature to affect up to 60% of dialysis patients. Several case series of MPC were described in 1960s and 1970s. Patients are generally asymptomatic or may present with acute respiratory distress. This entity is associated with up to 60% mortality. We hereby report a case of chronic kidney disease on maintenance hemodialysis who presented with unexplained recurrent dyspnea despite adequate hemodialysis. She was evaluated and found to have a rare presentation of...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: R Kauntia V Bhargava P Gupta DS Rana Source Type: research

C1q nephropathy in a patient of neurofibromatosis type 1: A rare case report
UT Varyani, NM Shah, PR Shah, VB Kute, MR Balwani, HL TrivediIndian Journal of Nephrology 2019 29(2):125-127 C1q nephropathy is a rare glomerular disease defined by the presence of characteristic mesangial dominant or codominant C1q deposition on immunofluorescence microscopy. Neurofibromatosis type 1 (NF-1) is an autosomal dominant syndrome caused by a mutation of a gene located on chromosomal segment 17q11.2. Nephrotic syndrome has rarely been reported in patients of NF-1, and the relation of NF-1 with nephrotic syndrome is unclear. Here, we present a rare case of C1q nephropathy in a patient of NF-1. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: UT Varyani NM Shah PR Shah VB Kute MR Balwani HL Trivedi Source Type: research

Cytomegalovirus induced collapsing glomerulopathy and necrotizing glomerulonephritis in a renal allograft recipient
This study will add on to the various glomerular changes associated with CMV infection. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: K. S. J Prema N. D. S Prasad AA Kurien Source Type: research

Post-renal transplant metabolic acidosis: A neglected entity
ME Fernando, J Jayanivash, ND Srinivasaprasad, S Suren, K ThirumalvalavanIndian Journal of Nephrology 2019 29(2):116-121 Metabolic acidosis is a prevalent yet overlooked entity among renal transplant recipients (RTRs) and incurs adverse effects on graft function. Although graft dysfunction and calcineurin inhibitor usage have been linked with renal tubular acidosis (RTA), there is no Indian data on prevalence or risk factors of post-transplant acidosis. A cross-sectional study was conducted on 106 adult RTRs, with a transplant duration of >6 months and an estimated glomerular filtration rate (GFR) >40 ml/min/1.73 ...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: ME Fernando J Jayanivash ND Srinivasaprasad S Suren K Thirumalvalavan Source Type: research

Clinicopathological spectrum of xanthogranulomatous pyelonephritis
R Kundu, A Baliyan, H Dhingra, V Bhalla, RS PuniaIndian Journal of Nephrology 2019 29(2):111-115 Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the clinicopathologic spectrum of XGP. Forty cases of XGP were diagnosed on histopathology over a period of 13 years (2005–2017). Relevant clinical details and radiological findings were recorded from the case files. Out of a total...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: R Kundu A Baliyan H Dhingra V Bhalla RS Punia Source Type: research

Volume assessment in hemodialysis: A comparison of present methods in clinical practice with sonographic lung comets
The objectives of this study are (1) to determine the reliability of clinical signs and symptoms for volume assessment, (2) to compare lung ultrasound with High Resolution Computed Tomography (HRCT) chest-A noninvasive gold standard tool for detecting pulmonary congestion and with inferior vena cava diameter (IVCD) – another time-tested volume assessment method, and (3) to analyze if lung ultrasound could detect dialysis induced fluid status variations. The cross-sectional study involves 50 patients on maintenance hemodialysis. Lung ultrasound for B line estimation and ultrasonographic measurement of IVCD performed b...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Ishwarya Annamalai Suhasini Balasubramaniam M Edwin Fernando ND Srinivasaprasad S Suren K Thirumalvalavan AM Veerakumar Source Type: research

Pulmonary hypertension in various stages of chronic kidney disease in Indian patients
Kalpana S Mehta, Abhishek K Shirkande, Sandip P Bhurke, Atim E Pajai, Rudramani S Swami, Swapnil N JadhavIndian Journal of Nephrology 2019 29(2):95-101 The prevalence of pulmonary hypertension (PH) in chronic kidney disease (CKD) in Indian patients has been evaluated in this study. In addition, association of PH with CKD etiology, its prevalence in various CKD stages, correlation between the severity of PH with CKD duration, various related biochemical parameters, and their relation to PH in CKD patients were analyzed. This cross-sectional and prospective study included 200 CKD patients. Detailed history and clinical exam...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Kalpana S Mehta Abhishek K Shirkande Sandip P Bhurke Atim E Pajai Rudramani S Swami Swapnil N Jadhav Source Type: research

Loss of subpodocytic space predicts poor response to tacrolimus in steroid-resistant calcineurin inhibitor-na & #239;ve adult-onset primary focal segmental glomerulosclerosis
P Agrawal, R Nada, R Ramachandran, CS Rayat, A Kumar, HS KohliIndian Journal of Nephrology 2019 29(2):90-94 Focal segmental glomerulosclerosis (FSGS) is the most common cause of adult-onset nephrotic syndrome, but its pathophysiology is poorly understood. The question as to why only a subset of patients responds to treatment in unanswered. In the past few years, change of podocytic phenotype from stationary type in health to migratory type in disease has been described, of which loss of subpodocytic space is a surrogate marker. Diagnostic biopsies of adult-onset steroid-resistant calcineurin inhibitor-naïve primary F...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: P Agrawal R Nada R Ramachandran CS Rayat A Kumar HS Kohli Source Type: research

Persistent metabolic acidosis on regular hemodialysis or peritoneal dialysis
K. T. C Goutham, KT Harichandrakumar, P Dhanin, PS Priyamvada, S Haridasan, S ParameswaranIndian Journal of Nephrology 2019 29(2):84-89 Metabolic acidosis is known to have adverse consequences in patients with chronic kidney disease (CKD) including protein-energy wasting, inflammation, bone disease, and disturbance in endocrine function. Unlike in the management of patients with predialysis CKD, bicarbonate levels were not being routinely monitored in dialysis patients at our center. The KDOQI guidelines recommend serum bicarbonate levels ≥22 mEq/L in patients on dialysis. We measured the predialysis serum bicarbona...
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: K. T. C Goutham KT Harichandrakumar P Dhanin PS Priyamvada S Haridasan S Parameswaran Source Type: research

Burden, access, and disparities in kidney disease
Deidra C Crews, Aminu K Bello, Gamal Saadi, for the World Kidney Day Steering Committee Indian Journal of Nephrology 2019 29(2):77-83 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Deidra C Crews Aminu K Bello Gamal Saadi for the World Kidney Day Steering Committee Source Type: research

A rare case report of emphysematous cyst infection in autosomal dominant polycystic kidney disease
Jasmine Sethi, Raja Ramachandran, Vivek Kumar, Manish Rathi, Harbir S Kohli, Krishan L GuptaIndian Journal of Nephrology 2019 29(1):74-75 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Jasmine Sethi Raja Ramachandran Vivek Kumar Manish Rathi Harbir S Kohli Krishan L Gupta Source Type: research

Acute renal failure after Amanita ovoidea eating
Li Cavoli Gioacchino, Bono Luisa, Schillaci Onofrio, Servillo Franca, Carollo Camillo, Zagarrigo Carmela, Amato Antonio, Li Cavoli Tancredi Vincenzo, Azzolina Vitalba, Caputo FlaviaIndian Journal of Nephrology 2019 29(1):73-74 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Li Cavoli Gioacchino Bono Luisa Schillaci Onofrio Servillo Franca Carollo Camillo Zagarrigo Carmela Amato Antonio Li Cavoli Tancredi Vincenzo Azzolina Vitalba Caputo Flavia Source Type: research

Type B lactic acidosis: A rare initial presentation of childhood acute lymphoblastic leukemia
S Narayani, P Balu, R Santhanam, JX ScottIndian Journal of Nephrology 2019 29(1):71-73 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: S Narayani P Balu R Santhanam JX Scott Source Type: research

Early recurrent primary membranous nephropathy detected in an allograft biopsy
T Kaur, TK Saha, S Krishnaprasad, M De Padua, S GowrishankarIndian Journal of Nephrology 2019 29(1):70-71 (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: T Kaur TK Saha S Krishnaprasad M De Padua S Gowrishankar Source Type: research

Missed monoclonal disease manifesting in early post-renal transplant period
N Singh, N Pattanashetti, K Joshi, HS Kohli, KL Gupta, R RamachandranIndian Journal of Nephrology 2019 29(1):65-69 A 63-year-old diabetic gentleman with microvascular complications presented with advanced azotemia and anemia. He was stabilized with blood transfusion and hemodialysis. With the probable diagnosis of diabetic nephropathy-related end-stage renal disease, he underwent kidney transplantation. He had delayed graft function. Graft biopsy done on the 2nd postoperative day showed acute tubular necrosis. Graft biopsy repeated after 2 weeks for persistent graft dysfunction showed myeloma cast nephropathy (MCN) and li...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: N Singh N Pattanashetti K Joshi HS Kohli KL Gupta R Ramachandran Source Type: research

Systemic lupus erythematosus and myasthenia gravis: A rare association
We report a 38-year-old female with biopsy-proven lupus nephritis on steroids and cyclophosphamide, later developed MG. Nerve conduction studies showed the decremental response of 15%–25% over facial muscles with no decremental response over limb muscles. Although antianticholinesterase receptor (AchR) antibodies were negative, she was treated with oral pyridostigmine 60 mg twice daily and clinical improvement of ocular symptoms was seen within 48 h. At present, she is on oral prednisolone and mycophenolate mofetil with follow-up creatinine of 1.4 mg/dl and no neurological symptoms. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: M Nagarajan AT Maasila J Dhanapriya T Dineshkumar R Sakthirajan D Rajasekar T Balasubramaniyan N Gopalakrishnan Source Type: research

Familial hypomagnesemia, hypercalciuria and nephrocalcinosis with novel mutation
S Margabandhu, M DoshiIndian Journal of Nephrology 2019 29(1):57-61 Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder that is caused by mutation in genes coding for tight junction proteins claudin-16 and claudin-19. It is characterized by renal wasting of magnesium and calcium associated with the development of nephrocalcinosis and renal stones by early childhood. Most of them progress to end-stage renal failure by the second or third decade. Here, we report two siblings with FHHNC, who presented with nephrocalcinosis without any extrarenal manifestations, one ...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: S Margabandhu M Doshi Source Type: research

Ileal tuberculosis causing hypercalcemia and renal failure
We report a 22-year-old woman, who presented with pain abdomen and vomiting. She was found to have features of acute pancreatitis, both biochemically and radiologically. She had hypercalcemia on presentation and this was attributed to be the cause for pancreatitis as other causes were ruled out. 1, 25-dihydroxyvitamin D level was high with normal parathyroid hormone level. Whole-body positron emission tomography-computed tomography showed increased fluorodeoxyglucose uptake in the terminal ileum and histology from that area showed noncaseating granuloma with acid-fast bacilli in the tissue. She was treated with antitubercu...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: K Vinod Kumar VN Unni N Kachare N John PK Bipi J Pullockara Source Type: research

Monoclonal gammopathy of renal significance triggered by viral E hepatitis
P Agrawal, V Kumar, A Kumar, M. U. S Sachdeva, P Malhotra, R NadaIndian Journal of Nephrology 2019 29(1):50-52 Monoclonal gammopathy of undetermined significance does not have end organ damage, but a proportion of cases manifest with renal injury when it is called monoclonal gammopathy of renal significance (MGRS). Herein, we describe a case of acute hepatitis E infection, which precipitated the development of MGRS. The patient underwent kidney biopsy for elevated creatinine with clinical suspicion of drug-induced interstitial nephritis. On light microscopy, there were periodic acid–Schiff negative-fractured casts i...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: P Agrawal V Kumar A Kumar M. U. S Sachdeva P Malhotra R Nada Source Type: research

Diabetic muscle infarction: An uncommon cause for acute limb pain in dialysis patients
YJ Anupama, Praveen UpadhyayaIndian Journal of Nephrology 2019 29(1):46-49 Diabetic muscle infarction (DMI) is one of the unusual complications of poorly controlled diabetes. It is usually seen in association with other microvascular complications. This condition is reported rarely, probably due to it's under recognition. It is also seen in patients with chronic kidney disease and should be considered in patients presenting with acute onset of limb pain. Here we present two cases of DMI in dialysis patients and discuss the available literature to highlight the clinical characteristics of the cases. We also present a d...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: YJ Anupama Praveen Upadhyaya Source Type: research

Iatrogenic central vein perforation: A nonsurgical therapeutic approach
We report a case where during the placement of the dialysis catheter, it inadvertently perforated the left innominate vein. A potential disaster was prevented by deploying a covered stent over the site. This alternative percutaneous approach when available can be a safe alternative to open surgical intervention and represents a paradigm shift in our approach. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Vishal Singh Source Type: research

Efficacy of mycophenolate mofetil as a remission maintaining agent in idiopathic childhood nephrotic syndrome
M Nandi, SK Mandal, M Samanta, A Majhi, MK DasIndian Journal of Nephrology 2019 29(1):34-41 Of all cases of idiopathic steroid-sensitive nephrotic syndrome (NS) in children, 40%–75% cases need long-term continuous steroids and/or other immunosuppressants to maintain remission, the effects of which on growth and renal function remain an issue of concern. The study aimed at exploring the safety and efficacy of mycophenolate mofetil (MMF) as a remission-maintaining agent in children with a diagnosis of frequent relapsing or steroid-dependent NS (FRNS/SDNS) requiring continuous medication for at least 1 year. Th...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: M Nandi SK Mandal M Samanta A Majhi MK Das Source Type: research

Early predictors of renal dysfunction in pediatric patients with sickle cell disease
This study was conducted among 70 children with SCD and 40 age and sex-matched children as a control group. All subjects underwent a full medical history, through physical examination, laboratory investigations including blood urea, serum creatinine, serum ferritin, estimated glomerular filtration rate (eGFR) using the Schwartz formula, creatinine clearance, urinary albumin/creatinine ratio, serum cystatin-C, and β-2 microglobulin levels. Pediatric patients with SCD had significantly higher serum cystatin-C and β-2 microglobulin levels compared to controls. In addition, serum cystatin-C and β-2 microglobulin...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Mohamed Abdelaziz El-Gamasy Wageh S El-Naghy Source Type: research

Comparison of normal saline, ringer & #39;s lactate, and sodium bicarbonate for prevention of contrast-induced nephropathy in patients with coronary angiography: A randomized double-blind clinical trial
In this study, patients with coronary angiography indication were divided into three groups by simple randomization method: NLS, RL, and Bi solution groups. Creatinine (Cr) alterations, glomerular filtration rate, and urine pH were evaluated prior and after the procedure. Data were analyzed with SPSS and P value less than 0.05 was taken as significant. In this study, 300 patients [150 men (50%), mean age 59.1 ± 10.6 years] were studied. The CIN incidence overall was 10% (30 patients): 8.3% (8 patients) in NLS; 16.5% (17 patients) in RL; and 5% (5 patients) in Bi group. It was significantly differen...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Maryam Pakfetrat Leila Malekmakan Zahra Salmanpour Mohammad Hossein Nikoo Peyman Izadpanah Source Type: research

Clinical characteristic and risk factors of acute kidney injury among dengue viral infections in adults: A retrospective analysis
This study was conducted to investigate the incidence, clinical characteristics, and risk factors for AKI in DVI. This was a retrospective study of patients with confirmed DVI presenting as dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) at our center over a period of 2 years. A total of 620 subjects fulfilling inclusion criteria were studied. Patients were divided into two cohorts (90 patients with AKI and 530 patients without AKI) to determine independent predictors of AKI. Among 620 patients, 454 (73.22%) had classical DF, 141 (22.74%) patients had DHF, and 25 (4.03%) patients h...
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: Munna L Patel D Himanshu SC Chaudhary Virendra Atam Rekha Sachan Ravi Misra Shivabrata D Mohapatra Source Type: research

Time of cold ischemia and delayed graft function in a cohort of renal transplant patients in a reference center
In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant. (Source: Indian Journal of Nephrology)
Source: Indian Journal of Nephrology - January 30, 2019 Category: Urology & Nephrology Authors: JF Nieto-Rios CL Ochoa-Garc & #237;a A Serna-Campuzano B Benavides-Hermosa LL Calder & #243;n-Puentes A Aristizabal-Alzate C Ocampo-Kohn G Zuluaga-Valencia LM Serna-Higuita Source Type: research