The role of microRNA and long non-coding RNA in cholestatic liver diseases
Am J Pathol. 2024 Feb 26:S0002-9440(24)00075-0. doi: 10.1016/j.ajpath.2024.02.006. Online ahead of print.ABSTRACTCholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis according to the location of occurrence. The etiology of cholestatic liver diseases are complex, which include drugs, poisons, viruses, parasites, bacteria, autoim...
Source: The American Journal of Pathology - February 28, 2024 Category: Pathology Authors: Yudian Zhang Ying Liu Wen Huo Longfei He Bowen Li Hui Wang Fanyin Meng Chenggang Duan Bingru Zhou Jinbo Wu Rong Chen Juan Xing Ying Wan Source Type: research
The role of microRNA and long non-coding RNA in cholestatic liver diseases
Am J Pathol. 2024 Feb 26:S0002-9440(24)00075-0. doi: 10.1016/j.ajpath.2024.02.006. Online ahead of print.ABSTRACTCholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis according to the location of occurrence. The etiology of cholestatic liver diseases are complex, which include drugs, poisons, viruses, parasites, bacteria, autoim...
Source: Am J Pathol - February 28, 2024 Category: Pathology Authors: Yudian Zhang Ying Liu Wen Huo Longfei He Bowen Li Hui Wang Fanyin Meng Chenggang Duan Bingru Zhou Jinbo Wu Rong Chen Juan Xing Ying Wan Source Type: research
The role of microRNA and long non-coding RNA in cholestatic liver diseases
Am J Pathol. 2024 Feb 26:S0002-9440(24)00075-0. doi: 10.1016/j.ajpath.2024.02.006. Online ahead of print.ABSTRACTCholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis according to the location of occurrence. The etiology of cholestatic liver diseases are complex, which include drugs, poisons, viruses, parasites, bacteria, autoim...
Source: The American Journal of Pathology - February 28, 2024 Category: Pathology Authors: Yudian Zhang Ying Liu Wen Huo Longfei He Bowen Li Hui Wang Fanyin Meng Chenggang Duan Bingru Zhou Jinbo Wu Rong Chen Juan Xing Ying Wan Source Type: research
Liver imaging and pregnancy: what to expect when your patient is expecting
Insights Imaging. 2024 Feb 27;15(1):66. doi: 10.1186/s13244-024-01622-x.ABSTRACTLiver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: ...
Source: Herpes - February 27, 2024 Category: Infectious Diseases Authors: Giorgia Porrello Roberto Cannella Jacques Bernuau Antoine Agman Giuseppe Brancatelli Marco Dioguardi Burgio Val érie Vilgrain Source Type: research
Liver imaging and pregnancy: what to expect when your patient is expecting
AbstractLiver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy...
Source: Insights into Imaging - February 27, 2024 Category: Radiology Source Type: research
GSE234260 sc-RNA sequencing data of primary liver cells from wildtype, YAPKO,TAZKO and DKO mice
ConclusionsYAP inactivation causes severe liver damage in vivo and concomitant TAZ deletion does not enhance but moderately reduce this phenotype. Furthermore, we describe a new mechanism how YAP inactivation in HCs/BECs contributes to YAP-driven heterologous cell communication originating from NPCs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
The role of microRNA and long non-coding RNA in cholestatic liver diseases
Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis according to the location of occurrence. The etiology of cholestatic liver diseases are complex, which include drugs, poisons, viruses, parasites, bacteria, autoimmune responses, tumors and genetic metabolism. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 26, 2024 Category: Pathology Authors: Yudian Zhang, Ying Liu, Wen Huo, Longfei He, Bowen Li, Hui Wang, Fanyin Meng, Chenggang Duan, Bingru Zhou, Jinbo Wu, Rong Chen, Juan Xing, Ying Wan Tags: Review Source Type: research
The Role of miRNA and Long Noncoding RNA in Cholestatic Liver Diseases
Cholestatic liver diseases encompass a range of organic damages, metabolic disorders, and dysfunctions within the hepatobiliary system, arising from various pathogenic causes. These factors contribute to disruptions in bile production, secretion, and excretion. Cholestatic liver diseases can be classified into intrahepatic and extrahepatic cholestasis, according to the location of occurrence. The etiology of cholestatic liver diseases is complex, and includes drugs, poisons, viruses, parasites, bacteria, autoimmune responses, tumors, and genetic metabolism. (Source: American Journal of Pathology)
Source: American Journal of Pathology - February 26, 2024 Category: Pathology Authors: Yudian Zhang, Ying Liu, Wen Huo, Longfei He, Bowen Li, Hui Wang, Fanyin Meng, Chenggang Duan, Bingru Zhou, Jinbo Wu, Rong Chen, Juan Xing, Ying Wan Tags: Review Source Type: research
Gradual dosing of ursodeoxycholic acid in mothers with intrahepatic cholestasis of pregnancy may improve composite neonatal outcome
CONCLUSIONS: Compared to the administration of a full UDCA dose, the administration of a gradually increasing dose of UDCA may be associated with a greater gestational age at delivery and fewer events of unfavorable composite neonatal outcomes. These novel findings should be retested prospectively in a large cohort of patients.PMID:38403070 | DOI:10.1016/j.aohep.2024.101490 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 25, 2024 Category: Gastroenterology Authors: Amir Hamud Matan J Cohen Drorith Hochner-Celnikier Benjamin Bar-Oz Zvi Ackerman Source Type: research
NR1H4 mutation and rapid progressive intrahepatic cholestasis in infancy: A case report and literature review
AbstractFarnesoid X receptor (FXR) is a nuclear bile acid receptor encoded by theNR1H4 gene, a vital regulator of bile acid homeostasis. Pathogenic mutations ofNR1H4 manifest as low gamma-glutamyl transferase (GGT) cholestasis with rapid progression to liver failure, which is referred to as progressive familial intrahepatic cholestasis 5 (PFIC-5). Herein, we present a case with rapid progressive cholestasis, liver failure in early infancy with theNR1H4 termination mutation. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 24, 2024 Category: General Medicine Authors: Chiao ‐Yu Yang,
Hung‐Wen Tsai,
Yen‐Yin Chou,
Yao‐Jong Yang Tags: CASE REPORT Source Type: research
Biliary atresia with splenic malformation with associated ductal plate malformation and duodenal atresia: A case report
We describe a BASM associated with DPM and duodenal atresia in a 35-day-old infant, who succumbed at 40 days, before portoenterostomy could be performed. Duodenal atresia can be one of the associated malformations associated with BASM and ductal plate abnormalities. In our case, the child did not survive.PMID:38394407 | DOI:10.4103/ijpm.ijpm_182_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Raktim Mukherjee Aniket Halder Suman Kumar Das Suchandra Mukherjee Uttara Chatterjee Source Type: research
Biliary atresia with splenic malformation with associated ductal plate malformation and duodenal atresia: A case report
We describe a BASM associated with DPM and duodenal atresia in a 35-day-old infant, who succumbed at 40 days, before portoenterostomy could be performed. Duodenal atresia can be one of the associated malformations associated with BASM and ductal plate abnormalities. In our case, the child did not survive.PMID:38394407 | DOI:10.4103/ijpm.ijpm_182_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Raktim Mukherjee Aniket Halder Suman Kumar Das Suchandra Mukherjee Uttara Chatterjee Source Type: research
Biliary atresia with splenic malformation with associated ductal plate malformation and duodenal atresia: A case report
We describe a BASM associated with DPM and duodenal atresia in a 35-day-old infant, who succumbed at 40 days, before portoenterostomy could be performed. Duodenal atresia can be one of the associated malformations associated with BASM and ductal plate abnormalities. In our case, the child did not survive.PMID:38394407 | DOI:10.4103/ijpm.ijpm_182_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Raktim Mukherjee Aniket Halder Suman Kumar Das Suchandra Mukherjee Uttara Chatterjee Source Type: research
Biliary atresia with splenic malformation with associated ductal plate malformation and duodenal atresia: A case report
We describe a BASM associated with DPM and duodenal atresia in a 35-day-old infant, who succumbed at 40 days, before portoenterostomy could be performed. Duodenal atresia can be one of the associated malformations associated with BASM and ductal plate abnormalities. In our case, the child did not survive.PMID:38394407 | DOI:10.4103/ijpm.ijpm_182_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Raktim Mukherjee Aniket Halder Suman Kumar Das Suchandra Mukherjee Uttara Chatterjee Source Type: research
