The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | PMC:PMC10962286 | DOI:10.1080/07853890.2024.2331059 (Source: Annals of Medicine)
Source: Annals of Medicine - March 22, 2024 Category: Internal Medicine Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
Metabolomic Profiling of Serum and Tongue Coating of Pregnant Women with Intrahepatic Cholestasis in Pregnancy
In this study, we performed untargeted metabolomic profiling of the serum, tongue coating, and saliva of 66 pregnant women, including 22 with ICP. The metabolomic profiles of the serum and tongue coatings showed marked differences between the two clinical groups. Forty-six differentially abundant metabolites were identified, and their relative concentrations correlated with total bile acid levels. These differential metabolites included bile acids, lipids, microbiota- and diet-related metabolites, and exposomes. Conventional biochemical markers, including serum aminotransferases and bilirubin, were not significantly increa...
Source: International Journal of Clinical Chemistry - March 21, 2024 Category: Chemistry Authors: Feng Zhang Fang Liu Xiaoyi Xu Weilan Su Yu Rong Fu-Ying Tian Weimin Xiao Yichun Wu Kai P Law Ping Wen Source Type: research
Metabolomic Profiling of Serum and Tongue Coating of Pregnant Women with Intrahepatic Cholestasis in Pregnancy
In this study, we performed untargeted metabolomic profiling of the serum, tongue coating, and saliva of 66 pregnant women, including 22 with ICP. The metabolomic profiles of the serum and tongue coatings showed marked differences between the two clinical groups. Forty-six differentially abundant metabolites were identified, and their relative concentrations correlated with total bile acid levels. These differential metabolites included bile acids, lipids, microbiota- and diet-related metabolites, and exposomes. Conventional biochemical markers, including serum aminotransferases and bilirubin, were not significantly increa...
Source: International Journal of Clinical Chemistry - March 21, 2024 Category: Chemistry Authors: Feng Zhang Fang Liu Xiaoyi Xu Weilan Su Yu Rong Fu-Ying Tian Weimin Xiao Yichun Wu Kai P Law Ping Wen Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
Clinical, biochemical, and genotypical characteristics in urea cycle mitochondrial transporter disorders
CONCLUSIONS: Increasing patients' caloric intake with HHH syndrome improves their ornithine levels. Our patients with citrin deficiency recovered clinically and biochemically before seven months.PMID:38497870 | DOI:10.26355/eurrev_202403_35601 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: H Bilgin S Bilge M Binici S Tekes Source Type: research
