Is the Risk of Intrahepatic Cholestasis Increased with Supplemental Progesterone?
Conclusion Contrary to recent evidence, no association was seen with the use of supplemental progesterone. It is possible that the associated risk with supplemental progesterone is dependent on medication formulation or route of administration.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 7, 2024 Category: Perinatology & Neonatology Authors: Rohn, Matthew C.H. Vignali, Lindsey Reeder, Isabel Khosravian, Kiana Petersen, Scott Tags: Original Article Source Type: research
1068 novel intraduodenal fecal microbiota transplantation methodology ameliorates gut atrophy and cholestasis in an ambulatory pediatric parenteral nutrition piglet model
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Ajay K. Jain, Chandrashekhara Manithody, Christine Denton, Kento Kurashima, Sree L. Kolli, Jasmine Carter, Shaurya Mehta, Ashlesha Bagwe, Marzena Swiderska-Syn, Miguel A. Guzman, Sherri Besmer, Sonali Jain, Mathew McHale, John Long, Chien-Jung Lin, Chelse Tags: AGA Abstracts Source Type: research
Ep77 paraneoplastic cholestasis from classic hodgkin lymphoma
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Christina Joya, Keaton Maguire, Scott Diamond, Vishvinder Sharma Tags: AASLD Abstracts Source Type: research
Tu1593 ELEVATED CXCL10 AGGRAVATED HEPATIC INFLAMMATORY RESPONSE IN CHOLESTASIS
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Sen Liang, Xiaojia Huang, Liangjun Zhang, Xiaoxun Zhang, Nan Zhao, Qiong Pan, Jin Chai Tags: AASLD Abstracts Source Type: research
Mo1605 INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN A PATIENT WITH UNDERLYING MUTATIONS OF ABCB4 AND UGT1A1
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Gowthami Kanagalingam, Sayed Obaidullah Aseem, Abiraam Kanagalingam Tags: AASLD Abstracts Source Type: research
Arthrogryposis, renal dysfunction, cholestasis syndrome with a novel mutation in two siblings
Key Clinical MessageThis current case series adds to the spectrum of Arthrogryposis renal dysfunction cholestasis (ARC)-associated variants. Increased awareness and early genetic testing for ARC are suggested in cases with failure to thrive, renal tubular dysfunction, and rickets, even when the degree of cholestasis is mild. Prompt identification and intervention may improve the quality of life. (Source: Clinical Case Reports)
Source: Clinical Case Reports - May 2, 2024 Category: General Medicine Authors: Rahiya Rehman,
Leslia Gonzalez,
Kelsey Kolbe,
Mohammed Khurram Faizan,
William Brucker,
Carolina Cerezo Tags: CASE REPORT Source Type: research
Hepatic phenotypes of EFL1-related Shwachman-Diamond syndrome in a biopsy-validated study
Shwachman Diamond Syndrome (SDS), an inherited bone marrow failure syndrome, is characterized by exocrine pancreatic deficiency, predisposition to myeloid malignancies, and skeletal dysplasia. Other symptoms also include hepatic and renal involvement. Hepatomegaly and aminotransaminase elevation can be observed at an early age in SDS patients, typically with an overall good prognosis. A follow-up with mild cholestasis may reflect primary alterations in liver metabolism in SDS. During the long follow-up, no major liver abnormalities appeared [1]. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Bing Zhu, Yibing Guo, Sa Lv, Xiuxin Ling, Shaoli You Source Type: research
Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy
CONCLUSION: Compared with the NP group, significant alterations were observed in the SCFAs of maternal serum and cord blood in the ICP group, although they displayed distinct patterns of change. Furthermore, the SCFA levels in maternal serum and cord blood were significantly positively correlated. Notably, certain maternal serum SCFAs, specifically caproic and acetic acids, demonstrated excellent diagnostic efficiency for ICP.PMID:38689740 | PMC:PMC11056904 | DOI:10.4254/wjh.v16.i4.601 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Shuai-Jun Ren Jia-Ting Feng Ting Xiang Cai-Lian Liao Yu-Ping Zhou Rong-Rong Xuan Source Type: research
The role of Ca < sup > 2+ < /sup > signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy
CONCLUSIONS: Our results revealed that the expression of InsP3R and serum Ca2+ levels was significantly decreased in the liver tissue of ICP model rats. Additionally, Ca2+ levels were found to be negatively correlated with the level of glycocholic acid.PMID:38685831 | DOI:10.1080/01443615.2024.2345276 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - April 30, 2024 Category: OBGYN Authors: Dan Pan Mengting Jiang Guoxian Tao Jinmei Shi Zhiwei Song Ren Chen Dongguo Wang Source Type: research
Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Conclusion: Hypoxic/ischemic injury and infection are the predominant etiologies of NALF in China. The overall prognosis of NALF is poor, but its short-term prognosis is determined by the etiology. What is Known: • Neonatal acute liver failure (NALF) is a rare disorder with limited cohort studies, especially in China. • Gestational alloimmune liver disease, viral infections (especially herpes simplex virus), metabolic diseases and ischemic insults are common etiologies of NALF, which are significantly different from other populations. • There are no reliable biochemical markers to predict the outcome of NALF. What is...
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Suhua Xu Peng Zhang Mengmeng Ge Yuanyuan Shan Guoqiang Cheng Source Type: research
Research development and trend of intrahepatic cholestasis of pregnancy: A bibliometric analysis
Asian J Surg. 2024 Apr 29:S1015-9584(24)00740-1. doi: 10.1016/j.asjsur.2024.04.080. Online ahead of print.NO ABSTRACTPMID:38688759 | DOI:10.1016/j.asjsur.2024.04.080 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 30, 2024 Category: Surgery Authors: Yan-Nan Zhou Hong-Ying Luo Jing Lin Source Type: research
