Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in Liver Disease
Senescent cells are play a role in the onset and progression of near every age-related condition. Cells become senescent constantly throughout the body and throughout life, most because they have reached the Hayflick limit to replication. In youth, senescent cells are efficiently removed, either through programmed cell death or by the immune system. With age, the immune system declines in effectiveness. Senescent cells begin to linger and grow in number. These errant cells secrete a mix of pro-growth, pro-inflammation signals that, when present over the long term, disrupt cell and tissue function.
Today's open acce...
Source: Fight Aging! - January 20, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What's new in midwifery - 31st March 2021
COVID-19Two that appeared in a Medline alert I have running for Long COVID:Kotlar B; Gerson E; Petrillo S; Langer A; Tiemeier H. The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review. Reproductive Health. 18(1):10, 2021 Jan 18.Vardhelli V; Pandita A; Pillai A; Badatya SK. Perinatal COVID-19: review of current evidence and practical approach towards prevention and management. European Journal of Pediatrics. 180(4):1009-1031, 2021 Apr.Then, a systematic review looking atintrauterine fetal death in women who had tested positive for COVID on admission for delivery. A systematic review from...
Source: Browsing - March 31, 2021 Category: Databases & Libraries Tags: midwifery Source Type: blogs
What's new in midwifery - 2nd October 2019
Some recent things...University of Leicester members are welcome to contact me for advice on accessing full text of the research cited below. Other readers should contact their librarian!ResearchEnhanced communication and staff training could improve the experience of maternity services for asylum-seeking women (NIHR Signals)Summary of research reported inMidwifery.Treatment for liver disorder in pregnancy ineffective, finds studyNews item about the PITCHES trial of ursodeoxycholic acid for intrahepatic cholestasis of pregnancy. The trial was published inthe Lancet.Planned delivery reduces impact of poten...
Source: Browsing - October 2, 2019 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Naturopaths: Able to turn even Epsom salt potentially deadly
Naturopathy and naturopaths are a fairly frequent topic on this blog —and for very good reason. If there is an example of a pseudomedical " discipline " that has been gaining undeserved " respectability, " it ' s naturopathy. It ' s licensed in all too many states, and physicians who have fallen under the spell of so-called " integrative medicine, " a specialty that rebrands science-based lifestyle medical interventions as somehow " alternative " or " integrative " and uses them as a vessel to " integrate " quackery into medicine, seem to have a special affinity for naturopaths. Indeed, so common has the presence of natu...
Source: Respectful Insolence - October 6, 2017 Category: Surgery Authors: oracknows Source Type: blogs
