NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH oxidase-generated reactive oxygen species are involved in estradiol 17 ß-d-glucuronide-induced cholestasis
Biochimie. 2024 Apr 10;223:41-53. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cultures, we sho...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia S Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
Ursodeoxycholic acid loaded dual-modified graphene oxide nanocomposite alleviates cholestatic liver injury through inhibiting hepatocyte apoptosis
Colloids Surf B Biointerfaces. 2024 Apr 7;238:113904. doi: 10.1016/j.colsurfb.2024.113904. Online ahead of print.ABSTRACTUrsodeoxycholic acid (UDCA) is the preferred treatment for various types of cholestasis, however, its effectiveness is limited because of its insolubility in water. We used polyethylene glycol (PEG) and cationic polymer polyethylenimine (PEI) to double-modify graphite oxide (PPG) as a drug delivery system. UDCA was successfully loaded onto PPG through intermolecular interactions to form UDCA-PPG nanoparticles. UDCA-PPG nanoparticles not only improve the solubility and dispersibility of UDCA, but also hav...
Source: Colloids and Surfaces - April 11, 2024 Category: Biotechnology Authors: Wanyi Zhou Xinrui Yang Yaru Yin Si Chen Luxun Yang Tao Li Jing Liu Binghui Lu Zhangyou Yang Rong Li Mingman Zhang Source Type: research
Ursodeoxycholic acid loaded dual-modified graphene oxide nanocomposite alleviates cholestatic liver injury through inhibiting hepatocyte apoptosis
Colloids Surf B Biointerfaces. 2024 Apr 7;238:113904. doi: 10.1016/j.colsurfb.2024.113904. Online ahead of print.ABSTRACTUrsodeoxycholic acid (UDCA) is the preferred treatment for various types of cholestasis, however, its effectiveness is limited because of its insolubility in water. We used polyethylene glycol (PEG) and cationic polymer polyethylenimine (PEI) to double-modify graphite oxide (PPG) as a drug delivery system. UDCA was successfully loaded onto PPG through intermolecular interactions to form UDCA-PPG nanoparticles. UDCA-PPG nanoparticles not only improve the solubility and dispersibility of UDCA, but also hav...
Source: Colloids and Surfaces - April 11, 2024 Category: Biotechnology Authors: Wanyi Zhou Xinrui Yang Yaru Yin Si Chen Luxun Yang Tao Li Jing Liu Binghui Lu Zhangyou Yang Rong Li Mingman Zhang Source Type: research
Discovery of PXR agonists from Hypericum japonicum: A class of novel nonaromatic acylphloroglucinol-terpenoid adducts
Bioorg Chem. 2024 Apr 8;147:107354. doi: 10.1016/j.bioorg.2024.107354. Online ahead of print.ABSTRACTPregnane X receptor (PXR) has been considered as a promising therapeutic target for cholestasis due to its crucial regulation in bile acid biosynthesis and metabolism. To search promising natural PXR agonists, the PXR agonistic activities of five traditional Chinese medicines (TCMs) with hepatoprotective efficacy were assayed, and Hypericum japonicum as the most active one was selected for subsequent phytochemical investigation, which led to the isolation of eight nonaromatic acylphloroglucinol-terpenoid adducts including s...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Haiguo Su Hangfei Liang Jianing Tian Lei Zheng Huilin Li Xiao Yang Sheng Yin Huichang Bi Source Type: research
Discovery of PXR agonists from Hypericum japonicum: A class of novel nonaromatic acylphloroglucinol-terpenoid adducts
Bioorg Chem. 2024 Apr 8;147:107354. doi: 10.1016/j.bioorg.2024.107354. Online ahead of print.ABSTRACTPregnane X receptor (PXR) has been considered as a promising therapeutic target for cholestasis due to its crucial regulation in bile acid biosynthesis and metabolism. To search promising natural PXR agonists, the PXR agonistic activities of five traditional Chinese medicines (TCMs) with hepatoprotective efficacy were assayed, and Hypericum japonicum as the most active one was selected for subsequent phytochemical investigation, which led to the isolation of eight nonaromatic acylphloroglucinol-terpenoid adducts including s...
Source: Bioorganic Chemistry - April 10, 2024 Category: Chemistry Authors: Haiguo Su Hangfei Liang Jianing Tian Lei Zheng Huilin Li Xiao Yang Sheng Yin Huichang Bi Source Type: research
Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease
Biomed Pharmacother. 2024 Apr 6;174:116567. doi: 10.1016/j.biopha.2024.116567. Online ahead of print.ABSTRACTBile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal bloo...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Ziyi Zhang Tingting Lv Xiang Wang Menglu Wu Ruolin Zhang Xiaopeng Yang Yongping Fu Zheng Liu Source Type: research
Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease
Biomed Pharmacother. 2024 Apr 6;174:116567. doi: 10.1016/j.biopha.2024.116567. Online ahead of print.ABSTRACTBile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal bloo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Ziyi Zhang Tingting Lv Xiang Wang Menglu Wu Ruolin Zhang Xiaopeng Yang Yongping Fu Zheng Liu Source Type: research
Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease
Biomed Pharmacother. 2024 Apr 6;174:116567. doi: 10.1016/j.biopha.2024.116567. Online ahead of print.ABSTRACTBile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal bloo...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Ziyi Zhang Tingting Lv Xiang Wang Menglu Wu Ruolin Zhang Xiaopeng Yang Yongping Fu Zheng Liu Source Type: research
Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease
Biomed Pharmacother. 2024 Apr 6;174:116567. doi: 10.1016/j.biopha.2024.116567. Online ahead of print.ABSTRACTBile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal bloo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Ziyi Zhang Tingting Lv Xiang Wang Menglu Wu Ruolin Zhang Xiaopeng Yang Yongping Fu Zheng Liu Source Type: research
Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease
Biomed Pharmacother. 2024 Apr 6;174:116567. doi: 10.1016/j.biopha.2024.116567. Online ahead of print.ABSTRACTBile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle cells, indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic BAs are cardiotoxic, while hydrophilic BAs are cardioprotective. For example, fetal cardiac insufficiency in maternal intrahepatic cholestasis during pregnancy, and the degree of fetal cardiac abnormality, is closely related to the level of hydrophobic BAs in maternal bloo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Ziyi Zhang Tingting Lv Xiang Wang Menglu Wu Ruolin Zhang Xiaopeng Yang Yongping Fu Zheng Liu Source Type: research
The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study
To investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on pregnancy outcomes. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 6, 2024 Category: OBGYN Authors: Qian Gao, Xuejiao Li, Li Wang, Xiaozhi Tan, Zhe Li and Chengfang Xu Tags: Research Source Type: research
