A cross-sectional study on the proper administration of eye medications and its determinants among outpatients attending Brhan Aini Ophthalmic National Referral Hospital in Asmara, Eritrea
Conclusion
This research revealed that there was an inappropriate administration technique and disposal practices of eye medications among ophthalmic outpatients. This requires immediate attention from policy-makers, programme managers and healthcare professionals to ensure the appropriate use of eye medications by the patients. (Source: BMJ Open)
Source: BMJ Open - April 11, 2024 Category: General Medicine Authors: Abdu, N., Weldemariam, D. G., Goitom Tesfagaber, A., Tewelde, T., Tesfamariam, E. H. Tags: Open access, Ophthalmology Source Type: research
TGF β overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataract
Mol Biol Cell. 2024 Apr 10:mbcE24010040. doi: 10.1091/mbc.E24-01-0040. Online ahead of print.ABSTRACTIn order to cause vision-disrupting fibrotic secondary cataract (PCO), lens epithelial cells that survive cataract surgery must migrate to the posterior of the lens capsule and differentiate into myofibroblasts. During this process, the cells become exposed to the FGF that diffuses out of the vitreous body. In normal development, such relatively high levels of FGF induce lens epithelial cells to differentiate into lens fiber cells. It has been a mystery as to how lens cells could instead undergo a mutually exclusive cell fa...
Source: Mol Biol Cell - April 10, 2024 Category: Molecular Biology Authors: Judy K VanSlyke Bruce A Boswell Linda S Musil Source Type: research
TGF β overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataract
Mol Biol Cell. 2024 Apr 10:mbcE24010040. doi: 10.1091/mbc.E24-01-0040. Online ahead of print.ABSTRACTIn order to cause vision-disrupting fibrotic secondary cataract (PCO), lens epithelial cells that survive cataract surgery must migrate to the posterior of the lens capsule and differentiate into myofibroblasts. During this process, the cells become exposed to the FGF that diffuses out of the vitreous body. In normal development, such relatively high levels of FGF induce lens epithelial cells to differentiate into lens fiber cells. It has been a mystery as to how lens cells could instead undergo a mutually exclusive cell fa...
Source: Mol Biol Cell - April 10, 2024 Category: Molecular Biology Authors: Judy K VanSlyke Bruce A Boswell Linda S Musil Source Type: research
The use of lens anterior capsule disc for corneal endothelium protection during femtosecond laser-assisted cataract surgery in eyes with low endothelial cell density
Adv Ophthalmol Pract Res. 2024 Feb 28;4(2):65-68. doi: 10.1016/j.aopr.2024.02.002. eCollection 2024 May-Jun.NO ABSTRACTPMID:38590554 | PMC:PMC10999371 | DOI:10.1016/j.aopr.2024.02.002 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Nina Asrini Noor Johan Hutauruk Tjahjono D Gondhowiardjo Source Type: research
Phacolytic Glaucoma Diagnosed by Cytopathology: A Clinicopathologic Case Series
CONCLUSIONS: Phacolytic glaucoma is a rare complication of mature/hypermature cataracts that presents with ocular pain, decreased vision, and anterior chamber inflammation. AC paracentesis with cytopathologic evaluation is a minimally invasive, rapid technique that can aid in the diagnosis and management of this disease.PMID:38592742 | DOI:10.1080/09273948.2024.2328109 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Matthew Camacho Yoseph Sayegh Sander R Dubovy Source Type: research
Transcriptome exploration of ferroptosis-related genes in TGF β- induced lens epithelial to mesenchymal transition during posterior capsular opacification development
CONCLUSIONS: Our RNA-Seq data identified 38 ferroptosis-related genes in TGF-β2 treated and untreated pLECs, which is the first observation of ferroptosis related genes in primary human lens epithelial cells under TGF-β2 stimulation.PMID:38594623 | DOI:10.1186/s12864-024-10244-y (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Cong Fan Chao Wang Yan Wang Jian Jiang Source Type: research
Phacolytic Glaucoma Diagnosed by Cytopathology: A Clinicopathologic Case Series
CONCLUSIONS: Phacolytic glaucoma is a rare complication of mature/hypermature cataracts that presents with ocular pain, decreased vision, and anterior chamber inflammation. AC paracentesis with cytopathologic evaluation is a minimally invasive, rapid technique that can aid in the diagnosis and management of this disease.PMID:38592742 | DOI:10.1080/09273948.2024.2328109 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Matthew Camacho Yoseph Sayegh Sander R Dubovy Source Type: research
Transcriptome exploration of ferroptosis-related genes in TGF β- induced lens epithelial to mesenchymal transition during posterior capsular opacification development
Posterior capsular opacification (PCO) is the main reason affecting the long-term postoperative result of cataract patient, and it is well accepted that fibrotic PCO is driven by transforming growth factor bet... (Source: BMC Genomics)
Source: BMC Genomics - April 9, 2024 Category: Genetics & Stem Cells Authors: Cong Fan, Chao Wang, Yan Wang and Jian Jiang Tags: Research Source Type: research
The Role of Complement System's C3 and C4 Fractions in the Pathogenesis of Uveitis
CONCLUSION: Our findings are in line with our initial hypothesis, that the complement system's C3 and C4 fractions may have a role in the pathogenesis of uveitis.PMID:38588040 | DOI:10.1080/09273948.2024.2337838 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 8, 2024 Category: Allergy & Immunology Authors: Lusine Kambulyan Armine Chopikyan Sevan Iritsyan Armen Mkhitaryan Anna Hovakimyan Source Type: research
Central subfield thickness of diabetic macular edema: Correlation with the aqueous humor proteome
CONCLUSION: Elevated levels of pro-inflammatory proteins, including the complement components LBP and CD14, were observed in DME. DME was associated with the loss of basal membrane proteins, compromised desmosomal integrity, and perturbation of glycolysis.PMID:38586604 | PMC:PMC10994682 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: Lasse J ørgensen Cehofski Kentaro Kojima Natsuki Kusada Mathilde Schlippe Hansen Danson Vasanthan Muttuvelu No ëlle Bakker Ingeborg Klaassen Jakob Grauslund Henrik Vorum Bent Honor é Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve
CONCLUSIONS: The intraoperative complications of FLACS were reported, and the learning curve is associated with a significant reduction in the incidence of intraoperative complications. The length of the basic learning curve of FLACS is 100 cases, and the length of the advanced learning curve was 150 cases. This study demonstrated that FLACS is characterised by a relatively straightforward and secure operative technique.PMID:38589209 | DOI:10.1136/bjo-2023-323897 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 8, 2024 Category: Opthalmology Authors: Xiaobo Zhang Wen Xu Xingchao Shentu Peiqing Chen Yibo Yu Kairan Lai Jiayong Li Wei Wang Xinyi Chen Ke Yao Source Type: research
The Role of Complement System's C3 and C4 Fractions in the Pathogenesis of Uveitis
CONCLUSION: Our findings are in line with our initial hypothesis, that the complement system's C3 and C4 fractions may have a role in the pathogenesis of uveitis.PMID:38588040 | DOI:10.1080/09273948.2024.2337838 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 8, 2024 Category: Allergy & Immunology Authors: Lusine Kambulyan Armine Chopikyan Sevan Iritsyan Armen Mkhitaryan Anna Hovakimyan Source Type: research
Central subfield thickness of diabetic macular edema: Correlation with the aqueous humor proteome
CONCLUSION: Elevated levels of pro-inflammatory proteins, including the complement components LBP and CD14, were observed in DME. DME was associated with the loss of basal membrane proteins, compromised desmosomal integrity, and perturbation of glycolysis.PMID:38586604 | PMC:PMC10994682 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: Lasse J ørgensen Cehofski Kentaro Kojima Natsuki Kusada Mathilde Schlippe Hansen Danson Vasanthan Muttuvelu No ëlle Bakker Ingeborg Klaassen Jakob Grauslund Henrik Vorum Bent Honor é Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
