Unraveling the impact of the p.R107L mutation on the structure and function of human αB-Crystallin: Implications for cataract formation
In this study, we investigated the structure, chaperone function, stability, oligomerization, and amyloidogenic properties of the p.R107L human αB-Crystallin using a number of different techniques. Our results suggest that the p.R107L mutation can cause significant changes in the secondary, tertiary, and quaternary structures of αB-Crystallin. This cataractogenic mutation led to the formation of protein oligomers with larger sizes than the wild-type protein and reduced the chemical and thermal stability of the mutant chaperone. Both fluorescence and microscopic assessments indicated that this mutation significantly alter...
Source: Biochimie - March 17, 2024 Category: Biochemistry Authors: Farid Nasiri Parisa Ebrahimi Mohammad Bagher Shahsavani Anis Barati Issa Zarei Jun Hong Masaru Hoshino Ali Akbar Moosavi-Movahedi Reza Yousefi Source Type: research
Unraveling the impact of the p.R107L mutation on the structure and function of human αB-Crystallin: Implications for cataract formation
In this study, we investigated the structure, chaperone function, stability, oligomerization, and amyloidogenic properties of the p.R107L human αB-Crystallin using a number of different techniques. Our results suggest that the p.R107L mutation can cause significant changes in the secondary, tertiary, and quaternary structures of αB-Crystallin. This cataractogenic mutation led to the formation of protein oligomers with larger sizes than the wild-type protein and reduced the chemical and thermal stability of the mutant chaperone. Both fluorescence and microscopic assessments indicated that this mutation significantly alter...
Source: Biochimie - March 17, 2024 Category: Biochemistry Authors: Farid Nasiri Parisa Ebrahimi Mohammad Bagher Shahsavani Anis Barati Issa Zarei Jun Hong Masaru Hoshino Ali Akbar Moosavi-Movahedi Reza Yousefi Source Type: research
Unraveling the impact of the p.R107L mutation on the structure and function of human αB-Crystallin: Implications for cataract formation
In this study, we investigated the structure, chaperone function, stability, oligomerization, and amyloidogenic properties of the p.R107L human αB-Crystallin using a number of different techniques. Our results suggest that the p.R107L mutation can cause significant changes in the secondary, tertiary, and quaternary structures of αB-Crystallin. This cataractogenic mutation led to the formation of protein oligomers with larger sizes than the wild-type protein and reduced the chemical and thermal stability of the mutant chaperone. Both fluorescence and microscopic assessments indicated that this mutation significantly alter...
Source: Biochimie - March 17, 2024 Category: Biochemistry Authors: Farid Nasiri Parisa Ebrahimi Mohammad Bagher Shahsavani Anis Barati Issa Zarei Jun Hong Masaru Hoshino Ali Akbar Moosavi-Movahedi Reza Yousefi Source Type: research
CircRNA HLCS regulates lens epithelial cell apoptosis via miR-338-3p/BPNT1 axis
ConclusionTaken together, these data suggested that circ_HLCS inhibited apoptosis of UV-treated SRA01/04 cells by miR-338-3p/BPNT1 axis. Therefore, circ_HLCS might be a potential therapeutic target for ARC. (Source: International Ophthalmology)
Source: International Ophthalmology - March 17, 2024 Category: Opthalmology Source Type: research
Radiation Exposure to the Interventional Echocardiographers and Sonographers: A Call to Action
J Am Soc Echocardiogr. 2024 Mar 13:S0894-7317(24)00109-3. doi: 10.1016/j.echo.2024.03.002. Online ahead of print.ABSTRACTInterventional echocardiography is a rapidly growing field with the disciplines of cardiology and anesthesiology, with the rise of advanced transcatheter procedures making skilled imagers more important than ever. However, these procedures also involve frequent manipulation of the transesophageal echocardiography (TEE) probe, which means interventional echocardiographers (IE) are at risk of long-term occupational radiation exposure. Studies have shown that radiation exposure is linked to various health i...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Enrique Garcia-Sayan Renuka Jain Priscilla Wessly G Burkhard Mackensen Brianna Johnson Nishath Quader Source Type: research
Radiation Exposure to the Interventional Echocardiographers and Sonographers: A Call to Action
J Am Soc Echocardiogr. 2024 Mar 13:S0894-7317(24)00109-3. doi: 10.1016/j.echo.2024.03.002. Online ahead of print.ABSTRACTInterventional echocardiography is a rapidly growing field with the disciplines of cardiology and anesthesiology, with the rise of advanced transcatheter procedures making skilled imagers more important than ever. However, these procedures also involve frequent manipulation of the transesophageal echocardiography (TEE) probe, which means interventional echocardiographers (IE) are at risk of long-term occupational radiation exposure. Studies have shown that radiation exposure is linked to various health i...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Enrique Garcia-Sayan Renuka Jain Priscilla Wessly G Burkhard Mackensen Brianna Johnson Nishath Quader Source Type: research
Genetically and Clinically Confirmed Atypical Cerebrotendinous Xanthomatosis with Normal Cholestanol and Marked Elevations of Bile Acid Precursors and Bile Alcohols
Cerebrotendinous xanthomatosis (CTX, OMIM 213700) is a rare autosomal recessive disorder associated with deficiency of the CYP27A1 enzyme (sterol 27-hydroxylase), encoded by the CYP27A1 gene1, 2. The presentation of clinical features in CTX is complex, with heterogeneous symptoms, variable severity and evolution of complications, and diverse differences in progression of disease even within the same family1, 2. In a series of 43 cases in the United States, the mean age at diagnosis was 32 years3. In these patients, 53% experienced chronic diarrhea in childhood, 74% had cognitive impairment in childhood adolescence, 70% wer...
Source: Journal of Clinical Lipidology - March 15, 2024 Category: Lipidology Authors: Andrea E DeBarber, Ernst J. Schaefer, Jenny Do, Joseph W Ray, Austin Larson, Samantha Redder, Maya Fowler, P Barton Duell Tags: Original Research Source Type: research
Effect of topical bromfenac on intraretinal cystoid lesion in simultaneous cataract and idiopathic epiretinal membrane surgery
To investigate the effect of topical nonsteroidal anti-inflammatory drugs (NSAIDs,) bromfenac on the intraretinal cystic lesions (IRC) when performing simultaneous cataract and idiopathic epiretinal membrane (... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - March 15, 2024 Category: Opthalmology Authors: EunAh Kim, Han Jo Kwon, Sung Who Park and Iksoo Byon Tags: Research Source Type: research
Comorbidities associated with adult asthma: a population-based matched cohort study in Finland
CONCLUSIONS: The most common and most severe comorbidity of adult asthma in this study was chronic obstructive pulmonary disease. Other common comorbidities of adult asthma include acute rhinosinusitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis, allergic rhinitis, dysfunctional breathing, diabetes, pneumonia, sleep apnoea and gastro-oesophageal reflux disease.PMID:38485249 | DOI:10.1136/bmjresp-2023-001959 (Source: Respiratory Care)
Source: Respiratory Care - March 14, 2024 Category: Respiratory Medicine Authors: Riikka Emilia Lemmetyinen Sanna Katriina Toppila-Salmi Anna But Risto Renkonen Juha Pekkanen Jari Haukka Jussi Karjalainen Source Type: research
Phacoemulsification Plus Intraocular Lens Implantation with Gold Nanoparticles for Complicated Cataract Secondary to Uveitis: Efficacy Analysis
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - March 14, 2024 Category: Nanotechnology Authors: Kuang, Guoping Li, Ying Li, Zheng Ou, Yulun Li, Zhenghua Tags: research-article Source Type: research
Chloroprocaine 3% Gel as a Novel Ocular Topical Anesthetic: Results from a Multicenter, Randomized Clinical Trial in Patients Undergoing Cataract Surgery
Journal of Ocular Pharmacology and Therapeutics,Volume 40, Issue 2, Page 117-125, March 2024. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - March 14, 2024 Category: Opthalmology Authors: Michele Figus Fabrizio Giansanti Edoardo Villani Jorge L. Ali ó Ladislav Jan čo Stefano Mercuri Stefano Camnasio Carlo Cagini Source Type: research
Radiation Exposure to the Interventional Echocardiographers and Sonographers: A Call to Action
Interventional echocardiography is a rapidly growing field with the disciplines of cardiology and anesthesiology, with the rise of advanced transcatheter procedures making skilled imagers more important than ever. However, these procedures also involve frequent manipulation of the transesophageal echocardiography (TEE) probe, which means interventional echocardiographers (IE) are at risk of long-term occupational radiation exposure. Studies have shown that radiation exposure is linked to various health issues, including cancer, cataracts, hypertension, hyperlipidemia, endothelial dysfunction, vascular aging, and early athe...
Source: Journal of the American Society of Echocardiography - March 13, 2024 Category: Cardiology Authors: Enrique Garcia-Sayan, Renuka Jain, Priscilla Wessly, G. Burkhard Mackensen, Brianna Johnson, Nishath Quader Tags: Special Article Source Type: research
Radiation Exposure to the Interventional Echocardiographers and Sonographers: A Call to Action
Interventional echocardiography is a rapidly growing field within the disciplines of cardiology and anesthesiology, with the rise of advanced transcatheter procedures making skilled imagers more important than ever. However, these procedures also involve frequent manipulation of the transesophageal echocardiography probe, which means interventional echocardiographers (IEs) are at risk of long-term occupational radiation exposure. Studies have shown that radiation exposure is linked to various health issues, including cancer, cataracts, hypertension, hyperlipidemia, endothelial dysfunction, vascular aging, and early atheros...
Source: Journal of the American Society of Echocardiography - March 13, 2024 Category: Cardiology Authors: Enrique Garcia-Sayan, Renuka Jain, Priscilla Wessly, G. Burkhard Mackensen, Brianna Johnson, Nishath Quader Source Type: research
miR-143 promotes cell proliferation, invasion and migration via directly binding to BRD2 in lens epithelial cells
CONCLUSION: MiR-143 suppresses lens epithelial cell proliferation, invasion and migration by regulating BRD2, which may support a novel therapeutic strategy for cataract patients.PMID:38463605 | PMC:PMC10918123 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: You Chen Tong Zhao Mengyu Han Yi Chen Source Type: research
