Central subfield thickness of diabetic macular edema: Correlation with the aqueous humor proteome
CONCLUSION: Elevated levels of pro-inflammatory proteins, including the complement components LBP and CD14, were observed in DME. DME was associated with the loss of basal membrane proteins, compromised desmosomal integrity, and perturbation of glycolysis.PMID:38586604 | PMC:PMC10994682 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: Lasse J ørgensen Cehofski Kentaro Kojima Natsuki Kusada Mathilde Schlippe Hansen Danson Vasanthan Muttuvelu No ëlle Bakker Ingeborg Klaassen Jakob Grauslund Henrik Vorum Bent Honor é Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve
CONCLUSIONS: The intraoperative complications of FLACS were reported, and the learning curve is associated with a significant reduction in the incidence of intraoperative complications. The length of the basic learning curve of FLACS is 100 cases, and the length of the advanced learning curve was 150 cases. This study demonstrated that FLACS is characterised by a relatively straightforward and secure operative technique.PMID:38589209 | DOI:10.1136/bjo-2023-323897 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 8, 2024 Category: Opthalmology Authors: Xiaobo Zhang Wen Xu Xingchao Shentu Peiqing Chen Yibo Yu Kairan Lai Jiayong Li Wei Wang Xinyi Chen Ke Yao Source Type: research
Corneal endothelial changes seven years after phacoemulsification cataract surgery
ConclusionAfter phacoemulsification cataract surgery, long-term ECC and morphology appear to converge towards a comparable steady state regardless of initial corneal swelling and endothelial cell loss. (Source: International Ophthalmology)
Source: International Ophthalmology - April 8, 2024 Category: Opthalmology Source Type: research
Impact of thermo-mechanical skin treatment on refraction and keratometry in patients with dry eye disease and the implications for cataract surgery
To determine the changes in keratometry measurements and refraction in patients having the thermo-mechanical periorbital skin treatment, Tixel ®, to treat dry eye disease (DED). (Source: Contact Lens and Anterior Eye)
Source: Contact Lens and Anterior Eye - April 8, 2024 Category: Opthalmology Authors: Marta Blanco-V ázquez, Raquel Gil-Cazorla, Ankur Barua, Mukesh Taneja, Ludger Hanneken, Sunil Shah Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
Can (Natural) deep eutectic systems increase the efficacy of ocular therapeutics?
Eur J Pharm Biopharm. 2024 Apr 4:114276. doi: 10.1016/j.ejpb.2024.114276. Online ahead of print.ABSTRACTThe eye is one of the most complex organs in the human body, with a unique anatomy and physiology, being divided into anterior and posterior segments. Ocular diseases can occur in both segments, but different diseases affect different segments. Glaucoma and cataracts affect the anterior segment, while macular degeneration and diabetic retinopathy occur in the posterior segment. The easiest approach to treat ocular diseases, especially in the anterior segment, is through the administration of topical eye drops, but this r...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 6, 2024 Category: Drugs & Pharmacology Authors: C élia Sarmento Ana Rita C Duarte Ana Rita Jesus Source Type: research
Worsening of early DME after cataract surgery. The DICAT II Study report #2
CONCLUSION: The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.PMID:38576315 | DOI:10.1177/11206721241245743 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Marco R Pastore Alex Lucia Vinciguerra Giulia Dalla Mura Abdallah El Jabali Daniele Tognetto Giacomo Panozzo Source Type: research
Worsening of early DME after cataract surgery. The DICAT II Study report #2
CONCLUSION: The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.PMID:38576315 | DOI:10.1177/11206721241245743 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Marco R Pastore Alex Lucia Vinciguerra Giulia Dalla Mura Abdallah El Jabali Daniele Tognetto Giacomo Panozzo Source Type: research
Worsening of early DME after cataract surgery. The DICAT II Study report #2
CONCLUSION: The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.PMID:38576315 | DOI:10.1177/11206721241245743 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Marco R Pastore Alex Lucia Vinciguerra Giulia Dalla Mura Abdallah El Jabali Daniele Tognetto Giacomo Panozzo Source Type: research
Worsening of early DME after cataract surgery. The DICAT II Study report #2
CONCLUSION: The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.PMID:38576315 | DOI:10.1177/11206721241245743 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Marco R Pastore Alex Lucia Vinciguerra Giulia Dalla Mura Abdallah El Jabali Daniele Tognetto Giacomo Panozzo Source Type: research
Worsening of early DME after cataract surgery. The DICAT II Study report #2
CONCLUSION: The study provides parameters to be considered when assessing the risk of developing persistent DME after cataract surgery in diabetic patients. In particular, CFT at baseline and dropout time have been reported to be an effective and predictable OCT biomarkers when evaluating DME progression. During the evaluation of the systemic disease, similar results were found for the glycated hemoglobin at baseline.PMID:38576315 | DOI:10.1177/11206721241245743 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 5, 2024 Category: Opthalmology Authors: Marco R Pastore Alex Lucia Vinciguerra Giulia Dalla Mura Abdallah El Jabali Daniele Tognetto Giacomo Panozzo Source Type: research
Femtosecond laser-assisted astigmatic keratotomy versus toric IOL implantation for correcting astigmatism in cataract patients: a systematic review and meta-analysis with trial sequential analysis
CONCLUSIONS: For cataract patients, both FSAK and toric IOLs are effective methods for correcting astigmatism. However, toric IOLs offer less postoperative astigmatism and result in better postoperative UDVA compared with FSAK. In vector analysis of astigmatism, toric IOLs can also produce higher TIA and SIA. Additionally, neither method is associated with severe untreatable complications. Therefore, the conclusion is that toric IOLs are the preferred choice for astigmatism correction in cataract patients and FSAK serves as a viable alternative when toric IOLs are contraindicated.PMID:38575199 | DOI:10.1136/bjo-2024-325195...
Source: The British Journal of Ophthalmology - April 4, 2024 Category: Opthalmology Authors: Wei-Ting Yen Tzu-Heng Weng Ting-Yi Lin Ming-Cheng Tai Yi-Hao Chen Yu-Min Chang Source Type: research
