Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research
Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia
ConclusionsAmylin and CGRP could both be local peptide agonists for CTR-based receptors in upper cervical DRG, potentially acting through autocrine and/or paracrine signalling mechanisms to modulate neuron function. Amylin and its receptors could represent novel pain targets. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - March 14, 2024 Category: Neurology Source Type: research
Third-order Nonlinear Optical Properties of Highly Electron Deficient, Nonplanar Push-Pull Porphyrins: β-Nitro-Hexa-Substituted Porphyrins Bearing Bromo, Phenyl, and Phenylethynyl groups
Dalton Trans., 2024, Accepted Manuscript DOI: 10.1039/D4DT00045E, PaperRenu K Rohal, Dipanjan Banerjee, Nivedita Rana, Venugopal Rao Soma, Sankar Muniappan β-Heptasubstituted porphyrins [MTPP(NO2)X6; M = 2H, Ni(II), Cu(II), and ZnII; X = Br, Ph, and PE] were synthesized and explored their third-order nonlinear optical (NLO) properties using single-beam Z-scan technique... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - March 12, 2024 Category: Chemistry Authors: Renu K Rohal Source Type: research
Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure
CONCLUSIONS: Our study identifies LA microglial activation as a critical mediator of noise-induced anxiety-like behaviors, leading to neuronal and behavioral changes through selective synapse phagocytosis. Our results highlight the pivotal but previously unrecognized roles of LA microglia in chronic moderate noise-induced behavioral changes.PMID:38468130 | DOI:10.1111/cns.14674 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xiaoqi Peng Yunfeng Mao Yehao Liu Qian Dai Yingju Tai Bin Luo Yue Liang Ruirui Guan Wenjie Zhou Lin Chen Zhi Zhang Guoming Shen Haitao Wang Source Type: research
Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure
CONCLUSIONS: Our study identifies LA microglial activation as a critical mediator of noise-induced anxiety-like behaviors, leading to neuronal and behavioral changes through selective synapse phagocytosis. Our results highlight the pivotal but previously unrecognized roles of LA microglia in chronic moderate noise-induced behavioral changes.PMID:38468130 | DOI:10.1111/cns.14674 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xiaoqi Peng Yunfeng Mao Yehao Liu Qian Dai Yingju Tai Bin Luo Yue Liang Ruirui Guan Wenjie Zhou Lin Chen Zhi Zhang Guoming Shen Haitao Wang Source Type: research
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons
by Vir ág Takács, Zsuzsanna Bardóczi, Áron Orosz, Abel Major, Luca Tar, Péter Berki, Péter Papp, Márton I. Mayer, Hunor Sebők, Luca Zsolt, Katalin E. Sos, Szabolcs Káli, Tamás F. Freund, Gábor Nyiri
GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical circuits. A major subset of these neurons contains somatostatin (SOM); these cells play crucial roles in neuroplasticity, learning, and memory in many brain areas including the hippocampus, and are implicated in several neuropsychiatric diseases and neurodegenerative disorders. Two main types of SOM-containing cells in area CA1 ...
Source: PLoS Biology: Archived Table of Contents - March 12, 2024 Category: Biology Authors: Vir ág Takács Source Type: research
The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain
Res Sq [Preprint]. 2024 Feb 26:rs.3.rs-3812442. doi: 10.21203/rs.3.rs-3812442/v1.ABSTRACTThe primary cilium, a 1-3 μm long hair-like structure protruding from the surface of almost all cells in the vertebrate body, is critical for neuronal development and also functions in the adult. As the migratory neural crest settles into dorsal root ganglia (DRG) sensory neurons elaborate a single primary cilium at their soma that is maintained into adult stages. While it is not known if primary cilia are expressed in nociceptors, or their potential function in the mature DRG neuron, recent studies have shown a role for Hedgehog, who...
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Kerry Tucker Lindsey Fitzsimons Larissa Staurengo-Ferrari Oliver Bogen Dioneia Araldi Ivan Bonet Ethan Jordan Jon Levine Source Type: research
Tapeworm Infection Diagnosed after Campylobacter jejuni-induced Enteritis
This report presents a rare case of coinfection with Diphyllobothrium nihonkaiensis and Campylobacter jejuni. Therefore, it is important to consider the coexistence of other intestinal infections when diagnosing parasitic infections in patients with fever.PMID:38462514 | DOI:10.2169/internalmedicine.3388-23 (Source: Internal Medicine)
Source: Internal Medicine - March 10, 2024 Category: Internal Medicine Authors: Sotaro Ozaka Ryusuke Soma Haruhiko Takahashi Yuta Shimomori Masahide Fukuda Koshiro Tsutsumi Yuka Hirashita Kensuke Fukuda Ryo Ogawa Kazuhiro Mizukami Yomei Kagoshima Nozomi Sachi Naganori Kamiyama Hideo Hasegawa Takashi Kobayashi Masaaki Kodama Kazunari Source Type: research
