Microglial activation in the lateral amygdala promotes anxiety-like behaviors in mice with chronic moderate noise exposure

CONCLUSIONS: Our study identifies LA microglial activation as a critical mediator of noise-induced anxiety-like behaviors, leading to neuronal and behavioral changes through selective synapse phagocytosis. Our results highlight the pivotal but previously unrecognized roles of LA microglia in chronic moderate noise-induced behavioral changes.PMID:38468130 | DOI:10.1111/cns.14674

Source: CNS Neuroscience and Therapeutics - March 12, 2024 Category: Neuroscience Authors: Xiaoqi Peng Yunfeng Mao Yehao Liu Qian Dai Yingju Tai Bin Luo Yue Liang Ruirui Guan Wenjie Zhou Lin Chen Zhi Zhang Guoming Shen Haitao Wang Source Type: research