Homeostatic control of stearoyl desaturase expression via patched-like receptor PTR-23 ensures the survival of < i > C < /i > . < i > elegans < /i > during heat stress
This study provides evidence for the negative regulation of fatty acid desaturase expression in the soma ofC.elegans via the non-canonical role of a patched receptor signaling component. Taken together, this constitutes a skin-gut axis for the regulation of lipid desaturation to promote the survival of worms during heat stress. (Source: PLoS Genetics)
Source: PLoS Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Siddharth R. Venkatesh Source Type: research
Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection
Front Cell Infect Microbiol. 2023 Nov 29;13:1285193. doi: 10.3389/fcimb.2023.1285193. eCollection 2023.ABSTRACTBacterial infections and the concurrent inflammation have been associated with increased long-term cardiovascular (CV) risk. In patients receiving peritoneal dialysis (PD), bacterial peritonitis is a common occurrence, and each episode further increases late CV mortality risk. However, the underlying mechanism(s) remains to be elucidated before safe and efficient anti-inflammatory interventions can be developed. Damage-Associated Molecular Patterns (DAMPs) have been shown to contribute to the acute inflammatory re...
Source: Atherosclerosis - December 14, 2023 Category: Cardiology Authors: Esra Cetin Morgane Mazzarino Guadalupe T Gonz ález-Mateo Valeria Kopytina Soma Meran Donald Fraser Manuel L ópez-Cabrera Mario O Lab éta Anne-Catherine Raby Source Type: research
Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection
Front Cell Infect Microbiol. 2023 Nov 29;13:1285193. doi: 10.3389/fcimb.2023.1285193. eCollection 2023.ABSTRACTBacterial infections and the concurrent inflammation have been associated with increased long-term cardiovascular (CV) risk. In patients receiving peritoneal dialysis (PD), bacterial peritonitis is a common occurrence, and each episode further increases late CV mortality risk. However, the underlying mechanism(s) remains to be elucidated before safe and efficient anti-inflammatory interventions can be developed. Damage-Associated Molecular Patterns (DAMPs) have been shown to contribute to the acute inflammatory re...
Source: Atherosclerosis - December 14, 2023 Category: Cardiology Authors: Esra Cetin Morgane Mazzarino Guadalupe T Gonz ález-Mateo Valeria Kopytina Soma Meran Donald Fraser Manuel L ópez-Cabrera Mario O Lab éta Anne-Catherine Raby Source Type: research
GSE247594 A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons (10X)
Contributors : Carla C Winter ; Anne Jacobi ; Junfeng Su ; Leeyup Chung ; Cindy J van Velthoven ; Zizhen Yao ; Changkyu Lee ; Zicong Zhang ; Shuguang Yu ; Kun Gao ; Geraldine D Salazar ; Evgenii Kegeles ; Yu Zhang ; Makenzie C Tomihiro ; Yiming Zhang ; Zhiyun Yang ; Junjie Zhu ; Jing Tang ; Xuan Song ; Ryan J Donahue ; Qing Wang ; Delissa McMillen ; Michael Kunst ; Ning Wang ; Kimberly A Smith ; Gabriel E Romero ; Michelle M Frank ; Alexandra Krol ; Riki Kawaguchi ; Daniel H Geschwind ; Guoping Feng ; Lisa V Goodrich ; Yuanyuan Liu ; Bosiljka Tasic ; Hongkui Zeng ; Zhigang HeSeries Type : Expressi...
Source: GEO: Gene Expression Omnibus - December 14, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE247597 A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons (SmartSeq)
Contributors : Carla C Winter ; Anne Jacobi ; Junfeng Su ; Leeyup Chung ; Cindy J van Velthoven ; Zizhen Yao ; Changkyu Lee ; Zicong Zhang ; Shuguang Yu ; Kun Gao ; Geraldine D Salazar ; Evgenii Kegeles ; Yu Zhang ; Makenzie C Tomihiro ; Yiming Zhang ; Zhiyun Yang ; Junjie Zhu ; Jing Tang ; Xuan Song ; Ryan J Donahue ; Qing Wang ; Delissa McMillen ; Michael Kunst ; Ning Wang ; Kimberly A Smith ; Gabriel E Romero ; Michelle M Frank ; Alexandra Krol ; Riki Kawaguchi ; Daniel H Geschwind ; Guoping Feng ; Lisa V Goodrich ; Yuanyuan Liu ; Bosiljka Tasic ; Hongkui Zeng ; Zhigang HeSeries Type : Expressi...
Source: GEO: Gene Expression Omnibus - December 14, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Modoru: Clos nanosecond optical switching for distributed deep training [Invited]
Distributed deep training has become a significant consumer of bandwidth across datacenter-scale networks. The diverse parallel strategies ... (Source: Journal of Optical Communications and Networking)
Source: Journal of Optical Communications and Networking - December 13, 2023 Category: Physics Authors: Cen Wang Noboru Yoshikane Daniel Elson Yuta Wakayama Daiki Soma Shohei Beppu Takehiro Tsuritani Source Type: research
Human sperm heads harbor modified YsRNA as transgenerationally inherited non-coding RNAs
We described the profiles of non-coding RNAs bound to Ro60 in the human sperm head and detected specific binding profiles of RNA to Ro60 but no YRNA bound to Ro60. We hypothesize that the sperm head Ro60 system is functional. An adaptive phenotype mediated by the presence of a large amount of YsRNA in the sperm head, and thus as a paternal contribution in the zygote, might be related to an association of YsRNA with YRNA that prevents the adoption of a YRNA secondary structure capable of binding to Ro60. We hypothesize that preventing YRNAs from acting as Ro60-associated gatekeepers for misfolded RNAs in the zygote and earl...
Source: Frontiers in Genetics - December 13, 2023 Category: Genetics & Stem Cells Source Type: research
Spectrum of renal vascular lesions among patients with lupus nephritis: An experience from a tertiary care center
CONCLUSIONS: Renal vascular lesions are common in systemic lupus erythematosus patients with nephritis and may be associated with aggressive clinical course.PMID:38084527 | DOI:10.4103/ijpm.ijpm_327_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Madhumita Paul Soma Addya Moumita Sengupta Keya Basu Arpita Roychowdhury Manimoy Bandopadhyay Source Type: research
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
This study presents a functionally annotated proximity network for NRF2 and suggests a link between ZNF746 overexpression in Parkinson's disease and inhibition of NRF2-driven neuroprotection.PMID:38085818 | DOI:10.1126/scisignal.adi9018 (Source: Science Signaling)
Source: Science Signaling - December 12, 2023 Category: Biomedical Science Authors: Kyle M LaPak Soma Saeidi Ilah Bok Nathan T Wamsley Isaac B Plutzer Dhaval P Bhatt Jingqin Luo Ghazaleh Ashrafi M Ben Major Source Type: research
Spectrum of renal vascular lesions among patients with lupus nephritis: An experience from a tertiary care center
CONCLUSIONS: Renal vascular lesions are common in systemic lupus erythematosus patients with nephritis and may be associated with aggressive clinical course.PMID:38084527 | DOI:10.4103/ijpm.ijpm_327_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Madhumita Paul Soma Addya Moumita Sengupta Keya Basu Arpita Roychowdhury Manimoy Bandopadhyay Source Type: research
Spectrum of renal vascular lesions among patients with lupus nephritis: An experience from a tertiary care center
CONCLUSIONS: Renal vascular lesions are common in systemic lupus erythematosus patients with nephritis and may be associated with aggressive clinical course.PMID:38084527 | DOI:10.4103/ijpm.ijpm_327_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Madhumita Paul Soma Addya Moumita Sengupta Keya Basu Arpita Roychowdhury Manimoy Bandopadhyay Source Type: research
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
This study presents a functionally annotated proximity network for NRF2 and suggests a link between ZNF746 overexpression in Parkinson's disease and inhibition of NRF2-driven neuroprotection.PMID:38085818 | DOI:10.1126/scisignal.adi9018 (Source: Science Signaling)
Source: Science Signaling - December 12, 2023 Category: Biomedical Science Authors: Kyle M LaPak Soma Saeidi Ilah Bok Nathan T Wamsley Isaac B Plutzer Dhaval P Bhatt Jingqin Luo Ghazaleh Ashrafi M Ben Major Source Type: research
Spectrum of renal vascular lesions among patients with lupus nephritis: An experience from a tertiary care center
CONCLUSIONS: Renal vascular lesions are common in systemic lupus erythematosus patients with nephritis and may be associated with aggressive clinical course.PMID:38084527 | DOI:10.4103/ijpm.ijpm_327_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Madhumita Paul Soma Addya Moumita Sengupta Keya Basu Arpita Roychowdhury Manimoy Bandopadhyay Source Type: research
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
This study presents a functionally annotated proximity network for NRF2 and suggests a link between ZNF746 overexpression in Parkinson's disease and inhibition of NRF2-driven neuroprotection.PMID:38085818 | DOI:10.1126/scisignal.adi9018 (Source: Science Signaling)
Source: Science Signaling - December 12, 2023 Category: Biomedical Science Authors: Kyle M LaPak Soma Saeidi Ilah Bok Nathan T Wamsley Isaac B Plutzer Dhaval P Bhatt Jingqin Luo Ghazaleh Ashrafi M Ben Major Source Type: research
Spectrum of renal vascular lesions among patients with lupus nephritis: An experience from a tertiary care center
CONCLUSIONS: Renal vascular lesions are common in systemic lupus erythematosus patients with nephritis and may be associated with aggressive clinical course.PMID:38084527 | DOI:10.4103/ijpm.ijpm_327_22 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - December 12, 2023 Category: Pathology Authors: Madhumita Paul Soma Addya Moumita Sengupta Keya Basu Arpita Roychowdhury Manimoy Bandopadhyay Source Type: research
