Homeostatic control of stearoyl desaturase expression via patched-like receptor PTR-23 ensures the survival of < i > C < /i > . < i > elegans < /i > during heat stress

This study provides evidence for the negative regulation of fatty acid desaturase expression in the soma ofC.elegans via the non-canonical role of a patched receptor signaling component. Taken together, this constitutes a skin-gut axis for the regulation of lipid desaturation to promote the survival of worms during heat stress.

Source: PLoS Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Siddharth R. Venkatesh Source Type: research