Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

This study presents a functionally annotated proximity network for NRF2 and suggests a link between ZNF746 overexpression in Parkinson's disease and inhibition of NRF2-driven neuroprotection.PMID:38085818 | DOI:10.1126/scisignal.adi9018

Source: Science Signaling - December 12, 2023 Category: Biomedical Science Authors: Kyle M LaPak Soma Saeidi Ilah Bok Nathan T Wamsley Isaac B Plutzer Dhaval P Bhatt Jingqin Luo Ghazaleh Ashrafi M Ben Major Source Type: research