Computational Fluid Dynamic Assessment of Patients with Congenital Heart Disease from 3D Rotational Angiography
We report a single center retrospective feasibility study comprising four patients with 3DRA imaging and a complete set of hemodynamic data. 3DRA was processed and segmented to reconstruct vascular regions of interest (ROI), and a computational grid for CFD modeling of blood flow through the ROI was generated. Blood flow was simulated by integrating catheter hemodynamic data to devise boundary conditions at vascular ROI inlets and outlets. The 3DRA-based workflow successfully generated key computational outputs commonly used for cardiovascular applications, including flow patterns, distribution fractions, wall shear stress...
Source: Mammalian Genome - March 15, 2024 Category: Genetics & Stem Cells Source Type: research
Use of inhaled treprostinil in patients with interstitial lung disease and pulmonary hypertension: to boldly go where no other pulmonary vasodilator has gone before?
Pulmonary hypertension (PH) is a feared complication in patients with any chronic lung disease,1 but those with lung fibrosis have an especially poor mortality and the morbidity burden is very high.2 3 Up to very recently, there has been an almost nihilistic attitude towards these patients, since the lack of treatment options restricted the indication of a definitive diagnosis through right heart catheterisation (RHC) to lung transplant evaluation and enrolment in a clinical trial.4 Although with sound rationale, randomised placebo-controlled trials (RCT) with pulmonary vasodilators, have been negative or at worse detrimen...
Source: Thorax - March 15, 2024 Category: Respiratory Medicine Authors: Piccari, L., Wort, S. J. Tags: Thorax Editorial Source Type: research
Impact of epicardial adipose tissue on cardiac function and morphology in patients with diastolic dysfunction
ConclusionsPatients with diastolic dysfunction and increased EAT show more pronounced signs of diastolic functional failure and adverse structural remodelling. Despite similar morphological characteristics, patients with high EAT show significant cardiac functional impairment, in particular in the atria. Our results indicate that regionally increased EAT directly induces atrial functional failure, which represents a distinct pathophysiological feature in HFpEF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - March 14, 2024 Category: Cardiology Authors: Alexander Schulz,
S ören J. Backhaus,
Torben Lange,
Ruben Evertz,
Shelby Kutty,
Johannes T. Kowallick,
Gerd Hasenfuß,
Andreas Schuster Tags: Original Article Source Type: research
Development of a routine bedside CYP2C19 genotype assessment program for antiplatelet therapy guidance in a community hospital catheterization laboratory
Abstract Genotype based personalized antiplatelet therapy in the setting of percutaneous coronary intervention (PCI) has been studied in clinical trials. Despite the demonstrated risk associated withCYP2C19 loss-of-function(LoF) carriage in clopidogrel-treated PCI patients, real-world implementation of genotyping for PCI has been low. The goal of the current study was to provideCYP2C19 genotype information to the interventionalist prior to the completion of the catheterization to facilitate immediate personalized antiplatelet therapy. Routine personalization of P2Y12 inhibitor therapy for PCI in a community hospital cardia...
Source: Journal of Thrombosis and Thrombolysis - March 13, 2024 Category: Hematology Source Type: research
Feasibility, safety and diagnostic yield of interventional cardiac magnetic resonance for routine right heart catheterization in adults
CONCLUSIONS: CMR-RHC seems to be a feasible and safe procedure that can be used in routine daily practice in consecutive adults with an impactful clinical yield.PMID:38472043 | DOI:10.1016/j.acvd.2024.01.004 (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - March 12, 2024 Category: Cardiology Authors: Francesca Sanguineti Philippe Garot Solenn Toupin Th éo Pezel Yohann Bohbot Chlo é Tawa Mathieu Poupineauc Victor Boileve Valentin Landon Suzanne Duhamel J érôme Garot Source Type: research
Feasibility, safety and diagnostic yield of interventional cardiac magnetic resonance for routine right heart catheterization in adults
CONCLUSIONS: CMR-RHC seems to be a feasible and safe procedure that can be used in routine daily practice in consecutive adults with an impactful clinical yield.PMID:38472043 | DOI:10.1016/j.acvd.2024.01.004 (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - March 12, 2024 Category: Cardiology Authors: Francesca Sanguineti Philippe Garot Solenn Toupin Th éo Pezel Yohann Bohbot Chlo é Tawa Mathieu Poupineauc Victor Boileve Valentin Landon Suzanne Duhamel J érôme Garot Source Type: research
Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease
CONCLUSIONS: CPET detected deficient SV augmentation more accurately than echocardiography. CPET-determined O2·pulseAT/O2·pulserest may have a prominent role for noninvasive screening of patients at risk for pulmonary vascular disease, such as patients with persistent dyspnea after pulmonary embolism.PMID:38468264 | DOI:10.1186/s12931-024-02746-w (Source: Respiratory Care)
Source: Respiratory Care - March 12, 2024 Category: Respiratory Medicine Authors: Mona Alotaibi Jenny Z Yang Demosthenes G Papamatheakis W Cameron McGuire Timothy M Fernandes Timothy A Morris Source Type: research
Feasibility, safety and diagnostic yield of interventional cardiac magnetic resonance for routine right heart catheterization in adults
CONCLUSIONS: CMR-RHC seems to be a feasible and safe procedure that can be used in routine daily practice in consecutive adults with an impactful clinical yield.PMID:38472043 | DOI:10.1016/j.acvd.2024.01.004 (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - March 12, 2024 Category: Cardiology Authors: Francesca Sanguineti Philippe Garot Solenn Toupin Th éo Pezel Yohann Bohbot Chlo é Tawa Mathieu Poupineauc Victor Boileve Valentin Landon Suzanne Duhamel J érôme Garot Source Type: research
Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease
CONCLUSIONS: CPET detected deficient SV augmentation more accurately than echocardiography. CPET-determined O2·pulseAT/O2·pulserest may have a prominent role for noninvasive screening of patients at risk for pulmonary vascular disease, such as patients with persistent dyspnea after pulmonary embolism.PMID:38468264 | DOI:10.1186/s12931-024-02746-w (Source: Respiratory Care)
Source: Respiratory Care - March 12, 2024 Category: Respiratory Medicine Authors: Mona Alotaibi Jenny Z Yang Demosthenes G Papamatheakis W Cameron McGuire Timothy M Fernandes Timothy A Morris Source Type: research
Novel uses for implanted haemodynamic monitoring in adults with subaortic right ventricles
Conclusions
Uses of IHM in patients with sRV are described which may minimise the need for serial catheterisations in a population where PH is prevalent. HFHs were low overall but not impacted by IHM. One device-related complication occurred without long-term consequence. (Source: Heart)
Source: Heart - March 12, 2024 Category: Cardiology Authors: Marshall V, W. H., Mah, M. L., DeSalvo, J., Rajpal, S., Lastinger, L. T., Salavitabar, A., Armstrong, A. K., Berman, D., Lampert, B., Wright, L. K., Hickey, J., Metzger, R., Nandi, D., Gajarski, R., Daniels, C. J. Tags: Congenital heart disease Source Type: research
The clinical and hemodynamic characteristics of pulmonary hypertension in patients with OSA-COPD overlap syndrome
CONCLUSIONS: Patients with OS showed higher prevalence of PH, along with higher PAWP, CVP and RAP. Worse nocturnal hypoxemia was found in OS patients with PH.PMID:38467374 | DOI:10.1016/j.amjms.2024.03.014 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 11, 2024 Category: General Medicine Authors: Bing Zhu Hu Cheng Jiang Yong Jie Ding Wei Qin Wei Yu Yi Shi Fa Jiu Li Cheng Hong Li Qing Yun Li Source Type: research
The clinical and hemodynamic characteristics of pulmonary hypertension in patients with OSA-COPD overlap syndrome
CONCLUSIONS: Patients with OS showed higher prevalence of PH, along with higher PAWP, CVP and RAP. Worse nocturnal hypoxemia was found in OS patients with PH.PMID:38467374 | DOI:10.1016/j.amjms.2024.03.014 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 11, 2024 Category: General Medicine Authors: Bing Zhu Hu Cheng Jiang Yong Jie Ding Wei Qin Wei Yu Yi Shi Fa Jiu Li Cheng Hong Li Qing Yun Li Source Type: research
The clinical and hemodynamic characteristics of pulmonary hypertension in patients with OSA-COPD overlap syndrome
CONCLUSIONS: Patients with OS showed higher prevalence of PH, along with higher PAWP, CVP and RAP. Worse nocturnal hypoxemia was found in OS patients with PH.PMID:38467374 | DOI:10.1016/j.amjms.2024.03.014 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 11, 2024 Category: General Medicine Authors: Bing Zhu Hu Cheng Jiang Yong Jie Ding Wei Qin Wei Yu Yi Shi Fa Jiu Li Cheng Hong Li Qing Yun Li Source Type: research
Left atrial myxoma with cardiogenic shock following a myocardial infarction: a case report
ConclusionThis patient ’s case of cardiogenic shock following revascularization was complicated by the identification of an atrial myxoma, which, when large enough, can obstruct blood flow through the mitral valve leading to acute mitral dynamic stenosis. This condition results in circulatory collapse due to obstruction of the left ventricle in diastole as the myxoma occludes the mitral valve. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 11, 2024 Category: General Medicine Source Type: research
