Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial
CONCLUSIONS: KE treatment for 14 days was associated with higher CO at rest and lower filling pressures, cardiac volumes, and NT-proBNP levels compared with isocaloric comparator. These changes persisted during exercise and were achieved on top of optimal medical therapy. Sustained modulation of circulating ketone bodies is a potential treatment principle in patients with heart failure with reduced ejection fraction.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05161650.PMID:38533643 | DOI:10.1161/CIRCULATIONAHA.123.067971 (Source: Circulation)
Source: Circulation - March 27, 2024 Category: Cardiology Authors: Kristoffer Berg-Hansen Nigopan Gopalasingam Kristian Hylleberg Christensen Bertil Ladefoged Mads J ønsson Andersen Steen Hvitfeldt Poulsen Barry A Borlaug Roni Nielsen Niels M øller Henrik Wiggers Source Type: research
Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial
CONCLUSIONS: KE treatment for 14 days was associated with higher CO at rest and lower filling pressures, cardiac volumes, and NT-proBNP levels compared with isocaloric comparator. These changes persisted during exercise and were achieved on top of optimal medical therapy. Sustained modulation of circulating ketone bodies is a potential treatment principle in patients with heart failure with reduced ejection fraction.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05161650.PMID:38533643 | DOI:10.1161/CIRCULATIONAHA.123.067971 (Source: Circulation)
Source: Circulation - March 27, 2024 Category: Cardiology Authors: Kristoffer Berg-Hansen Nigopan Gopalasingam Kristian Hylleberg Christensen Bertil Ladefoged Mads J ønsson Andersen Steen Hvitfeldt Poulsen Barry A Borlaug Roni Nielsen Niels M øller Henrik Wiggers Source Type: research
Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation
AbstractRight ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group. Animals were assessed at 1 and 8 months by right heart catheterization, cardiac magn...
Source: Basic Research in Cardiology - March 27, 2024 Category: Cardiology Source Type: research
Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension
This study aimed to compare echocardiography-derived RV diastolic stiffness and invasively measured pressure-volume loop-derived RV diastolic stiffness in patients with precapillary PH. We studied 50 consecutive patients with suspected or confirmed precapillary PH who underwent cardiac catheterization, magnetic resonance imaging, and echocardiography within a 1-week interval. Single-beat RV pressure-volume analysis was performed to determine the gold standard for RV diastolic stiffness. Elevated RV end-diastolic pressure (RVEDP) was defined as RVEDP ≥ 8 mmHg. Using continuous-wave Doppler and M-mode echocardiography...
Source: The International Journal of Cardiovascular Imaging - March 27, 2024 Category: Radiology Source Type: research
PICC insertion and veins of the arm size variation during dialysis treatment: A prospective observational study
CONCLUSIONS: Upper arm vascular access placement in dialysed patients with fluid removal of less than 2000 ml should be performed after the dialysis session. Conversely, in dialysed patients with fluid removal of more than 2000 ml, where a significant increase in vein size was observed, vascular access placement should be performed before the dialysis session when the veins are smaller. Additionally, it should be noted that in patients with chronic kidney disease, the venous system of the upper limbs should be preserved as much as possible to prevent thrombosis and stenosis in potential arteriovenous fistula creation.PMID:...
Source: The Journal of Vascular Access - March 22, 2024 Category: Surgery Authors: Elena Ajello Antonio Arresta Riccardo Rutili Salvatore Aronica Rigo Lorenzo Elia Monti Martina Galletti Luigi Cannizzo Luciano Giannini Alberto Lucchini Federico Pieruzzi Stefano Elli Source Type: research
