Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
Aberrant Long-Chain Fatty Acid Metabolism Associated with Evolving Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00057.2024. Online ahead of print.ABSTRACTWe sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (n=22) while under surveillance in a longitudinal cohort from Johns Hopkins, then compared to metabolites assayed in matched SSc patients who did not develop P...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 23, 2024 Category: Cytology Authors: Julie C Coursen Tijana Tuhy Mario Naranjo Adrianne Woods Laura K Hummers Ami A Shah Karthik Suresh Scott H Visovatti Stephen C Mathai Paul M Hassoun Rachel L Damico Catherine E Simpson Source Type: research
A case of coronary artery compression syndrome resulting from peri-valvular regurgitation and long-standing atrial fibrillation
J Cardiol Cases. 2024 Jan 6;29(4):157-160. doi: 10.1016/j.jccase.2023.12.003. eCollection 2024 Apr.ABSTRACTA man in his 70s with a history of mitral valve replacement (MVR) and long-standing persistent atrial fibrillation (AF) presented with effort angina. Coronary angiography revealed severe stenosis of the left main coronary artery (LMCA). As it was an emergent case, PCI (percutaneous coronary intervention) was selected for treatment. Intravascular ultrasonography revealed no atherosclerotic lesions in the LMCA. The LMCA was effectively dilated by the drug-eluting stent. No elevation in intracardiac pressure was observed...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Keisuke Suzuki Yoshiaki Mibiki Mai Suzuki Hiroshi Nakagata Kosuke Aoki Eiji Sato Yoshihiro Yamashina Takehiko Miyashita Akihiko Ishida Tetsuo Yagi Source Type: research
Addressing comprehensive complexities a striking familial hypercholesterolemia case study
CONCLUSION: The case study underscores the urgency of comprehensive management strategies in confronting the myriad challenges of FH, emphasizing the value of early intervention, innovative therapies, and rigorous imaging modalities for unraveling the intricate cardiovascular manifestations of this condition.PMID:38643314 | PMC:PMC11032294 | DOI:10.1186/s43044-024-00483-5 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Shazia Rasheed Ghulam Kubra Lubna Baqai Muhammad Liaquat Raza Fariha Hassan Syed Ghazi Abbas Rizvi Source Type: research
