Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease
In conclusion, co-treatment with ACEIs and L-dopa, such as perindopril, captopril, and enalapril, may mitigate the severity of L-DOPA-induced dyskinesia in a mouse model of PD.PMID:38642669 | DOI:10.1016/j.ejphar.2024.176573 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Hye-Yeon Park Ga Seul Lee Jun Go Young-Kyoung Ryu Chul-Ho Lee Jeong Hee Moon Kyoung-Shim Kim Source Type: research
Alleviation of microcystin-leucine arginine -induced hepatotoxicity: An updated overview
CONCLUSION: The reviewed agents through blocking the OATP transporters (nontoxic nostocyclopeptide-M1, captopril, and naringin), then inhibition of MC-LR uptake (naringin, rifampin, cyclosporin-A, silymarin and captopril), and finally at restoration of PPAse activity (silybin, quercetin, morin, naringin, rifampin, captopril, azo dyes) exert hepatoprotective effect against MC-LR.PMID:38636613 | DOI:10.1016/j.toxicon.2024.107715 (Source: Toxicon)
Source: Toxicon - April 18, 2024 Category: Toxicology Authors: Habibeh Mashayekhi-Sardoo Ramin Rezaee Bamdad Riahi-Zanjani Gholamreza Karimi Source Type: research
Correlation Between the Severity of Coronary Artery Disease and Retinal Artery Disease and the Therapeutic Effect of Captopril
CONCLUSION: A significant positive correlation was observed between the severity of coronary artery lesions and retinal artery lesions. Assessing alterations in retinal blood vessels in hypertensive patients can effectively indicate the extent of coronary artery stenosis indirectly. Concerning medication, the antihypertensive drug captopril demonstrated the potential to alleviate the severity of coronary artery and retinal artery lesions in hypertensive patients. However, specific treatment methods should be tailored to individual patient circumstances.PMID:38607208 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xing Ge Xiaoli Liu Tienan Sun Xinxiao Gao Hongya Han Yujie Zhou Source Type: research
Correlation Between the Severity of Coronary Artery Disease and Retinal Artery Disease and the Therapeutic Effect of Captopril
CONCLUSION: A significant positive correlation was observed between the severity of coronary artery lesions and retinal artery lesions. Assessing alterations in retinal blood vessels in hypertensive patients can effectively indicate the extent of coronary artery stenosis indirectly. Concerning medication, the antihypertensive drug captopril demonstrated the potential to alleviate the severity of coronary artery and retinal artery lesions in hypertensive patients. However, specific treatment methods should be tailored to individual patient circumstances.PMID:38607208 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xing Ge Xiaoli Liu Tienan Sun Xinxiao Gao Hongya Han Yujie Zhou Source Type: research
Correlation Between the Severity of Coronary Artery Disease and Retinal Artery Disease and the Therapeutic Effect of Captopril
CONCLUSION: A significant positive correlation was observed between the severity of coronary artery lesions and retinal artery lesions. Assessing alterations in retinal blood vessels in hypertensive patients can effectively indicate the extent of coronary artery stenosis indirectly. Concerning medication, the antihypertensive drug captopril demonstrated the potential to alleviate the severity of coronary artery and retinal artery lesions in hypertensive patients. However, specific treatment methods should be tailored to individual patient circumstances.PMID:38607208 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xing Ge Xiaoli Liu Tienan Sun Xinxiao Gao Hongya Han Yujie Zhou Source Type: research
Correlation Between the Severity of Coronary Artery Disease and Retinal Artery Disease and the Therapeutic Effect of Captopril
CONCLUSION: A significant positive correlation was observed between the severity of coronary artery lesions and retinal artery lesions. Assessing alterations in retinal blood vessels in hypertensive patients can effectively indicate the extent of coronary artery stenosis indirectly. Concerning medication, the antihypertensive drug captopril demonstrated the potential to alleviate the severity of coronary artery and retinal artery lesions in hypertensive patients. However, specific treatment methods should be tailored to individual patient circumstances.PMID:38607208 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xing Ge Xiaoli Liu Tienan Sun Xinxiao Gao Hongya Han Yujie Zhou Source Type: research
Comparison of saline infusion test and captopril challenge test in the diagnosis of Chinese with primary aldosteronism in different age groups
ConclusionCompared with SIT, CCT had a higher diagnostic value when post-CCT PAC was used as the diagnostic criterion in Chinese people, while the selection of diagnostic thresholds depended on patient age. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 22, 2024 Category: Endocrinology Source Type: research
Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae
In conclusion, pantoprazole can be used in combination with meropenem as a new strategy for treating serious infections caused by metallo-β-lactamases producing K. pneumoniae. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Renin-Angiotensin System Inhibitors Suppress the Growth of Leukemia Cells
CONCLUSION: RAS inhibitors can be repurposed as molecular-targeted drugs for leukemia. However, the concentrations of the inhibitors were much higher than those in the plasma of patients with hypertension. Therefore, further investigation is required for their clinical use.PMID:38423665 | DOI:10.21873/anticanres.16913 (Source: Cell Research)
Source: Cell Research - February 29, 2024 Category: Cytology Authors: Mai Itoh Shun Sasaki Shuji Tohda Source Type: research
Nintedanib in systemic sclerosis treatment: a case report
ConclusionTreatment with nintedanib is crucial for slowing lung function decline. Diarrhea was the most common adverse event. Scleroderma renal crisis occurs in 10% of patients and typically presents with an abrupt onset of hypertension and kidney failure. The optimal antihypertensive agent for scleroderma renal crisis is an ACE inhibitor. The mainstay of therapy in scleroderma renal crisis has been shown to improve or stabilize renal function in approximately 70% of patients and improve survival in nearly 80% at 1 year. Nintedanib may be effective, and fairly safe to use. Further exploration is anticipated to advance a ...
Source: Journal of Medical Case Reports - February 23, 2024 Category: General Medicine Source Type: research
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress
ConclusionThe pharmacological mechanism of QLQX in improving HF is partly attributed to its regulatory effect on the miR133a-IRE1/XBP1 pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 22, 2024 Category: Internal Medicine Source Type: research
Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy
ConclusionCTSC and PDE5A were identified as key targets for RAAS inhibitors in the treatment of DN, which might provide some clinical significance in helping to diagnose and treat DN. Among the targets of RAAS inhibitors, PTGS2, ITGA4 and ANPEP have a causal relationship with acute kidney injury, which is worthy of further clinical research. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 25, 2024 Category: Endocrinology Source Type: research
Biological Activity of a Coumarin Derivative on Heart Failure Using
an Ischemia/Reperfusion Injury Model
Drug Res (Stuttg) DOI: 10.1055/a-2228-4258Heart failure is a health problem worldwide. There are some drugs for it,
including digoxin, spironolactone, captopril, and valsartan, but some of these
drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia,
hyponatremia and hypotension. The aim of this research was to evaluate the
biological activity of coumarin (2H-chromen-2-one) and its derivatives
(3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against
ischemia/reperfusion injury as a therapeutic alternative for heart
fa...
Source: Drug Research - January 17, 2024 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Melgarejo-Guti érrez, Montserrat Mateu-Armand, Virginia Garcimarrero-Espino, Alejandra Tags: Original Article Source Type: research
Captopril to Lisinopril Conversion in Pediatric Cardiothoracic Surgery Patients Less Than 7 Years of Age (RISE-7)
This study evaluated safety and efficacy of converting from captopril to lisinopril in patients utilizing a pre-defined conversion of 3 mg captopril to 1 mg lisinopril. This was a single center, retrospective study including patients less than 7 years of age admitted for cardi othoracic surgery who received both captopril and lisinopril from 01/01/2017 to 06/01/2022.The primary outcome was mean change in systolic blood pressure (SBP) from baseline for 72 h after conversion of captopril to lisinopril. A total of 99 patients were enrolled. There was a significant decrease in mean SBP (99.12 mmHg vs 94.86 mmHg;p = 0...
Source: Pediatric Cardiology - December 28, 2023 Category: Cardiology Source Type: research
