Renin-Angiotensin System Inhibitors Suppress the Growth of Leukemia Cells
CONCLUSION: RAS inhibitors can be repurposed as molecular-targeted drugs for leukemia. However, the concentrations of the inhibitors were much higher than those in the plasma of patients with hypertension. Therefore, further investigation is required for their clinical use.PMID:38423665 | DOI:10.21873/anticanres.16913 (Source: Cell Research)
Source: Cell Research - February 29, 2024 Category: Cytology Authors: Mai Itoh Shun Sasaki Shuji Tohda Source Type: research

Nintedanib in systemic sclerosis treatment: a case report
ConclusionTreatment with nintedanib is crucial for slowing lung function decline. Diarrhea was the most common adverse event. Scleroderma renal crisis occurs in 10% of patients and typically presents with an abrupt onset of hypertension and kidney failure. The optimal antihypertensive agent for scleroderma renal crisis is an ACE inhibitor. The mainstay of therapy in scleroderma renal crisis has been shown to improve or stabilize renal function in approximately 70% of patients and improve survival in nearly 80% at 1  year. Nintedanib may be effective, and fairly safe to use. Further exploration is anticipated to advance a ...
Source: Journal of Medical Case Reports - February 23, 2024 Category: General Medicine Source Type: research

Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress
ConclusionThe pharmacological mechanism of QLQX in improving HF is partly attributed to its regulatory effect on the miR133a-IRE1/XBP1 pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 22, 2024 Category: Internal Medicine Source Type: research

Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy
ConclusionCTSC and PDE5A were identified as key targets for RAAS inhibitors in the treatment of DN, which might provide some clinical significance in helping to diagnose and treat DN. Among the targets of RAAS inhibitors, PTGS2, ITGA4 and ANPEP have a causal relationship with acute kidney injury, which is worthy of further clinical research. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 25, 2024 Category: Endocrinology Source Type: research

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model
Drug Res (Stuttg) DOI: 10.1055/a-2228-4258Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatremia and hypotension. The aim of this research was to evaluate the biological activity of coumarin (2H-chromen-2-one) and its derivatives (3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against ischemia/reperfusion injury as a therapeutic alternative for heart fa...
Source: Drug Research - January 17, 2024 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Melgarejo-Guti érrez, Montserrat Mateu-Armand, Virginia Garcimarrero-Espino, Alejandra Tags: Original Article Source Type: research

Captopril to Lisinopril Conversion in Pediatric Cardiothoracic Surgery Patients Less Than 7  Years of Age (RISE-7)
This study evaluated safety and efficacy of converting from captopril to lisinopril in patients utilizing a pre-defined conversion of 3 mg captopril to 1 mg lisinopril. This was a single center, retrospective study including patients less than 7 years of age admitted for cardi othoracic surgery who received both captopril and lisinopril from 01/01/2017 to 06/01/2022.The primary outcome was mean change in systolic blood pressure (SBP) from baseline for 72 h after conversion of captopril to lisinopril. A total of 99 patients were enrolled. There was a significant decrease in mean SBP (99.12 mmHg vs 94.86 mmHg;p = 0...
Source: Pediatric Cardiology - December 28, 2023 Category: Cardiology Source Type: research

Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study
CONCLUSION: MMP2 inhibition by anthraquinones, notably Pulmatin, may be a useful therapeutic approach for cancer treatment.PMID:38123060 | DOI:10.1016/j.biosystems.2023.105103 (Source: Biosystems)
Source: Biosystems - December 20, 2023 Category: Biotechnology Authors: Shokoofeh Jamshidi Ali Rostami Setareh Shojaei Amir Taherkhani Heshmatollah Taherkhani Source Type: research

Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study
CONCLUSION: MMP2 inhibition by anthraquinones, notably Pulmatin, may be a useful therapeutic approach for cancer treatment.PMID:38123060 | DOI:10.1016/j.biosystems.2023.105103 (Source: Biosystems)
Source: Biosystems - December 20, 2023 Category: Biotechnology Authors: Shokoofeh Jamshidi Ali Rostami Setareh Shojaei Amir Taherkhani Heshmatollah Taherkhani Source Type: research

Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation
Conclusion: These findings show that small molecule FXIIa inhibitors, designed to target its active site, also inhibit the enzymatic activity of FXII zymogen. Combined inhibition of FXII zymogen and FXIIa may thereby suppress both the initiation and amplification of KKS activation that contribute to hereditary angioedema attacks and other FXII-mediated diseases. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Source Type: research

Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy
In this study, CTP-incorporated biomaterials for antihypertensive therapy were synthesized from chitosan, carboxymethyl cellulose, and plasticizers. The physicochemical properties of the prepared biomaterials were characterized using FE-SEM, FT-IR analysis, and physical properties. CTP release experiments were carried out in buffer solutions at various pH values and temperatures. Results indicated that above 99.0 % of CTP was released within 180 min. Optimization of the experimental conditions for CTP release was analyzed by using response surface methodology (RSM). Results of CTP release through artificial skin indicated ...
Source: International Journal of Biological Macromolecules - November 18, 2023 Category: Biochemistry Authors: Kyeong-Jung Kim Min-Jin Hwang Wang-Geun Shim Young-Nam Youn Soon-Do Yoon Source Type: research

Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Brain Research - November 11, 2023 Category: Neurology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research

Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Cell Research - November 11, 2023 Category: Cytology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research

Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Brain Research - November 11, 2023 Category: Neurology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research

Snake Venom Components as Therapeutic Drugs in Ischemic Heart Disease
Biomolecules. 2023 Oct 18;13(10):1539. doi: 10.3390/biom13101539.ABSTRACTIschemic heart disease (IHD), especially myocardial infarction (MI), is a leading cause of death worldwide. Although coronary reperfusion is the most straightforward treatment for limiting the MI size, it has nevertheless been shown to exacerbate ischemic myocardial injury. Therefore, identifying and developing therapeutic strategies to treat IHD is a major medical challenge. Snake venoms contain biologically active proteins and peptides that are of major interest for pharmacological applications in the cardiovascular system (CVS). This has led to the...
Source: Atherosclerosis - October 28, 2023 Category: Cardiology Authors: Erij Messadi Source Type: research