Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study
This study investigated whether captopril can reverse drug resistance in metallo-β-lactamase (MBL)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and increase their sensitivity to antimicrobial agents. And also aimed to further characterize the affinity of captopril for imipenemase 4 (IMP-4) to explore the drug resistance treatment of MBL-producing bacteria. Five clinically isolated MBL-producing strains of CRKP were screened and the combined effects of captopril and meropenem were examined in vitro and in vivo to analyze whether captopril can reverse antimicrobial resistance in drug-resistant bacteria. A...
Source: Journal of Inorganic Biochemistry - March 1, 2021 Category: Biochemistry Authors: Dongmei Zhao Hongru Li Chengcheng Yue Kaili Sun Yuanyuan Dai Hui Zhang Yanyan Liu Yufeng Gao Jiabin Li Source Type: research

Sodium palatability in male spontaneously hypertensive rats
Horm Behav. 2021 Feb 26:104952. doi: 10.1016/j.yhbeh.2021.104952. Online ahead of print.ABSTRACTSpontaneously hypertensive rats (SHRs) ingest more NaCl than normotensive strains. Here we investigated NaCl intake and taste reactivity in adult male SHRs and normotensive Holtzman rats treated or not with AT1 receptor antagonist centrally in euhydrated condition and after fluid depletion. Taste reactivity was measured by the number of orofacial expressions to intra-oral infusions of 0.3 M NaCl. In euhydrated condition, intra-oral infusions of 0.3 M NaCl produced greater number of hedonic responses in SHRs than in normotensive ...
Source: Hormones and Behavior - March 1, 2021 Category: Endocrinology Authors: E D Pereira A M Faria G M F Andrade-Franz é J V Menani L A De Luca C A F Andrade Source Type: research

Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study
This study investigated whether captopril can reverse drug resistance in metallo-β-lactamase (MBL)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and increase their sensitivity to antimicrobial agents. And also aimed to further characterize the affinity of captopril for imipenemase 4 (IMP-4) to explore the drug resistance treatment of MBL-producing bacteria. Five clinically isolated MBL-producing strains of CRKP were screened and the combined effects of captopril and meropenem were examined in vitro and in vivo to analyze whether captopril can reverse antimicrobial resistance in drug-resistant bacteria. A...
Source: Journal of Inorganic Biochemistry - March 1, 2021 Category: Biochemistry Authors: Dongmei Zhao Hongru Li Chengcheng Yue Kaili Sun Yuanyuan Dai Hui Zhang Yanyan Liu Yufeng Gao Jiabin Li Source Type: research

Sodium palatability in male spontaneously hypertensive rats
Horm Behav. 2021 Feb 26:104952. doi: 10.1016/j.yhbeh.2021.104952. Online ahead of print.ABSTRACTSpontaneously hypertensive rats (SHRs) ingest more NaCl than normotensive strains. Here we investigated NaCl intake and taste reactivity in adult male SHRs and normotensive Holtzman rats treated or not with AT1 receptor antagonist centrally in euhydrated condition and after fluid depletion. Taste reactivity was measured by the number of orofacial expressions to intra-oral infusions of 0.3 M NaCl. In euhydrated condition, intra-oral infusions of 0.3 M NaCl produced greater number of hedonic responses in SHRs than in normotensive ...
Source: Hormones and Behavior - March 1, 2021 Category: Endocrinology Authors: E D Pereira A M Faria G M F Andrade-Franz é J V Menani L A De Luca C A F Andrade Source Type: research

Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study
This study investigated whether captopril can reverse drug resistance in metallo-β-lactamase (MBL)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and increase their sensitivity to antimicrobial agents. And also aimed to further characterize the affinity of captopril for imipenemase 4 (IMP-4) to explore the drug resistance treatment of MBL-producing bacteria. Five clinically isolated MBL-producing strains of CRKP were screened and the combined effects of captopril and meropenem were examined in vitro and in vivo to analyze whether captopril can reverse antimicrobial resistance in drug-resistant bacteria. A...
Source: Journal of Inorganic Biochemistry - March 1, 2021 Category: Biochemistry Authors: Dongmei Zhao Hongru Li Chengcheng Yue Kaili Sun Yuanyuan Dai Hui Zhang Yanyan Liu Yufeng Gao Jiabin Li Source Type: research

Clathriolide from marine demosponge < em > Clathria (Thalysias) vulpina < /em > (Lamarck, 1814): previously undescribed macrocylic lactone with attenuating potential against angiotensin converting enzyme
Nat Prod Res. 2021 Feb 23:1-9. doi: 10.1080/14786419.2021.1887177. Online ahead of print.ABSTRACTAngiotensin-I converting enzyme catalyses the rate-determined step of the conversion of angiotensin-I to angiotensin-II that narrows the blood vessels, and angiotensin-I converting enzyme inhibitors were recognised as important medications for hypertension-related diseases. Chemical investigation of angiotensin-I converting enzyme inhibitors from marine demospongiae Clathria (Thalysias) vulpina (family Microcionidae), resulted in a previously undescribed 22-membered macrocyclic lactone derivative, named as clathriolide. The stu...
Source: Natural Product Research - February 23, 2021 Category: Biochemistry Authors: Kajal Chakraborty Prima Francis Source Type: research

Clathriolide from marine demosponge < em > Clathria (Thalysias) vulpina < /em > (Lamarck, 1814): previously undescribed macrocylic lactone with attenuating potential against angiotensin converting enzyme
Nat Prod Res. 2021 Feb 23:1-9. doi: 10.1080/14786419.2021.1887177. Online ahead of print.ABSTRACTAngiotensin-I converting enzyme catalyses the rate-determined step of the conversion of angiotensin-I to angiotensin-II that narrows the blood vessels, and angiotensin-I converting enzyme inhibitors were recognised as important medications for hypertension-related diseases. Chemical investigation of angiotensin-I converting enzyme inhibitors from marine demospongiae Clathria (Thalysias) vulpina (family Microcionidae), resulted in a previously undescribed 22-membered macrocyclic lactone derivative, named as clathriolide. The stu...
Source: Natural Product Research - February 23, 2021 Category: Biochemistry Authors: Kajal Chakraborty Prima Francis Source Type: research

The role of TRPA1 and TRPV4 channels in bronchoconstriction and plasma extravasation in airways of rats treated with captopril
Publication date: Available online 19 February 2021Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Janiana Raíza Jentsch Matias de Oliveira, Mayara Alves Amorim, Eunice André (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 20, 2021 Category: Respiratory Medicine Source Type: research

Molecules, Vol. 26, Pages 824: Development and Validation of an Automated Zone Fluidics-Based Sensor for In Vitro Dissolution Studies of Captopril Using Total Error Concept
haris In the present research, a zone fluidics-based automated sensor for the analysis of captopril in in vitro dissolution samples is reported. Captopril is reacted under flow conditions with Ni(II) (10 mmol L−1) in alkaline medium (0.15 % v/v NH3) to form a stable derivate, which is monitored spectrophotometrically at 340 nm. The chemical and instrumental parameters were carefully investigated and optimized. The validation of the developed method was performed in the range of 5 to 120% of the expected maximum concentration using the accuracy profiles as a graphical decision-making tool. The β-expectation t...
Source: Molecules - February 5, 2021 Category: Chemistry Authors: Theano D. Karakosta Paraskevas D. Tzanavaras Constantinos K. Zacharis Tags: Article Source Type: research

Phthalamide derivatives as ACE/AChE/BuChE inhibitors against cardiac hypertrophy: an in silico, in vitro, and in vivo modeling approach
This study aimed to synthesize three phthalamide derivatives (M-01, M-02, and M-03) and evaluate them as three-target (ACE/AChE/BuChE) inhibitors with the possible dual effect of reducing hypertension and r everting cardiac hypertrophy. After in silico and in vitro experiments, one compound was tested in vivo on rats. All three phthalamides were synthesized in good yields, showing good competitive inhibition of the three-target enzymes in silico and in vitro. M-01 (10 mg/kg) significantly reversed ca rdiomyocite hypertrophy (by 87.3%;p 
Source: Medicinal Chemistry Research - February 3, 2021 Category: Chemistry Source Type: research

Safety in Dermatologic Procedures: Hypertensive Crises and Potentially Fatal Arrhythmias.
Chicharro P Abstract As dermatologic surgeons often have to perform long surgeries with local anesthetic only, they should be familiar with the fundamentals of how to manage 2 potentially serious complications: hypertensive crises and intraoperative arrhythmias. Hypertensive crises can be classified as 1) hypertensive urgencies, characterized by a significant spike in blood pressure (BP) (>180/110 mm Hg) without target-organ dysfunction or 2) hypertensive emergencies, characterized by a BP above 180/110 mm Hg with progressive target-organ damage. In emergencies, the BP needs to be reduced immediat...
Source: Actas Dermo-Sifiliograficas - January 27, 2021 Category: Dermatology Authors: Rodríguez-Jiménez P, Sampedro-Ruiz R, Imaz I, Chicharro P Tags: Actas Dermosifiliogr Source Type: research

Access to Essential Cardiovascular Medicines in Pakistan: A National Survey on the Availability, Price and Affordability, using WHO/HAI Methodology
Objective: This national survey was aimed at measuring the access to cardiovascular diseases (CVD) medicines in terms of their availability, price and affordability in Pakistan. This was done by using the standard WHO/ Health Action International (HAI) methodology. Methods: The price and availability data for 18 CVD medicines were collected from public sector hospitals (n=40) and private sector retail pharmacies (n=40) in eight cities of Pakistan. The outcome measures were availability (calculated as percentage of health facilities stocked with listed medicines), medicine price to the international reference price ratio ...
Source: Frontiers in Pharmacology - January 25, 2021 Category: Drugs & Pharmacology Source Type: research

Angiotensin-Converting Enzyme Inhibitor, Captopril, Improves Scar Healing in Hypertensive Rats.
Authors: Rha EY, Kim JW, Kim JH, Yoo G Abstract Pathological cutaneous scars, with aberrant extracellular matrix accumulation, have multiple origins. Antihypertensive medications, such as calcium channel blockers, have been used to treat pathological scars. However, a relationship between angiotensin-converting enzyme (ACE) inhibitors, pathological scars, and blood pressure (BP) has never been reported. Here, we aimed to compare the differences in scar development and the effects of the administration of systemic ACE inhibitor on scar tissue in a normotensive rat, the Wistar Kyoto rat (WKY), a hypertensive rat, and...
Source: International Journal of Medical Sciences - January 20, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice.
ra SM Abstract Fibromyalgia is a potentially disabling chronic disease, characterized by widespread pain and a range of comorbidities such as hypertension. Among the mechanisms involved in fibromyalgia-like pain symptoms are kinins and their B1 and B2 receptors. Moreover, angiotensin I converting enzyme (ACE) inhibitors, commonly used as antihypertensive drugs, can enhance pain by blocking the degradation of peptides such as substance P and bradykinin, besides enhancing kinin receptors signalling. We investigated the effect of ACE inhibitors on reserpine-induced fibromyalgia-like pain symptoms and the involvement ...
Source: European Journal of Pharmacology - January 18, 2021 Category: Drugs & Pharmacology Authors: Brusco I, Justino AB, Silva CR, Scussel R, Machado-de-Ávila RA, Oliveira SM Tags: Eur J Pharmacol Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Characteristics of Patients with Hypertension at a Nicaraguan Clinic
CONCLUSIONS: Hypertension is common in this clinic population and most commonly treated with angiotension-receptor blockers or angiotensin converting enzyme inhibitors.PMID:33416694 | DOI:10.1353/hpu.2020.0094 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - January 8, 2021 Category: International Medicine & Public Health Authors: Jennifer S Lee Mark Humphrey Morgan Adams Myriam Torres Timothy N Crawford Jeff Hall Source Type: research

Immunomodulatory properties of molecules from animal venoms.
IMMUNOMODULATORY PROPERTIES OF MOLECULES FROM ANIMAL VENOMS. Toxicon. 2021 Jan 05;: Authors: Minutti-Zanella C, Gil-Leyva EJ, Vergara I Abstract The immune system can amplify or decrease the strength of its response when it is stimulated by chemical or biological substances that act as immunostimulators, immunosuppressants, or immunoadjuvants. Immunomodulation is a progressive approach to treat a diversity of pathologies with promising results, including autoimmune disorders and cancer. Animal venoms are a mixture of chemical compounds that include proteins, peptides, amines, salts, polypeptides, enzy...
Source: Toxicon - January 5, 2021 Category: Toxicology Authors: Minutti-Zanella C, Gil-Leyva EJ, Vergara I Tags: Toxicon Source Type: research

Drug-induced pemphigus: A systematic review of 170 patients.
In conclusion, some specific groups of treatments can induce pemphigus, including penicillamine, captopril, and bucillamine; despite the similar clinical and pathological manifestations to classical pemphigus, most of the cases are less severe and have a better prognosis. PMID: 33418246 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - January 5, 2021 Category: Allergy & Immunology Authors: Ghaedi F, Etesami I, Aryanian Z, Kalantari Y, Goodarzi A, Teymourpour A, Tavakolpour S, Mahmoudi H, Daneshpazhooh M Tags: Int Immunopharmacol Source Type: research

Drug Repositioning in Oncology
Conclusions: Therefore, drug repositioning represents a promising alternative for the treatment of oncological disorders; however, the support from funding agencies and from the government is still needed, the latter regarding regulatory issues. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - December 31, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?
ConclusionsData summarized in this review support the theory that prokaryotic proteins represent targets for non-antibiotics because of a common evolutionary origin of bacterial- and mammalian targets resulting in highly conserved active centres of both, pro- and eukaryotic proteins with which the non-antibiotics interact and exert antibacterial actions. (Source: Infection)
Source: Infection - December 15, 2020 Category: Infectious Diseases Source Type: research

Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.
Abstract β-lactam antibiotics have long been the mainstay for the treatment of bacterial infections. New Delhi metallo-β-lactamase 1 (NDM-1) is able to hydrolyze nearly all β-lactam antibiotics and even clinically used serine-β-lactamase inhibitors. The wide and rapid spreading of NDM-1 gene among pathogenic bacteria has attracted extensive attention, therefore high potency NDM-1 inhibitors are urgently needed. Here we report a series of structure-guided design of D-captopril derivatives that can inhibit the activity of NDM-1 in vitro and at cellular levels. Structural comparison indicates the ...
Source: Bioorganic and Medicinal Chemistry - December 3, 2020 Category: Chemistry Authors: Ma G, Wang S, Wu K, Zhang W, Ahmad A, Hao Q, Lei X, Zhang H Tags: Bioorg Med Chem Source Type: research

Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K+ current (Ito) reduction via CaMKII inhibition in myocardial infarction.
CONCLUSION: Over-expression of Kv4.3 can not only attenuate cardiac electrophysiological instability and cardiac performance, but also reduce myocardial infarct area and cardiac fibrosis. Like traditional anti-remodeling therapy-angiotensin converting enzyme inhibitor (ACEI) combined with β-adrenergic receptor blocker, over-expression of Kv4.3 seems to be an effective and safe therapy for both structural and electrical remodeling induced by MI via CaMKII inhibition. PMID: 33254430 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2020 Category: Drugs & Pharmacology Authors: Tao B, Liu Z, Wei F, Fan S, Cui S, Xia H, Xu L Tags: Biomed Pharmacother Source Type: research

Assessment of practices for suspended oral drugs by tablet crushing in pediatric units.
Abstract The aim of this study was to assess the impact of suspended drug by tablet crushing in our pediatric hospital in term of targeted dose and to identify parameters involved in the potential variability. Four usually crushed pediatric drug substances were selected: amiodarone, warfarin, hydrocortisone and captopril. Each tablet was crushed in a bag using a crusher device. Once crushed, a pre-determined volume of water was added using oral syringes before taking the necessary volume to obtain the targeted drug amount. For each drug, operators among pharmacy technicians and nurses investigated 2 targeted doses...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2020 Category: Drugs & Pharmacology Authors: Nguyen D, Secretan PH, Auvity S, Vidal F, Postaire M, Cisternino S, Schlatter J Tags: Eur J Pharm Biopharm Source Type: research

Evaluation of the clinical outcome of captopril use for hypertensive urgency in Khartoum State's emergency centres
Publication date: Available online 19 November 2020Source: African Journal of Emergency MedicineAuthor(s): Amgad H.H. Obied, Aimun A.E. Ahmed (Source: African Journal of Emergency Medicine)
Source: African Journal of Emergency Medicine - November 21, 2020 Category: Emergency Medicine Source Type: research

Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats.
CONCLUSION: The ZY and metformin combined treatment showed a clear therapeutic effect on kidney damage in DN. This study provides a potential mechanism for the treatment of diabetic nephropathy with ZY combined with metformin. PMID: 33191822 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Nerolidol improves cardiac function in spontaneously hypertensive rats by inhibiting Cardiac Inflammation and remodelling associated TLR4/ NF- κB signalling cascade.
In this study, the potential of nerolidol to ameliorate hypertension induced cardiac injuries and the underlying mechanism of action was explored by using in vitro and in vivo models. The in vitro analysis was performed on AngII challenged H9c2 cells and their ability to overcome cardiac inflammation and cardiac remodelling effects was determined by evaluating TLR4/NF-κB signalling cascade using Western blot analysis and immunofluorescence. The results were further ascertained using in vivo experiments. Eighteen week old male rats were randomly allocated into different groups i.e. Wistar Kyoto (WKY) rats, hypertensiv...
Source: Food and Chemical Toxicology - November 16, 2020 Category: Food Science Authors: Lin YM, Badrealam KF, Kuo WW, Lai PF, Shao-Tsu Chen W, Hsuan Day C, Ho TJ, Viswanadha VP, Shibu MA, Huang CY Tags: Food Chem Toxicol Source Type: research

Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect
Publication date: Available online 13 November 2020Source: Neuroscience LettersAuthor(s): Ahmet Sevki Taskiran, Onur Avci (Source: Neuroscience Letters)
Source: Neuroscience Letters - November 15, 2020 Category: Neuroscience Source Type: research

DRESS syndrome following furosemide administration: An unusual association.
CONCLUSION: We add to the literature another case of furosemide-induced DRESS with the particularity of cross reactivity with bumetanide. PMID: 33203615 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 14, 2020 Category: Urology & Nephrology Authors: Ben Fadhel N, Ben Romdhane H, Chaabane A, Belhadj Ali H, Boughattas NA, Aouam K, Ben Fredj N Tags: Nephrol Ther Source Type: research

Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor- β1, and oxidative stress.
Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-β1, and oxidative stress. Clin Exp Pharmacol Physiol. 2020 Nov 13;: Authors: Bunbupha S, Apaijit K, Potue P, Maneesai P, Pakdeechote P Abstract The protective effect of hesperidin on vascular and renal alterations and possible underlying mechanisms involved in Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats were investigated in this study. Male Sprague-Dawley rats were administered L-NAME (40 mg/kg/day), L-NAME p...
Source: Clinical and Experimental Pharmacology and Physiology - November 13, 2020 Category: Drugs & Pharmacology Authors: Bunbupha S, Apaijit K, Potue P, Maneesai P, Pakdeechote P Tags: Clin Exp Pharmacol Physiol Source Type: research

Interference with the renin-angiotensin system reduces the palatability of 0.3  M NaCl in sodium-deplete rats.
Interference with the renin-angiotensin system reduces the palatability of 0.3 M NaCl in sodium-deplete rats. Appetite. 2020 Nov 10;158:105037 Authors: Zenatti AA, Pereira ED, Possari J, Andrade CAF, Menani JV, De Luca LA Abstract The renin-angiotensin system (RAS) controls hypertonic NaCl intake driven by sodium appetite. Here we investigated whether the antagonism of RAS interferes with hedonic and aversive orofacial motor responses, or palatability, to intraoral infusion of 0.3 M NaCl (hNaCl). Adult rats were depleted of sodium by combined sc injection of furosemide and 24 h removal ...
Source: Appetite - November 10, 2020 Category: Nutrition Authors: Zenatti AA, Pereira ED, Possari J, Andrade CAF, Menani JV, De Luca LA Tags: Appetite Source Type: research

Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter.
This study may be helpful in revealing the complex molecular mechanisms underlying PM-induced lung toxicity and provide some new therapeutic targets for PM-related pulmonary diseases. PMID: 33150508 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - November 5, 2020 Category: Environmental Health Authors: Zhu M, Wang J, Chen C, Song Y, Pan J Tags: Environ Sci Pollut Res Int Source Type: research

Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis- γ-pyrone polypropionates attenuate angiotensin-converting enzyme.
Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-γ-pyrone polypropionates attenuate angiotensin-converting enzyme. Nat Prod Res. 2020 Nov 02;:1-12 Authors: Chakraborty K, Francis P Abstract Angiotensin I-converting enzyme (ACE) catalyses the biosynthesis of angiotensin II, a potent blood vessel constrictor, from angiotensin I, and ACE inhibitors were recognised as medications for hypertension. Undescribed bis-γ-pyrone polypropionate compounds, callypyrones A and B were purified from the organic extract of Callyspongiidae sponge species Callyspongia...
Source: Natural Product Research - November 2, 2020 Category: Biochemistry Authors: Chakraborty K, Francis P Tags: Nat Prod Res Source Type: research

Construction of thiol-capped ultrasmall Au-Bi bimetallic nanoparticles for X-ray CT imaging and enhanced antitumor therapy efficiency.
Abstract Thiol capped gold nanoparticles with small size, high dispersity, and broad light absorption covering ultraviolet (UV) to near infrared (NIR) region have been developed for catalysis, fluorescence imaging and photodynamic therapy (PDT). The constitution of the metal core in such nanoparticles can strongly influence the luminescence, catalysis, and stability properties. However, to date, a corresponding investigation of the influence of the metallic core on the generation of reaction oxygen species (ROS) and its therapeutic efficiency towards tumor cells remains to be lacking. Herein, we fabricated bimetal...
Source: Biomaterials - October 13, 2020 Category: Materials Science Authors: He F, Ji H, Feng L, Wang Z, Sun Q, Zhong C, Yang D, Gai S, Yang P, Lin J Tags: Biomaterials Source Type: research

Metabolites of the ellagitannin, geraniin inhibit human ACE; in  vitro and in silico evidence.
Metabolites of the ellagitannin, geraniin inhibit human ACE; in vitro and in silico evidence. Int J Food Sci Nutr. 2020 Oct 09;:1-8 Authors: Looi D, Goh BH, Khan SU, Ahemad N, Palanisamy UD Abstract Hypertension is defined as the persistence of elevated blood pressure in the circulation system. The renin-angiotensin-aldosterone system is a major modulator of blood pressure. Among the risk factors of cardiovascular disease, hypertension is the most preventable and treatable, with drugs such as ACE inhibitors. Many ACE inhibitors are known to have undesirable side effects and hence, natural alternat...
Source: International Journal of Food Sciences and Nutrition - October 10, 2020 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

Removal of captopril pharmaceutical from synthetic pharmaceutical-industry wastewaters: Use of activated carbon derived from Butia catarinensis
Publication date: December 2020Source: Journal of Environmental Chemical Engineering, Volume 8, Issue 6Author(s): Mariene R. Cunha, Eder C. Lima, Diana R. Lima, Raphaelle S. da Silva, Pascal S. Thue, Moaaz K. Seliem, Farooq Sher, Glaydson S. dos Reis, Sylvia H. Larsson (Source: Journal of Environmental Chemical Engineering)
Source: Journal of Environmental Chemical Engineering - October 7, 2020 Category: Chemistry Source Type: research

Effect of Aqueous Extract of Adansonia digitata Stem Bark on the Development of Hypertension in L-NAME-Induced Hypertensive Rat Model.
Authors: Ntchapda F, Bonabe C, Atsamo AD, Kemeta Azambou DR, Bekono Fouda Y, Imar Djibrine S, Seke Etet PF, Théophile D Abstract Background: Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods: The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynam...
Source: Evidence-based Complementary and Alternative Medicine - October 7, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Syzygium gratum Extract Alleviates Vascular Alterations in Hypertensive Rats.
Abstract Background and Objectives: Syzygium gratum (SG) is a local vegetable and widely consumed in Thailand. Previously, a strong antioxidative effect of SG extract has been reported. The effects of SG extract on hypertension have remained unknown. The effect of SG aqueous extract on blood pressure and vascular changes were examined in L-NAME-induced hypertensive rats (LHR), and its potential active constituents were also explored. Materials and Methods: Male Sprague Dawley rats were allocated to control, L-NAME (40 mg/kg/day), L-NAME + SG (100, 300, 500 mg/kg/day), or captopril (5 mg/kg/day) groups. The compone...
Source: Medicina (Kaunas) - September 29, 2020 Category: Universities & Medical Training Authors: Pakdeechote P, Meephat S, Sakonsinsiri C, Phetcharaburanin J, Bunbupha S, Maneesai P Tags: Medicina (Kaunas) Source Type: research

N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice.
Abstract Silicosis is a major public health concern with various contributing factors. The renin-angiotensin system (RAS)is a critical regulator in the pathogenesis of this disease. We focused on two key RAS enzymes, angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2), to elucidate the activation of the ACE-angiotensin II (Ang II)-angiotensin II receptor 1 (AT1) axis and the inhibition of the ACE2-angiotensin-(1-7) [Ang-(1-7)]-Mas receptor axis in C57BL/6mice following SiO2 treatment. Silica exposure caused nodule formation, pulmonary interstitial fibrosis, epithelial-mesenchymal transit...
Source: Toxicology and Applied Pharmacology - September 28, 2020 Category: Toxicology Authors: Li S, Li Y, Zhang Y, Li S, Zhang M, Jin F, Wei Z, Yang Y, Gao X, Mao N, Ge X, Xu H, Yang F Tags: Toxicol Appl Pharmacol Source Type: research

Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin-induced Diabetes Mellitus.
CONCLUSIONS: Captopril showed a promising protective effect against DM vascular complications, at least via nitric oxide modulating effect, antioxidant effect and anti-inflammatory activity that appeared in biochemical and histopathological findings, lipid profile, renal function and architecture improvements. Combining gliclazide with captopril gives an additive effect through enhanced glycemic control and increased anti-oxidant and anti-inflammatory properties above captopril alone. PMID: 32955003 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 23, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Blockade of Bradykinin Receptors or Angiotensin II Type 2 Receptor Prevents Paclitaxel ‐Associated Acute Pain Syndrome in Mice
ConclusionOur results demonstrated the involvement of bradykinin receptors B1 and B2 as well as AT2R in the induction of P ‐APS in mice and suggest the use of AT2R antagonists as a potential therapy for the prevention of P‐APS in humans. (Source: European Journal of Pain)
Source: European Journal of Pain - September 22, 2020 Category: Anesthesiology Authors: Graziele C. Zanata, Larissa G. Pinto, Nicole R. da Silva, Alexandre H.P. Lopes, Francisco F.B. de Oliveira, Ieda R.S. Schivo, Fernando Q. Cunha, Peter McNaughton, Thiago M. Cunha, Rangel L. Silva Tags: ORIGINAL ARTICLE Source Type: research

Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice
In this report, we used the MRL/lpr lupus-prone mouse model, an established model to study NPSLE, to determine the in vivo effects of captopril on Type I IFN and associated immune responses in the periphery and brain and effects on behavior. Administering captopril to MRL/lpr mice decreased expression of IRGs in brain, spleen and kidney, decreased circulating and tissue IFNα levels, decreased microglial activation (IBA-1 expression) and reduced depressive-like behavior. Serotonin levels that are decreased in depression were increased by captopril treatment. Captopril also reduced autoantibody levels in plasma and imm...
Source: Frontiers in Immunology - September 14, 2020 Category: Allergy & Immunology Source Type: research

[Ruptura septal de localizaci ón atípica posterior a infarto del miocardio. Caso clínico].
[Ruptura septal de localización atípica posterior a infarto del miocardio. Caso clínico]. Arch Cardiol Mex. 2020 Sep 13;90(4): Authors: Incontri-Abraham D, Juárez-Vignon-Whaley JJ, González-Velásquez PJ, Flores-García AN, Espinola-Zavaleta N Abstract Paciente masculino de 46 años de edad con antecedentes personales de hipertensión arterial sistémica, tabaquismo y etilismo y heredofamiliares de hipertensión arterial sistémica. El padecimiento inició con cuadro de astenia, adinamia, disnea progresiva, edema de mie...
Source: Archivos de Cardiologia de Mexico - September 12, 2020 Category: Cardiology Authors: Incontri-Abraham D, Juárez-Vignon-Whaley JJ, González-Velásquez PJ, Flores-García AN, Espinola-Zavaleta N Tags: Arch Cardiol Mex Source Type: research

Interleukin-1 β in hypothalamic paraventricular nucleus mediates excitatory renal reflex.
Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. Pflugers Arch. 2020 Sep 11;: Authors: Zheng F, Ye C, Wan GW, Zhou B, Tong Y, Lei JZ, Chen Q, Li YH, Kang YM, Zhu GQ Abstract Chemical stimulation of kidney causes sympathetic activation and pressor responses in rats. The excitatory renal reflex (ERR) is mediated by angiotensin type 1 receptor (AT1R) and superoxide anions in hypothalamic paraventricular nucleus (PVN). The aim of this study is to determine whether interleukin-1β (IL-1β) in the PVN mediates the ERR, and whether the IL-1β productio...
Source: Pflugers Archiv : European Journal of Physiology - September 10, 2020 Category: Physiology Authors: Zheng F, Ye C, Wan GW, Zhou B, Tong Y, Lei JZ, Chen Q, Li YH, Kang YM, Zhu GQ Tags: Pflugers Arch Source Type: research

Prediction of unilateral hyperaldosteronism on adrenal vein sampling using captopril challenge test in patients with primary aldosteronism.
Authors: Wada N, Miyoshi A, Usubuchi H, Terae S, Shibayama Y, Takahashi B, Baba S, Sugawara H, Obara S Abstract Captopril challenge test (CCT) is a simple and safe confirmatory test for primary aldosteronism (PA). We investigated the effectiveness of the indices after captopril administration for prediction of unilateral hyperaldosteronism (UHA) on adrenal vein sampling (AVS). We studied 238 patients with PA who had CCT and successful AVS between July 2007 and December 2019 in Sapporo City General Hospital. Receiver operating characteristic (ROC) curve analysis showed that the diagnostic performance for prediction ...
Source: Endocrine Journal - August 29, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Molecules, Vol. 25, Pages 3875: Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways
lia González-Martínez Eduardo Campos-Góngora Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, ...
Source: Molecules - August 25, 2020 Category: Chemistry Authors: Gerardo I. Arredondo-Mendoza Zacar ías Jiménez-Salas Francisco Javier Guzm án-de la Garza Elizabeth Sol ís-Pérez Manuel L ópez-Cabanillas-Lomelí Blanca Edelia Gonz ález-Martínez Eduardo Campos-G óngora Tags: Article Source Type: research