Variation in Price of Cardiovascular and Diabetes Medicine in Indonesia, and Relationship with Quality: A Mixed Methods Study in East Java
Am J Trop Med Hyg. 2023 May 9:tpmd220692. doi: 10.4269/ajtmh.22-0692. Online ahead of print.ABSTRACTLower-middle income Indonesia, the world's fourth most populous country, has struggled to contain costs in its mandatory, single-payer public health insurance system since the system's inception in 2014. Public procurement policies radically reduced prices of most medicines in public facilities and the wider market. However, professional associations and the press have questioned the quality of these low-cost, unbranded generic medicines. We collected 204 samples of four cardiovascular and one antidiabetic medicines from hea...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Elizabeth Pisani Aksari Dewi Anna Palagyi Devarsetty Praveen Bachtiar Rifai Pratita Ihsan Ayuk Lawuningtyas Hariadini Diana Lyrawati None Sujarwoto Asri Maharani Gindo Tampubolon Anushka Patel Source Type: research
Variation in Price of Cardiovascular and Diabetes Medicine in Indonesia, and Relationship with Quality: A Mixed Methods Study in East Java
Am J Trop Med Hyg. 2023 May 9:tpmd220692. doi: 10.4269/ajtmh.22-0692. Online ahead of print.ABSTRACTLower-middle income Indonesia, the world's fourth most populous country, has struggled to contain costs in its mandatory, single-payer public health insurance system since the system's inception in 2014. Public procurement policies radically reduced prices of most medicines in public facilities and the wider market. However, professional associations and the press have questioned the quality of these low-cost, unbranded generic medicines. We collected 204 samples of four cardiovascular and one antidiabetic medicines from hea...
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Elizabeth Pisani Aksari Dewi Anna Palagyi Devarsetty Praveen Bachtiar Rifai Pratita Ihsan Ayuk Lawuningtyas Hariadini Diana Lyrawati None Sujarwoto Asri Maharani Gindo Tampubolon Anushka Patel Source Type: research
Variation in Price of Cardiovascular and Diabetes Medicine in Indonesia, and Relationship with Quality: A Mixed Methods Study in East Java
Am J Trop Med Hyg. 2023 May 9:tpmd220692. doi: 10.4269/ajtmh.22-0692. Online ahead of print.ABSTRACTLower-middle income Indonesia, the world's fourth most populous country, has struggled to contain costs in its mandatory, single-payer public health insurance system since the system's inception in 2014. Public procurement policies radically reduced prices of most medicines in public facilities and the wider market. However, professional associations and the press have questioned the quality of these low-cost, unbranded generic medicines. We collected 204 samples of four cardiovascular and one antidiabetic medicines from hea...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Elizabeth Pisani Aksari Dewi Anna Palagyi Devarsetty Praveen Bachtiar Rifai Pratita Ihsan Ayuk Lawuningtyas Hariadini Diana Lyrawati None Sujarwoto Asri Maharani Gindo Tampubolon Anushka Patel Source Type: research
Variation in Price of Cardiovascular and Diabetes Medicine in Indonesia, and Relationship with Quality: A Mixed Methods Study in East Java
Am J Trop Med Hyg. 2023 May 9:tpmd220692. doi: 10.4269/ajtmh.22-0692. Online ahead of print.ABSTRACTLower-middle income Indonesia, the world's fourth most populous country, has struggled to contain costs in its mandatory, single-payer public health insurance system since the system's inception in 2014. Public procurement policies radically reduced prices of most medicines in public facilities and the wider market. However, professional associations and the press have questioned the quality of these low-cost, unbranded generic medicines. We collected 204 samples of four cardiovascular and one antidiabetic medicines from hea...
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Elizabeth Pisani Aksari Dewi Anna Palagyi Devarsetty Praveen Bachtiar Rifai Pratita Ihsan Ayuk Lawuningtyas Hariadini Diana Lyrawati None Sujarwoto Asri Maharani Gindo Tampubolon Anushka Patel Source Type: research
Variation in Price of Cardiovascular and Diabetes Medicine in Indonesia, and Relationship with Quality: A Mixed Methods Study in East Java
Am J Trop Med Hyg. 2023 May 9:tpmd220692. doi: 10.4269/ajtmh.22-0692. Online ahead of print.ABSTRACTLower-middle income Indonesia, the world's fourth most populous country, has struggled to contain costs in its mandatory, single-payer public health insurance system since the system's inception in 2014. Public procurement policies radically reduced prices of most medicines in public facilities and the wider market. However, professional associations and the press have questioned the quality of these low-cost, unbranded generic medicines. We collected 204 samples of four cardiovascular and one antidiabetic medicines from hea...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Elizabeth Pisani Aksari Dewi Anna Palagyi Devarsetty Praveen Bachtiar Rifai Pratita Ihsan Ayuk Lawuningtyas Hariadini Diana Lyrawati None Sujarwoto Asri Maharani Gindo Tampubolon Anushka Patel Source Type: research
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway
Biochem Pharmacol. 2023 May 1:115578. doi: 10.1016/j.bcp.2023.115578. Online ahead of print.ABSTRACTThe brain renin-angiotensin system (RAS) has recently been implicated in the development of substance abuse and addiction. However, the integrative roles of the two counter-regulating RAS arms, including the ACE1/Ang II/AT1R axis and the ACE2/Ang(1-7)/MasR axis, in alcohol addiction remain unclear. Using the 20% ethanol intermittent-access two-bottle-choice (IA2BC) paradigm, we observed significant alcohol preference and addictive behaviors in rats. Additionally, we observed significant disruption in the RAS and redox homeos...
Source: Biochemical Pharmacology - May 3, 2023 Category: Drugs & Pharmacology Authors: Ming Sun Chao Wu Lixin Liu Liang Gu Zihao Wang Feng Xu Donglin Zhu Source Type: research
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway
Biochem Pharmacol. 2023 May 1:115578. doi: 10.1016/j.bcp.2023.115578. Online ahead of print.ABSTRACTThe brain renin-angiotensin system (RAS) has recently been implicated in the development of substance abuse and addiction. However, the integrative roles of the two counter-regulating RAS arms, including the ACE1/Ang II/AT1R axis and the ACE2/Ang(1-7)/MasR axis, in alcohol addiction remain unclear. Using the 20% ethanol intermittent-access two-bottle-choice (IA2BC) paradigm, we observed significant alcohol preference and addictive behaviors in rats. Additionally, we observed significant disruption in the RAS and redox homeos...
Source: Biochemical Pharmacology - May 3, 2023 Category: Drugs & Pharmacology Authors: Ming Sun Chao Wu Lixin Liu Liang Gu Zihao Wang Feng Xu Donglin Zhu Source Type: research
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway
Biochem Pharmacol. 2023 May 1:115578. doi: 10.1016/j.bcp.2023.115578. Online ahead of print.ABSTRACTThe brain renin-angiotensin system (RAS) has recently been implicated in the development of substance abuse and addiction. However, the integrative roles of the two counter-regulating RAS arms, including the ACE1/Ang II/AT1R axis and the ACE2/Ang(1-7)/MasR axis, in alcohol addiction remain unclear. Using the 20% ethanol intermittent-access two-bottle-choice (IA2BC) paradigm, we observed significant alcohol preference and addictive behaviors in rats. Additionally, we observed significant disruption in the RAS and redox homeos...
Source: Biochemical Pharmacology - May 3, 2023 Category: Drugs & Pharmacology Authors: Ming Sun Chao Wu Lixin Liu Liang Gu Zihao Wang Feng Xu Donglin Zhu Source Type: research
GSE230077 Lupus autoantibodies initiate a maladaptive homeostasis sustained by HMGB1:RAGE signaling and reversed by LAIR-1:C1q signaling
Contributors : Kaitlin Carroll ; Mark Mizrachi ; Sean Simmons ; Jeffrey Wingard ; Bahtiyar Toz ; Nazila Tehrani ; Aida Zarfeshani ; Nina Kello ; Czeslawa Kowal ; Joshua Levin ; Bruce Volpe ; Betty DiamondSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), present in up to 80% of patients and leading to a diminished quality of life. We have developed a model of lupus-like cognitive impairment which is initiated when anti-DNA, anti-N-methyl D-aspartate receptor (NMDAR) cro...
Source: GEO: Gene Expression Omnibus - May 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Captopril
(Source: Reactions Weekly)
Source: Reactions Weekly - May 1, 2023 Category: Drugs & Pharmacology Source Type: research
All-trans retinoic acid inhibits oxidative stress via ACE2/Ang (1-7)/MasR pathway in renal tubular epithelial cells stimulated with high glucose
Drug Dev Res. 2023 Apr 28. doi: 10.1002/ddr.22070. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effects of all-trans retinoic acid (atRA) on oxidative stress in renal tubular epithelial cells induced by high glucose (HG) and its potential mechanism. We investigated the effects of atRA in HG-induced renal epithelial cell line HK-2. Seven groups were designed for this experiment: negative control, mannitol, high-glucose (HG), HG combined with a low concentration of atRA, HG combined with a middle concentration of atRA, HG combined with a high concentration of atRA, and HG combined with captopril...
Source: Cell Research - April 28, 2023 Category: Cytology Authors: Xiaojuan Zhu Zhixiang Mou Wei Han Lan Chen Source Type: research
LC-MS/MS Bioanalytical Method for the Quantitative Analysis of Nifedipine, Bisoprolol, and Captopril in Human Plasma: Application to Pharmacokinetic Studies
In this study, the development and validation of an accurate and highly sensitive LC-MS/MS method were performed for the estimation of nifedipine, bisoprolol, and captopril in real human plasma. Liquid-liquid extraction using tert-butyl methyl ether was efficiently applied for extraction of the analytes from plasma samples. The chromatographic separation was carried out using an isocratic elution mode on the X-terra MS C18 column (4.6 × 50 mm, 3.5 μm). The mobile phase consisted of methanol: 0.1 % formic acid (95:5, v/v) for determination of nifedipine and bisoprolol and acetonitrile: 0.1 % formic acid (70:30, v/v) for d...
Source: Biomedical Chromatography : BMC - April 28, 2023 Category: Biomedical Science Authors: Ahmed M Abdel-Megied Sergiy Kovalenko Fawzy A Elbarbry Marjan Piponski Oleksandra Oleshchuk Sami El Deeb Galal Magdy Fathalla Belal Taras Grochovuy Liliya Logoyda Source Type: research
Molecules, Vol. 28, Pages 3650: Synergism of Photo-Induced Electron Transfer and Aggregation-Induced Quenching Mechanisms for Highly Sensitive Detection of Silver Ion and Captopril
Zhongxia Wang
Carbon-based nanoprobes, with excellent physicochemical performance and biocompatibility, are a kind of ideal nanomaterial for biosensing. Herein, we designed and prepared novel oxygen-doped nitrogen-enrichment carbon nanoribbons (ONCNs) with an excellent optical performance and uniform morphology, which could be used as a dual-mode fluorescence probe for the detection of Ag+ ion and captopril (Ctl) based on the synergism of photo-induced electron transfer and aggregation-induced quenching mechanisms. By recording the changes in fluorescent intensities of ONCNs, the Ag+ ion and Ctl concentrations can be e...
Source: Molecules - April 22, 2023 Category: Chemistry Authors: Jing Zhu Lei Hu Xiangying Meng Feng Li Wenjuan Wang Guiyang Shi Zhongxia Wang Tags: Article Source Type: research
Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1 α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction
Conclusion: Linggui Zhugan Decoction can improve the cardiac function of heart failure rats by enhancing myocardial antioxidant capacity and protecting the mitochondrial function, the mechanism is related to activating SIRT1/AMPK/PGC-1α signaling pathway. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 5, 2023 Category: Drugs & Pharmacology Source Type: research
Exploration and characterization of a novel cocrystal hydrate consisting of captopril, an amino acid-derived drug
CrystEngComm, 2023, Advance Article DOI: 10.1039/D3CE00181D, PaperRyotaro Haku, Kazuhiko Takatori, Naoto Suzuki, Makoto Ono, Varin Titapiwatanakun, Toshiro Fukami We found a novel cocrystal consisting of captopril, which is an amino acid-derived drug having a thiol group, andL-proline by using nano-spot-screening with LF-Raman. This cocrystal hydrate showed high hygroscopicity resulted from changes in intermolecular interactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - March 31, 2023 Category: Chemistry Authors: Ryotaro Haku Source Type: research
