A new machine learning-based prediction model for subtype diagnosis in primary aldosteronism
DiscussionWe developed a machine learning-based predictive model for PA subtype diagnosis based on ten clinical parameters without CT imaging. In the future, artificial intelligence-based prediction models might become a robust prediction tool for PA subtype diagnosis, thereby, might reducing at least some of the requests for CT or AVS and assisting clinical decision-making. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 23, 2022 Category: Endocrinology Source Type: research
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor
This study investigates the role of RAS on the overproduction of corticosterone in diabetic mice. Diabetes was induced by intravenous injection of alloxan into fasted Swiss-webster mice. Captopril (angiotensin-converting enzyme inhibitor), Olmesartan (AT1 receptor antagonist), CGP42112A (AT2 receptor agonist) or PD123319 (AT2 receptor antagonist) were administered daily for 14 consecutive days, starting 7 days post-alloxan. Plasma corticosterone was evaluated by ELISA, while adrenal gland expressions of AT1 receptor, AT2 receptor, adrenocorticotropic hormone receptor MC2R, pro-steroidogenic enzymes steroidogenic acute regu...
Source: Frontiers in Endocrinology - November 17, 2022 Category: Endocrinology Source Type: research
Prevention of radiation-induced bladder injury: A murine study using captopril.
Pelvic radiotherapy (RT) can cause debilitating bladder toxicities but few clinical interventions exist to prevent injury or alleviate symptoms. From a large GWAS in prostate cancer patients it was previously reported that SNPs tagging AGT, part of the renin-angiotensin system (RAS), correlated with patient-reported late hematuria identifying a potential targetable pathway to prevent RT-induced bladder injury. To investigate this association, we performed a pre-clinical study to determine if RAS modulation protected the bladder against RT injury. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 15, 2022 Category: Radiology Authors: Angela M. Groves, Nicole Paris, Eric Hernady, Carl J. Johnston, Omar Aljitawi, Yi-Fen Lee, Sarah L. Kerns, Brian Marples Source Type: research
Prevention of Radiation-Induced Bladder Injury: A Murine Study Using Captopril
Pelvic radiation therapy (RT) can cause debilitating bladder toxicities but few clinical interventions exist to prevent injury or alleviate symptoms. From a large genome-wide association study in patients with prostate cancer it was previously reported that SNPs tagging AGT, part of the renin-angiotensin system (RAS), correlated with patient-reported late hematuria, identifying a potential targetable pathway to prevent RT-induced bladder injury. To investigate this association, we performed a preclinical study to determine whether RAS modulation protected the bladder against RT injury. (Source: International Journal of Rad...
Source: International Journal of Radiation Oncology * Biology * Physics - November 15, 2022 Category: Radiology Authors: Angela M. Groves, Nicole Paris, Eric Hernady, Carl J. Johnston, Omar Aljitawi, Yi-Fen Lee, Sarah L. Kerns, Brian Marples Tags: BIOLOGY CONTRIBUTION Source Type: research
Exclusion tests in Unilateral Primary Aldosteronism (ExcluPA) Study
CONCLUSIONS AND RELEVANCE: The apparently high diagnostic accuracy of the CCT and the SIT was due to the selection of patients with an elevated ARR and thus a high pre-test probability of unilateral PA; however, neither test furnished a diagnostic gain over the ARR. Therefore, the systematic use of these exclusion tests in clinical practice is not justified by available evidence.PMID:36373399 | DOI:10.1210/clinem/dgac654 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 14, 2022 Category: Endocrinology Authors: Rui Zhu Tungalagtamir Shagjaa Giacomo Rossitto Brasilina Caroccia Teresa Maria Seccia Dario Gregori Gian Paolo Rossi Source Type: research
Exclusion tests in Unilateral Primary Aldosteronism (ExcluPA) Study
CONCLUSIONS AND RELEVANCE: The apparently high diagnostic accuracy of the CCT and the SIT was due to the selection of patients with an elevated ARR and thus a high pre-test probability of unilateral PA; however, neither test furnished a diagnostic gain over the ARR. Therefore, the systematic use of these exclusion tests in clinical practice is not justified by available evidence.PMID:36373399 | DOI:10.1210/clinem/dgac654 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 14, 2022 Category: Endocrinology Authors: Rui Zhu Tungalagtamir Shagjaa Giacomo Rossitto Brasilina Caroccia Teresa Maria Seccia Dario Gregori Gian Paolo Rossi Source Type: research
Cardiovascular Effects of < em > Cydonia oblonga < /em > Miller (Quince)
This study paves the way for further studies on the cardiovascular effect of quince consumption as a beneficial nutraceutical in humans.PMID:36262168 | PMC:PMC9576383 | DOI:10.1155/2022/3185442 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 20, 2022 Category: Complementary Medicine Authors: Atefeh Amerizadeh Golnaz Vaseghi Nazgol Esmaeilian Sedigheh Asgary Source Type: research
Antihypertensive potential of Brassica rapa leaves: An in vitro and in silico approach
Conclusion: We conclude that leaves of Brassica rapa can successfully lower hypertension by inhibiting ACE, however; in vivo investigations are required to confirm this antihypertensive activity. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Source Type: research
Control of aging by the renin –angiotensin system: a review of C. elegans, Drosophila, and mammals
The free-living, non-parasitic nematode Caenorhabditis elegans is a premier model organism for the study of aging and longevity due to its short lifespan, powerful genetic tools, and conservation of fundamental mechanisms with mammals. Approximately 70 percent of human genes have homologs in C. elegans, including many that encode proteins in pathways that influence aging. Numerous genetic pathways have been identified in C. elegans that affect lifespan, including the dietary restriction pathway, the insulin/insulin-like growth factor (IGF) signaling pathway, and the disruption of components of the mitochondrial electron tr...
Source: Frontiers in Pharmacology - September 14, 2022 Category: Drugs & Pharmacology Source Type: research
Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis
Evidence from experimental and clinical studies implicates immuno-inflammatory responses as playing an important role in epilepsy-induced brain injury. Captopril, an angiotensin-converting enzyme inhibitor (AC... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 14, 2022 Category: Neurology Authors: Xinyan Dong, Jianchen Fan, Donghui Lin, Xuehui Wang, Haoyu Kuang, Lifen Gong, Chen Chen, Jie Jiang, Ningxiao Xia, Dahong He, Weida Shen, Peifang Jiang, Rong Kuang, Linghui Zeng and Yicheng Xie Tags: Research Source Type: research
Molecules, Vol. 27, Pages 5930: Identification of a Potential Inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo- & beta;-Lactamase-1 (NDM-1) Using In Silico and In Vitro Approaches
Molecules, Vol. 27, Pages 5930: Identification of a Potential Inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) Using In Silico and In Vitro Approaches
Molecules doi: 10.3390/molecules27185930
Authors:
Ghazala Muteeb
Md Tabish Rehman
Mohamed F. AlAjmi
Mohammad Aatif
Mohd Farhan
Sheeba Shafi
New Delhi metallo-&beta;-lactamase-1 (NDM-1), expressed in different Gram-negative bacteria, is a versatile enzyme capable of hydrolyzing &beta;-lactam rings containing antibiotics such as penicillins, cephalosporins, and even carbapenems. Multidrug resistance in bact...
Source: Molecules - September 13, 2022 Category: Chemistry Authors: Ghazala Muteeb Md Tabish Rehman Mohamed F. AlAjmi Mohammad Aatif Mohd Farhan Sheeba Shafi Tags: Article Source Type: research
QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology
Conclusion: QSYQ ameliorated myocardial I/R injury via suppressing excessive autophagy and NLRP3 Inflammasome. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 9, 2022 Category: Drugs & Pharmacology Source Type: research
Tidal Volume–Dependent Activation of the Renin-Angiotensin System in Experimental Ventilator-Induced Lung Injury*
CONCLUSIONS:
VILI is accompanied by a strong activation of the RAS. Based on circulating Ang metabolite levels and tissue expression of RAS enzymes, classical ACE-dependent and alternative RAS cascades were activated in the HVT group, whereas classical RAS activation prevailed with VHVT ventilation. Ang 1–7 or captopril protected from VILI primarily by modifying the systemic RAS profile. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
