Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study
CONCLUSION: MMP2 inhibition by anthraquinones, notably Pulmatin, may be a useful therapeutic approach for cancer treatment.PMID:38123060 | DOI:10.1016/j.biosystems.2023.105103 (Source: Biosystems)
Source: Biosystems - December 20, 2023 Category: Biotechnology Authors: Shokoofeh Jamshidi Ali Rostami Setareh Shojaei Amir Taherkhani Heshmatollah Taherkhani Source Type: research
Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study
CONCLUSION: MMP2 inhibition by anthraquinones, notably Pulmatin, may be a useful therapeutic approach for cancer treatment.PMID:38123060 | DOI:10.1016/j.biosystems.2023.105103 (Source: Biosystems)
Source: Biosystems - December 20, 2023 Category: Biotechnology Authors: Shokoofeh Jamshidi Ali Rostami Setareh Shojaei Amir Taherkhani Heshmatollah Taherkhani Source Type: research
Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation
Conclusion: These findings show that small molecule FXIIa inhibitors, designed to target its active site, also inhibit the enzymatic activity of FXII zymogen. Combined inhibition of FXII zymogen and FXIIa may thereby suppress both the initiation and amplification of KKS activation that contribute to hereditary angioedema attacks and other FXII-mediated diseases. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Source Type: research
Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy
In this study, CTP-incorporated biomaterials for antihypertensive therapy were synthesized from chitosan, carboxymethyl cellulose, and plasticizers. The physicochemical properties of the prepared biomaterials were characterized using FE-SEM, FT-IR analysis, and physical properties. CTP release experiments were carried out in buffer solutions at various pH values and temperatures. Results indicated that above 99.0 % of CTP was released within 180 min. Optimization of the experimental conditions for CTP release was analyzed by using response surface methodology (RSM). Results of CTP release through artificial skin indicated ...
Source: International Journal of Biological Macromolecules - November 18, 2023 Category: Biochemistry Authors: Kyeong-Jung Kim Min-Jin Hwang Wang-Geun Shim Young-Nam Youn Soon-Do Yoon Source Type: research
Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Brain Research - November 11, 2023 Category: Neurology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research
Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Cell Research - November 11, 2023 Category: Cytology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research
Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells
Brain Res. 2023 Nov 9:148669. doi: 10.1016/j.brainres.2023.148669. Online ahead of print.ABSTRACTCerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the sequestration of infected red blood cells to the brain microvasculature. In disease, endothelial activation is followed by reduced monocyte rolling and increased adhesion. Nowadays, an important challenge is to identify potential pro-inflammatory stimuli that can modulate monocytes behavior. Our group have demonstrated that bradykinin (BK), a pro-inflammatory peptide invo...
Source: Brain Research - November 11, 2023 Category: Neurology Authors: Sarah A S Alves Douglas E Teixeira Diogo B Peruchetti Leandro S Silva Luiz Felipe P Brand ão Celso Caruso-Neves Ana Acacia S Pinheiro Source Type: research
Snake Venom Components as Therapeutic Drugs in Ischemic Heart Disease
Biomolecules. 2023 Oct 18;13(10):1539. doi: 10.3390/biom13101539.ABSTRACTIschemic heart disease (IHD), especially myocardial infarction (MI), is a leading cause of death worldwide. Although coronary reperfusion is the most straightforward treatment for limiting the MI size, it has nevertheless been shown to exacerbate ischemic myocardial injury. Therefore, identifying and developing therapeutic strategies to treat IHD is a major medical challenge. Snake venoms contain biologically active proteins and peptides that are of major interest for pharmacological applications in the cardiovascular system (CVS). This has led to the...
Source: Atherosclerosis - October 28, 2023 Category: Cardiology Authors: Erij Messadi Source Type: research
Snake Venom Components as Therapeutic Drugs in Ischemic Heart Disease
Biomolecules. 2023 Oct 18;13(10):1539. doi: 10.3390/biom13101539.ABSTRACTIschemic heart disease (IHD), especially myocardial infarction (MI), is a leading cause of death worldwide. Although coronary reperfusion is the most straightforward treatment for limiting the MI size, it has nevertheless been shown to exacerbate ischemic myocardial injury. Therefore, identifying and developing therapeutic strategies to treat IHD is a major medical challenge. Snake venoms contain biologically active proteins and peptides that are of major interest for pharmacological applications in the cardiovascular system (CVS). This has led to the...
Source: Atherosclerosis - October 28, 2023 Category: Cardiology Authors: Erij Messadi Source Type: research
Clinical Value of the Combination Detection of Captopril Renal Scintigraphy and Plasma Renin Activity in the Diagnosis of Renal Hypertension
CONCLUSION: The combined detection of PRA and CRS can provide considerable evidence for the early diagnosis and treatment of RHR, which has a certain clinical value.PMID:37867339 | DOI:10.56434/j.arch.esp.urol.20237607.66 (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - October 23, 2023 Category: Urology & Nephrology Authors: Qiannan Zhao Jianfeng Shi Yujuan Wu Min Zhang Shuyun Zheng Xiaohua Wang Source Type: research
