Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol
Hypotension that is resistant to phenylephrine is a complication that occurs in anesthetized patients treated with angiotensin converting enzyme (ACE) inhibitors. We tested the hypothesis that Ang 1 –7 and the ... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 29, 2022 Category: Anesthesiology Authors: Mary E. Schulz, Joseph C. Hockenberry, Boran Katunaric, Paul S. Pagel and Julie K. Freed Tags: Research Source Type: research
Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study
Several cytokines and growth factors start and progress the destruction process of joint hyaline cartilage and fibrosis formation. Captopril is classified as an Angiotensin-converting enzyme inhibitor in which... (Source: Journal of Experimental Orthopaedics)
Source: Journal of Experimental Orthopaedics - July 28, 2022 Category: Orthopaedics Authors: Seyed Ali Hashemi, Ali Azad, Amirhossein Erfani, Reza Shahriarirad and Negar Azarpira Tags: Original Paper Source Type: research
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF- β1/Smad3 signalling pathway
This study aims to determine the effect and mechanism of Pirfenidone (PFD), an anti-lung fibrosis medicine, in the treatment of cardiac fibrosis and heart failure induced by pressure overload. Male C57BL/6 mice were subjected to thoracic aorta constriction (TAC) or sham surgery with the vehicle, PFD (300 mg/kg/day) or Captopril (CAP, 20 mg/kg/day). After 8 weeks of surgery, mice were tested by echocardiography, and then sacrificed followed by morphological and molecular biological analysis. Compared to the sham mice, TAC mice showed a remarkable cardiac hypertrophy, interstitial and perivascular fibrosis and resultant hear...
Source: J Cell Mol Med - July 21, 2022 Category: Molecular Biology Authors: Na Li Weijian Hang Hongyang Shu Ning Zhou Source Type: research
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF- β1/Smad3 signalling pathway
This study aims to determine the effect and mechanism of Pirfenidone (PFD), an anti-lung fibrosis medicine, in the treatment of cardiac fibrosis and heart failure induced by pressure overload. Male C57BL/6 mice were subjected to thoracic aorta constriction (TAC) or sham surgery with the vehicle, PFD (300 mg/kg/day) or Captopril (CAP, 20 mg/kg/day). After 8 weeks of surgery, mice were tested by echocardiography, and then sacrificed followed by morphological and molecular biological analysis. Compared to the sham mice, TAC mice showed a remarkable cardiac hypertrophy, interstitial and perivascular fibrosis and resultant hear...
Source: Molecular Medicine - July 21, 2022 Category: Molecular Biology Authors: Na Li Weijian Hang Hongyang Shu Ning Zhou Source Type: research
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF- β1/Smad3 signalling pathway
This study aims to determine the effect and mechanism of Pirfenidone (PFD), an anti-lung fibrosis medicine, in the treatment of cardiac fibrosis and heart failure induced by pressure overload. Male C57BL/6 mice were subjected to thoracic aorta constriction (TAC) or sham surgery with the vehicle, PFD (300 mg/kg/day) or Captopril (CAP, 20 mg/kg/day). After 8 weeks of surgery, mice were tested by echocardiography, and then sacrificed followed by morphological and molecular biological analysis. Compared to the sham mice, TAC mice showed a remarkable cardiac hypertrophy, interstitial and perivascular fibrosis and resultant hear...
Source: J Cell Mol Med - July 21, 2022 Category: Molecular Biology Authors: Na Li Weijian Hang Hongyang Shu Ning Zhou Source Type: research
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF- β1/Smad3 signalling pathway
This study aims to determine the effect and mechanism of Pirfenidone (PFD), an anti-lung fibrosis medicine, in the treatment of cardiac fibrosis and heart failure induced by pressure overload. Male C57BL/6 mice were subjected to thoracic aorta constriction (TAC) or sham surgery with the vehicle, PFD (300 mg/kg/day) or Captopril (CAP, 20 mg/kg/day). After 8 weeks of surgery, mice were tested by echocardiography, and then sacrificed followed by morphological and molecular biological analysis. Compared to the sham mice, TAC mice showed a remarkable cardiac hypertrophy, interstitial and perivascular fibrosis and resultant hear...
Source: Molecular Medicine - July 21, 2022 Category: Molecular Biology Authors: Na Li Weijian Hang Hongyang Shu Ning Zhou Source Type: research
Effects of captopril on glucose metabolism and autophagy in liver and muscle from mice with type 1 diabetes and diet-induced obesity
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 30:166477. doi: 10.1016/j.bbadis.2022.166477. Online ahead of print.ABSTRACTImpaired metabolic functions underlie the pathophysiology of diabetes and obesity. The renin-angiotensin system (RAS) is one pathway related to the pathophysiology of both diseases. RAS activation in metabolically active tissues exerts pro-inflammatory effects via angiotensin II (Ang II), linked to dysfunction in cellular processes such as autophagy, which is associated with obesity and diabetes. Here, we determined whether RAS is involved in metabolic dysregulations in a Type 1 Diabetes (T1D) mouse mode...
Source: Biochimica et Biophysica Acta - July 5, 2022 Category: Biochemistry Authors: Jo ão Pedro Tôrres Guimarães Kalhara R Menikdiwela Theresa Ramalho Luiz A D Queiroz Nishan S Kalupahana Sonia Jancar Latha Ramalingam Joilson O Martins Naima Moustaid-Moussa Source Type: research
Effects of captopril on glucose metabolism and autophagy in liver and muscle from mice with type 1 diabetes and diet-induced obesity
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 30:166477. doi: 10.1016/j.bbadis.2022.166477. Online ahead of print.ABSTRACTImpaired metabolic functions underlie the pathophysiology of diabetes and obesity. The renin-angiotensin system (RAS) is one pathway related to the pathophysiology of both diseases. RAS activation in metabolically active tissues exerts pro-inflammatory effects via angiotensin II (Ang II), linked to dysfunction in cellular processes such as autophagy, which is associated with obesity and diabetes. Here, we determined whether RAS is involved in metabolic dysregulations in a Type 1 Diabetes (T1D) mouse mode...
Source: Biochimica et Biophysica Acta - July 5, 2022 Category: Biochemistry Authors: Jo ão Pedro Tôrres Guimarães Kalhara R Menikdiwela Theresa Ramalho Luiz A D Queiroz Nishan S Kalupahana Sonia Jancar Latha Ramalingam Joilson O Martins Naima Moustaid-Moussa Source Type: research
Influence of Hypersensitive C-Reactive Protein on the Effect of Continuous Antihypertensive Pharmacological Therapy
Abstract:
Systemic chronic inflammation, represented by hypersensitive C-reactive protein (hsCRP), is an essential contributing factor to hypertension. However, the influence of hsCRP levels on the effect of antihypertensive pharmacological therapy remains unknown. We evaluated hsCRP levels in 3756 newly diagnosed, untreated hypertensive subjects. Participants were grouped by tertiles of hsCRP and were randomly treated with nitrendipine + captopril, nitrendipine + spironolactone hydrochlorothiazide + captopril, and hydrochlorothiazide + spironolactone. Blood pressure (BP) was recorded every 2 weeks. A multivariate mixe...
Source: Journal of Cardiovascular Pharmacology - July 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure
In conclusion, we found Glycyrrhiza promoted the metabolism of toxic components of Aconitum by up regulating the expression of CYP3A , and reduced the content of BNP, Ang II and ALD, improved the energy metabolism disorder of myocardium, alleviated the development of CHF. (Source: PLoS One)
Source: PLoS One - June 27, 2022 Category: Biomedical Science Authors: Lulu Ni Source Type: research
Liddle syndrome misdiagnosed as primary aldosteronism is caused by inaccurate aldosterone-rennin detection while a novel < em > SCNN1G < /em > mutation is discovered
CONCLUSION: inaccurate ARR detection might misdiagnose Liddle syndrome. A Gene test is an important method for the diagnosis of Liddle syndrome. A novel SCNN1G missense mutation, c.1729 C > T, is found in a Chinese family.PMID:35723567 | DOI:10.1080/08037051.2022.2088471 (Source: Blood Pressure)
Source: Blood Pressure - June 20, 2022 Category: Hematology Authors: Yaling Yang Chenwei Wu Duoduo Qu Xinyue Xu Lili Chen Quanya Sun Xiaolong Zhao Source Type: research
ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells
Reprod Biol. 2022 Jun 7;22(3):100666. doi: 10.1016/j.repbio.2022.100666. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells via receptor angiotensin-converting enzyme 2 (ACE2) and co-receptor transmembrane serine protease 2 (TMPRSS2). However, patients with SARS-CoV-2 infection receiving ACE1 inhibitors had higher ACE2 expression and were prone to poorer prognostic outcomes. Until now, information on the expression of ACE1, ACE2, and TMPRSS2 in human endometrial tissues, and the effects of ACE inhibitors on embryo implantation are limited. We found human endometria e...
Source: Reproductive Biology - June 10, 2022 Category: Reproduction Medicine Authors: Sudini R Fernando Xian Chen Kiu-Wai Cheng Benancy Pc Wong Shiwen Qi Luhan Jiang Suranga P Kodithuwakku Ernest Hy Ng William Sb Yeung Kai-Fai Lee Source Type: research
[ASAP] Hierarchical-Structured Pd Nanoclusters Catalysts < italic toggle="yes" > x < /italic > -PdNCs/CoAl(O)/rGO- < italic toggle="yes" > T < /italic > by the Captopril-Capped Pd Cluster Precursor Method for the Highly Efficient 4-Nitrophenol Reduction
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c01378 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - June 9, 2022 Category: Materials Science Authors: Qinglin Wang, Zhuojun Wei, Jin Li, Danyang Feng, An Feng, and Hui Zhang Source Type: research
