Immuno-Nanoparticles Developed Using Dexamethasone and Captopril Co-Loaded PLGA Improve Glomerulonephritis Through Modulating Macrophage Polarization
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - October 14, 2023 Category: Nanotechnology Authors: Zhang, Linping Zhu, Yanting Wang, Xiaoming Li, Zhenjiang Dong, Qianlan Tags: research-article Source Type: research
Molecules, Vol. 28, Pages 7086: In Vitro Permeability Study of Homotaurine Using a High-Performance Liquid Chromatography with Fluorescence Detection Pre-Column Derivatization Method
rkopoulou
Homotaurine (HOM) is considered a promising drug for the treatment of Alzheimer’s and other neurodegenerative diseases. In the present work, a new high-performance liquid chromatography with fluorescence detection (HPLC–FLD) (λex. = 340 nm and λem. = 455 nm) method was developed and validated for the study of substance permeability in the central nervous system (CNS). Analysis was performed on a RP-C18 column with a binary gradient elution system consisting of methanol–potassium phosphate buffer solution (pH = 7.0, 0.02 M) as mobile phase...
Source: Molecules - October 14, 2023 Category: Chemistry Authors: Marianna Ntorkou Eleni Tsanaktsidou Konstantina Chachlioutaki Dimitrios G. Fatouros Catherine K. Markopoulou Tags: Article Source Type: research
Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1
In conclusion, TGP has the potential to improve CHF and PARP-1 may be a potential target.PMID:37831380 | DOI:10.1007/s12265-023-10440-3 (Source: Cell Research)
Source: Cell Research - October 13, 2023 Category: Cytology Authors: Wenjuan Wei Caiyan Li Baoyong Zhang Deyun Huang Zheming Li Jiaer Gao Source Type: research
Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1
In conclusion, TGP has the potential to improve CHF and PARP-1 may be a potential target.PMID:37831380 | DOI:10.1007/s12265-023-10440-3 (Source: Cell Research)
Source: Cell Research - October 13, 2023 Category: Cytology Authors: Wenjuan Wei Caiyan Li Baoyong Zhang Deyun Huang Zheming Li Jiaer Gao Source Type: research
Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1
In conclusion, TGP has the potential to improve CHF and PARP-1 may be a potential target.Graphical Abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - October 13, 2023 Category: Cardiology Source Type: research
Angiotensin II-mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats
DISCUSSION: Hippocampal vascular dysfunction contributes to hypertension-induced memory decline through angiotensin II signaling, highlighting the therapeutic potential of HAs in protecting neurocognitive health later in life.HIGHLIGHTS: Vascular dysfunction in the hippocampus contributes to vascular cognitive impairment. Memory declines with age during chronic hypertension. Angiotensin II causes endothelial dysfunction in the hippocampus in hypertension. Angiotensin II-mediated hippocampal arteriole dysfunction reduces blood flow. Vascular dysfunction in the hippocampus impairs perfusion and memory function.PMID:37817376 ...
Source: The Journal of Alzheimers Association - October 11, 2023 Category: Psychiatry Authors: Olivia Gannon Sarah M Tremble Conor McGinn Ruby Guth Nadia Scoppettone Ryan D Hunt Kirtika Prakash Abbie C Johnson Source Type: research
Primary Aldosteronism
Am Fam Physician. 2023 Sep;108(3):273-277.ABSTRACTPrimary aldosteronism is the underlying cause of hypertension in primary care settings in approximately 6% of cases, and it is even more common in patients with resistant hypertension. However, it is estimated that only about 2% of patients who have risk factors for primary aldosteronism have been formally tested or diagnosed. The first step in the diagnosis of primary aldosteronism is case detection and involves testing patients who are at risk, including individuals with resistant hypertension, as well as those with well-controlled hypertension and a first-degree relative...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Keith B Quencer J B Rugge Olga Senashova Source Type: research
Primary Aldosteronism
Am Fam Physician. 2023 Sep;108(3):273-277.ABSTRACTPrimary aldosteronism is the underlying cause of hypertension in primary care settings in approximately 6% of cases, and it is even more common in patients with resistant hypertension. However, it is estimated that only about 2% of patients who have risk factors for primary aldosteronism have been formally tested or diagnosed. The first step in the diagnosis of primary aldosteronism is case detection and involves testing patients who are at risk, including individuals with resistant hypertension, as well as those with well-controlled hypertension and a first-degree relative...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Keith B Quencer J B Rugge Olga Senashova Source Type: research
Rational Design of Porous Ionic Liquids for Coupling Natural Gas Purification with Waste Gas Conversion
Angew Chem Int Ed Engl. 2023 Sep 14:e202310741. doi: 10.1002/anie.202310741. Online ahead of print.ABSTRACTRemoval of trace impurities for natural gas purification coupled with waste gas conversion is highly desired in industry. We here report a type of porous ionic liquids (PILs) that can realize the continuous flow separation of CH4/CO2/H2S and the conversion of the captured H2S to useful products. The PILs are synthesized through a step-by-step surface modification of ionic liquids (ILs) onto UiO-66-OH nanocrystals. The introduction of free tertiary amine groups on the nanocrystal surface endows these PILs with an excep...
Source: Angewandte Chemie - September 14, 2023 Category: Chemistry Authors: Hailong Ning Mingzhen Shi Qian Yang Jingwei Huang Xiaomin Zhang Youting Wu Kecheng Jie Source Type: research
Rational Design of Porous Ionic Liquids for Coupling Natural Gas Purification with Waste Gas Conversion
Angew Chem Int Ed Engl. 2023 Sep 14:e202310741. doi: 10.1002/anie.202310741. Online ahead of print.ABSTRACTRemoval of trace impurities for natural gas purification coupled with waste gas conversion is highly desired in industry. We here report a type of porous ionic liquids (PILs) that can realize the continuous flow separation of CH4/CO2/H2S and the conversion of the captured H2S to useful products. The PILs are synthesized through a step-by-step surface modification of ionic liquids (ILs) onto UiO-66-OH nanocrystals. The introduction of free tertiary amine groups on the nanocrystal surface endows these PILs with an excep...
Source: Angewandte Chemie - September 14, 2023 Category: Chemistry Authors: Hailong Ning Mingzhen Shi Qian Yang Jingwei Huang Xiaomin Zhang Youting Wu Kecheng Jie Source Type: research
Snake venom toxins: Potential anticancer therapeutics
AbstractSnake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment of these diseases. In this regard, Captopril used in the treatment of cardiovascular diseases was the first animal venom toxin-based drug approved by the US Food and Drug Administration and the European Medicines Agency. Cancers cause morbidity and mortality worldwide. Due to...
Source: Journal of Applied Toxicology - September 12, 2023 Category: Toxicology Authors: Benedict C. Offor,
Lizelle A. Piater Tags: REVIEW ARTICLE Source Type: research
