Network analysis of smoking-related sleep characteristics in Chinese adults
This study aimed to explore the associations between smoking status/intensity and multiple sleep characteristics and to identify the potential core domain of smoking-related sleep using network analysis. Data were obtained from a survey of cancer-related risk factors among Chinese adults. Logistic regression models were used to quantify the associations between sleep characteristics and smoking status/intensity. Network analyses were employed to identify the core sleep characteristics. A total of 5,228 participants with a median age of 44 years old were included in the study. Current smoking was significantly positively as...
Source: Annals of Medicine - March 25, 2024 Category: Internal Medicine Authors: Yuting Xie Peiyuan Sun Huang Huang Jianjun Wu Yue Ba Guoyu Zhou Fangfang Yu Daming Zhang Yaqun Zhang Ranran Qie Zhuolun Hu Kaiyong Zou Yawei Zhang Source Type: research
Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing
AbstractOsteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in unsatisfactory outcomes, particularly for metastatic cases. The tumor microenvironment (TME) has been recognized as a crucial determinant in OS progression. However, the intercellular dynamics between high TP53-expressing OS cells and neighboring cell types within the TME are yet to be thoroughly understood. In our study, we harnessed the single-cell RNA sequencing (scRNA-seq) technology in combination with the computational tool –Cellchat, aiming to elucidate the inter...
Source: Medical Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614)
CONCLUSIONS: Pepinemab (20 mg/kg) is safe, well tolerated and resulted in adequate and sustained target saturation in pediatric patients. Encouraging disease control in two patients with osteosarcoma warrants further investigation with novel combination strategies to modulate the tumor microenvironment and antitumor immune response.CLINICAL TRIAL REGISTRY: This trial is registered as NCT03320330 at Clinicaltrials.gov.DISCLAIMER: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.PMID:38520670 | DOI:10.1002/pbc.30938 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Emily Greengard Robin Williams Branden Moriarity Xiaowei Liu Charles G Minard Joel M Reid Terrence Fisher Elizabeth Evans Desa Rae Pastore Maurice Zauderer Stephan Voss Elizabeth Fox Brenda J Weigel Source Type: research
Physical function patient ‐reported outcomes among adolescent and young adult cancer survivors: A systematic review
ConclusionsThe results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health-related quality of life from a physical function perspective than their cancer-free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross-sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey. (Source: Cancer Medicine)
Source: Cancer Medicine - March 23, 2024 Category: Cancer & Oncology Authors: Sarah Tanner,
Teyl Engstrom,
Cheryl Forbes,
Dhaval Patel,
Wen Ray Lee,
Rick Walker,
Natalie Bradford,
Jason D. Pole Tags: REVIEW Source Type: research
Association between different regional lymph node metastases of papillary thyroid carcinoma in adolescents and young adults
Oncol Lett. 2024 Mar 11;27(5):204. doi: 10.3892/ol.2024.14337. eCollection 2024 May.ABSTRACTAdolescents and young adults (AYA) describe the demographic aged between 15-39 years diagnosed with cancer. This group is particularly at risk of papillary thyroid carcinoma (PTC) with a greater severity compared with other ages. Through comparative design, the present study aimed to quantify central lymph node metastasis (CLNM) risk in AYAs. A total of 463 AYA patients with PTC and 489 patients >39 years old with PTC from Ningbo Medical Center Lihuili Hospital (Ningbo, China) were enrolled. Details such as demographic data, seru...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Lili Wang Yahua Zheng Yingpeng Ye Zhekang Jiang Jinling Lu Gaoxiang Chen Source Type: research
Serious games for mental health promotion in adolescents with chronic diseases: a scoping review
This study aims to synthesize the existing serious games designed to promote mental health in adolescents with chronic illnesses.This study conducted a review following the guidelines of Joanna Briggs Institute and Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. Searches were conducted in databases PubMed, Scopus, Web of Science, Cochrane Library, cumulative index to nursing and allied health literature, PsycINFO, China national knowledge infrastructure Wanfang, VIP Database for Chinese Technical Periodicals and SinoMed from inception to February 12, 2023.A total of 14 stud...
Source: Mental Health Review Journal - March 21, 2024 Category: Psychiatry Authors: Yi Wu Tianxue Long Jing Huang Yiyun Zhang Qi Zhang Jiaxin Zhang Mingzi Li Source Type: research
Humoral and cellular immunity to SARS-CoV-2 following vaccination with non-mRNA vaccines in adolescent/young adults with cancer: A prospective cohort study
CONCLUSION: Among AYA cancer patients, a single non-mRNA vaccine dose confers robust hybrid humoral immunity with limited benefit from a second dose.PMID:38514355 | DOI:10.1016/j.vaccine.2024.03.042 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Archana Sasi Jyotsna Dandotiya Jyotsana Kaushal Shuvadeep Ganguly Akshay Binayke K M Ambika Akshi Shree Farhana Jahan Priyanka Sharma Tejas Menon Suri Amit Awasthi Sameer Bakhshi Source Type: research
Two Case Reports on Financial Toxicity and Healthcare Transitions in Adolescent and Young Adult Cancer Survivors
Clin J Oncol Nurs. 2024 Mar 15;28(2):227-231. doi: 10.1188/24.CJON.227-231.ABSTRACTA team conducted semistructured interviews and developed case reports about financial toxicity (FT) and healthcare transitions (HCTs) with two adolescent and young adult (AYA) cancer survivors. These reports found poor HCTs f.PMID:38511924 | DOI:10.1188/24.CJON.227-231 (Source: Clinical Journal of Oncology Nursing)
Source: Clinical Journal of Oncology Nursing - March 21, 2024 Category: Nursing Authors: Jean Edward Katie Anne Brown Mackenzie Caldwell Elizabeth Ann Ruschman Haafsah Fariduddin Kimberly D Northrip John A D'Orazio Source Type: research
Humoral and cellular immunity to SARS-CoV-2 following vaccination with non-mRNA vaccines in adolescent/young adults with cancer: A prospective cohort study
CONCLUSION: Among AYA cancer patients, a single non-mRNA vaccine dose confers robust hybrid humoral immunity with limited benefit from a second dose.PMID:38514355 | DOI:10.1016/j.vaccine.2024.03.042 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Archana Sasi Jyotsna Dandotiya Jyotsana Kaushal Shuvadeep Ganguly Akshay Binayke K M Ambika Akshi Shree Farhana Jahan Priyanka Sharma Tejas Menon Suri Amit Awasthi Sameer Bakhshi Source Type: research
Two Case Reports on Financial Toxicity and Healthcare Transitions in Adolescent and Young Adult Cancer Survivors
Clin J Oncol Nurs. 2024 Mar 15;28(2):227-231. doi: 10.1188/24.CJON.227-231.ABSTRACTA team conducted semistructured interviews and developed case reports about financial toxicity (FT) and healthcare transitions (HCTs) with two adolescent and young adult (AYA) cancer survivors. These reports found poor HCTs f.PMID:38511924 | DOI:10.1188/24.CJON.227-231 (Source: Clinical Journal of Oncology Nursing)
Source: Clinical Journal of Oncology Nursing - March 21, 2024 Category: Nursing Authors: Jean Edward Katie Anne Brown Mackenzie Caldwell Elizabeth Ann Ruschman Haafsah Fariduddin Kimberly D Northrip John A D'Orazio Source Type: research
