Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Toward a Unified Theory of Why Young People Develop Cancer
Cold Spring Harb Perspect Med. 2024 May 1:a041658. doi: 10.1101/cshperspect.a041658. Online ahead of print.ABSTRACTEpidemiologic and genetic studies have now defined specific patterns of incidence and distinct molecular features of cancers in young versus aging people. Here, I review a general framework for the causes of cancer in children and young adults by relating somatic genetic mosaicism and developmental tissue mutagenesis. This framework suggests how aging-associated cancers such as carcinomas, glioblastomas, and myelodysplastic leukemias are causally distinct from cancers that predominantly affect children and you...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Alex Kentsis Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | PMC:PMC11068426 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | PMC:PMC11068426 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | PMC:PMC11068426 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | PMC:PMC11068426 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Optimizing Communication on HPV Vaccination to Parents of 11- to 14-Year-Old Adolescents in France: A Discrete Choice Experiment
DiscussionUsing DCEs to elicit parents ’ preferences around communication messages, notably on cancer prevention, vaccine coverage and information about vaccine safety, could help to optimize HPV vaccination promotion efforts. (Source: The Patient - Patient-Centered Outcomes Research)
Source: The Patient - Patient-Centered Outcomes Research - May 1, 2024 Category: International Medicine & Public Health Source Type: research
Addressing childhood cancer: actions taken in the Dominican Republic
This report provides a summary of childhood cancer and the efforts made in the Dominican Republic to address child and adolescent cancer in line with the World Health Organization's Global Initiative for Childhood Cancer. Information was obtained by review of recent local and international literature on pediatric oncology. As a result of the Global Initiative, a meeting was held by the Council of Ministers of Health of Central America to support the development of national pediatric cancer plans for each country. The objectives of these plans are to improve overall survival and quality of care for children with cancer thro...
Source: Pan American Journal of Public Health - April 30, 2024 Category: International Medicine & Public Health Authors: Wendy C G ómez García Andelys de la Rosa Vhania Batista Alexandra Matos de Purcell Source Type: research
