Which Aspects of Inflammation are Important in Alzheimer's Disease?
Researchers are coming to see chronic inflammation as an important driving mechanism of Alzheimer's disease, as well as many other age-related conditions. But inflammation is by no means a single, simple state. The immune system is complex, and inflammation is a complex collection of contributions and behaviors undertaken by varied cell populations. Researchers here find a way to gain some insight into which aspects of the inflammatory state are more or less important in the progression of Alzheimer's disease.
Inflammation is a central component of Alzheimer's disease (AD) pathophysiology, downstream of amyloid be...
Source: Fight Aging! - January 24, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
10 Dietary Ways To Stop Cognitive Decline And Memory Loss
The latest research on dietary adjustments that could help to reduce memory loss and lower dementia risk and brain age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 23, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Brain Health in 2030: Navigating Neuroplasticity & the Digital Health Market
Brain Health in 2030: Navigating Neuroplasticity & the Digital Health Market from SharpBrains
Keynote delivered by Álvaro Fernández, CEO of SharpBrains, during corporate retreat.
Key message: Our very human brains and minds are the most sophisticated technology at our disposal, so we should invest more time learning about how they work and harnessing neuroplasticity-based methods ways to improve them, augmented by digital tools –before jumping into invasive interventions.
What’s New:
Lifelong neurogenesis and neuroplasticity
Building Cognitive Reserve
New toolkit & mindset: think Function, not Disease
The ...
Source: SharpBrains - January 23, 2024 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation brain health brain training brain-performance cognitive-enhancement cognitive-health digital health digital medicine digital mental health neuroplasticity Neurotechnology Source Type: blogs
Why People Value Things More When They Cost More (M)
People are more likely to watch an obviously bad movie to the end if they paid $10 to see it, compared with when it is free. Why? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 23, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience subscribers-only Source Type: blogs
Does Peripheral Blood Amyloid- β Contribute to Alzheimer's Disease via Inflammatory Mechanisms?
Amyloid-β is found in the bloodstream and blood vessels as well as in the brain, and an increase in this peripheral amyloid-β is noted in Alzheimer's disease patients who exhibit the characteristic amyloid-β aggregates in their brains. Current thinking is that there is a dynamic equilibrium between amyloid-β in the brain and body, and based on this view some success has been achieved in reducing amyloid-β in the brain by clearing amyloid-β in the rest of the body. Does this peripheral amyloid-β contribute to the onset of Alzheimer's disease in other ways, however? Researchers here suggest that it may increase the bu...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The words we use to talk about pain
Are you a ‘pain sufferer’? A ‘pain warrior’? A ‘pain victim’? Do you ‘ache’ or is it a ‘stabbing’ pain? Do you even know what ‘lancinating’ means?
And let’s add in: are you a ‘catastrophiser’? Has your pain been developed through ‘chronification’? Is your body ‘unbalanced’ or ‘asymmetrical’? Do you ‘comply’ or ‘adhere’? Are you ‘motivated’?
The ways we talk about pain are weird! We blithely use words, us clinicians and researchers (and yes, people with pain)...
Source: HealthSkills Weblog - January 21, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Chronic pain Clinical reasoning Professional topics Resilience/Health Science in practice biopsychosocial healthcare Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How To Approach Exercise in 2024
This article was reviewed by psychologist Fouad Monzer)
The post How To Approach Exercise in 2024 appeared first on Pick the Brain | Motivation and Self Improvement. (Source: PickTheBrain | Motivation and Self Improvement)
Source: PickTheBrain | Motivation and Self Improvement - January 19, 2024 Category: Consumer Health News Authors: Rayen Monzer Tags: featured health and fitness productivity tips exercise Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
OXR1 and Retromer Function in Aging
Researchers here employ a combination of genetic manipulation and calorie restriction in order to find mechanisms that might be important in aging. This leads them to retromer function, where the retromer is a complex system involved in recycling receptor proteins found in the cell membrane. Reduced retromer function leads to changes in cell behavior and survival that contribute to aging and disease. The gene OXR1 is necessary for retromer function, but its expression declines with age, suggesting it as a target for therapies to slow this aspect of age-related cellular dysfunction.
Dietary restriction (DR) delays ...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chronic Inflammation and Mitochondrial Dysfunction Interact in the Production of Sarcopenia
Sarcopenia is the name given to the later stages of the characteristic loss of muscle mass and strength that occurs in every individual with aging, eventually leading to weakness and the state of frailty. There are many possible contributing mechanisms, and those mechanisms interact with one another. One important cause is loss of muscle stem cell activity, but this may be driven by any number of other aspects of aging. Another important contribution is dysfunction of neuromuscular junctions, as loss of innervation tends to have a negative impact on tissue maintenance. This again may be driven by any number of causative me...
Source: Fight Aging! - January 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Step-By-Step Guide To Measuring Sleep
This study provides indirect evidence that the genes predisposing adults to insomnia may also contribute to poor sleep from toddlerhood through adolescence, suggesting the existence of a ‘poor sleeper’ trait that persists throughout a lifetime.
Regardless of our genes, we don’t learn as children how to achieve (the best possible) quality sleep nor understand what good sleep specifically means for us as individuals.
We previously have written about sleep tracking multiple times, you can also check back here for example.
Let’s quickly get over a few basic questions!
Is it fundamental to ...
Source: The Medical Futurist - January 18, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF digital health sleep tracking sleep optimization how to sleep better Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
6 Intriguing Psychology Studies On Human Intelligence
Answers to: Is IQ dropping around the world? Where does human intelligence come from? What are the signs of a high IQ brain? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 17, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Intelligence Source Type: blogs
