A Novel HDAC1/2 Inhibitor Improves Measures of Tissue Function in Aged Mice
Researchers here report on the results of a drug screen focused on mimicking the transcriptional changes that occur in a number of interventions shown to modestly slow aging in short-lived species. They find an inhibitor of histone deacetylases HDAC1 and HDAC2 achieves this outcome, and note that in mice this drug candidate can produce positive changes in a number of measures of tissue function. Further studies will have to explore longer-term effects, dosing, and side-effects. Histone decacetylases influence the structure of the nuclear genome, and thus also influence gene expression quite broadly. Understanding how and w...
Source: Fight Aging! - February 7, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Study Exposes The Hidden Cause Of The Worst Alzheimer ’ s Symptoms (M)
The unforeseen impact of the brain's immune cells on the most perplexing symptoms of Alzheimer's disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 6, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
A intern ’ s journey in delivering tough diagnoses
I was an intern who had recently graduated from medical school with little hands-on experience when the patient signaled me to his bedside. Initially, I did a double-take, wondering if the man would be asking for me. I glanced anxiously at the morning rounds as they hurried to the next patient. I’d just watched my
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A intern’s journey in delivering tough diagnoses originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 6, 2024 Category: General Medicine Authors: Francisco M. Torres, MD Tags: Physician Neurology Source Type: blogs
Rune Labs Unveils $12 Million Strategic Round to Accelerate Adoption of Novel Parkinson ’s Technologies
Brings Total Raised to Over $42 Million
Co-Founder of Nexus NeuroTech and Former Verily President of Medical Devices Jordi Parramon Joins as New Board Member
Rune Labs, a precision neurology software and data company, today announced a strategic round of $12 million, increasing the total amount raised by the company to over $42 million. The round was led by new brain disorder fund, Nexus NeuroTech Ventures, with participation from existing investors, including Eclipse, DigiTx Partners, Moment Ventures, and TruVenturo GmbH. Jordi Parramon, PhD, CEO, General Partner, and Co-Founder of Nexus NeuroTech Ventures and former Pre...
Source: EMR and HIPAA - February 6, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Aspen Neuroscience Benjamin Stecher BlueRock Therapeutics Brian Pepin DigiTx Partners Eclipse Health IT Funding Health IT Fundings Health IT Investment Jordi Parramon Moment Ventures Nexus NeuroTec Source Type: blogs
What is the correlation between number of doctors in a society & health of population ?
This query is lingering ever since I entered the medical profession. Though, this question might appear absurd , no correct answer is found yet .When we search the literature, the relationship between doctors and health can be 1.linear, 2.non linear, and 3. even inverse . 1 & 2 are ok 3 is forbidden.
However, to put it in a nut-shell, healthiness of a society is little to do with Doctor population alone, is well known and I think it needs no proof. The following scattergram gives some idea about the Issue.
Where to get answer for this controversial question ? Great times we are in. We have taught the machine...
Source: Dr.S.Venkatesan MD - February 6, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized doctors health healthcare medicine Source Type: blogs
Treating inflammation provides hope in the fight against Parkinson ’ s
The acceleration of new Parkinson’s disease cases outpaces other age-related conditions, and as a result, the patient population is growing quickly. In 2022 there were about 90,000 new diagnoses in the U.S., versus the previous prevailing estimate of 60,000. While some of the increase can doubtless be attributed to improved diagnostics and improved access to
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Treating inflammation provides hope in the fight against Parkinson’s originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 5, 2024 Category: General Medicine Authors: Ken Blaker Tags: Conditions Neurology Source Type: blogs
Decoding digestive discomfort: the science behind FODMAPs
FODMAPs are Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols.
Digestive discomfort – excessive flatulence, “bloating”, loose stool, or constipation – is a prevalent issue for many, and it often finds its roots in a group of fermentable carbohydrates collectively known as FODMAPs. Understanding the science behind FODMAPs could help in establishing a more comfortable and gratifying relationship with food.
In the realm of our digestive system, envision a system akin to an intricate ecosystem, teeming with activity. Various nutrients act as its constituents, powering this intern...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 5, 2024 Category: Science Authors: David Bradley Tags: Food Health and Medicine Source Type: blogs
Further Exploration of Drainage Pathways for Cerebrospinal Fluid
Considerable progress has been made in recent years in mapping the pathways by which cerebrospinal fluid drains from the brain into the body, many of which were only recently discovered. The present consensus is that the progressive loss of this drainage with advancing age is likely important in the development of neurodegenerative conditions, allowing molecular waste such as amyloid-β to build up in the brain. Researchers here discuss a new branch of the system of cerebrospinal fluid drainage that passes behind the nose. Like the related cribriform plate pathway, this makes it off interest in the development of Alzheimer...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Money ’ s in the Wrong Place. How to Fund Primary Care
By MATTHEW HOLT
I was invited on the Health Tech Talk Show by Kat McDavitt and Lisa Bari and I kinda ranted (go to 37.16 here) about why we don’t have primary care, and where we should find the money to fix it. I finally got around to writing it up. It’s a rant but a rant with a point!
We’re spending way too much money on stuff that is the wrong thing.
30 years ago, I was taught that we were going to have universal health care reform. And then we were going to have capitated at-risk entities. then below that, you have all these tech enabled services, which are going to make all this stuff work an...
Source: The Health Care Blog - February 5, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt ACA ACO CVS FQHCs Health Systems hedge funds Hospitals Medisync primary care Walgreens Walmart Source Type: blogs
Want to Build A Sequencer? 454.bio Opens Up Their Plans
Just as the AGBT hype cycle was firing up (with me contributing multiple sparks), serial entrepreneur Jonathan Rothberg's latest sequencing startup 454.bio fully de-stealthed their technology this weekend, going so far as to release open source plans to build an instrument prototype. 454.bio is aiming to build a Keurig-sized device to retail for $100, with sequencing runs in the $20 range. To accomplish this, they're attempting a novel twist on sequencing-by-synthesis. It's an unconventional strategy by someone who has succeeded twice before in DNA sequencing (454 and Ion Torrent) and has multiple oth...
Source: Omics! Omics! - February 5, 2024 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
poem
Winter BreakAfter the end of year holiday rushWhen nothing is ever enoughNo matter how muchYou think you have given,When innocence is negligence,Extravagance forgets its shameAnd the long con unravelsInto scraps of New Year ’s Eve confetti,We come to the southern beach Ostensibly to be refreshed By the predictableCrashing of waves against a wetGraveyard of broken bones, wavesThat flatten like black tongues And retreat with seized Fragments of old shieldsCeded by soft bodiesForever lost.It ’s too cold in January, even down Here just north of the Tropic of Cancer.We ’re wearing sweaters a...
Source: Buckeye Surgeon - February 5, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
2 Wonderful Mental Skills That Come With Age (M)
While older brains inevitably decline, their owners automatically adopt strategies to use them more efficiently than the young. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 4, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Cognitive Psychology subscribers-only Source Type: blogs
Reverse Brain Aging With This Surprising Juice Hack (M)
After consuming this juice, blood flows more strongly to brain regions involved in the emotions, memory, language and judgement. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 4, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Brain Health subscribers-only Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A dementia patient ’ s poignant return to childhood
I recently watched an Indian movie called The Three of Us, which revolves around a woman named Shelujah. She is in her late 30s, very charming, traditional, and intelligent. She works as a marriage counselor, leading a happy married life with one son studying abroad. Shelujah diligently maintains a diary, documenting even her minor daily
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A dementia patient’s poignant return to childhood originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 2, 2024 Category: General Medicine Authors: Dr. Damane Zehra Tags: Conditions Neurology Source Type: blogs
