Skin Biopsy as an Approach to Diagnose Parkinson's Disease
Researchers here demonstrate that the presence of phosphorylated α-synuclein in a skin biopsy is a good indicator of the presence of Parkinson's disease and other synucleinopathies. A skin biopsy is a more invasive procedure than most people want to undergo, but a greater ability to diagnose progressive diseases in their early stages will nonetheless tend to encourage the development of a greater ability to manage, treat, and avoid the later stages.
Affecting an estimated 2.5 million people in the United States, the synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple syst...
Source: Fight Aging! - April 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Transient Pockets of Hypoxia in the Mammalian Brain
Evidence suggests that the mammalian brain is operating at the very edge of its capacity, supplied with just enough oxygen and nutrients to barely get by. That exercise produces measurable short-term gains in cognitive function, while blood flow is increased, is one point in favor of this view. Another is provided here, in which researchers note that it is entirely normal to observe transient areas of hypoxia in the brain at rest, and that the occurrence of these regions is diminished by the increased blood flow of exercise. It is an open question as to what to do with this finding: we can imagine future technologies that ...
Source: Fight Aging! - April 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Remarkably Simple Treatment Reverses Brain Damage In Parkinson ’ s (M)
Parkinson’s is characterised by problems with cognition and movement — often a slow shaking of the hand, arm, foot or leg. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 4, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Parkinson's subscribers-only Source Type: blogs
Does Herpes Simplex Virus cause Alzheimer ’ s Disease?
by Gertrud U. Rey Alzheimer’s Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Although its exact cause is unclear, an increasing body of evidence suggests that an infection with herpes simplex virus (HSV) may contribute to onset of AD later in life. Both types of HSV (HSV-1 and HSV-2) infect … Does Herpes Simplex Virus cause Alzheimer’s Disease? Read More » (Source: virology blog)
Source: virology blog - April 4, 2024 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey alzheimer's disease amyloid beta amyloid plaque APOE-ɛ4 association causation cognitive defect cognitive function correlation dementia herpes simplex virus herpes simplex virus 1 herpesvirus mechan Source Type: blogs
Using mRNA to Generate Therapeutic Antibodies in the Brain
It may turn out to be cost-effective to replace delivery of therapeutic monoclonal antibodies with delivery of messenger RNA (mRNA), encapsulated in a lipid nanoparticle or linked to a cell penetrating molecule of some sort in order to reach the desired tissues and be taken up into the cytoplasm. Researchers here consider this in the context of treating Alzheimer's disease, where the primary thrust of therapeutic development involves the use of antibodies targeting the various protein aggregates thought to contribute to disease progression.
Monoclonal antibodies have emerged as a leading therapeutic agent for the ...
Source: Fight Aging! - April 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dephosphorylation-Targeting Chimeras to Clear Tau Aggregates in Alzheimer's Disease
Researchers here describe an interesting evolution of proteolysis targeting chimera (PROTAC) technology into a form that upregulates the dephosphorylation of tau protein. Tau becomes pathogenic in the aging brain when hyperphosphorylated, and thus reducing it back to its unphosphorylated form should provide benefits to patients in tauopathies such as Alzheimer's disease. The PROTAC style of approach, when applied to this situation, is to produce a molecule capable of binding to phosphorylated tau at one end and a phosphatase at the other. By encouraging phosphatase molecules into close proximity to phosphorylated tau, the ...
Source: Fight Aging! - April 4, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Technobabble To English: A Buzzword Guide For Medical AI And Digital Health
Navigating AI in medicine and digital health can feel like ordering a coffee at that new hipster café downtown: exciting yet slightly overwhelming with a menu that seems to be in a different language. A while ago we published a buzzword dictionary to help you decode the most frequently repeated terms. Back then artificial intelligence and machine learning were rarely heard exotic expressions, but as quite a few years have passed, a whole new set of mambo-jambo emerged, waiting to be explained.
You’re probably sick of hearing the latest digital health buzzwords without any actual context, so let’s translat...
Source: The Medical Futurist - April 4, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine buzzword AI in medicine generative AI in medicine Source Type: blogs
Breaking through the cobwebs of dementia
“Some memories are unforgettable, remaining ever vivid and heartwarming!” – Joseph B. Wirthlin I love my role as a hospice volunteer mostly because I enjoy meeting the patients and hearing their life stories. I heard a tale from the Vietnam vet who won the Congressional Medal of Honor, which he humbly said was for “just
Read more…
Breaking through the cobwebs of dementia originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 3, 2024 Category: General Medicine Authors: Althea Halchuck, EJD Tags: Conditions Neurology Source Type: blogs
How To Reduce The Harmful Effects Of Neuroticism
Neuroticism is a personality trait that is strongly linked to anxiety, sadness, irritability and self-consciousness. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 3, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Anxiety Source Type: blogs
The Best Lifestyle Change To Prevent Cognitive Decline
It takes 20-30 years for the brain changes leading to Alzheimer's to occur. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 2, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Chronic Pain Accelerates Brain Aging, Perhaps via Inflammation
A range of conditions produce chronic pain in muscle and skeletal tissue. While conditions such as osteoathritis are comparatively well understood, the etiology of chronic muscular pain disorders such as myofascial pain syndrome is poorly understood and treatment options are consequently limited. Here, researchers analyze available epidemiological data on knee osteoarthritis, and show that it suggests an inflammatory link between chronic pain and an accelerated pace of degenerative brain aging.
Individuals suffering from chronic musculoskeletal pain (CMP) may face a higher high risk of brain aging. CMP is a leadin...
Source: Fight Aging! - April 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lewy Body Disease May Be More Common than Thought
Access to human brain tissue for medical research is more limited than most people realize is the case, and, for obvious reasons, far too little of the available tissue data covers the early stages of disease. This limitation is one of the factors slowing the pace of research into age-related neurodegenerative conditions. Here, for example, researchers make use of an unusual resource to show that the prevalence of Lewy body disease may be greater than presently thought, with pathology beginning in the 50s, even if there are no outright symptoms of disease at that stage.
Lewy body disease is the second most common ...
Source: Fight Aging! - April 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Problematic B Cells Accumulate in Visceral Fat and Indirectly Provoke Inflammation
The authors of today's open access paper present an interesting and novel way in which visceral fat tissue provokes chronic inflammation. It has been noted that dysfunctional B cells accumulate with age. Here, dysfunctional B cells of a specific subtype are shown to accumulate in aged visceral fat tissue, acting to provoke other immune cells in visceral fat tissue, such as macrophages, into a more pro-inflammatory state. The researchers demonstrate that removing the B cell population helps to reduce the age-related inflammation generated by visceral fat by removing the contribution to inflammatory macrophage behavior.
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Source: Fight Aging! - March 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Long and Tortured History of Alpha-Synuclein and Parkinson ’s Disease
This study tracks the decades-long journey to harness alpha-synuclein as a treatment for Parkinson’s disease. Steven Zecola an activist who tracks Parkinson’s research and was on THCB last month discussing it, offers three key changes needed to overcome the underlying challenges.
A Quick Start for Alpha-Synuclein R&D
In the mid-1990’s, Parkinson’s patient advocacy groups had become impatient by the absence of any major therapeutic advances in the 25 years since L-dopa had been approved for Parkinson’s disease (PD).
The Director of National Institute of Neurological Disorders and Stroke (NINDS) se...
Source: The Health Care Blog - March 29, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Parkinson's Disease Steven Zecola Source Type: blogs
