Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Senescent cells are created throughout the body at all stages of life, largely when somatic cells reach the Hayflick limit on replication. Senescent cells cease replication and begin to energetically produce pro-growth, pro-inflammatory factors, attracting the attention of the immune system and otherwise changing the behavior of surrounding cells. Cell stress and mutational damage can induce senescence, and in this case senescence is a mechanism that acts to limit the risk of cancer. Tissue injury also produces senescent cells, and here they help to coordinate the activities of the many different cell types that become inv...
Source: Fight Aging! - December 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Unlocking the power of open-minded conversations
An excerpt from From Hurting to Healing: Delivering Love to Medicine and Healthcare. Before we speak Many people enter a conversation with preconceived ideas of how it will go. We constantly make assumptions, and our brains often jump to conclusions based on experience, previous interactions with a particular person, our current emotional state, and our
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Unlocking the power of open-minded conversations originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 26, 2023 Category: General Medicine Authors: Dr. Simon Craig Tags: Physician OB/GYN Source Type: blogs
10 Most Surprising Psychology Studies Of 2023
Can an old brain learn at the same rate as a young one? Do the selfish prefer to exploit the selfless? Some surprising answers to these, and more questions revealed. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 25, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Most popular Source Type: blogs
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative diseases such as Alzheimer's disease, produced long-lasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer's disease. Furthermore, we found that the prevention of memory deficits was mediated through the upregulation of neuronal arborization and spine density, as well as an increase in brain-derived neurotrophic factor (BDNF). A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer's disease model mice caused complete ...
Source: Fight Aging! - December 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Adjustment of the Gut Microbiome to Slow Aging
This paper makes the reasonable argument that means of modestly slowing aging will emerge from ways to reverse age-related changes in the varied microbial populations making up the gut microbiome. The gut microbiome changes with age, in ways that provoke chronic inflammation while also diminishing the supply of metabolites necessary for tissue function. Given the evidence generated from human and animal studies over the past decade, it is reasonable to think that the gut microbiome has as much influence on the course of long-term health as lifestyle choices relating to diet and exercise.
Aging is a complex natural...
Source: Fight Aging! - December 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
