Inflammatory Microglia in Degenerative Aging and Alzheimer's Disease
Microglia, the innate immune cells of the central nervous system, can enter an aggressive, inflammatory state in response to the presence of molecular waste, inflammatory signaling, mitochondrial damage, and so forth. They can also become senescent, which is also a pro-inflammatory state. The aging brain, and particularly the brains of patients with neurodegenerative conditions, exhibit a state of chronic inflammation, producing dysfunction, cell stress, and cell death. It remains to be seen as to how effective anti-inflammatory therapies targeting microglia will be in the treatment of neurodegenerative conditions and the ...
Source: Fight Aging! - January 3, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Calorie Restriction Mimetics as an Approach to Slow Demyelination
Myelin sheathes axons, the connections between neurons. This sheath is essential to nervous system function, and a range of unpleasant diseases result from loss of myelin, such as through the autoimmune activity of multiple sclerosis. Demyelination occurs to a lesser degree over the course of aging, the standard problem of a complex system becoming disarrayed as the result of various forms of molecular damage and maladaptive reactions to that damage. Here, as elsewhere, chronic inflammation appears to be a contributing cause. Calorie restriction is known to dampen chronic inflammation and favorably alter the behavior of ce...
Source: Fight Aging! - January 3, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Trial By Error: Update on NICE Response to “ Anomalies ” Paper; Higher ME/CFS Population Estimates in CDC Survey
By David Tuller, DrPH In July, the Journal of Neurology, Neurosurgery and Psychiatry published a “whine de coeur” called “Anomalies in the review process and interpretation of the evidence in the NICE guideline for chronic fatigue syndrome and myalgic encephalomyelitis.” The lead author was Professor Peter White, lead author of the discredited and arguably fraudulent … Trial By Error: Update on NICE Response to “Anomalies” Paper; Higher ME/CFS Population Estimates in CDC Survey Read More » (Source: virology blog)
Source: virology blog - January 3, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized anomalies CDC JNNP Source Type: blogs
Failing Mitochondrial Quality Control in Aging and Neurodegeneration
Every one of our cells contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now fully integrated into our biochemistry. Mitochondria contain their own small remnant genome, the mitochondrial DNA, replicate like bacteria, and toil to produce adenosine triphosphate (ATP), a chemical energy store molecule used to power cell processes. Mitochondrial function declines with age, unfortunately, and our cells suffer for it. This contributes meaningfully to many age-related conditions. This decline appears to result in large part from changes in gene expression that impair the various quality control pro...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Some fun brain teasers to warm up 2024 … Happy New Year, ¡Feliz Año Nuevo!
The post Some fun brain teasers to warm up 2024 … Happy New Year, ¡Feliz Año Nuevo! appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - January 2, 2024 Category: Neuroscience Authors: SharpBrains Tags: Brain Teasers fun brain teasers Source Type: blogs
A Tongue Twister's Guide to Mastering Anatomy Pronunciation | Winter Shorts | TAPP 145
Episode 145 of The A&P Professor podcast is one of ourwinter shorts, where I replay interesting segments from previous episodes. In this one, you ' ll hear about the trials and tribulations of teaching and learningpronunciations of anatomy and physiology terminology. Including why the instructor is ALWAYS correct!00:00 | Introduction01:07 | Variations in Anatomy& Physiology Pronunciations10:24 | Say Anatomy& Physiology Terms Out Loud20:30 | Staying Connected★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-145.html🏅 Apply for your credential (badge/certificate)...
Source: The A and P Professor - January 2, 2024 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Personality Trait Is A Sign Of High Fluid Intelligence
Fluid intelligence refers to the raw speed at which the brain works. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 31, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Intelligence Personality Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Econoclasm Chapter Two, continued: " Insurance "
Health insurance – again I’m using
the term because everybody else does, not because I think it’s accurate – can
work in many ways. One of the most important broad dimensions is how the
benefit gets delivered. ·Indemnity
plans are the most like fire insurance. They pay money when the beneficiary
incurs medical expenses. (The money could be paid to the beneficiary, or
directly to the provider. That doesn ’t much matter.)·Service
benefit plans have negotiated arrangements with providers to pay them a
certain amount for a given service, when it is provided.·Service
delivery plans actually provide the s...
Source: Stayin' Alive - December 28, 2023 Category: American Health Source Type: blogs
Amyloid- β Specific Regulatory T Cells to Treat Alzheimer's Disease
T cells of the adaptive immune system do find their way into the brain to some degree, even given the existence of the blood-brain barrier that separates the brain from the vasculature. Researchers here report on an effort to engineer regulatory T cells to recognize amyloid-β, associated with the onset of Alzheimer's disease. In an animal model of Alzheimer's disease, mice engineered to generate amyloid-β aggregates, these engineered regulatory T cells reduced the resulting pathology by migrating into the brain and dampening the maladaptive inflammatory responses characteristic of neurodegenerative conditions.
R...
Source: Fight Aging! - December 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Lifestyle Matters: Let ’s optimize cognition, health and life in 2024
Welcome to a new edition of SharpBrains e‑newsletter, featuring fascinating research findings on lifestyle, protective brain structures, Internet access, mental health, brain imaging, and more.
#1. Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
“Actor Chris Hemsworth…watched his grandfather live with Alzheimer’s and is making lifestyle changes after learning he has two copies of the APOE4 gene. This gene is a risk factor for Alzheimer’s, and having two copies significantly increases his risk of developing the same condition.” (Smart move reg...
Source: SharpBrains - December 27, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health SharpBrains Monthly eNewsletter Technology & Innovation adhd Alzheimer’s APOE4 gene Brain-Imaging dementia symptoms frontotemporal dementia lifestyle Neurophet Source Type: blogs
