Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ambience Healthcare Raises $70M to Scale the Most Comprehensive AI Operating System for Healthcare Organizations
Ambience Healthcare, the most comprehensive AI operating system for healthcare organizations, has announced a $70M Series B raise co-led by Kleiner Perkins and OpenAI Startup Fund. The raise also includes existing investors Andreessen Horowitz and Optum Ventures.
“Healthcare is one of AI’s most promising opportunities to create an outsized positive impact on the world. Ambience Healthcare has built an incredible team to focus on providing a complete ecosystem of products that seamlessly fit into the workflow of practitioners, pushing both AI and medicine forward,” said Brad Lightcap, COO at OpenAI and...
Source: EMR and HIPAA - February 23, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AdvancedMD Ambience Healthcare Andreessen Horowitz athenahealth Brad Lightcap Cerner Dr. Priti Patel eClinicalWorks eCW Elation Epic Eventus WholeHealth GI Alliance Health IT Funding Health Source Type: blogs
RNA Transfer Between Cells is Tightly Regulated, and Disruption Shortens Life Span
It is not always the case that genetic alterations that shorten life span are interesting: there are many ways to break a complex system, and only some of those breakages are relevant to the dysfunction of aging. Researchers here explore the transfer of RNA between cells in nematode worms, showing that too much RNA uptake causes reduced life span. Is this relevant to aging, however? Most likely only if this set of regulatory processes become changed in maladaptive ways in later life. Otherwise, this is just another one of the countless different ways to break the complex regulatory systems of a living organism.
In...
Source: Fight Aging! - February 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Unexpected Twist In How Your Brain Recalls Traumatic Events (M)
What people remember most from distressing events is not what you'd think. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 22, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: PTSD subscribers-only Source Type: blogs
Digital Health, Menopause, And The $150 Billion Ignorance
The idea of this story came from personal experience. During the past year, I have spent countless hours and a bucketload of money trying to figure out what the heck is wrong with my health. I was feeling worse and worse, having various symptoms, totally inexplicable with my impeccable test results. During this journey, not a single doctor asked or suggested that my symptoms may come from entering perimenopause – the stage of life of women preceding menopause.
I am 47 years old, and as I have learned since then, extremely average in starting to have perimenopause symptoms at the age of 47. Also very average ...
Source: The Medical Futurist - February 22, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Lifestyle medicine female health menopause tech Source Type: blogs
How social media alters young brains [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join Marc Arginteanu, a neurosurgeon, as we delve into a 2023 study revealing the alarming effects of social media and electronic addiction on the developing brains of middle school-aged children. Discover the intricacies of the study’s findings, the connection between TikTok
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How social media alters young brains [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 22, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Pediatrics Source Type: blogs
Beyond opioids: a new hope for chronic pain relief
Opioids work through the mu opiate receptors throughout the body and brain, dampening pain signals being sent through the peripheral nervous system and spinal cord. It also acts on the ventral tegmental area, causing the release of dopamine in the nucleus accumbens, creating a sensation of euphoria. It is this euphoric effect that seems to
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Beyond opioids: a new hope for chronic pain relief originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 21, 2024 Category: General Medicine Authors: L. Joseph Parker, MD Tags: Meds Pain Management Source Type: blogs
Circulating Claudin-5 Correlates with Age and Alzheimer's Disease
In this study, we developed a blood-based assay for CLDN-5 and investigated its diagnostic utility using 100 cognitively normal (control) subjects, 100 patients with MCI, and 100 patients with AD. Plasma CLDN-5 levels were increased in patients with AD (3.08 ng/mL) compared with controls (2.77 ng/mL).
The BBB functions as a selective gate for the uptake of essential molecules from blood into the brain and the excretion of harmful molecules from the brain into blood via transporters and receptors on cellular membranes. In addition, the BBB prevents the influx of blood-borne neurotoxins, cells, and pathogens into the ...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Best books on cognitive ability and skills according to ChatSpot and ChatGPT
As a follow-up to the article Best books on brain health and cognitive fitness according to ChatSpot and ChatGPT we decided to find out what these popular AI chatbots say about books to understand and improve cognitive ability and skills.
Here you are:
(Links open corresponding Amazon book pages)
Best books on cognitive ability and skills, per ChatSpot:
Here are some highly recommended books on cognitive ability and skills:
1. “Thinking, Fast and Slow” by Daniel Kahneman: This book explores the two systems of thinking that drive our decision-making processes and provides insights into cognitive biases and how to improv...
Source: SharpBrains - February 21, 2024 Category: Neuroscience Authors: SharpBrains Tags: Books Education & Lifelong Learning Brain Teasers Brain-Plasticity ChatGPT ChatSpot cognitive biases cognitive-abilities cognitive-ability cognitive-skills decision-making-skills Source Type: blogs
Astrocyte Reactivity in the Development of Alzheimer's Disease
Glial fibrillary acidic protein (GFAP) consistently shows up in proteomic analyses of age-related neurodegenerative processes, particularly now that more research groups are engaged in building early warning biomarker profiles for the later development of Alzheimer's disease. Such studies are usually focused on Alzheimer's disease because that is where most neuroscience funding is directed, but the presence of GFAP as a marker is more generally applicable to the aging of the brain and its supporting cell populations.
Astrocyte cells exhibit increased expression of GFAP when they become reactive, it is a well-known m...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
More Visceral Fat, Greater Cognitive Decline in Later Life
Modern studies of the effects of excess body weight on long term health use measures, such as waist circumference or weight-adjusted waist index, that are more sensitive to visceral fat than subcutaneous fat. Excess visceral fat in the abdomen is actively harmful, in large part via causing an increased level of chronic inflammation via a variety of distinct mechanisms. Chronic inflammation accelerates the onset and drives the progression of neurodegenerative conditions, and thus might be expected to correlate with cognitive decline.
Some studies suggest that excessive obesity can lead to cognitive decline and deme...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Circulating Protein Biomarkers Correlate with Future Risk of Dementia
Researchers here demonstrate a predictive biomarker panel for Alzheimer's disease risk based on protein levels assessed in a blood sample. This is a one of a number of similar tests developed in recent years. The question is what one might do given a measurement that suggests high risk of Alzheimer's disease. At present, the only option is to generally improve lifestyle choices, but Alzheimer's is not as correlated with lifestyle factors as is the case for, say, type 2 diabetes. Based on the suggestion that senescent cells are important to neurodegeneration, one might take senolytic drugs intermittently, a few times a year...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
To What Degree is Alzheimer's Disease a Modern Phenomenon?
Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer's disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer's disease is a creation of modernity, some combination of a longer life expectancy for a greater fraction of the population coupled with increased calorie intake and less active lives. Yet unlike type 2 diabetes, risk of Alzheimer's risk doesn't correlate well with the usual suspect lifestyle choices that raise the risk of age-related disease and lower life expectancy.
This line of thinking has l...
Source: Fight Aging! - February 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The 7 Decade History of ChatGPT
By MIKE MAGEE
Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.”
This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs
The difficult balance between evidence-based healthcare … and person-centred self-management
For decades I’ve been an advocate for evidence-based healthcare because the alternative is ’eminence-based healthcare’ (for healthcare, read ‘medicine’ in the original!). Eminence-based healthcare is based on opinion and leverages power based on a hierarchy from within biomedicine (read this for more!). EBHC appealed because in clinical practice I heard the stories of people living with chronic pain who had experienced treatment after treatment of often invasive and typically unhelpful therapies, and EBHC offered a sifting mechanism to filter out the useless from the useful.
Where has EBHC...
Source: HealthSkills Weblog - February 18, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Coping strategies Pain conditions Professional topics Research Science in practice pain management Therapeutic approaches Source Type: blogs
