Why People Value Things More When They Cost More (M)
People are more likely to watch an obviously bad movie to the end if they paid $10 to see it, compared with when it is free. Why? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 23, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience subscribers-only Source Type: blogs
Does Peripheral Blood Amyloid- β Contribute to Alzheimer's Disease via Inflammatory Mechanisms?
Amyloid-β is found in the bloodstream and blood vessels as well as in the brain, and an increase in this peripheral amyloid-β is noted in Alzheimer's disease patients who exhibit the characteristic amyloid-β aggregates in their brains. Current thinking is that there is a dynamic equilibrium between amyloid-β in the brain and body, and based on this view some success has been achieved in reducing amyloid-β in the brain by clearing amyloid-β in the rest of the body. Does this peripheral amyloid-β contribute to the onset of Alzheimer's disease in other ways, however? Researchers here suggest that it may increase the bu...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The words we use to talk about pain
Are you a ‘pain sufferer’? A ‘pain warrior’? A ‘pain victim’? Do you ‘ache’ or is it a ‘stabbing’ pain? Do you even know what ‘lancinating’ means?
And let’s add in: are you a ‘catastrophiser’? Has your pain been developed through ‘chronification’? Is your body ‘unbalanced’ or ‘asymmetrical’? Do you ‘comply’ or ‘adhere’? Are you ‘motivated’?
The ways we talk about pain are weird! We blithely use words, us clinicians and researchers (and yes, people with pain)...
Source: HealthSkills Weblog - January 21, 2024 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Chronic pain Clinical reasoning Professional topics Resilience/Health Science in practice biopsychosocial healthcare Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How To Approach Exercise in 2024
This article was reviewed by psychologist Fouad Monzer)
The post How To Approach Exercise in 2024 appeared first on Pick the Brain | Motivation and Self Improvement. (Source: PickTheBrain | Motivation and Self Improvement)
Source: PickTheBrain | Motivation and Self Improvement - January 19, 2024 Category: Consumer Health News Authors: Rayen Monzer Tags: featured health and fitness productivity tips exercise Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
OXR1 and Retromer Function in Aging
Researchers here employ a combination of genetic manipulation and calorie restriction in order to find mechanisms that might be important in aging. This leads them to retromer function, where the retromer is a complex system involved in recycling receptor proteins found in the cell membrane. Reduced retromer function leads to changes in cell behavior and survival that contribute to aging and disease. The gene OXR1 is necessary for retromer function, but its expression declines with age, suggesting it as a target for therapies to slow this aspect of age-related cellular dysfunction.
Dietary restriction (DR) delays ...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chronic Inflammation and Mitochondrial Dysfunction Interact in the Production of Sarcopenia
Sarcopenia is the name given to the later stages of the characteristic loss of muscle mass and strength that occurs in every individual with aging, eventually leading to weakness and the state of frailty. There are many possible contributing mechanisms, and those mechanisms interact with one another. One important cause is loss of muscle stem cell activity, but this may be driven by any number of other aspects of aging. Another important contribution is dysfunction of neuromuscular junctions, as loss of innervation tends to have a negative impact on tissue maintenance. This again may be driven by any number of causative me...
Source: Fight Aging! - January 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Step-By-Step Guide To Measuring Sleep
This study provides indirect evidence that the genes predisposing adults to insomnia may also contribute to poor sleep from toddlerhood through adolescence, suggesting the existence of a ‘poor sleeper’ trait that persists throughout a lifetime.
Regardless of our genes, we don’t learn as children how to achieve (the best possible) quality sleep nor understand what good sleep specifically means for us as individuals.
We previously have written about sleep tracking multiple times, you can also check back here for example.
Let’s quickly get over a few basic questions!
Is it fundamental to ...
Source: The Medical Futurist - January 18, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF digital health sleep tracking sleep optimization how to sleep better Source Type: blogs
The Inflammasome as a Target for the Next Generation of Anti-Inflammatory Therapies
With advancing age, a wide range of mechanisms act to provoke the immune system into a state of constant inflammatory signaling and activation. Age-related mitochondrial dysfunction leads to mislocalized mitochondrial DNA fragments that trigger the cGAS-STING pathway to provoke inflammation. Senescent cells produce pro-inflammatory signaling, and their numbers increase with age. Visceral fat tissue produces signaling similar that resulting from infected cells. The increased presence of protein aggregates aggravates immune cells inside and outside of the brain. And so forth. Given all of this, actually fixing the issue of a...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
6 Intriguing Psychology Studies On Human Intelligence
Answers to: Is IQ dropping around the world? Where does human intelligence come from? What are the signs of a high IQ brain? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 17, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Intelligence Source Type: blogs
Research Organism Superheroes: Fruit Flies
Credit: iStock.
Those pesky little bugs flying around the overripe bananas in your kitchen may hold the key to understanding something new about how our bodies work. That’s right, the fruit fly (Drosophila melanogaster) is a widely used research organism in genetics because of its superpower of reproducing quickly with similar genes to people.
Researchers have been studying fruit flies for over a century for many reasons. First, they’re easy to please—just keep them at room temperature and feed them corn meal, sugar, and yeast (or those bananas on your counter!). Second, they reproduce more quickly and have shor...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Tools and Techniques Cool Creatures Research Organisms Source Type: blogs
Ppp1r17 Upregulation in the Hypothalamus Slows the Aging of Metabolism in Mice
Researchers here describe a specific issue in the aging of metabolism connected to the activity of Ppp1r17 in the hypothalamus in the brain. This affects the sympathetic nervous system, leading to reduced innervation of fat tissue, which in turn negatively affects many tissues via altered availability of circulating nutrients, signal molecules, and the like. The researchers note a few points at which they can intervene to stop this decline, either Ppp1r17 in the brain, or the circulating molecule eNAMPT released by fat cells. The effect size on life span in mice is modest, and there is the remaining question of why this de...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Suppressing Inflammatory Activity of Supporting Cells in the Brain as a Treatment for ALS
Constant, unresolved inflammatory behavior in the supporting cells of the brain is implicated in the pathology of diverse neurodegenerative conditions. Here, researchers find that dampening this inflammation can help restore function in animal models of amyotrophic lateral sclerosis (ALS). This joins many other conceptually similar demonstrations conducted in the laboratory for a range of different neurodegenerative diseases. It remains to be seen as to how well these anti-inflammatory strategies will perform in human clinical trials.
ALS is caused by the loss of upper motor neurons, located in the brain, and lowe...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Vulnerable Defendants and Neuroscience in Courtrooms Worldwide
Deborah W. Denno (Fordham University), Vulnerable Defendants and Neuroscience in Courtrooms Worldwide (Fordham L. Legal Stud. Rsch. Paper No. 4647101) (2023): This chapter examines how different criminal justice systems treat vulnerable defendants through a comparative analysis of empirical research on... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 17, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
